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At least 757 records · Page 42

Connective tissue integrity is lost in vitamin B-6-deficient chicks

The objective of the present investigation was to characterize further the connective tissue disorder produced by pyridoxine (vitamin B-6) deficiency, as previously evidenced by electron microscopy. Following the second post-natal week, fast growing male chicks were deprived of pyridoxine for a 1-mo period. Six weeks post-natally, blood concentrations in the experimental deficiency group had declined to deficiency levels as registered by low concentrations of pyridoxal phosphate (coenzyme form) in erythrocytes, but did not reach levels associated with neurological symptoms. Light microscopic study showed abnormalities in the extracellular matrix of the connective tissues. Collagen cross-links and the aldehyde contents were not significantly lower in cartilage and tendon collagens of vitamin B-6-deficient animals than in age-matched controls; also, their proteoglycan degrading protease and collagenase activities measured in articular cartilages were not greater. Thus, proteolysis was an unlikely alternative mechanism to account for the loss of connective tissue integrity. These results point to the need for further investigation into adhesive properties of collagen associated proteoglycans or other proteins in vitamin B-6-deficient connective tissue.

Non-NASA Center↗

Presentation of antigen to T lymphocytes by non-immune B-cell hybridoma clones: evidence for specific and non-specific presentation

Non-immune SJL (H-2s) spleen cells were fused with non-secreting, non-antigen presenting (H-2d) Balb/c 653-myeloma cells and the hybridomas were cloned by two limiting dilutions. The resulting hybrid B-cell clones were tested for their antigen presentation capability to SJL T-cell lines that were specific for either lysozyme or myoglobin. In proliferative assays, 53% of the antigen presenting B-cell clones presented both myoglobin and lysozyme (general presenters) while the other 47% presented specifically either myoglobin or lysozyme (specific presenters). The ability to selectively present either myoglobin or lysozyme indicates that antigen presentation at the clonal level can be specific or non-specific depending on the particular B-cell clone.

B-Lymphocytes/immunology↗

Presentation of antigen to T lymphocytes by non-immune B-cell hybridoma clones: evidence for specific and non-specific presentation

Non-immune SJL (H-2s) spleen cells were fused with (H-2d) Balb/c 653-myeloma cells and the hybridomas were cloned by two limiting dilutions. The resulting hybrid B- cell clones were tested for their antigen presentation capability to SJL T-cell lines that were specific for either lysozyme or myoglobin. In proliferative assays, 53% of the antigen presenting B-cell clones were able to present both myoglobin and lysozyme (general presenters) while the other 47% presented specifically either myoglobin or lysozyme (specific presenters). The ability to selectively present either myoglobin or lysozyme indicates that antigen presentation at the clonal level can be specific or non-specific depending on the particular B-cell clone.

T-Lymphocytes/immunology↗

Characterization of the Gaseous Companion k Andromedae B* New Keck and LBTI High-contrast Observations

Context. We previously reported the direct detection of a low mass companion at a projected separation of 55+/-2 astronomical units around the B9 type star kappa Andromedae. The properties of the system (mass ratio, separation) make it a benchmark for the understanding of the formation and evolution of gas giant planets and brown dwarfs on wide-orbits. Aims. We present new angular differential imaging (ADI) images of the system at 2.146 (K(sub s)), 3.776 (L'), 4.052 (NB 4.05) and 4.78 micrometers (M') obtained with Keck/NIRC2 and LBTI/LMIRCam, as well as more accurate near-infrared photometry of the star with the MIMIR instrument. We aim to determine the near-infrared spectral energy distribution (SED) of the companion and use it to characterize the object. Methods. We used analysis methods adapted to ADI to extract the companion flux. We compared the photometry of the object to reference young/old objects and to a set of seven PHOENIX-based atmospheric models of cool objects accounting for the formation of dust. We used evolutionary models to derive mass estimates considering a wide range of plausible initial conditions. Finally, we used dedicated formation models to discuss the possible origin of the companion. Results. We derive a more accurate J = 15.86 +/- 0.21, H = 14.95 +/- 0.13, K(sub s) = 14.32 +/- 0.09 mag for kappa And b. We redetect the companion in all our high contrast observations. We confirm previous contrasts obtained at K(sub s) and L' band. We derive NB 4.05 = 13.0 +/- 0.2 and M' = 13.3 +/- 0.3 mag and estimate Log(base 10)(L/solar luminosity) = −3.76 +/- 0.06. Atmospheric models yield T(sub eff) = 1900(+100/−200) K. They do not set constrains on the surface gravity. "Hot-start" evolutionary models predict masses of 14(+25/−2) Jupiter mass based on the luminosity and temperature estimates, and considering a conservative age range for the system (30(+120/−10) million years). "warm-start" evolutionary tracks constrain the mass to M greater than or equal to 11 Jupiter mass. Conclusions. The mass of kappa Andromedae b mostly falls in the brown-dwarf regime, due to remaining uncertainties in age and mass-luminosity models. According to the formation models, disk instability in a primordial disk could account for the position and a wide range of plausible masses of kappa and b.

spectral energy distribution (SED)↗

Understanding the Atmosphere of 51 Eri b: Do Photochemical Hazes Cloud the Planets Spectrum?

The first young giant planet to be discovered by the Gemini Planet Imager was the (is) approximately 2MJ planet 51 Eri b. This approximately 20 Myr old young Jupiter is the first directly imaged planet to show unmistakable methane in H band. To constrain the planet's mass, atmospheric temperature, and composition, the GPI J and H band spectra as well as some limited photometric points were compared to the predictions of substellar atmosphere models. The best fitting models reported in the discovery paper (Macintosh et al. 2015) relied upon a combination of clear and cloudy atmospheric columns to reproduce the data. However for an object as cool as 700 K, the origin of the cloud coverage is somewhat puzzling, as the global silicate and iron clouds would be expected to have sunk well below the photosphere by this effective temperature. While strong vertical mixing in these low gravity atmospheres remains a plausible explanation, we have explored whether atmospheric photochemistry, driven by the UV flux from the primary star, may yield hazes that also influence the observed spectrum of the planet. To explore this possibility we have modeled the atmospheric photochemistry of 51 Eri b using two state-of-the-art photochemical models, both capable of predicting yields of complex hydrocarbons under various atmospheric conditions. In our presentation we will summarize the modeling approach employed to characterize 51 Eri b, explaining constraints on the planet's effective temperature, gravity, and atmospheric composition and also present results of our studies of atmospheric photochemistry. We will discuss whether photochemical hazes could indeed be responsible for the particulate opacity that apparently sculpts the spectrum of the planet.

GPI - Gemini Planet Imager↗

SLS Block 1-B and Exploration Upper Stage Navigation System Design

The SLS Block 1B vehicle is planned to extend NASA's heavy lift capability beyond the initial SLS Block 1 vehicle. The most noticeable change for this vehicle from SLS Block 1 is the swapping of the upper stage from the Interim Cryogenic Propulsion stage (ICPS), a modified Delta IV upper stage, to the more capable Exploration Upper Stage (EUS). As the vehicle evolves to provide greater lift capability and execute more demanding missions so must the SLS Integrated Navigation System to support those missions. The SLS Block 1 vehicle carries two independent navigation systems. The responsibility of the two systems is delineated between ascent and upper stage flight. The Block 1 navigation system is responsible for the phase of flight between the launch pad and insertion into Low-Earth Orbit (LEO). The upper stage system assumes the mission from LEO to payload separation. For the Block 1B vehicle, the two functions are combined into a single system intended to navigate from ground to payload insertion. Both are responsible for self-disposal once payload delivery is achieved. The evolution of the navigation hardware and algorithms from an inertial-only navigation system for Block 1 ascent flight to a tightly coupled GPS-aided inertial navigation system for Block 1-B is described. The Block 1 GN&C system has been designed to meet a LEO insertion target with a specified accuracy. The Block 1-B vehicle navigation system is designed to support the Block 1 LEO target accuracy as well as trans-lunar or trans-planetary injection accuracy. This is measured in terms of payload impact and stage disposal requirements. Additionally, the Block 1-B vehicle is designed to support human exploration and thus is designed to minimize the probability of Loss of Crew (LOC) through high-quality inertial instruments and Fault Detection, Isolation, and Recovery (FDIR) logic. The preliminary Block 1B integrated navigation system design is presented along with the challenges associated with meeting the design objectives. This paper also addresses the design considerations associated with the use of Block 1 and Commercial Off-the-Shelf (COTS) avionics for Block 1-B/EUS as part of an integrated vehicle suite for orbital operations.

Oliver, T. Emerson↗

HD 202772A b: A Transiting Hot Jupiter Around a Bright, Mildly Evolved Star in a Visual Binary Discovered by TESS

We report the first confirmation of a hot Jupiter discovered by the Transiting Exoplanet Survey Satellite (TESS) mission: HD 202772A b. The transit signal was detected in the data from TESS Sector 1, and was confirmed to be of planetary origin through radial velocity (RV) measurements. HD 202772A b is orbiting a mildly evolved star with a period of 3.3 days. With an apparent magnitude of V = 8.3, the star is among the brightest and most massive known to host a hot Jupiter. Based on the 27 days of TESS photometry and RV data from the CHIRON, HARPS, and Tillinghast Reflector Echelle Spectrograph, the planet has a mass of 1.017(Sup +0.070, sub 0.068) M(J) and radius of 1.545(sup +0.052, sub -0.060) R(J), making it an inflated gas giant. HD 202772A b is a rare example of a transiting hot Jupiter around a quickly evolving star. It is also one of the most strongly irradiated hot Jupiters currently known.

Songhu Wang↗

TOI-3568 b: A Super-Neptune in the Sub-Jovian Desert

The sub-Jovian desert is a region in the mass–period and radius–period parameter space that typically encompasses short-period ranges between super-Earths and hot Jupiters, and exhibits an intrinsic dearth of planets. This scarcity is likely shaped by photo evaporation caused by the stellar irradiation received by giant planets that have migrated inward. We report the detection and characterization ofTOI-3568 b, a transiting super-Neptune with a mass of26.4±1.0M⊕, a radius of5.30±0.27R⊕, a bulk density of0.98±0.15g cm−3, and an orbital period of 4.417965 (5) d situated in the vicinity of the sub-Jovian desert. This planet orbiting a K dwarf star with solar metallicity was identified photometrically by the Transiting Exoplanet Survey Satellite (TESS). It was characterized as a planet by our high-precision radial-velocity (RV) monitoring program using MAROON-X at Gemini North, supplemented with additional observations from the SPICE large program with SPIRou at CFHT. We performed a Bayesian MCMC joint analysis of the TESSand ground-based photometry, and MAROON-X and SPIRou RVs, to measure the orbit, radius, and mass of the planet, as well as a detailed analysis of the high-resolution flux and polarimetric spectra to determine the physical parameters and elemental abundances of the host star. Our results reveal TOI-3568 b to be a hot super-Neptune rich in hydrogen and helium, with a core of heavier elements of between 10 and 25 M⊕in mass. We analyzed the photo evaporation status of TOI-3568 b and find that it experiences one of the highest extreme-ultraviolet (EUV) luminosities among planets with a mass of Mp<2MNep, yet it has an evaporation lifetime exceeding 5 Gyr. Positioned in the transition between two significant populations of exoplanets on the mass–period and energy diagrams, this planet presents an opportunity to test theories concerning the origin of the sub-Jovian desert.

stars: individual: TOI-3568↗

FY23 status report on the development of new ASME Section III, Division 5 Class B rules

This report summarizes the work done in Fiscal Year 2023 on the development of the new American Society of Mechanical Engineers Boiler and Pressure Vessel Code, Section III, Division 5, Class B rules to address the gaps identified for high temperature reactor designs. The summary of the design-by-analysis strain limit evaluation and creep-fatigue damage assessment is presented. The proposed design-by-analysis creep-fatigue damage calculation approach uses a new elastic follow-up-based Isochronous Stress Strain Curve stress relaxation procedure. This approach captures the elastic follow-up generated due to interactions of components with adjacent components, supports, and other connections in the power plant. A set of sample problems are selected to validate the proposed design-by-analysis rules for creep-fatigue damage assessment. The proposed Class B rules are evaluated against the Class A elastic design rules, and the experimental data obtained from a family of Simplified Model Test based key-feature test results. The proposed Class B creep-fatigue damage assessment methodology yields conservative design cycles estimates compared to the experimental results.

22 GENERAL STUDIES OF NUCLEAR REACTORS↗

Angular analysis of the rare decay $B_s^0$ → $\phi μ^+μ^-$

An angular analysis of the rare decay B$^0_s$ → $\phi μ^+μ^-$ is presented, using proton-proton collision data collected by the LHCb experiment at centre-of-mass energies of 7, 8 and 13 TeV, corresponding to an integrated luminosity of 8.4 fb -1 . The observables describing the angular distributions of the decay B$^0_s$ → $\phi μ^+μ^-$ are determined in regions of q 2 , the square of the dimuon invariant mass. The results are consistent with Standard Model predictions.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

First observation of the decay of the 13/2 + isomer in 183 Hg and B(M 2) systematics of neutron transitions across the nuclear chart

The decay of the 13/2 + isomeric state in 183 Hg was observed for the first time following the a decay of the 13/2 + isomer in 187 Pb produced in the 142 Nd( 50 Cr, 2p3n) reaction. Using $\alpha - \gamma$ delayed coincidence measurements, the half-life of this isomer was measured to be 290(30) μs. This isomer is proposed to deexcite by an unobserved low-energy M2 transition to the known 9/2 - member of a strongly prolate-deformed 7/2 - [514] band, followed by a 105-keV M1 transition to the bandhead. A lower limit of B(M2) >= 0.018 W.u. was deduced for the unobserved transition. The presumed retardation is proposed to be due to the notable shape change between the initial, nearly spherical, and the final, strongly deformed, states. A similar scenario is also considered for the 13/2 + isomer in 181 Hg, suggesting both are cases of shape isomers. The B(M2) systematics of neutron transitions across the nuclear chart is discussed.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

Search for the decay B s 0 → π 0 π 0 at Belle

We report the results of the first search for the decay B$^{0}_{s}$ → π 0 ⁢π 0 using 121.4 fb -1 of data collected at the Y⁡(5⁢S) resonance with the Belle detector at the KEKB asymmetric-energy e + ⁢e - collider. We observe no signal and set a 90% confidence level upper limit of 7.7 ×10 -6 on the B$^{0}_{s}$ → π 0 π 0 decay branching fraction.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Test of Lepton Universality in b → $s$$\ell$ + $\ell$ – Decays

The first simultaneous test of muon-electron universality using $B^+$ → $K^+$$\ell^+$$\ell^–$ and $B^0$ → $K^{*0}$$\ell^+$$\ell^–$ decays is performed, in two ranges of the dilepton invariant-mass squared, q 2 . The analysis uses beauty mesons produced in proton-proton collisions collected with the LHCb detector between 2011 and 2018, corresponding to an integrated luminosity of 9 fb –1 . Each of the four lepton universality measurements reported is either the first in the given q 2 interval or supersedes previous LHCb measurements. The results are compatible with the predictions of the Standard Model.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Evidence of a $J/$$\psi$$K_S^0$ Structure in $B^0$ → $J/$$\psi$$\phi$$K_S^0$

An amplitude analysis of $B^0$ → $J/$$\psi$$\phi$$K_S^0$ decays is performed using proton-proton collision data, corresponding to an integrated luminosity of 9 fb –1 , collected with the LHCb detector at center-of-mass energies of 7, 8, and 13 TeV. Evidence with a significance of 4.0 standard deviations of a structure in the $J/$$\psi$$K_S^0$ system, named $T_{ψs1}^{θ}$⁢⁢(4000) 0 , is seen, with its mass and width measured to be 3991$_{–10 –17}^{+12 +9}$ MeV/⁢c 2 and 105$_{–25 –23}^{+29 +17}$ MeV, respectively, where the first uncertainty is statistical and the second systematic. The $T_{ψs1}^{θ}$⁢⁢(4000) 0 state is likely to be the isospin partner of the $T_{ψs1}^{θ}$⁢⁢(4000) + state, previously observed in the $J/ψK^+$ system of the $B^+$→$J/ψ$$\phi$$K^+$ decay. When isospin symmetry for the charged and neutral $T_{ψs1}^{θ}$⁢⁢(4000) states is assumed, the signal significance increases to 5.4 standard deviations.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Measurement of C P Violation in B 0 → ψ ( → ℓ + ℓ − ) K S 0 ( → π + π − ) Decays

A measurement of time-dependent C P violation in the decays of B 0 and B ¯ 0 mesons to the final states J / ψ ( → μ + μ − ) K S 0 , ψ ( 2 S ) ( → μ + μ − ) K S 0 and J / ψ ( → e + e − ) K S 0 with K S 0 → π + π − is presented. The data correspond to an integrated luminosity of 6 fb − 1 collected at a center-of-mass energy of s = 13 TeV with the LHCb detector. The C P -violation parameters are measured to be S ψ K S 0 = 0.717 ± 0.013 ( stat ) ± 0.008 ( syst ) and C ψ K S 0 = 0.008 ± 0.012 ( stat ) ± 0.003 ( syst ) . This measurement of S ψ K S 0 represents the most precise single measurement of the CKM angle β to date and is more precise than the current world average. In addition, measurements of the C P -violation parameters of the individual channels are reported and a combination with the LHCb Run 1 measurements is performed. © 2024 CERN, for the LHCb Collaboration 2024 CERN

Aaij, R. (ORCID:0000000305331952)↗

Amplitude Analysis of the B 0 → K * 0 μ + μ − Decay

An amplitude analysis of the B 0 → K * 0 μ + μ − decay is presented using a dataset corresponding to an integrated luminosity of 4.7 fb − 1 of p p collision data collected with the LHCb experiment. For the first time, the coefficients associated to short-distance physics effects, sensitive to processes beyond the standard model, are extracted directly from the data through a q 2 -unbinned amplitude analysis, where q 2 is the μ + μ − invariant mass squared. Long-distance contributions, which originate from nonfactorizable QCD processes, are systematically investigated, and the most accurate assessment to date of their impact on the physical observables is obtained. The pattern of measured corrections to the short-distance couplings is found to be consistent with previous analyses of b - to s -quark transitions, with the largest discrepancy from the standard model predictions found to be at the level of 1.8 standard deviations. The global significance of the observed differences in the decay is 1.4 standard deviations. © 2024 CERN, for the LHCb Collaboration 2024 CERN

Aaij, R. (ORCID:0000000305331952)↗

Measurement of $\tau _\text {L}$ using the ${B} _s^0 \rightarrow J/\psi \eta$ decay mode

Using a proton–proton collision data sample collected by the LHCb detector and corresponding to an integrated luminosity of $5.7~\text {fb}^{-1}$ , the lifetime of the light ${{B} ^0_{s}}$ mass eigenstate, $\tau _{L}$ , is measured using the $B^0_s \rightarrow J/\psi \eta$ decay mode to be $\begin{aligned} \tau _{\text {L}} = 1.445 \pm 0.016 \text {(stat)} \pm 0.008 \text {(syst)} \,\text {ps}. \end{aligned}$ A combination of this result with a previous LHCb analysis using an independent dataset corresponding to 3 fb –1 of integrated luminosity gives $\begin{aligned} \tau _{\text {L}} = 1.452 \pm 0.014 \pm 0.007 \pm 0.002 \,\text {ps}, \end{aligned}$ where the first uncertainty is statistical, the second due to the uncorrelated part of the systematic uncertainty and the third due to the correlated part of the systematic uncertainty.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗