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At least 739 records · Page 41

Rapid Detection of the Varicella Zoster Virus

1.Technology Description-Researchers discovered that when the Varicella Zoster Virus (VZV) reactivates from latency in the body, the virus is consistently present in saliva before the appearance of skin lesions. A small saliva sample is mixed with a specialized reagent in a test kit. If the virus is present in the saliva sample, the mixture turns a red color. The sensitivity and specificity emanates from an antibody-antigen reaction. This technology is a rapid, non-invasive, point of-of-care testing kit for detecting the virus from a saliva sample. The device is easy to use and can be used in clinics and in remote locations to quickly detect VZV and begin treatment with antiviral drugs. 2.Market Opportunity- RST Bioscience will be the first and only company to market a rapid, same day test kit for the detection of VZV in saliva. The RST detection test kit will have several advantages over existing, competitive technology. The test kit is self contained and laboratory equipment is not required for analysis of the sample. Only a single saliva sample is required to be taken instead of blood or cerebral spinal fluid. The test kit is portable, sterile and disposable after use. RST detection test kits require no electrical power or expensive storage equipment and can be used in remote locations. 3.Market Analysis- According to the CDC, it is estimated that 1 million cases of shingles occur each year in the U.S. with more than half over the age of sixty. There is a high demand for rapid diagnostics by the public. The point-of-care testing (POCT) market is growing faster than other segments of in vitro diagnostics. According to a July 2007 InteLab Corporation industry report the overall market for POCT was forecast to increase from $10.3 billion in 2005 to $18.7 billion by 2011. The market value of this test kit has not been determined. 4.Competition- The VZV vaccine prevents 50% of cases and reduces neuralgia by 66%. The most popular test detects VZV-specific IgM antibody in blood. Other tests include running a sample in a polymerase chain reaction analyzer, enzyme immunoassay, latex agglutination, indirect fluorescent antibody and fluorescent antibody to membrane antigen assay. These existing tests require laboratory analysis by trained personnel, expensive equipment, invasive procedures and a longer period of time to obtain test results.

Lewis, Michelle P.↗

Compact Augmented Spark Igniters for Liquid Rocket Engines

The objective of this dissertation is to characterize augmented spark impinging (torch) igniters. Torch igniters inject propellants into a small prechamber where a spark igniter imparts the activation energy to initiate combustion. The flame stabilizes within the prechamber and exits into the main combustion chamber where it ignites the main flow directly or by mixing with a coaxial flow to create a secondary flame. The underlying phenomena that promote reliable ignition are multifaceted and required a broad scope of investigations. Initial efforts focused on spark discharges across an annular geometry. Gaseous propellent projects the electrical arc toward the prechamber, where the arc and the thermal energy is imparted to the surrounding fluid then meets with a combustible mixture. Discharges are parametrically examined against pressure, spark-gap size, and exciter types to emulate transient engine startup. The energy imparted to the flow, approximate velocity, and distance traveled by the exhaust plume are determined. Spark quenching (no energy deposition) and its effects on perceived versus actual measurements are shown. Results outline the prechamber target zone where a combustible mixture is necessary for ignition. Next, three-dimensional, time-accurate, and nonreacting computational fluid dynamics simulations assess effects of geometric and mass flow differences on the size, location, and composition of a combustible mixture. Fluid dynamic phenomena are elucidated. Correlations between nondimensional variables are found. Results are coupled with a conservation-law analysis to produce novel objective functions. Lastly, a full-scale, modular torch igniter is tested. Injector sizes, mixture ratios, and injector momentum ratios are systematically varied to map ignition probability and ignition delay. Results show the importance of local mixture ratios, provide injector momentum ratios guidelines, and demonstrate reliable ignition of core mixture ratios typically outside flammability limits. The deliverable of this project is not a torch igniter or derivative thereof. Instead, this dissertation produces novel objective-functions for igniter design. These equations are functions of variables that may be constrained by engine-level requirements, physics, and experimental results from this work. They provide a foundation for future igniter design and will minimize iterative processes from the design cycle for next-generation ignition hardware.

Torch Igniter↗

Temperature Homogeneity under Selective and Localized Microwave Heating in Structured Flow Reactors

Selective heating of different phases of multiphase systems via microwaves can result in energy savings and suppression of side reactions. However, materials properties and operating conditions that maximize temperature gradients are poorly understood. Here we utilize computational fluid dynamics (CFD) computations and temperature measurements in structured flow reactors (monoliths) in a monomodal microwave cavity to assess the temperature difference between the walls and the fluid and develop a simple lumped model to estimate when temperature gradients exist. We also explore the material’s thermal and electrical properties of structured reactors for isothermal catalyst conditions. We propose that CFD simulations can be used as a nonintrusive, predictive tool of temperature homogeneity. Importantly, we demonstrate that localized heating in the bed under several conditions rather than selective heating is responsible for the selectivity enhancement. Furthermore, our results indicate that structured beds made of high thermal conductivity materials avoid arcing and enable temperature homogeneity and low electrical conductivity materials allow microwaves to penetrate the domain.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Electrical impedance imaging in two-phase, gas-liquid flows: 1. Initial investigation

The determination of interfacial area density in two-phase, gas-liquid flows is one of the major elements impeding significant development of predictive tools based on the two-fluid model. Currently, these models require coupling of liquid and vapor at interfaces using constitutive equations which do not exist in any but the most rudimentary form. Work described herein represents the first step towards the development of Electrical Impedance Computed Tomography (EICT) for nonintrusive determination of interfacial structure and evolution in such flows.

Lin, J. T.↗

Rotational fluid flow experiment

This project which began in 1986 as part of the Worcester Polytechnic Institute (WPI) Advanced Space Design Program focuses on the design and implementation of an electromechanical system for studying vortex behavior in a microgravity environment. Most of the existing equipment was revised and redesigned by this project team, as necessary. Emphasis was placed on documentation and integration of the electrical and mechanical subsystems. Project results include reconfiguration and thorough testing of all hardware subsystems, implementation of an infrared gas entrainment detector, new signal processing circuitry for the ultrasonic fluid circulation device, improved prototype interface circuits, and software for overall control of experiment operation.

Source record↗

Numerical modeling of fluid and electromagnetic phenomena in an arcjet

An explicit numerical technique is used to solve the axisymmetric reduced electromagnetic field equation. The effect of an electrical arc on a viscous, axisymmetric flow is approximated using an implicit thin layer Navier-Stokes solver with additional electromagnetic source terms in conjunction with the explicit finite difference code.

Flowe, Anita C.↗

Select Variables Affecting Thermal System Design of a Liquid-Cooled Stator

NASA Glenn Researchers have endeavored to create a high-power-density, efficient electric motor called the High Efficiency Megawatt Motor (HEMM) with a goal of exceeding 98% efficiency and 1.46 MW of power. These aggressive goals were set because increasing the power density and efficiency of electric machines (motors and generators) is integral to bringing electrified aircraft (EA) to commercial realization. Resistive losses in the stator windings are by far the largest (34%) contributor to this design’s total energy losses. Previous testing of a HEMM-like stator test article (statorette) showed good agreement between measured performance and model predictions. Therefore, a foundation was provided to test other engineering parameters that are encountered when designing an electric machine. Of particular interest are the effects of changes to the thickness of the epoxy from the potting process, changes in the fluid volume/flow path around the end windings, and changes in the viscosity of the cooling fluid on the overall thermal performance of the unit. The impact of those parameters as revealed through a third-generation build, test, and finite element model analysis of a statorette test section is the focus of this paper.

EAP↗

Concurrent Optimization of Capital Cost and Expected O&M

Concentrating solar power (CSP) technologies can utilize heat from concentrated sunlight from a field of tracking mirrors to generate electricity, reform fuel, provide process heat, or augment fossil plant heat sources. Electricity-generating power tower systems focus light from thousands of independent heliostats onto a thermal receiver, which uses the focused light to warm a heat transfer fluid (HTF), typically, a molten nitrate salt. The HTF is then sent to a power generation cycle or diverted into thermal energy storage (TES) for later use. Thermal storage is – in principle – a straightforward proposition. However, optimal utilization of a TES resource is complex and multi-faceted: thermal energy may be dispatched to produce electricity immediately upon first availability, or thermal energy may be reserved for next-day peak periods at risk of filling storage and dumping energy, or a portion of the thermal energy can be reserved to maintain equipment temperatures, reducing power cycle startup time, etc. Many possible dispatch permutations variously emphasize producing peak power, operating through transients, expediting daily startup, etc. The best operation strategy can change day-to-day throughout the year, depending on the weather and market pricing forecasts. The project we describe in this report develops a software package that allows users to explore design optimization, operations decisions, and performance characterization of concentrating solar power tower plants. Users interface with the tool through a scripting language, and results are reported in time series tables, plots, runtime logs, and design outputs. Users choose from a list of variables such as tower height, solar multiple, design-point irradiance, thermal storage size, etc., and specify information about the system using a list of parameters. The software can then optimize the specified variables to reduce the cost of energy produced by the system while meeting certain production requirements, accounting for uncertain weather and electricity price forecasts, and correcting for equipment failures or repair time. The software we develop is the first comprehensive design tool of its kind to incorporate all of these aspects while being deployed as open source.

14 SOLAR ENERGY↗

Electrically Conducting, Ca-Rich Brines, Rather Than Water, Expected in the Martian Subsurface

If Mars ever possessed a salty liquid hydrosphere, which later partly evaporated and froze down, then any aqueous fluids left near the surface could have evolved to become dense eutectic brines. Eutectic brines, by definition, are the last to freeze and the first to melt. If CaC12-rich, such brines can remain liquid until temperatures below 220 K, close to the average surface temperature of Mars. In the Martian subsurface, in intimate contact with the Ca-rich basaltic regolith, NaC1-rich early brines should have reacted to become Ca-rich. Fractional crystallization (freezing) and partial melting would also drive brines toward CaC12-rich compositions. In other words, eutectic brine compositions could be present in the shallow subsurface of Mars, for the same reasons that eutectic magma compositions are common on Earth. Don Juan Pond, Antarctica, a CaC12-rich eutectic brine, provides a possible terrestrial analog, particularly because it is fed from a basaltic aquifer. Owing to their relative density and fluid nature, brines in the Martian regolith should eventually become sandwiched between ice above and salts beneath. A thawing brine sandwich provides one explanation (among many) for the young gullies recently attributed to seepage of liquid water on Mars. Whether or not brine seepage explains the gullies phenomenon, dense, CaC12-rich brines are to be expected in the deep subsurface of Mars, although they might be somewhat diluted (temperatures permitting) and of variable salt composition. In any case, they should be good conductors of electricity.

Burt, D. M.↗

High-Fidelity Aerodynamic Analysis and Optimization of the SUSAN Electrofan Concept

The Subsonic Single Aft Engine (SUSAN) Electrofan is a new single-aisle regional jet class transport aircraft being studied by NASA, which benefits from reduced fuel consumption through a reduction in the number of hydrocarbon fuel-burning engines from two to one. This is achieved through a hybrid-electric system architecture, where a series of generators are used to extract power from a fuel-consuming tail cone thruster to drive electric propulsors mounted on the wings. To support the development of these propulsion systems, which involve high levels of propulsion-airframe integration, this paper presents high-fidelity analyses through computational fluid dynamics (CFD) simulations provided by the Launch Ascent and Vehicle Aerodynamics (LAVA) framework, which also includes capabilities for modeling the effect of active propulsors. A trade space exploration is performed to investigate the advantages of several wing mounted distributed electric propulsion system configurations, including over-wing, under-wing, and trailing-edge arrangements. For the aft fuselage propulsor, focus is on the sizing of the inlet, core, and bypass ducts. High-fidelity aerodynamic shape optimization is also used to help minimize the inlet distortion intensity experienced by the aft propulsor fan through a reshaping of the fuselage.

CAS↗

The Zero Boil-Off Tank Experiment Ground Testing and Verification of Fluid and Thermal Performance

The Zero Boil-Off Technology (ZBOT) Experiment involves performing a small scale International Space Station (ISS) experiment to study tank pressurization and pressure control in microgravity. The ZBOT experiment consists of a vacuum jacketed test tank filled with an inert fluorocarbon simulant liquid. Heaters and thermo-electric coolers are used in conjunction with an axial jet mixer flow loop to study a range of thermal conditions within the tank. The objective is to provide a high quality database of low gravity fluid motions and thermal transients which will be used to validate Computational Fluid Dynamic (CFD) modeling. This CFD can then be used in turn to predict behavior in larger systems with cryogens. This paper will discuss the work that has been done to demonstrate that the ZBOT experiment is capable of performing the functions required to produce a meaningful and accurate results, prior to its launch to the International Space Station. Main systems discussed are expected to include the thermal control system, the optical imaging system, and the tank filling system.This work is sponsored by NASAs Human Exploration Mission Directorates Physical Sciences Research program.

Fluid management↗

Development of a Direct Contact Heat Exchanger, Phase 1 Study Report

Electric power generation from geothermal brine requires, first, bringing the hot brine to the surface and then converting the heat to electric power. Binary conversion schemes were proposed, with the heat transfer between the brine and the working organic fluid taking place in a conventional tube and shell heat exchanger. If the brine is heavily laden with dissolved solids, however, solids buildup on the heat exchanger surfaces leads to a considerable degree of fouling and an accompanying drop in performance is experienced. A possible solution to this problem is the use of a direct contact exchanger with the secondary fluid power cycle. The proposed concept involves the formation of fluid sheets and bells as heat angles. Results of a study concerning the fluid mechanics of such surfaces are given.

Manvi, R.↗

Electroformed Electrodes for Electrical-Discharge Machining

Copper electrodes replace graphite electrodes in many instances of electrical-discharge machining (EDM) of complex shapes. Copper electrodes wear longer and cause less contamination of EDM dielectric fluid than do graphite electrodes.

Werner, A.↗

Colloidal characterization of silicon nitride and silicon carbide

The colloidal behavior of aqueous ceramic slips strongly affects the forming and sintering behavior and the ultimate mechanical strength of the final ceramic product. The colloidal behavior of these materials, which is dominated by electrical interactions between the particles, is complex due to the strong interaction of the solids with the processing fluids. A surface titration methodology, modified to account for this interaction, was developed and used to provide fundamental insights into the interfacial chemistry of these systems. Various powder pretreatment strategies were explored to differentiate between true surface chemistry and artifacts due to exposure history. The colloidal behavior of both silicon nitride and carbide is dominated by silanol groups on the powder surfaces. However, the colloid chemistry of silicon nitride is apparently influenced by an additional amine group. With the proper powder treatments, silicon nitride and carbide powder can be made to appear colloidally equivalent. The impact of these results on processing control will be discussed.

Feke, Donald L.↗

Infrastructure for deployment of power systems

A preliminary effort in characterizing the types of stationary lunar power systems which may be considered for emplacement on the lunar surface from the proposed initial 100-kW unit in 2003 to later units ranging in power from 25 to 825 kW is presented. Associated with these power systems are their related infrastructure hardware including: (1) electrical cable, wiring, switchgear, and converters; (2) deployable radiator panels; (3) deployable photovoltaic (PV) panels; (4) heat transfer fluid piping and connection joints; (5) power system instrumentation and control equipment; and (6) interface hardware between lunar surface construction/maintenance equipment and power system. This report: (1) presents estimates of the mass and volumes associated with these power systems and their related infrastructure hardware; (2) provides task breakdown description for emplacing this equipment; (3) gives estimated heat, forces, torques, and alignment tolerances for equipment assembly; and (4) provides other important equipment/machinery requirements where applicable. Packaging options for this equipment will be discussed along with necessary site preparation requirements. Design and analysis issues associated with the final emplacement of this power system hardware are also described.

Sprouse, Kenneth M.↗

Crystal Growth of ZnSe and Related Ternary Compound Semiconductors by Vapor Transport

Crystal growth by vapor transport has several distinct advantages over melt growth techniques. Among various potential benefits from material processing in reduced gravity the followings two are considered to be related to crystal growth by vapor transport: (1) elimination of the crystal weight and its influence on the defect formation and (2) reduction of natural buoyancy-driven convective flows arising from thermally and/ or solutally induced density gradient in fluids. The previous results on vapor crystal growth of semiconductors showed the improvements in surface morphology, crystalline quality, electrical properties and dopant distribution of the crystals grown in reduced gravity as compared to the crystals grown on Earth. But the mechanisms, which are responsible for the improvements and cause the gravitational effects on the complicated and coupled processes of vapor mass transport and growth kinetics, are not well understood.

Su, Ching-Hua↗