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All sourcesNASA NTRSDOE OSTI
NASA NTRS2022

Coordinating Innovative Technology Development at NASA

Innovation requires continually using and coordinating new knowledge on the current, anticipated, and even unanticipated developments in a given area. You do not want to simply repeat what others are doing, so you must remain aware of other activities in your area of interest. You also have to maintain awareness of where the cutting edge is, because the limit of what’s possible is continually pushed and redefined. Finally, “smart” innovation involves not only seeking innovative solutions to anticipated problems but also being prepared to respond to unanticipated problems or even unanticipated solutions. As the leading U.S. agency for aeronautics development, cutting-edge scientific discovery, and human space exploration, the National Aeronautics and Space Administration (NASA) must remain at the forefront of innovation. NASA enables innovation in technology development through a coordinated effort among its internal mission directorates and its partners in government, commercial, and academic sectors. As an independent office, NASA’s Office of Technology, Policy, and Strategy (OTPS) provides the coordination effort necessary to ensure innovation. OTPS uses and coordinates inputs from a broad community of experts. With these inputs, OTPS identifies and communicates shared needs and opportunities for partnership. OTPS provides strategic advice to synergize and ultimately facilitate innovative technology development both within and outside NASA. This paper summarizes NASA’s approach to ensuring innovation through a deliberately coordinated effort. In this paper, we first provide examples of how this coordination has enabled innovative technology development. We then describe how NASA’s mission directorates use input from a broad community of experts to inform innovative technology development. Finally, we describe OTPS’s role in coordinating inputs from both internal and external experts, including standardizing communication about technology developments, facilitating conversations with external partners on shared technology needs and solutions, and advising on strategies and policies to ensure innovative technology development. This paper can help members of the aerospace community understand their role in NASA’s innovation efforts and how to engage OTPS in conversations about potential partnership.

Erica Rodgers↗
NASA NTRSDate not supplied

Coordinating Innovative Technology Development at NASA

Innovation requires continually using and coordinating new knowledge on the current, anticipated, and even unanticipated developments in a given area. You do not want to simply repeat what others are doing, so you must remain aware of other activities in your area of interest. You also have to maintain awareness of where the cutting edge is, because the limit of what’s possible is continually pushed and redefined. Finally, “smart” innovation involves not only seeking innovative solutions to anticipated problems but also being prepared to respond to unanticipated problems or even unanticipated solutions. As the leading U.S. agency for aeronautics development, cutting-edge scientific discovery, and human space exploration, the National Aeronautics and Space Administration (NASA) must remain at the forefront of innovation. NASA enables innovation in technology development through a coordinated effort among its internal mission directorates and its partners in government, commercial, and academic sectors. As an independent office, NASA’s Office of Technology, Policy, and Strategy (OTPS) provides the coordination effort necessary to ensure innovation. OTPS uses and coordinates inputs from a broad community of experts. With these inputs, OTPS identifies and communicates shared needs and opportunities for partnership. OTPS provides strategic advice to synergize and ultimately facilitate innovative technology development both within and outside NASA. This paper summarizes NASA’s approach to ensuring innovation through a deliberately coordinated effort. In this paper, we first provide examples of how this coordination has enabled innovative technology development. We then describe how NASA’s mission directorates use input from a broad community of experts to inform innovative technology development. Finally, we describe OTPS’s role in coordinating inputs from both internal and external experts, including standardizing communication about technology developments, facilitating conversations with external partners on shared technology needs and solutions, and advising on strategies and policies to ensure innovative technology development. This paper can help members of the aerospace community understand their role in NASA’s innovation efforts and how to engage OTPS in conversations about potential partnership.

Erica Rodgers↗
NASA NTRSDate not supplied

Coordinating Innovative Technology Development at NASA

Innovation requires continually using and coordinating new knowledge on the current, anticipated, and even unanticipated developments in a given area. You do not want to simply repeat what others are doing, so you must remain aware of other activities in your area of interest. You also have to maintain awareness of where the cutting edge is, because the limit of what’s possible is continually pushed and redefined. Finally, “smart” innovation involves not only seeking innovative solutions to anticipated problems but also being prepared to respond to unanticipated problems or even unanticipated solutions. As the leading U.S. agency for aeronautics development, cutting-edge scientific discovery, and human space exploration, the National Aeronautics and Space Administration (NASA) must remain at the forefront of innovation. NASA enables innovation in technology development through a coordinated effort among its internal mission directorates and its partners in government, commercial, and academic sectors. As an independent office, NASA’s Office of Technology, Policy, and Strategy (OTPS) provides the coordination effort necessary to ensure innovation. OTPS uses and coordinates inputs from a broad community of experts. With these inputs, OTPS identifies and communicates shared needs and opportunities for partnership. OTPS provides strategic advice to synergize and ultimately facilitate innovative technology development both within and outside NASA. This paper summarizes NASA’s approach to ensuring innovation through a deliberately coordinated effort. In this paper, we first provide examples of how this coordination has enabled innovative technology development. We then describe how NASA’s mission directorates use input from a broad community of experts to inform innovative technology development. Finally, we describe OTPS’s role in coordinating inputs from both internal and external experts, including standardizing communication about technology developments, facilitating conversations with external partners on shared technology needs and solutions, and advising on strategies and policies to ensure innovative technology development. This paper can help members of the aerospace community understand their role in NASA’s innovation efforts and how to engage OTPS in conversations about potential partnership.

Erica Rodgers↗
DOE OSTI2019

Designer quantum materials

Quantum materials have long promised to revolutionize everything from energy transmission (high temperature superconductors) to both quantum and classical information systems (topological materials). However, their discovery and application has proceeded in an Edisonian fashion due to both an incomplete theoretical understanding and the difficulty of growing and purifying new materials. This project leverages Sandia's unique atomic precision advanced manufacturing (APAM) capability to design small-scale tunable arrays (designer materials) made of donors in silicon. Their low-energy electronic behavior can mimic quantum materials, and can be tuned by changing the fabrication parameters for the array, thereby enabling the discovery of materials systems which can't yet be synthesized. In this report, we detail three key advances we have made towards development of designer quantum materials. First are advances both in APAM technique and underlying mechanisms required to realize high-yielding donor arrays. Second is the first-ever observation of distinct phases in this material system, manifest in disordered 2D sheets of donors. Finally are advances in modeling the electronic structure of donor clusters and regular structures incorporating them, critical to understanding whether an array is expected to show interesting physics. Combined, these establish the baseline knowledge required to manifest the strongly-correlated phases of the Mott-Hubbard model in donor arrays, the first step to deploying APAM donor arrays as analogues of quantum materials.

36 MATERIALS SCIENCE↗
DOE OSTI2025

E-Area Low-Level Waste Facility Inadvertent Human Intruder Limits and Doses in Support of the PA2022

This report documents the inadvertent human intruder (IHI) analysis for the E-Area Low-Level Waste Facility (ELLWF) at the Savannah River Site (SRS), near Aiken, South Carolina. This analysis supports the revised ELLWF Performance Assessment (PA), complying with the Department of Energy standard for operation of low-level waste disposal facilities (USDOE, 2017). The ELLWF is an operating waste disposal facility and is scheduled to continue accepting waste to 2065. One task of the revised PA is to establish waste inventory limits for the various disposal units at ELLWF. This is done by modeling future contaminant release and transport through applicable pathways to human receptors, comparing predicted doses per disposed curie with applicable performance measures, to obtain inventory limits which will assure that doses to receptors do not exceed performance measures. This report documents results of modeling future doses to one class of receptor, the inadvertent human intruder. It is assumed that after site closure, public knowledge of the site is lost, and IHIs will engage in activities on the ELLWF that will disrupt the closure cap, causing dose to the IHI. Following USDOE (2017), six different stylized exposure scenarios are considered, simulating activities by an IHI which could result in a radiological dose. The six scenarios are: • Acute – Basement Construction: IHI constructs a basement and encounters waste during excavation which is inadvertently mixed with clean soil and diluted. • Acute – Well Drilling: IHI drills a water well through waste and is exposed to drill cuttings mixed with clean soil that are brought to the surface. • Acute – Discovery: IHI begins constructing a basement but stops when encountering the riprap in the final closure cap and is exposed to photon radiation from unexcavated material residing in the undisturbed waste zone. • Chronic – Agriculture: Resident IHI is exposed to waste that was excavated for basement construction and mixed with native soil in the intruder’s vegetable garden. • Chronic – Post-Drilling: Resident IHI is exposed to waste from drill cuttings mixed with native soil and scattered in the garden area. • Chronic – Residential: Resident IHI is exposed to external radiation while in home located above waste with shielding provided by the concrete basement floor and any soil or engineered material remaining between the basement and waste. Dose calculations are performed using the SRNL Dose Toolkit (Aleman, 2023), following the approach of Smith et al (2019). Calculations are performed separately for 27 of the 33 disposal units (DUs) at ELLWF and are radionuclide specific. The results of the IHI analysis include: • Dose Factors: mrem per disposed curie (acute) and mrem/yr per disposed curie (chronic) for each parent radionuclide, for each DU. • Inventory Limits: in curies, for each parent radionuclide, for each DU. • Estimated Dose to IHI: mrem (acute) and mrem/yr (chronic), for each DU, given its projected closure inventory without inventory biases applied. Most DU-specific IHI inventory limits are in the range of 10 3 to 10 7 curies per nuclide. The lowest inventory limits are associated with gamma-emitters such as Sn-126, Ra-226, Th-232, and Cm-248. Radionuclides with short half-lives such as Pu-241, and nuclides which are pure beta emitters or which decay by electron capture, such as Ni-59 and Ni-63, have the highest limits. For the 27 evaluated DUs, predicted IHI doses are shown in Table ES-1. The maximum acute dose is 1.18 mrem, at ST23, much less than the DOE performance measure of 500 mrem (USDOE, 2017). The highest chronic dose is 37.2 mrem/yr at ST02, below the DOE performance measure of 100 mrem/yr. Also shown are estimated inventory sums of fractions (SOFs) at closure in 2065, for groundwater (GW) and IHI pathways. For each DU, the inventory is constrained by the GW pathway. For most DUs, the IHI SOFs are approximately 1000 times lower than the GW SOF values, and the IHI pathway does not drive risk for any disposal unit.

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗
DOE OSTI2019

Critical Parameters for Evaluating Coin Cells and Pouch Cells of Rechargeable Li-Metal Batteries

Lithium ion and lithium metal batteries have received tremendous interest in the last decade for a wide range of energy storage applications. Although great progress has been made in developing new electrode materials and concepts, it is difficult to rapidly incorporate these advances in battery technologies. A key challenge is the knowledge gap between the fundamental materials research and the cell-level understanding of the relationship between high energy and stable cycling. As a result, the literature reports are based on a wide range of experimental conditions that cannot be easily realized in realistic cells. Taking lithium metal batteries as an example, this paper briefly discusses the fundamental mechanisms that lead to the inconsistent observations in battery research. We then propose development of a standard testing protocol based on the requirements of high-energy lithium metal cells. The importance of building a standard testing protocol is emphasized to accelerate the discovery of solutions for real challenges as well as inspire innovations that are readily adaptable to real batteries.

Chen, Shuru↗
DOE OSTI2018

Computer-aided discovery of a metal–organic framework with superior oxygen uptake

Current advances in materials science have resulted in the rapid emergence of thousands of functional adsorbent materials in recent years. This clearly creates multiple opportunities for their potential application, but it also creates the following challenge: how does one identify the most promising structures, among the thousands of possibilities, for a particular application? Here, we present a case of computer-aided material discovery, in which we complete the full cycle from computational screening of metal–organic framework materials for oxygen storage, to identification, synthesis and measurement of oxygen adsorption in the top-ranked structure. We introduce an interactive visualization concept to analyze over 1000 unique structure–property plots in five dimensions and delimit the relationships between structural properties and oxygen adsorption performance at different pressures for 2932 already-synthesized structures. We also report a world-record holding material for oxygen storage, UMCM-152, which delivers 22.5% more oxygen than the best known material to date, to the best of our knowledge.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
NASA NTRS1989

The Real Time Display Builder (RTDB)

The Real Time Display Builder (RTDB) is a prototype interactive graphics tool that builds logic-driven displays. These displays reflect current system status, implement fault detection algorithms in real time, and incorporate the operational knowledge of experienced flight controllers. RTDB utilizes an object-oriented approach that integrates the display symbols with the underlying operational logic. This approach allows the user to specify the screen layout and the driving logic as the display is being built. RTDB is being developed under UNIX in C utilizing the MASSCOMP graphics environment with appropriate functional separation to ease portability to other graphics environments. RTDB grew from the need to develop customized real-time data-driven Space Shuttle systems displays. One display, using initial functionality of the tool, was operational during the orbit phase of STS-26 Discovery. RTDB is being used to produce subsequent displays for the Real Time Data System project currently under development within the Mission Operations Directorate at NASA/JSC. The features of the tool, its current state of development, and its applications are discussed.

Kindred, Erick D.↗
NASA NTRS1992

Space Station Freedom Gateway to the Future

The first inhabited outpost on the frontier of space will be a place to live, work, and discover. Experiments conducted on Freedom will advance scientific knowledge about our world, our environment, and ourselves. We will learn how to adapt to the space environment and to build and operate new spacecraft with destinations far beyond Earth, continuing the tradition of exploration that began with a journey to the Moon. What we learn from living and working on Freedom will strengthen our expertise in science and engineering, promote national research and development initiatives and inspire another generation of Americans to push forward and onward. On the eve of the 21st century, Space Station Freedom will be our gateway to the future. This material covers gateways to space, research, discovery, utilization, benefits, and NASA.

Source record↗
NASA NTRS1999

Bantam: A Systematic Approach to Reusable Launch Vehicle Technology Development

The Bantam technology project is focused on providing a low cost launch capability for very small (100 kilogram) NASA and University science payloads. The cost goal has been set at one million dollars per launch. The Bantam project, however, represents much more than a small payload launch capability. Bantam represents a unique, systematic approach to reusable launch vehicle technology development. This technology maturation approach will enable future highly reusable launch concepts in any payload class. These launch vehicle concepts of the future could deliver payloads for hundreds of dollars per pound, enabling dramatic growth in civil and commercial space enterprise. The National Aeronautics and Space Administration (NASA) has demonstrated a better, faster, and cheaper approach to science discovery in recent years. This approach is exemplified by the successful Mars Exploration Program lead by the Jet Propulsion Laboratory (JPL) for the NASA Space Science Enterprise. The Bantam project represents an approach to space transportation technology maturation that is very similar to the Mars Exploration Program. The NASA Advanced Space Transportation Program (ASTP) and Future X Pathfinder Program will combine to systematically mature reusable space transportation technology from low technology readiness to system level flight demonstration. New reusable space transportation capability will be demonstrated at a small (Bantam) scale approximately every two years. Each flight demonstration will build on the knowledge derived from the previous flight tests. The Bantam scale flight demonstrations will begin with the flights of the X-34. The X-34 will demonstrate reusable launch vehicle technologies including; flight regimes up to Mach 8 and 250,000 feet, autonomous flight operations, all weather operations, twenty-five flights in one year with a surge capability of two flights in less than twenty-four hours and safe abort. The Bantam project will build on this initial capability to expand the capability of a reusable first stage, including ground launch, powered return to the launch site, and a fully reusable rocket propulsion system. A Bantam technology goal is to demonstrate twenty-five flights with no unplanned rocket engine maintenance and only minor planned maintenance or inspections. The design goal of the propulsion system is a mission life of one hundred.

Griner, Carolyn↗
DOE OSTI2022

DNA Sequence-Based Identification of Fusarium : A Work in Progress

Accurate species-level identification of an etiological agent is crucial for disease diagnosis and management because knowing the agent’s identity connects it with what is known about its host range, geographic distribution, and toxin production potential. This is particularly true in publishing peer-reviewed disease reports, where imprecise and/or incorrect identifications weaken the public knowledge base. This can be a daunting task for phytopathologists and other applied biologists that need to identify Fusarium in particular, because published and ongoing multilocus molecular systematic studies have highlighted several confounding issues. Paramount among these are: (i) this agriculturally and clinically important genus is currently estimated to comprise more than 400 phylogenetically distinct species (i.e., phylospecies), with more than 80% of these discovered within the past 25 years; (ii) approximately one-third of the phylospecies have not been formally described; (iii) morphology alone is inadequate to distinguish most of these species from one another; and (iv) the current rapid discovery of novel fusaria from pathogen surveys and accompanying impact on the taxonomic landscape is expected to continue well into the foreseeable future. To address the critical need for accurate pathogen identification, our research groups are focused on populating two web-accessible databases (FUSARIUM-ID v.3.0 and the nonredundant National Center for Biotechnology Information nucleotide collection that includes GenBank) with portions of three phylogenetically informative genes (i.e., TEF1, RPB1, and RPB2) that resolve at or near the species level in every Fusarium species. The objectives of this Special Report, and its companion in this issue ( Torres-Cruz et al. 2022 ), are to provide a progress report on our efforts to populate these databases and to outline a set of best practices for DNA sequence-based identification of fusaria.

Plant Sciences↗
DOE OSTI2014

A PerR-like protein involved in response to oxidative stress in the extreme bacterium Deinococcus radiodurans

Highlights: • We report a novel PerR-like protein of Fur family in D. radiodurans that is not annotated in the current database. • drperR responses to H{sub 2}O{sub 2} and functions as a negative regulator of katE and dps. • We provided implications on how to utilize sequenced genome data and the importance of genome data mining. • This study adds knowledge to complicated regulatory network that responds to ROS stress in D. radiodurans. - Abstract: Response and defense systems against reactive oxygen species (ROS) contribute to the remarkable resistance of Deinococcus radiodurans to oxidative stress induced by oxidants or radiation. However, mechanisms involved in ROS response and defense systems of D. radiodurans are not well understood. Fur family proteins are important in ROS response. Only a single Fur homolog is predicted by sequence similarity in the current D. radiodurans genome database. Our bioinformatics analysis demonstrated an additional guanine nucleotide in the genome of D. radiodurans that is not in the database, leading to the discovery of another Fur homolog DrPerR. Gene disruption mutant of DrPerR showed enhanced resistance to hydrogen peroxide (H{sub 2}O{sub 2}) and increased catalase activity in cell extracts. Real-time PCR results indicated that DrPerR functions as a repressor of the catalase gene katE. Meanwhile, derepression of dps (DNA-binding proteins from starved cells) gene under H{sub 2}O{sub 2} stress by DrPerR point to its regulatory role in metal ions hemostasis. Thus, DrPerR might function as a Fur homolog protein which is involved in ROS response and defense. These results help clarify the complicated regulatory network that responds to ROS stress in D. radiodurans.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2016

Multi-objective optimization techniques to design the Pareto front of organic dielectric polymers

Here, we present two Monte Carlo algorithms to find the Pareto front of the chemical space of a class of dielectric polymers that is most interesting with respect to optimizing both the bandgap and dielectric constant. Starting with a dataset generated from density functional theory calculations, we used machine learning to construct surrogate models for the bandgaps and dielectric constants of all physically meaningful 4-block polymers (that is, polymer systems with a 4-block repeat unit). We parameterized these machine learning models in such a way that the surrogates built for the 4-block polymers were readily extendable to polymers beyond a 4-block repeat unit. By using translational invariance, chemical intuition, and domain knowledge, we were able to enumerate all possible 4, 6, and 8 block polymers and benchmark our Monte Carlo sampling of the chemical space against the exact enumeration of the surrogate predictions. We obtained exact agreement for the fronts of 4-block polymers and at least a 90% agreement for those of 6 and 8-block polymers. We present fronts for 10-block polymer that are not possible to obtain by direct enumeration. We note that our Monte Carlo methods also return polymers close to the predicted front and a measure of the closeness. Both quantities are useful information for the design and discovery of new polymers.

36 MATERIALS SCIENCE↗
DOE OSTI2017

Toward Predictive Theories of Nuclear Reactions Across the Isotopic Chart: Web Report

Recent years have seen exciting new developments and progress in nuclear structure theory, reaction theory, and experimental techniques, that allow us to move towards a description of exotic systems and environments, setting the stage for new discoveries. The purpose of the 5-week program was to bring together physicists from the low-energy nuclear structure and reaction communities to identify avenues for achieving reliable and predictive descriptions of reactions involving nuclei across the isotopic chart. The 4-day embedded workshop focused on connecting theory developments to experimental advances and data needs for astrophysics and other applications. Nuclear theory must address phenomena from laboratory experiments to stellar environments, from stable nuclei to weakly-bound and exotic isotopes. Expanding the reach of theory to these regimes requires a comprehensive understanding of the reaction mechanisms involved as well as detailed knowledge of nuclear structure. A recurring theme throughout the program was the desire to produce reliable predictions rooted in either ab initio or microscopic approaches. At the same time it was recognized that some applications involving heavy nuclei away from stability, e.g. those involving fi ssion fragments, may need to rely on simple parameterizations of incomplete data for the foreseeable future. The goal here, however, is to subsequently improve and refine the descriptions, moving to phenomenological, then microscopic approaches. There was overarching consensus that future work should also focus on reliable estimates of errors in theoretical descriptions.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗
DOE OSTI2023

Mixed Ionic Electronic Conducting Quaternary Perovskites: Materials by Design for Solar Thermochemical Hydrogen

The innovative research conducted by Arizona State University and Princeton University in the project "Mixed Ionic-Electronic Conducting Quaternary Perovskites: Materials by Design for Solar Thermochemical Hydrogen" marks a significant stride forward in thermochemical water splitting. Through an intricate blend of computational design and experimental validation, the project delved into the promising potential of Mixed Ionic Electronic Conducting (MIEC) perovskites. These complex materials, characterized by their unique redox-active nature and adaptability in stoichiometry, present a promising frontier for efficient solar thermochemical hydrogen production. Firstly, the research enhanced the science by utilizing state-of-the-art computational methodologies to unravel the nuanced chemical potentials of MIEC perovskites. By simulating various off-stoichiometric scenarios and redox conditions, the team was able to predict material behaviors under diverse environmental conditions, a feat unachievable through conventional experimental methodologies alone. This approach not only fast-tracks the material screening process, significantly reducing the time from laboratory re-search to practical application, but also uncovers trends and correlations that are pivotal for future materials innovation. Regarding technical effectiveness, the project stands out in its economic feasibility. Traditional methods of materials discovery are often marred by high costs and extensive timeframes, owing to the iterative nature of experimental processes. However, by employing theoretical computations and validating these findings with targeted experiments, the project introduced a cost-effective paradigm for materials discovery and the first ever prediction, synthesis, and preliminary validation of a material solely from computational and theoretical considerations. This synergy between computation and experimentation expedites the discovery of optimal materials conducive to high-efficiency solar-to-hydrogen conversion processes. Furthermore, the public stands to benefit substantially from this research. The success of MIEC perovskites in solar thermochemical applications heralds a shift towards lower cost and lower electricity input for clean hydrogen production, hence potentially impacting climate and energy resilience. By improving the efficiency of solar-to-hydrogen conversions, the research paves the way for reduced dependency on fossil fuels, addressing the urgent global need for accessible and renewable energy sources. Moreover, the project's advancements contribute to scientific literacy in renewable energy technologies, empowering society through knowledge and spurring future innovations. In essence, this research project demonstrates significant progress in the realm of advanced water splitting through solar thermochemistry. Through its groundbreaking approaches in computational materials science and its implications for real-world applications, it holds the promise of a cleaner, more energy-resilient future.

08 HYDROGEN↗
DOE OSTI2018

Optical and Near-infrared Radial Velocity Content of M Dwarfs: Testing Models with Barnard’s Star

High-precision radial velocity (RV) measurements have been central in the study of exoplanets during the last two decades, from the early discovery of hot Jupiters, to the recent mass measurements of Earth-sized planets uncovered by transit surveys. While optical RV is now a mature field, there is currently a strong effort to push the technique into the near-infrared domain (chiefly Y, J, H, and K bandpasses) to probe planetary systems around late-type stars. The combined lower mass and luminosity of M dwarfs leads to an increased reflex RV signal for planets in the habitable zone compared to Sun-like stars. The estimates on the detectability of planets rely on various instrumental characteristics but also on a prior knowledge of the stellar spectrum. While the overall properties of M dwarf spectra have been extensively tested against observations, the same is not true for their detailed line profiles, which leads to significant uncertainties when converting a given signal-to-noise ratio to a corresponding RV precision as attainable on a given spectrograph. By combining archival CRIRES and HARPS data with ESPaDOnS data of Barnard’s star, we show that state-of-the-art atmosphere models over-predict the Y- and J-band RV content by more than a factor of ∼2, while under-predicting the H- and K-band content by half.

79 ASTRONOMY AND ASTROPHYSICS↗
NASA NTRS2011

New Titanium Monosulfide Mineral Phase in Yamato 691 Enstatite Chondrite

Yamato 691, an EH3 enstatite chondrite, was among the first meteorites discovered by chance in Antarctica by the Japanese Antarctic Research Expedition (JARE) team in 1969. This discovery led to follow-up searches for meteorites in Antarctica [1]. These international searches have been very successful recovering over 40,000 total specimens (and still counting), including martian and lunar meteorites. Titanium is partly chalcophile in enstatite-rich meteorites. Previous occurrences of Ti-bearing sulfides include troilite, daubrelite and ferroan alabandite in enstatite chondrites and aubrites [2], and heideite with 28.5 wt% Ti in the Bustee aubrite [3]. Here we report a new mineral from Yamato 691, ideally stoichiometric TiS, titanium monosulfide, a simple two-element mineral phase, yet with a very unique crystal structure that, to our knowledge, has not been observed previously in nature.

Nakamura-Messenger, K↗
DOE OSTI2022

Cortical Proteins and Individual Differences in Cognitive Resilience in Older Adults

Background and objectives: Cognitive resilience is a well-recognized concept, but knowledge gaps about its underlying mechanisms have made it difficult to develop instruments that identify older adults with high or low resilience. We tested whether aggregating cortical peptides associated with cognitive resilience into an index can identify adults with higher or lower cognitive resilience. Methods: We used data from 1,192 older decedents, including annual clinical testing, indices of 10 Alzheimer disease (AD) and related dementia (ADRD) pathologies, and 226 proteotypic peptides measured in the dorsal lateral prefrontal cortex. We used linear mixed-effects models to identify peptides that were related to cognitive resilience (i.e., cognitive decline not explained by ADRD pathologies [false discovery rate <0.05]). We aggregated the expression levels of these resilience peptides into a person-specific cognitive resilience index and examined its association with AD clinical and pathologic phenotypes. Results: We constructed a resilience index from 52 of 226 peptides related to cognitive resilience. A higher index was associated with slower cognitive decline (estimate 0.05, SE 0.003, p < 0.001) and slower motor decline (estimate 0.005, SE 0.001, p < 0.001). Most resilience peptides (70%) were specific to cognitive decline, but 30% also provided resilience for motor decline. A higher index was also related to a lower burden of AD pathologies (odds ratio [OR] 0.41, SE 0.01, p < 0.001) and modified the association of AD pathology with cognition in that a higher index modified the negative effects of AD pathology on AD dementia proximate to death (OR 0.70, SE 0.14, p = 0.010). Up to 90% of cognitive resilience peptides were related to AD pathologic phenotypes. Discussion: Cortical proteins may provide some degree of cognitive resilience. These multifunctional proteins also seem to provide resilience to other AD clinical phenotypes and have independent associations with ADRD pathologies. Resilience proteins may be high-value therapeutic targets for drug discovery of interventions that maintain brain health in aging adults via multiple pathways.

60 APPLIED LIFE SCIENCES↗