Engineering Papers⌕ Search

SEARCH · Engineering Papers

Results for “predictive mapping”

Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 739 records · Page 41
All sourcesNASA NTRSDOE OSTI
NASA NTRS2005

Optimizing Parameters for Deep-Space Optical Communication

A paper discusses the optimization of the parameters of a high-rate, deep-space optical communication link that utilizes pulse-position modulation (PPM) and an error-correcting code (ECC). The parameters in question include the PPM order (number of pulse time slots in one symbol period), the ECC rate, and the uncoded symbol error rate. In simple terms, the optimization problem is to choose the combination of these parameters that maximizes the throughput data rate at a given bit-error-rate (BER), subject to several constraints, including limits on the average and peak power and possibly a limit on the uncoded symbol error rate. This is a complex, multidimensional optimization problem, the solution of which involves computation of channel capacities for various combinations of the parameters. The paper presents extensive theoretical analyses and numerical predictions that elucidate the many facets of the optimization problem. It shows how a nearly optimum solution can be obtained by choosing the optimum PPM order for the desired number of bits per slot and concatenating the PPM mapping with an error-correction code so that the decoded bits satisfy some BER threshold.

Moison, Bruce↗
NASA NTRS2018

Flux-Pinned Dynamics Model Parameterization and Sensitivity Study

Flux-pinned interfaces for spacecraft are an action-at-a-distance technology that can maintain a passively stable equilibrium between two spacecraft in close-proximity using the physics of magnetic flux pinning. Although flux pinning dynamics have been studied from a material-science perspective and at an interface level, there is a need to better understand the sensitivities and implications of system-level designs on the flux-pinned interface dynamics, especially in designs with multiple magnets and superconductors. These interfaces have highly nonlinear, coupled dynamics that are influenced by physical parameters including but not limited to strength of magnetic field sources, field-cooled position, and superconductor geometry. This paper addresses that gap by codifying parametric terms into an improved dynamics model, which can then be used to simulate the interaction of a multiple-superconductor-multiple-magnet interface. A standard starting point for modeling flux pinning dynamics is Kordyuk’s frozen image model, which defines a geometric mapping between magnetic field sources and their corresponding magnetic point source “images inside the volume of the superconductor.” The frozen image model successfully approximates the characteristics of flux pinning dynamics, but could provide more precise position and orientation predictions with the addition of various physical parameter refinements. The sensitivity of the general flux-pinned dynamics model is studied by varying the physical parameters and simulating the systems level dynamics. A predictive dynamics model is crucial to the maturation of this technology so it can be utilized in spacecraft systems, and this work represents a critical step in the development of that model.

Peck, Mason↗
NASA NTRS2020

Fusion Approach for Remotely-Sensed Mapping of Agriculture (FARMA): A Scalable Open Source Method for Land Cover Monitoring Using Data Fusion

The increasing availability of very-high resolution (VHR; <2 m) imagery has the potential to enable agricultural monitoring at increased resolution and cadence, particularly when used in combination with widely available moderate-resolution imagery. However, scaling limitations exist at the regional level due to big data volumes and processing constraints. Here, we demonstrate the Fusion Approach for Remotely-Sensed Mapping of Agriculture (FARMA), using a suite of open source software capable of efficiently characterizing time-series field-scale statistics across large geographical areas at VHR resolution. We provide distinct implementation examples in Vietnam and Senegal to demonstrate the approach using WorldView VHR optical, Sentinel-1 Synthetic Aperture Radar, and Sentinel-2 and Sentinel-3 optical imagery. This distributed software is open source and entirely scalable, enabling large area mapping even with modest computing power. FARMA provides the ability to extract and monitor sub-hectare fields with multisensor raster signals, which previously could only be achieved at scale with large computational resources. Implementing FARMA could enhance predictive yield models by delineating boundaries and tracking productivity of smallholder fields, enabling more precise food security observations in low and lower-middle income countries.

fusion↗
NASA NTRSDate not supplied

Additive Manufacturing Model-Based Process Metrics: Reduced Order Modeling of the Laser Powder Bed Fusion Process

The multi-scale and complex process of printing additively manufactured (AM) parts can have unexpected, but predictable, build conditions that result in material microstructure variability. In this work, we describe a fully parallel reduced order modeling approach that has been developed to evaluate the evolution of AM processes, termed the AM moment measure method. This method couples the known sequence of the AM process with a physically informed nearest neighbors’ calculation to map the conditions of a part-scale build. The result is a map of the build that is derived directly from build files or in-situ process monitoring sensors. The methodology and terminology of the approach will be described, and computed build maps will be calculated and compared for various laser powder bed fusion (LPBF) builds of Ti-6Al-4V. Such comparative results develop understanding of how the sequential process actions can affect the LPBF-AM build quality and microstructure variability.

Laser Powder Bed Fusion↗
NASA NTRS2010

Hybrid FEA/SEA Assessment for an Orthogrid Cylindrical Panel Section and Periodic Subsystem Modeling Evaluation

In the lower frequency range, where particular boundary conditions can make a significant difference to panel response characteristics Statistical Energy Analysis (SEA) has never been the analytical tool of choice. In addition to boundary condition effects, SEA is not well suited in frequency bands where no modes or less than a few modes exist. The advent of the Hybrid Module has enabled integration of Finite Element Analysis to expand and enhance the capability for response calculations within VA One into the lower frequency range. Exploration of several additional modeling approaches was completed for the cylindrical orthogrid panel test article that was examined in Reference 1. Comparison of the new analytical response predictions with the measured response data from ground test and the pure SEA results from the reference will be presented. One approach that is considered promising is the periodic subsystem capability. Initially, a detailed FEM of just one region of the test article is defined. After evaluating this small region using symmetric boundary conditions, the FEM may be expanded to determine the properties of the entire system using similar connected regions that map over the entire test article. Another approach is the direct use of a very detailed finite element model of the entire panel, explicitly modeling pocket and rib details of the structure. A third approach is to approximate localized structure geometry details with a smeared property generalization using a PCOMP (NASTRAN card used to define layered composite structures) to define skin layer and ribbed layer for the orthogrid panel. The authors expect to demonstrate that the integrated Hybrid/FEM approach increases confidence in response prediction in the lower frequency range (for example from 20-300 Hz for the test article under consideration). In addition the strength and weakness of each additional approach will be highlighted and compared to those reported with those reported in an earlier paper

Smith, Andrew M.↗
NASA NTRS2015

An Integrated 0-1 Hour First-Flash Lightning Nowcasting, Lightning Amount and Lightning Jump Warning Capability

Lightning one of the most dangerous weather-related phenomena, especially as many jobs and activities occur outdoors, presenting risk from a lightning strike. Cloud-to-ground (CG) lightning represents a considerable safety threat to people at airfields, marinas, and outdoor facilities-from airfield personnel, to people attending outdoor stadium events, on beaches and golf courses, to mariners, as well as emergency personnel. Holle et al. (2005) show that 90% of lightning deaths occurred outdoors, while 10% occurred indoors despite the perception of safety when inside buildings. Curran et al. (2000) found that nearly half of fatalities due to weather were related to convective weather in the 1992-1994 timeframe, with lightning causing a large component of the fatalities, in addition to tornadoes and flash flooding. Related to the aviation industry, CG lightning represents a considerable hazard to baggage-handlers, aircraft refuelers, food caterers, and emergency personnel, who all become exposed to the risk of being struck within short time periods while convective storm clouds develop. Airport safety protocols require that ramp operations be modified or discontinued when lightning is in the vicinity (typically 16 km), which becomes very costly and disruptive to flight operations. Therefore, much focus has been paid to nowcasting the first-time initiation and extent of lightning, both of CG and of any lightning (e.g, in-cloud, cloud-to-cloud). For this project three lightning nowcasting methodologies will be combined: (1) a GOESbased 0-1 hour lightning initiation (LI) product (Harris et al. 2010; Iskenderian et al. 2012), (2) a High Resolution Rapid Refresh (HRRR) lightning probability and forecasted lightning flash density product, such that a quantitative amount of lightning (QL) can be assigned to a location of expected LI, and (3) an algorithm that relates Pseudo-GLM data (Stano et al. 2012, 2014) to the so-called "lightning jump" (LJ) methodology (Shultz et al. 2011) to monitor lightning trends and to anticipate/forecast severe weather (hail > or =2.5 cm, winds > or =25 m/s, tornadoes). The result will be a time-continuous algorithm that uses GOES satellite, radar fields, and HRRR model fields to nowcast first-flash LI and QL, and subsequently monitors lightning trends on a perstorm basis within the LJ algorithm for possible severe weather occurrence out to > or =3 hours. The LI-QL-LJ product will also help prepare the operational forecast community for Geostationary Lightning Mapper (GLM) data expected in late 2015, as these data are monitored for ongoing convective storms. The LI-QL-LJ product will first predict where new lightning is highly probable using GOES imagery of developing cumulus clouds, followed by n analysis of NWS (dual-polarization) radar indicators (reflectivity at the -10 C altitude) of lightning occurrence, to increase confidence that LI is immanent. Once lightning is observed, time-continuous lightning mapping array and Pseudo-GLM observations will be analyzed to assess trends and the severe weather threat as identified by trends in lightning (i.e. LJs). Additionally, 5- and 15-min GOES imagery will then be evaluated on a per-storm basis for overshooting and other cloud-top features known to be associated with severe storms. For the processing framework, the GOES-R 0-1 hour convective initiation algorithm's output will be developed within the Warning Decision Support System - Integrated Information (WDSS-II) tracking tool, and merged with radar and lightning (LMA/Psuedo-GLM) datasets for active storms. The initial focus of system development will be over North Alabama for select lightning-active days in summer 2014, yet will be formed in an expandable manner. The lightning alert tool will also be developed in concert with National Weather Service (NWS) forecasters to meet their needs for real-time, accurate first-flash LI and timing, as well as anticipated lightning trends, amounts, continuation and cessation, so to provide key situational awareness and decision support information. The NASA Short-term Prediction Research and Transition (SPoRT) Center will provide important logistical and collaborative support and training, involving interactions with the NWS and broader user community.

Mecikalski, John↗
NASA NTRS1975

Development of an airborne laser bathymeter

An airborne laser depth sounding system was built and taken through a complete series of field tests. Two green laser sources were tried: a pulsed neon laser at 540 nm and a frequency-doubled Nd:YAG transmitter at 532 nm. To obtain a depth resolution of better than 20 cm, the pulses had a duration of 5 to 7 nanoseconds and could be fired up to at rates of 50 pulses per second. In the receiver, the signal was detected by a photomultiplier tube connected to a 28 cm diameter Cassegrainian telescope that was aimed vertically downward. Oscilloscopic traces of the signal reflected from the sea surface and the ocean floor could either be recorded by a movie camera on 35 mm film or digitized into 500 discrete channels of information and stored on magnetic tape, from which depth information could be extracted. An aerial color movie camera recorded the geographic footprint while a boat crew of oceanographers measured depth and other relevant water parameters. About two hundred hours of flight time on the NASA C-54 airplane in the area of Chincoteague, Virginia, the Chesapeake Bay, and in Key West, Florida, have yielded information on the actual operating conditions of such a system and helped to optimize the design. One can predict the maximum depth attainable in a mission by measuring the effective attenuation coefficient in flight. This quantity is four times smaller than the usual narrow beam attenuation coefficient. Several square miles of a varied underwater landscape were also mapped.

Kim, H., H.↗
NASA NTRS1987

Temporal observations of surface soil moisture using a passive microwave sensor

A series of 10 aircraft flights was conducted over agricultural fields to evaluate relationships between observed surface soil moisture and soil moisture predicted using passive microwave sensor observations. An a priori approach was used to predict values of surface soil moisture for three types of fields: tilled corn, no-till corn with soybean stubble, and idle fields with corn stubble. Acceptable predictions were obtained for the tilled corn fields, while poor results were obtained for the others. The source of error is suspected to be the density and orientation of the surface stubble layer; however, further research is needed to verify this explanation. Temporal comparisons between observed, microwave predicted, and soil water-simulated moisture values showed similar patterns for tilled well-drained fields. Divergences between the observed and simulated measurements were apparent on poorly drained fields. This result may be of value in locating and mapping hydrologic contributing areas.

Jackson, T. J.↗
NASA NTRS1992

Studies of shock/shock interaction on smooth and transpiration-cooled hemispherical nosetips in hypersonic flow

A program of experimental research and analysis was conducted to examine the heat transfer and pressure distributions in regions of shock/shock interaction over smooth and transpiration-cooled hemispherical noseshapes. The objective of this investigation was to determine whether the large heat transfer generated in regions of shock/shock interaction can be reduced by transpiration cooling. The experimental program was conducted at Mach numbers of 12 to 16 in the Calspan 48-Inch Shock Tunnel. Type 3 and type 4 interaction regions were generated for a range of freestream unit Reynolds numbers to provide shear layer Reynolds numbers from 10 exp 4 to 10 exp 6 to enable laminar and turbulent interaction regions to be studied. Shock/shock interactions were investigated on a smooth hemispherical nosetip and a similar transpiration-cooled nosetip, with the latter configuration being examined for a range of surface blowing rates up to one-third of the freestream mass flux. While the heat transfer measurements on the smooth hemisphere without shock/shock interaction were in good agreement with Fay-Riddell predictions, those on the transpiration-cooled nosetip indicated that its intrinsic roughness caused heating-enhancement factors of over 1.5. In the shock/shock interaction studies on the smooth nosetip, detailed heat transfer and pressure measurements were obtained to map the variation of the distributions with shock-impingement position for a range of type 3 and type 4 interactions. Such sets of measurements were obtained for a range of unit Reynolds numbers and Mach numbers to obtain both laminar and turbulent interactions. The measurements indicated that shear layer transition has a significant influence on the heating rates for the type 4 interaction as well as the anticipated large effects on type 3 interaction heating. In the absence of blowing, the peak heating in the type 3 and type 4 interaction regions, over the transpiration-cooled model, did not appear to be influenced by the model's rough surface characteristics. The studies of the effects of the transpiration cooling on type 3 and type 4 shock/shock interaction regions demonstrated that large surface blowing rates had significant effect on the structure of the flowfield, enlarging the shock layer and moving the region of peak-heating interaction around the body.

Holden, Michael S.↗
NASA NTRS1995

Radial alignment simulation of solar wind streams observed by Pioneers 10 and 11 in 1974

A particularly favorable radial lineup between spacecraft in Earth orbit and Pioneers 10 and 11 (near the ecliptic plane at approximately 5.5 AU and approximately 4.5 AU, respectively) occurred in mid-1974, when the solar corona was in a stable and well-defined warped-dipole configuration. The radial alignment study reported here differs from previous applications of the technique in two respects: (1) It is the first time a two-dimensional (2-D) MHD model has been tested over such a lengthy propagation interval; the 2-D capability is crucial for treatment of the nonradial shearing motions occurring across the stream interface. (2) The three-dimensional (3-D) structure observed in the white light corona at that time is related to the systematic patterns of nonradial flow deflections appearing at the Pioneer corotating interaction region (CIR) fronts. Comparison of predicted and observed flows for pairs of streams in two successive rotations reveals that when the parent coronal hole projects far across the solar equator in a predominantly north-south orientation (i.e., nearest the 2-D idealization), the mapping is accurate down to details of the flow structures. But where the spacecraft tracks along a latitudinal boundary of a hole or the associated stream front is inclined at a shallow angle to the equator, the numerical projections deviate systematically from the observations. Among the sources of error are 3-D dynamical interactions neglected in the model, differential rotation effects, and slow temporal evolution of the coronal structures. A characteristic pattern of north-south and east-west deflections indicative of the 3-D geometry appears across the CIRs, but these patterns evidently reflect primarily the local, as opposed to global, orientation of the 3-D stream fronts. Such patterns appear common in CIRs observed by Pioneer during this period. These findings thus hold special relevance for the analysis of Ulysses observations, since the present coronal configuration is similar to that of 1974.

Pizzo, V. J.↗
NASA NTRS1997

Registration assisted mosaic generation

This paper presents a general strategy for assembling mosaics from numerous individual images where uncertainty exists in the position and orientation of those images. Both of the presented applications relate to remotely operated camera platforms, the first being the Galileo solid state imaging (SSI) camera presently in orbit around Jupiter, and the second being the Imager for Mars Pathfinder (IMP) stereo camera on Mars. A basic strategy in both applications is to determine the correct relative camera pointing followed by direct map projection of the images. It is assumed that approximate camera pointing exists sufficient to locate adjacent images and to place initial tiepoints within reach of the correlator. Spatial correlation is used to fix tiepoints whose initial locations are predicted by the camera pointing. We use either an fast fourier transform (fft) algorithm or a variant of Gruen's scheme permitting limited image rotation and skew. The Gruen correlator has three hierarchical modes: 1) A classical spatial least squares correlation on integral pixel boundaries used when rotation is small. 2) An annealing non-deterministic search used when rotations are unknown. A simplex deterministic search used for the end game. The correlation operation can be performed either interactively or autonomously. The final camera pointing solution relies upon a simplex downhill search in 2n or 3n dimensions where n is the number of images comprising the mosaic and the objective function to be minimized is the disagreement between tiepoint locations predicted from the camera pointing with those observed by the correlator. For Galileo the 3n unknowns are euler angles defining camera pointing in planet coordinates, and for Mars Pathfinder they are 2n unknowns representing commanded azimuth and elevation in the Lander coordinate system.

Lorre, Jean J.↗
NASA NTRS1998

Tidal Disruption of Strengthless Rubble Piles: A Dimensional Analysis

A relatively simple prescription for estimating the number of debris clumps (n) that form after a catastrophic tidal disruption event is presented. Following the breakup event, it is assumed that the individual debris particles follow keplerian orbits about the planet until the debris' gravitational contraction timescale (t(sub c)) becomes shorter than its orbital spreading timescale (t(sub s)). When the two timescales become comparable, self-gravity breaks up the debris train into n = L/D clumps, which is the debris length/diameter ratio at that instant. The clumps subsequently orbit the planet independent of each other. The predicted number of clumps n is in good agreement with more sophisticated N-body treatments of tidal breakup for parabolic encounters, and the dependence of n upon the progenitor's density as well as its orbit is also mapped out for hyperbolic encounters. These findings may be used to further constrain both the orbits and densities of the tidally disrupted bodies that struck Callisto and Ganymede. A cursory analysis shows that the Gomul and Gipul crater chains on Callisto, which have the greatest number of craters among the known chains, were formed by projectiles having comet-like densities estimated at rho(sub o) < 1 gm/cc.

Hahn, Joseph M.↗
NASA NTRS2001

Real-Time Adaptive Control Allocation Applied to a High Performance Aircraft

Abstract This paper presents the development and application of one approach to the control of aircraft with large numbers of control effectors. This approach, referred to as real-time adaptive control allocation, combines a nonlinear method for control allocation with actuator failure detection and isolation. The control allocator maps moment (or angular acceleration) commands into physical control effector commands as functions of individual control effectiveness and availability. The actuator failure detection and isolation algorithm is a model-based approach that uses models of the actuators to predict actuator behavior and an adaptive decision threshold to achieve acceptable false alarm/missed detection rates. This integrated approach provides control reconfiguration when an aircraft is subjected to actuator failure, thereby improving maneuverability and survivability of the degraded aircraft. This method is demonstrated on a next generation military aircraft Lockheed-Martin Innovative Control Effector) simulation that has been modified to include a novel nonlinear fluid flow control control effector based on passive porosity. Desktop and real-time piloted simulation results demonstrate the performance of this integrated adaptive control allocation approach.

Davidson, John B.↗
NASA NTRS2005

A Model-based Approach to Controlling the ST-5 Constellation Lights-Out Using the GMSEC Message Bus and Simulink

Space Technology 5 (ST-5) is a three-satellite constellation, technology validation mission under the New Millennium Program at NASA to be launched in March 2006. One of the key technologies to be validated is a lights-out, model-based operations approach to be used for one week to control the ST-5 constellation with no manual intervention. The ground architecture features the GSFC Mission Services Evolution Center (GMSEC) middleware, which allows easy plugging in of software components and a standardized messaging protocol over a software bus. A predictive modeling tool built on MatLab's Simulink software package makes use of the GMSEC standard messaging protocol to interface to the Advanced Mission Planning System (AMPS) Scenario Scheduler which controls all activities, resource allocation and real-time re-profiling of constellation resources when non-nominal events occur. The key features of this system, which we refer to as the ST-5 Simulink system, are as follows: Original daily plan is checked to make sure that predicted resources needed are available by comparing the plan against the model. As the plan is run in real-time, the system re-profiles future activities in real-time if planned activities do not occur in the predicted timeframe or fashion. Alert messages are sent out on the GMSEC bus by the system if future predicted problems are detected. This will allow the Scenario Scheduler to correct the situation before the problem happens. The predictive model is evolved automatically over time via telemetry updates thus reducing the cost of implementing and maintaining the models by an order of magnitude from previous efforts at GSFC such as the model-based system built for MAP in the mid-1990's. This paper will describe the key features, lessons learned and implications for future missions once this system is successfully validated on-orbit in 2006.

Witt, Kenneth J.↗
NASA NTRS2006

Turbulent Chemical Interaction Models in NCC: Comparison

The performance of a scalar PDF hydrogen-air combustion model in predicting a complex reacting flow is evaluated. In addition the results are compared to those obtained by running the same case with the so-called laminar chemistry model and also a new model based on the concept of mapping partially stirred reactor data onto perfectly stirred reactor data. The results show that the scalar PDF model produces significantly different results from the other two models, and at a significantly higher computational cost.

Norris, Andrew T.↗
NASA NTRS2014

Temperature Knowledge and Model Correlation for the Soil Moisture Active and Passive (SMAP) Reflector Mesh

NASA's Earth observing Soil Moisture Active & Passive (SMAP) Mission is scheduled to launch in November 2014 into a 685 km near-polar, sun synchronous orbit. SMAP will provide comprehensive global mapping measurements of soil moisture and freeze/thaw state in order to enhance understanding of the processes that link the water, energy, and carbon cycles. The primary objectives of SMAP are to improve worldwide weather and flood forecasting, enhance climate prediction, and refine drought and agriculture monitoring during its 3 year mission. The SMAP instrument architecture incorporates an L-band radar and an L-band radiometer which share a common feed horn and parabolic mesh reflector. The instrument rotates about the nadir axis at approximately 15 rpm, thereby providing a conically scanning wide swath antenna beam that is capable of achieving global coverage within 3 days. In order to make the necessary precise surface emission measurements from space, a temperature knowledge of 60 deg C for the mesh reflector is required. In order to show compliance, a thermal vacuum test was conducted using a portable solar simulator to illuminate a non flight, but flight-like test article through the quartz window of the vacuum chamber. The molybdenum wire of the antenna mesh is too fine to accommodate thermal sensors for direct temperature measurements. Instead, the mesh temperature was inferred from resistance measurements made during the test. The test article was rotated to five separate angles between 10 deg and 90 deg via chamber breaks to simulate the maximum expected on-orbit solar loading during the mission. The resistance measurements were converted to temperature via a resistance versus temperature calibration plot that was constructed from data collected in a separate calibration test. A simple thermal model of two different representations of the mesh (plate and torus) was created to correlate the mesh temperature predictions to within 60 deg C. The on-orbit mesh temperature will be predicted using the correlated analytical thermal model since direct measurements from in-situ flight thermal sensors are not possible.

Mikhaylov, Rebecca↗
NASA NTRS2014

Implementation of Active Thermal Control (ATC) for the Soil Moisture Active and Passive (SMAP) Radiometer

NASA's Earth Observing Soil Moisture Active and Passive (SMAP) Mission is scheduled to launch in November 2014 into a 685 kilometer near-polar, sun-synchronous orbit. SMAP will provide comprehensive global mapping measurements of soil moisture and freeze/thaw state in order to enhance understanding of the processes that link the water, energy, and carbon cycles. The primary objectives of SMAP are to improve worldwide weather and flood forecasting, enhance climate prediction, and refine drought and agriculture monitoring during its three year mission. The SMAP instrument architecture incorporates an L-band radar and an L-band radiometer which share a common feed horn and parabolic mesh reflector. The instrument rotates about the nadir axis at approximately 15 revolutions per minute, thereby providing a conically scanning wide swath antenna beam that is capable of achieving global coverage within three days. In order to make the necessary precise surface emission measurements from space, the electronics and hardware associated with the radiometer must meet tight short-term (instantaneous and orbital) and long-term (monthly and mission) thermal stabilities. Maintaining these tight thermal stabilities is quite challenging because the sensitive electronics are located on a fast spinning platform that can either be in full sunlight or total eclipse, thus exposing them to a highly transient environment. A passive design approach was first adopted early in the design cycle as a low-cost solution. With careful thermal design efforts to cocoon and protect all sensitive components, all stability requirements were met passively. Active thermal control (ATC) was later added after the instrument Preliminary Design Review (PDR) to mitigate the threat of undetected gain glitches, not for thermal-stability reasons. Gain glitches are common problems with radiometers during missions, and one simple way to avoid gain glitches is to use the in-flight set point programmability that ATC affords to operate the radiometer component away from the problematic temperature zone. A simple ThermXL model (10 nodes) was developed to exercise quick trade studies among various proposed control algorithms: Modified P control vs. PI control. The ThermXL results were then compared with the detailed Thermal Desktop (TD) model for corroboration. Once done, the simple ThermXL model was used to evaluate parameter effects such as temperature digitization, heater size and gain margin, time step, and voltage variation of power supply on the ATC performance. A Modified P control algorithm was implemented into the instrument flight electronics based on the ThermXL results. The thermal short-term stability margin decreased by 10 percent with ATC and a wide temperature error band (plus or minus 0.1 degrees Centigrade) compared to the original passive thermal design. However, a tighter temperature error band (plus or minus 0.1 degrees Centigrade) increased the thermal short-term stability margin by a factor of three over the passive thermal design. The current ATC design provides robust thermal control, tighter stability, and greater in-flight flexibility even though its implementation was prompted by non-thermal performance concerns.

Mikhaylov, Rebecca↗
NASA NTRS2022

Free Energy Landscapes for Elucidating the Structural Consequences of Exon-20 mutations on the ErbB Family of Protein Kinases

The ErbB family of protein kinases plays an important role in major cellular functions and consequently mutations in the functional regions of these proteins are implicated in several types of cancer growths. To envision rational design of small molecule drugs that target the diseased proteins it is important to quantify the structural effects of the mutations, as some of these mutants render the protein resistant to tyrosine kinase inhibitors (TKIs). Herein we use advanced sampling techniques and long-timescale molecular dynamics simulations to predict the effect of major exon 20 mutations on the ErbB family, specifically EGFR and HER2 proteins. Exon 20 mutations have been clinically known to induce TKI resistance, though the mechanisms of such an effect is poorly understood. By mapping out the free energy landscape of the mutants and comparing them against the wild-type, we elucidate the structural differences in the binding pocket region that alter the nature of drug-protein interactions. We believe that these insights will play a pivotal role in developing small molecule drugs that overcome the TKI resistance.

Ashwin Ravichandran↗