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At least 739 records · Page 41

IBEX: An open infrastructure software platform to facilitate collaborative work in radiomics

Purpose: Radiomics, which is the high-throughput extraction and analysis of quantitative image features, has been shown to have considerable potential to quantify the tumor phenotype. However, at present, a lack of software infrastructure has impeded the development of radiomics and its applications. Therefore, the authors developed the imaging biomarker explorer (IBEX), an open infrastructure software platform that flexibly supports common radiomics workflow tasks such as multimodality image data import and review, development of feature extraction algorithms, model validation, and consistent data sharing among multiple institutions. Methods: The IBEX software package was developed using the MATLAB and C/C++ programming languages. The software architecture deploys the modern model-view-controller, unit testing, and function handle programming concepts to isolate each quantitative imaging analysis task, to validate if their relevant data and algorithms are fit for use, and to plug in new modules. On one hand, IBEX is self-contained and ready to use: it has implemented common data importers, common image filters, and common feature extraction algorithms. On the other hand, IBEX provides an integrated development environment on top of MATLAB and C/C++, so users are not limited to its built-in functions. In the IBEX developer studio, users can plug in, debug, and test new algorithms, extending IBEX’s functionality. IBEX also supports quality assurance for data and feature algorithms: image data, regions of interest, and feature algorithm-related data can be reviewed, validated, and/or modified. More importantly, two key elements in collaborative workflows, the consistency of data sharing and the reproducibility of calculation result, are embedded in the IBEX workflow: image data, feature algorithms, and model validation including newly developed ones from different users can be easily and consistently shared so that results can be more easily reproduced between institutions. Results: Researchers with a variety of technical skill levels, including radiation oncologists, physicists, and computer scientists, have found the IBEX software to be intuitive, powerful, and easy to use. IBEX can be run at any computer with the windows operating system and 1GB RAM. The authors fully validated the implementation of all importers, preprocessing algorithms, and feature extraction algorithms. Windows version 1.0 beta of stand-alone IBEX and IBEX’s source code can be downloaded. Conclusions: The authors successfully implemented IBEX, an open infrastructure software platform that streamlines common radiomics workflow tasks. Its transparency, flexibility, and portability can greatly accelerate the pace of radiomics research and pave the way toward successful clinical translation.

60 APPLIED LIFE SCIENCES↗

Sierra/SolidMechanics 5.6 User's Manual

Sierra/SolidMechanics (Sierra/SM) is a three-dimensional solid mechanics code with a versatile element library, nonlinear material models, large deformation capabilities, and contact. It is built on the SIERRA Framework. SIERRA provides a data management framework in a parallel computing environment that allows the addition of capabilities in a modular fashion. Contact capabilities are parallel and scalable. This document provides information about the functionality in Sierra/SM and the command structure required to access this functionality in a user input file. This document is divided into chapters based primarily on functionality. For example, the command structure related to the use of various element types is grouped in one chapter; descriptions of material models are grouped in another chapter. Sierra/SM provides both explicit transient dynamics and implicit quasistatics and dynamics capabilities. Both the explicit and implicit modules are highly scalable in a parallel computing environment. In the past, the explicit and implicit capabilities were provided by two separate codes, known as Presto and Adagio, respectively. These capabilities have been consolidated into a single code. The executable is named Adagio, but it provides the full suite of solid mechanics capabilities, for both implicit and explicit. The Presto executable has been disabled as a consequence of this consolidation.

97 MATHEMATICS AND COMPUTING↗

Study of mechanism which causes film formation on mercury surfaces

The mechanism by which small quantities of dissolved tin, sodium, and lithium lower the rate of evaporation of mercury in vacuum is determined. An apparatus was built in which dilute amalgams could be prepared and studied in an oxygen-free environment before being exposed to oxygen under controlled conditions. The apparatus was able to maintain a pressure of less than 1.3 x 0.000001 N/sqm (10 to the minus 8th power torr) of gases and vapors other than mercury and less than 1.3 x 10 to the minus 8th N/sq m (10 to the minus 10th power torr) partial pressure of oxygen; also, it provided for mechanical sweeping of the liquid metal surfaces in the vacuum environment. The rates of evaporation of pure mercury and of dilute amalgams of tin (52 ppm), sodium (229 ppm), and lithium (165 ppm) were determined at temperature between 25 and 55 C both before and after 70 minute exposures to an approximately 270 N/sq m (2 torr) pressure of oxygen. The rates of evaporation of the pure mercury and the amalgams as first prepared were similar but the rates for the amalgams were reduced by at least 80% at 25 C as a result of the exposure to oxygen. The effect of the oxygen treatment could be completely removed by sweeping the amalgam surfaces. It was concluded that the reduced rates of evaporation resulted from the formation of transparent, insoluble, oxide films on the amalgam surfaces.

Frohnsdorff, G.↗

Application of ecological, geological and oceanographic ERTS-1 imagery to Delaware's coastal resources planning

The author has identified the following significant results. Coastal vegetation species appearing in the ERTS-1 images taken of Delaware Bay have been correlated with ground truth vegetation maps and imagery obtained from high altitude overflights. Multispectral analysis of the high altitude photographs indicated that four major vegetation communities could be clearly discriminated from 60,000 feet altitude including: (1) salt marsh cord grass; (2) salt marsh hay and spike grass; (3) reed grass; and (4) high tide bush and sea myrtle. In addition, human impact can be detected in the form of fresh water impoundments built to attract water fowl, dredge-fill operations and other alterations of the coastal environment. Overlay maps matching the USGS topographic map size of 1:24,000 have been prepared showing the four wetland vegetation communities, fresh water impoundments, and alteration of wetlands by mosquito control ditching and dredge-fill operations. Using these maps, ERTS-1 images were examined by human interpreters and automated multispectral analyzers. Major plant communities of (1) Spartina alterniflora, (2) Spartina patens and Distichlis spicata, and (3) Iva frutescens and Baccharis halimifolia can be distinguished from each other and from surrounding uplands in ERTS-1 scanner bands 6 and 7.

Klemas, V.↗

Technology of civil usage of composites

The paper deals with the use of advanced composites in structural components of commercial aircraft. The need for testing the response of a material system to service environment is discussed along with methods for evaluating design and manufacturing aspects of a built-up structure under environmental conditions and fail-safe (damage-tolerance) evaluation of structures. Crashworthiness aspects, the fire-hazard potential, and electrical damage of composite structures are considered. Practical operational experience with commercial aircraft is reviewed for boron/epoxy foreflaps, Kevlar/epoxy fillets and fairings, graphite/epoxy spoilers, graphite/polysulfone spoilers, graphite/epoxy floor posts, boron/aluminum aft pylon skin panels, graphite/epoxy engine nose cowl outer barrels, and graphite/epoxy upper aft rudder segments.

Kemp, D. E.↗

Advanced orbiting systems front end

The Advanced Orbiting System (AOS) Front End System is being designed at NASA's Goddard Space Flight Center as a prototype front end to demonstrate the core front end functions required in the Customer Data Operations Systems (CDOS) in a realistic data processing requirement. The overall goal is to provide a low-cost environment for evaluating and verifying AOS and CDOS requirements before the actual operational systems are built. The architecture of the AOS Front End system, its core processing functions, and performance requirements are discussed, as are possible implementation architectures and solutions being developed to handle key AOS services.

Hand, Sarah↗

STS-47 Post Flight Press Conference

The flight crew of the STS-47 Space Shuttle Orbiter Endeavour Cmdr. Robert L. Gibson, Pilot Curtis L. Brown, Payload Cmdr. Mark C. Lee, Mission Specialists, N. Jan Davis, Jay Apt, Mae C. Jemison, and Payload Specialist, Mamoru Mohri, present an overview of their mission. This the 50th Shuttle flight marks the first NASA mission devoted primarily to Japan. Endeavour carries into Earth orbit Spacelab-J (SL-J), a 23-foot long pressurized laboratory built by the European Space Agency specifically for conducting experiments in a shirt-sleeve environment. SL-J contains 43 experiments, 34 provided by Japan, 7 from the United States and 2 joint experiments. Jemison becomes the first African American woman to fly in space and Mohri first Japanese to fly in space. Video footage includes the following: prelaunch and launch activities; various experiments including protein crystal growth, electronic materials, fluids, glasses and ceramics, metals and alloys, and the effects of microgravity on plants and animals; earth views of Japan, Tokyo Harbor, and Hurricane Bonnie; and the re-entry and landing of the orbiter.

Source record↗

Current Results From The Advanced Photovoltaic Solar Array (APSA) Program

The paper continues the status reporting of the ultralightweight flexible blanket, flatpack, foldout solar array testbed wing that was presented at the previous Meeting. The test bed wing has been built and subjected to a variety of critical functional tests after exposure to simulated launch environments.

Solar Array↗

MONTE Python for Deep Space Navigation

The Mission Analysis, Operations, and Navigation Toolkit Environment (MONTE) is the Jet Propulsion Laboratory’s (JPL) signature astrodynamic computing platform. It was built to support JPL’s deep space exploration program, and has been used to fly robotic spacecraft to Mars, Jupiter, Saturn, Ceres, and many solar system small bodies. At its core, MONTE consists of low-level astrodynamic libraries that are written in C++ and presented to the end user as an importable Python language module. These libraries form the basis on which Python-language applications are built for specific astrodynamic applications, such as trajectory design and optimization, orbit determination, flight path control, and more. The first half of this paper gives context to the MONTE project by outlining its history, the field of deep space navigation and where MONTE fits into the current Python landscape. The second half gives an overview of the main MONTE libraries and provides a narrative example of how it can be used for astrodynamic analysis.

aerospace↗

Microwave Photonics for Distributed Sensing

In the past few years, microwave-photonics technologies have been investigated for optical fiber sensing. By introducing microwave modulation into the optical system, the optical detection is synchronized with the microwave modulation frequency. As a result, the system has a high SNR and thus an improved detection limit. In addition, the phase of the microwave-modulated light can be obtained and Fourier transformed to find the time-of-arrival information for distributed sensing. Recently, an incoherent optical-carrier-based microwave interferometry (OCMI) technique has been demonstrated for fully distributed sensing with high spatial resolution and large measurement range. Since the modal interference has little influence on the OCMI signal, the OCMI is insensitive to the types of optical waveguide. Motivated by the eeds of distributed measurement in the harsh environment, in the first part of this paper, several OCMI-based sensing systems were built by using special multimode waveguides to perform sensing for heavy duty applications. Driven by an interest on the high-resolution sensing, in the second part of the paper, I propose a coherence-gated microwave photonics interferometry (CMPI) technique, which uses a coherent light source to obtain the optical interference signal from cascaded weak reflectors. The coherence length of the light source is carefully chosen or controlled to gate the signal so that distributed sensing can be achieved. The experimental results indicate that the strain resolution can be better than 0.6 μ using a Fabry-Perot interferometer (FPI) iii with a cavity length of 1.5 cm. Further improvement of the strain resolution to the 1 n level is achievable by increasing the cavity length of the FPI to over 1m. The CMPI has also been utilized for distributed dynamic measurement of vibration by using a new signal processing method. The fast time-varying optical interference intensity change induced by the sub-scan rate vibration is recorded in the frequency domain. After Fourier transform, distinctive features are shown at the vibration location in the time domain signal, where the vibration frequency and intensity can be retrieved. The signal processing method supports vibration measurement of multiple points with the measurable frequency of up to 20 kHz.

Hua, Liwei↗

A direct broadcast satellite-audio experiment

System studies have been carried out over the past three years at the Jet Propulsion Laboratory (JPL) on digital audio broadcasting (DAB) via satellite. The thrust of the work to date has been on designing power and bandwidth efficient systems capable of providing reliable service to fixed, mobile, and portable radios. It is very difficult to predict performance in an environment which produces random periods of signal blockage, such as encountered in mobile reception where a vehicle can quickly move from one type of terrain to another. For this reason, some signal blockage mitigation techniques were built into an experimental DAB system and a satellite experiment was conducted to obtain both qualitative and quantitative measures of performance in a range of reception environments. This paper presents results from the experiment and some conclusions on the effectiveness of these blockage mitigation techniques.

Vaisnys, Arvydas↗

Techniques for studying the effects of microgravity on model particle/cell systems

In an effort to learn more about the effects of a simulated low gravity environment on skeletal muscle, skeletal muscle cell cultures were grown within the lumen of XM-80 hollow fibers (i.d. = 0.5 mm) in a Clinostat rotating at 100 rpm. Cells were isolated from the thigh muscle tissue of 12 day embryos and were cultured for up to 14 days in the hollow fiber environment. Cells proliferated to confluency within several days, and fusion into multinucleated myotubes was then apparent. Fibers were stretched by a built-in spring mechanism to hold the fiber tightly at the center of rotation, and sections of the fiber were removed at 3, 7 and 14 days for electron microscopic analysis. When the Clinostat is rotated in the horizontal position, the gravity vector approaches zero and the cells are in an environment that simulates microgravity. Control experiments consist of one fiber rotated in the vertical position in the clinostat and another fiber that is held in a horizontal configuration in a comparable sized tube that is not rotated at all. Examination of skeletal muscle cells by electron microscopy revealed that myoblast fusion and myofibril accumulation were extensive. Two general conclusions were apparent. First, muscle cells undergo the normal progression of proliferation, fusion, and myofibril assembly in the presence of simulated microgravity for the first week in culture. After 14 days, however, many muscle fibers undergo degeneration such that myofibrillar structures are not extensive or well organized. Second, although no major abnormalities in myofibril assembly were detected in Clinostat-rotated cultures in comparison to controls that were not rotated in a Clinostat, the myofibrils in non-rotated controls tend to be more highly organized than those in either horizontally or vertically rotated Clinostat samples.

Young, Ronald B.↗

Extending the LWS Data Environment: Distributed Data Processing and Analysis

The final stages of this work saw changes to the original framework, as well as the completion and integration of several data processing services. Initially, it was thought that a peer-to-peer architecture was necessary to make this work possible. The peer-to-peer architecture provided many benefits including the dynamic discovery of new services that would be continually added. A prototype example was built and while it showed promise, a major disadvantage was seen in that it was not easily integrated into the existing data environment. While the peer-to-peer system worked well for finding and accessing distributed data processing services, it was found that its use was limited by the difficulty in calling it from existing tools and services. After collaborations with members of the data community, it was determined that our data processing system was of high value and that a new interface should be pursued in order for the community to take full advantage of it. As such; the framework was modified from a peer-to-peer architecture to a more traditional web service approach. Following this change multiple data processing services were added. These services include such things as coordinate transformations and sub setting of data. Observatory (VHO), assisted with integrating the new architecture into the VHO. This allows anyone using the VHO to search for data, to then pass that data through our processing services prior to downloading it. As a second attempt at demonstrating the new system, a collaboration was established with the Collaborative Sun Earth Connector (CoSEC) group at Lockheed Martin. This group is working on a graphical user interface to the Virtual Observatories and data processing software. The intent is to provide a high-level easy-to-use graphical interface that will allow access to the existing Virtual Observatories and data processing services from one convenient application. Working with the CoSEC group we provided access to our data processing tools from within their software. This now allows the CoSEC community to take advantage of our services and also demonstrates another means of accessing our system.

Narock, Thomas↗

Evidence of a rolling motion of a microparticle on a silicon wafer in a liquid environment

The interaction of micro- and nanometer-sized particles with surfaces plays a crucial role when small-scale structures are built in a bottom-up approach or structured surfaces are cleaned in the semiconductor industry. For a reliable quantification of the interaction between individual particles and a specific surface, however, the motion type of the particle must be known. We developed an approach to unambiguously distinguish between sliding and rolling particles. To this end, fluorescent particles were partially bleached in a confocal laser scanning microscope to tailor an optical inhomogeneity, which allowed for the identification of the characteristic motion pattern. For the manipulation, the water flow generated by a fast moving cantilever-tip of an atomic force microscope enabled the contactless pushing of the particle. We thus experimentally evidenced a rolling motion of a micrometer-sized particle directly with a fluorescence microscope. A similar approach could help to discriminate between rolling and sliding particles in liquid flows of microfluidic systems.

42 ENGINEERING↗

TomoPyUI : a user-friendly tool for rapid tomography alignment and reconstruction

The management and processing of synchrotron and neutron computed tomography data can be a complex, labor-intensive and unstructured process. Users devote substantial time to both manually processing their data ( i.e. organizing data/metadata, applying image filters etc. ) and waiting for the computation of iterative alignment and reconstruction algorithms to finish. In this work, we present a solution to these problems: TomoPyUI , a user interface for the well known tomography data processing package TomoPy . This highly visual Python software package guides the user through the tomography processing pipeline from data import, preprocessing, alignment and finally to 3D volume reconstruction. The TomoPyUI systematic intermediate data and metadata storage system improves organization, and the inspection and manipulation tools (built within the application) help to avoid interrupted workflows. Notably, TomoPyUI operates entirely within a Jupyter environment. Herein, we provide a summary of these key features of TomoPyUI , along with an overview of the tomography processing pipeline, a discussion of the landscape of existing tomography processing software and the purpose of TomoPyUI , and a demonstration of its capabilities for real tomography data collected at SSRL beamline 6-2c.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

Sierra/Solid Mechanics 4.48 User's Guide

Sierra/SolidMechanics (Sierra/SM) is a Lagrangian, three-dimensional code for finite element analysis of solids and structures. It provides capabilities for explicit dynamic, implicit quasistatic and dynamic analyses. The explicit dynamics capabilities allow for the efficient and robust solution of models with extensive contact subjected to large, suddenly applied loads. For implicit problems, Sierra/SM uses a multi-level iterative solver, which enables it to effectively solve problems with large deformations, nonlinear material behavior, and contact. Sierra/SM has a versatile library of continuum and structural elements, and a large library of material models. The code is written for parallel computing environments enabling scalable solutions of extremely large problems for both implicit and explicit analyses. It is built on the SIERRA Framework, which facilitates coupling with other SIERRA mechanics codes. This document describes the functionality and input syntax for Sierra/SM.

97 MATHEMATICS AND COMPUTING↗

Sierra/SolidMechanics 4.46 User's Guide

Sierra/SolidMechanics (Sierra/SM) is a Lagrangian, three-dimensional code for finite element analysis of solids and structures. It provides capabilities for explicit dynamic, implicit quasistatic and dynamic analyses. The explicit dynamics capabilities allow for the efficient and robust solution of models with extensive contact subjected to large, suddenly applied loads. For implicit problems, Sierra/SM uses a multi-level iterative solver, which enables it to effectively solve problems with large deformations, nonlinear material behavior, and contact. Sierra/SM has a versatile library of continuum and structural elements, and a large library of material models. The code is written for parallel computing environments enabling scalable solutions of extremely large problems for both implicit and explicit analyses. It is built on the SIERRA Framework, which facilitates coupling with other SIERRA mechanics codes. This document describes the functionality and input syntax for Sierra/SM.

97 MATHEMATICS AND COMPUTING↗

Sierra/SolidMechanics 4.56 User's Guide

Siera/SolidMechanics (Sierra / SM) is a Lagrangian, three-dimensional code for finite element analysis of solids and structures. It provides capabilities for explicit dynamic, implicit quasistatic and dynamic analyses. The explicit dynamics capabilities allow for the efficient and robust solution of models with extensive contact subjected to large, suddenly applied loads. For implicit problems, Sierra / SM uses a multi-level iterative solver, which enables it to effectively solve problems with large deformations, nonlinear material behavior, and contact. Sierra / SM has a versatile library of continuum and structural elements, and a large library of material models. The code is written for parallel computing environments enabling scalable solutions of extremely large problems for both implicit and explicit analyses. It is built on the SIERRA Framework, which facilitates coupling with other SIERRA mechanics codes . This document describes the functionality and input syntax for Sierra/SM.

97 MATHEMATICS AND COMPUTING↗