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At least 739 records · Page 41

Ocular Counter-Rolling During Centrifugation and Static Tilt

Activation of the gravity sensors in the inner ear-the otoliths-generates reflexes that act to maintain posture and gaze. Ocular counter-rolling (OCR) is an example of such a reflex. When the head is tilted to the side, the eyes rotate around the line of sight in the opposite direction (i.e., counter-rolling). While turning comers, undergoing centrifugation, or making side-to-side tilting head movements, the OCR reflex orients the eyes towards the sum of the accelerations from body movements and gravity. Deconditioning of otolith-mediated reflexes following adaptation to microgravity has been proposed as the basis of many of the postural, locomotor, and gaze control problems experienced by returning astronauts. Evidence suggests that OCR is reduced postflight in about 75% of astronauts tested; but the data are sparse, primarily due to difficulties in recording rotational eye movements. During the Neurolab mission, a short-arm human centrifuge was flown that generated sustained sideways accelerations of 0.5-G and one-G to the head and upper body. This produces OCR; and so for the first time, the responses to sustained centrifugation could be studied without the influence of Earth's gravity on the results. This allowed us to determine the relative importance of sideways and vertical acceleration in the generation of OCR. This also provided the first test of the effects of exposure to artificial gravity in space on postflight otolith-ocular reflexes. There was little difference between the responses to centrifugation in microgravity and on Earth. In both conditions, the induced OCR was roughly proportional to the applied acceleration, with the OCR magnitude during 0.5-G centrifugation approximately 60% of that generated during one-G centrifugation. The overall mean OCR from the four payload crewmembers in response to one-G of sideways acceleration was 5.7 plus or minus 1.1 degree (mean and SD) on Earth. Inflight one-G centrifugation generated 5.7 plus or minus 1.1 degree of OCR, which was a small but significant decrease in OCR magnitude. The postflight OCR was 5.9 plus or minus 1.4 degree, which was not significantly different from preflight values. During both 0.5-G and one-G centrifugation in microgravity, where the head vertical gravitational component was absent, the OCR magnitude was not significantly different from that produced by an equivalent acceleration during static tilt on Earth. This suggests that the larger OCR magnitude observed during centrifugation on Earth was due to the larger body vertical linear acceleration component, which may have activated either the otoliths or the body tilt receptors. In contrast to previous studies, there was no decrease in OCR gain postflight. Our findings raise the possibility that inflight exposure to artificial gravity, in the form of intermittent one-G and 0.5-G centripetal acceleration, may have been a countermeasure to deconditioning of otolith-based orientation reflexes.

Cohen, Bernard↗

A multi-length-scale investigation of the applicability of ductility laws for annealed and work-hardened copper

Small-scale mechanical testing provides unique advantages over conventional testing in investigating the mechanical response of nuclear materials. While small-scale testing enables accelerated materials research, it raises the question of comparability to large-scale properties for engineering design considerations. Among different mechanical properties for structural design considerations such as yield and ultimate tensile stress, ductility is of critical importance with respect to structural component health. The effectiveness of using small-scale mechanical testing for probing these mechanical properties is dictated by understanding how the mechanical responses translate from the microscale to the engineering scale. Therefore, a better understanding of size scaling effects via gathering and analysis of experimental data is required to bridge length-scales. Further, this work builds upon previous reports to provide statistical data on how mechanical response changes as the size of the specimens are reduced from conventional sizes. One hundred twenty mesoscale tensile coupons of oxygen-free high thermal conductivity (OFHC) copper in work-hardened and annealed state have been manufactured using micro-wire electrical discharge machining (EDM) and tested under uniaxial tension. The mesoscale specimens have dimensions dictated by pre-selected geometric ratios (i.e., gauge section length over the square root of the cross-section area) with gauge length dimensions of 3 mm (or less) and sub-millimeter gauge widths and thicknesses. The mesoscale responses were compared to bulkscale properties to reveal the effect of specimen size on the mechanical response as a function of grain size and material state for a single phase face-centered cubic metal.

36 MATERIALS SCIENCE↗

Early-life atomic-bomb irradiation accelerates immunological aging and elevates immune-related intracellular reactive oxygen species

Reactive oxygen species (ROS) play an important role in immune responses; however, their excessive production and accumulation increases the risk of inflammation-related diseases. Although irradiation is known to accelerate immunological aging, the underlying mechanism is still unclear. To determine the possible involvement of ROS in this mechanism, we examined 10,023 samples obtained from 3752 atomic-bomb survivors in Hiroshima and Nagasaki, who participated in repeated biennial examinations from 2008 to 2016, for the effects of aging and radiation exposure on intracellular ROS (H 2 O 2 and O 2 •- ) levels, percentages of T-cell subsets, and the effects of radiation exposure on the relationship between cell percentages and intracellular ROS levels in T-cell subsets. The cell percentages and intracellular ROS levels in T-cell subsets were measured using flow cytometry, with both fluorescently labeled antibodies and the fluorescent reagents, carboxy-DCFDA and hydroethidine. The percentages of naïve CD4 + and CD8 + T cells decreased with increasing age and radiation dose, while the intracellular O 2 •- levels in central and effector memory CD8 + T cells increased. Additionally, when divided into three groups based on the percentages of naïve CD4 + T cells, intracellular O 2 •- levels of central and effector memory CD8 + T cells were significantly elevated with the lowest radiation dose group in the naïve CD4 + T cells. Thus, the radiation exposure-induced decrease in the naïve CD4 + T cell pool size may reflect decreased immune function, resulting in increased intracellular ROS levels in central and effector memory CD8 + T cells, and increased intracellular oxidative stress.

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTAN↗

Warming-induced permafrost thaw exacerbates tundra soil carbon decomposition mediated by microbial community

BACKGROUND:It is well-known that global warming has effects on high-latitude tundra underlain with permafrost. This leads to a severe concern that decomposition of soil organic carbon (SOC) previously stored in this region, which accounts for about 50% of the world's SOC storage, will cause positive feedback that accelerates climate warming. We have previously shown that short-term warming (1.5 years) stimulates rapid, microbe-mediated decomposition of tundra soil carbon without affecting the composition of the soil microbial community (based on the depth of 42684 sequence reads of 16S rRNA gene amplicons per 3 g of soil sample). RESULTS:We show that longer-term (5 years) experimental winter warming at the same site altered microbial communities (p < 0.040). Thaw depth correlated the strongest with community assembly and interaction networks, implying that warming-accelerated tundra thaw fundamentally restructured the microbial communities. Both carbon decomposition and methanogenesis genes increased in relative abundance under warming, and their functional structures strongly correlated (R 2 > 0.725, p < 0.001) with ecosystem respiration or CH4 flux. CONCLUSIONS:Our results demonstrate that microbial responses associated with carbon cycling could lead to positive feedbacks that accelerate SOC decomposition in tundra regions, which is alarming because SOC loss is unlikely to subside owing to changes in microbial community composition. Video Abstract.

59 BASIC BIOLOGICAL SCIENCES↗

KSC Tech Transfer News, Volume 5, No. 1

In October 2011, the White House released a presidential memorandum titled "Accelerating Technology Transfer and Commercialization of Federal Research in Support of High-Growth Businesses." It emphasized the importance of technology transfer as a driver of successful innovation to fuel economic growth, create jobs, and make U.S. industries more competitive in a global market. In response to this memorandum, NASA developed a 5-year plan for accelerating its own technology transfer activities. This plan outlines key objectives for enhancing NASA's ability to increase the rate, volume, and quality of technology transfers to industry, academia, and other Government agencies. By doing so, we are increasing the economic impact and public benefit of Federal technology investments. In addition, NASA established technology transfer as a key element of one of its Agency High Priority Performance Goals: "Enable bold new missions and make new technologies available to Government agencies and U.S. industry."What does this mean to you? In the broadest sense, NASA defines technology transfer as the utilization of NASA's technological assets- technologies, innovations, unique facilities and equipment, and technical expertise- by public and private sectors to benefit the Nation. So, if your job involves developing new technologies, writing new software, creating innovative ways to do business, performing research, or developing new technical capabilities, you could be contributing to Kennedy Space Center's (KSC) technology transfer activities by creating the technological assets that may one day be used by external partners. Furthermore, anytime you provide technical expertise to external partners, you're participating in technology transfer. The single most important step you can take to support the technology transfer process is to report new technologies and innovations ro the Technology Transfer Office. This is the critical first step in fueling the technology transfer pipeline. This is also a requirement for all Federal employees (see NPD 2091.1 B) and most NASA contractors. Detailed information on when, where, and how ro report new technology is provided on the following page. In addition, it's important that all detailed-oriented discussions about technology between NASA and external partners are documented or that they occur under formal agreements such as Space Act Agreements and Nondisclosure Agreements. Our office can assist you in putting these agreements into place, protecting NASA's interests, and providing the means to accurately measure the Agency's technology transfer activities. Technology transfer is everyone's responsibility. We need your help to ensure that NASA remains the leader in Federal technology transfer, and that the great work done at KSC provides the maximum economic and societal benefit to the Nation.

Buckingham, Bruce↗

Biomedical support of man in space

In its broadest sense, biomedical support of man in space must not be limited to assisting spacecraft crew during the mission; such support should also ensure that flight personnel be able to perform properly during landing and after leaving the craft. Man has developed mechanisms that allow him to cope with specific stresses in his normal habitat; there is indisputable evidence that, in some cases, the space environment, by relieving these stresses, has also allowed the adaptive mechanisms to lapse, causing serious problems after re-entry. Inflight biomedical support must therefore include means to simulate some of the normal stresses of the Earth environment. In the area of cardiovascular performance, we have come to rely heavily on complex feedback mechanisms to cope with two stresses, often combined: postural changes, which alter the body axis along which gravitational acceleration acts, and physical exercise, which increases the total load on the system. Unless the appropriate responses are reinforced continuously during flight, crew members may be incapacitated upon return. The first step in the support process must be a study of the way in which changes in g, even of short duration, affect these responses. In particular we should learn more about effects of g on the "on" and "off" dynamics, using a variety of approaches: increased acceleration on one hand at recumbency, immersion, lower body positive pressure, and other means of simulating some of the effects of low g, on the other. Once we understand this, we will have to determine the minimal exposure dose required to maintain the response mechanisms. Finally, we shall have to design stresses that simulate Earth environment and can be imposed in the space vehicle. Some of the information is already at hand; we know that several aspects of the response to exercise are affected by posture. Results from a current series of studies on the kinetics of tilt and on the dynamics of readjustment to exercise in different postures will be presented and discussed.

NASA Discipline Cardiopulmonary↗

Investigating Carboxysome Morphology Dynamics with a Rotationally Invariant Variational Autoencoder

Carboxysomes are a class of bacterial microcompartments that form proteinaceous organelles within the cytoplasm of cyanobacteria and play a central role in photosynthetic metabolism by defining a cellular microenvironment permissive to CO2 fixation. Critical aspects of the assembly of the carboxysomes remain relatively unknown, especially with regard to the dynamics of this microcompartment. Progress in understanding carboxysome dynamics is impeded in part because analysis of the subtle changes in carboxysome morphology with microscopy remains a low-throughput and subjective process. Here we use deep learning techniques, specifically a Rotationally Invariant Variational Autoencoder (rVAE), to analyze fluorescence microscopy images of cyanobacteria bearing a carboxysome reporter and quantitatively evaluate how carboxysome shell remodelling impacts subtle trends in the morphology of the microcompartment over time. Toward this goal, we use a recently developed tool to control endogenous protein levels, including carboxysomal components, in the model cyanobacterium Synechococcous elongatus PCC 7942. By utilization of this system, proteins that compose the carboxysome can be tuned in real time as a method to examine carboxysome dynamics. We find that rVAEs are able to assist in the quantitative evaluation of changes in carboxysome numbers, shape, and size over time. Further, we propose that rVAEs may be a useful tool to accelerate the analysis of carboxysome assembly and dynamics in response to genetic or environmental perturbation and may be more generally useful to probe regulatory processes involving a broader array of bacterial microcompartments.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Mechanochemically responsive polymer enables shockwave visualization

Abstract Understanding the physical and chemical response of materials to impulsive deformation is crucial for applications ranging from soft robotic locomotion to space exploration to seismology. However, investigating material properties at extreme strain rates remains challenging due to temporal and spatial resolution limitations. Combining high-strain-rate testing with mechanochemistry encodes the molecular-level deformation within the material itself, thus enabling the direct quantification of the material response. Here, we demonstrate a mechanophore-functionalized block copolymer that self-reports energy dissipation mechanisms, such as bond rupture and acoustic wave dissipation, in response to high-strain-rate impacts. A microprojectile accelerated towards the polymer permanently deforms the material at a shallow depth. At intersonic velocities, the polymer reports significant subsurface energy absorption due to shockwave attenuation, a mechanism traditionally considered negligible compared to plasticity and not well explored in polymers. The acoustic wave velocity of the material is directly recovered from the mechanochemically-activated subsurface volume recorded in the material, which is validated by simulations, theory, and acoustic measurements. This integration of mechanochemistry with microballistic testing enables characterization of high-strain-rate mechanical properties and elucidates important insights applicable to nanomaterials, particle-reinforced composites, and biocompatible polymers.

Science & Technology - Other Topics↗

The heliospheric ambipolar potential inferred from sunward-propagating halo electrons

ABSTRACT We provide evidence that the sunward-propagating half of the solar wind electron halo distribution evolves without scattering in the inner heliosphere. We assume the particles conserve their total energy and magnetic moment, and perform a ‘Liouville mapping’ on electron pitch angle distributions measured by the Parker Solar Probe SPAN-E instrument. Namely, we show that the distributions are consistent with Liouville’s theorem if an appropriate interplanetary potential is chosen. This potential, an outcome of our fitting method, is compared against the radial profiles of proton bulk flow energy. We find that the inferred potential is responsible for nearly 100 per cent of the proton acceleration in the solar wind at heliocentric distances 0.18-0.79 AU. These observations combine to form a coherent physical picture: the same interplanetary potential accounts for the acceleration of the solar wind protons as well as the evolution of the electron halo. In this picture the halo is formed from a sunward-propagating population that originates somewhere in the outer heliosphere by a yet-unknown mechanism.

79 ASTRONOMY AND ASTROPHYSICS↗

Crystal measures short-term, large-magnitude forces

By using the magnitude of piezoelectric crystal response to distortion and compression, this device measures transient accelerations and their rate of change. The invention could be used in a servo control system by supplementing the accelerometer and taking over its function when its range was exceeded.

Pfeiffer, C. G.↗

Analytical and experimental investigations of human spine flexure.

The authors report on experiments to measure the resistance of fresh human spines to flexion in the upper lumbar and lower thoracic regions and evaluate results by using a combination of strength of materials theory and effects of shear and comparing with data reported by other authors. The test results indicate that the thoraco-lumbar spine behaves approximately as a linear elastic beam, without relaxation effects. The authors formulate a simple continuum dynamic model of the spine simulating aircraft ejection and solve the resulting boundary value problem to illustrate the importance of the flexural mode. A constant cross-section, the selected model is a sinusoidally curved elastic beam with an end mass subjected to a Heaviside axial acceleration at the other end. The paper presents transient response results for the spinal model axial and bending displacements and axial force.-

Moffatt, C. A.↗

Measurements on the development of cascades in a tungsten-scintillator ionization spectrometer

The response of a tungsten-scintillator ionization spectrometer to accelerated particle beams has been investigated. Results obtained from exposure of the approx. 1000 g/sq cm apparatus to 5, 10, and 15 GeV/c electrons and pions as well as to 2.1 GeV/nucleon C-12 and O-16 ions are presented. These results include cascade-development curves, fractions of the primary energy measured by the spectrometer, and resolutions of the apparatus for measuring the primary energies. For 15 GeV/c electrons, an average of about 82% of the incident energy is measured by the apparatus with resolution (normal standard deviation) of about 6%. For 15 GeV/c pions, an average of about 65% of the incident energy is measured with resolution of about 18%. The energy resolution improves with increasing energy and with increasing depth of the spectrometer.

Cheshire, D. L.↗

Compression of Jupiter's magnetosphere by the solar wind

Simultaneous sets of interplanetary and planetary data obtained by Pioneer 10 and Pioneer 11 are compared with a view toward identifying major changes in the solar wind and their possible influence on the Jovian magnetosphere. The results are discussed relative to variations in magnetopause location, pressure balance at the magnetopause, acceleration of energetic trapped radiation, plasma density from the response time of the Jovian magnetosphere, and time constants of magnetospheric circuit models. A major finding is that three out of four cases in which the Pioneers reentered the magnetosheath are the result of time variations associated with changing interplanetary conditions. The compressibility of the Jovian magnetosphere is enhanced because the field inside the magnetopause is not the planetary field but is primarily caused by currents inside the magnetosphere, presumably the equatorial current sheet.

Smith, E. J.↗

Quiet Clean Short-haul Experimental Engine (QCSEE). Aerodynamic and aeromechanical performance of a 50.8 cm (20 inch) diameter 1.34 PR variable pitch fan with core flow

The fan aerodynamic and aeromechanical performance tests of the quiet clean short haul experimental engine under the wing fan and inlet with a simulated core flow are described. Overall forward mode fan performance is presented at each rotor pitch angle setting with conventional flow pressure ratio efficiency fan maps, distinguishing the performance characteristics of the fan bypass and fan core regions. Effects of off design bypass ratio, hybrid inlet geometry, and tip radial inlet distortion on fan performance are determined. The nonaxisymmetric bypass OGV and pylon configuration is assessed relative to both total pressure loss and induced circumferential flow distortion. Reverse mode performance, obtained by resetting the rotor blades through both the stall pitch and flat pitch directions, is discussed in terms of the conventional flow pressure ratio relationship and its implications upon achievable reverse thrust. Core performance in reverse mode operation is presented in terms of overall recovery levels and radial profiles existing at the simulated core inlet plane. Observations of the starting phenomena associated with the initiation of stable rotor flow during acceleration in the reverse mode are briefly discussed. Aeromechanical response characteristics of the fan blades are presented as a separate appendix, along with a description of the vehicle instrumentation and method of data reduction.

Giffin, R. G.↗

Global crustal response model

A computer program was developed for calculating the radial displacement due to the body tide as a function of spatial position and time. The positions of the moon and sun were evaluated by means of the Hill-Brown and Newcomb theories, respectively. Green's functions were utilized to simulate the elastic Earth responses due to point loads, a convolution program has been developed to evaluate the elastic Earth responses due to ocean loading by a given ocean tide constituent. These responses include radial and horizontal displacement, tilt and gravity acceleration, and strain tensor components.

Source record↗

Sliding control of pointing and tracking with operator spline estimation

It is shown how a variable structure control technique could be implemented to achieve precise pointing and good tracking of a deformable structure subject to fast slewing maneuvers. The correction torque that has to be applied to the structure is based on estimates of upper bounds on the model errors. For a rapid rotation of the deformable structure, the elastic response can be modeled by oscillators driven by angular acceleration, and where stiffness and damping coefficients are also angular velocity and acceleration dependent. By transforming this slew-driven elastic dynamics into bilinear form (be regarding the vector made up of the angular velocity, squared angular velocity and angular acceleration components, which appear in the coefficients as the input to the deformation dynamics), an operator spline can be constructed, that gives a low order estimate of the induced disturbance. Moreover, a worst case error bound between the estimated deformation and the unknown exact deformation is also generated, which can be used where required in the sliding control correction.

Dwyer, Thomas A. W., III↗

Robust tracking of a flexible spacecraft subject to induced disturbances and parametric uncertainties

A variable structure control technique combined with an operator spline for bilinear systems is implemented to a fast moving deformable structure for purposes of achieving robust tracking performance. The control torque applied to the structure is based on estimates of the structure parameters and on upper bounds of the model errors. For a rapid rotation of the deformable structure, the elastic response can be modeled by oscillators driven by angular acceleration, where stiffness and damping coefficients are also angular velocity and acceleration dependent. By transforming this 'slew-driven' elastic dynamics into a bilinear form, an operator spline can be constructed, that gives a low order estimate of the induced disturbance. An upper bound between the estimated deformation and the unknown exact deformation is also generated, which can be used where required in the sliding control correction.

Karray, Fakhreddine↗

Kinematics and aerodynamics of the velocity vector roll

The velocity vector roll is an angular rotation of an aircraft about its instantaneous velocity vector, constrained to be performed at constant angle-of-attack (AOA), no sideslip, and constant velocity. Consideration of the aerodynamic force equations leads to requirements for body-axis yawing and pitching rotations that satisfy these constraints. Here, the body axis rotations, and the constraints, are used in the moment equations to determine the aerodynamic moments required to perform the velocity vector roll. For representative tactical aircraft, the conditions for maximum pitching moment are a function of orientation, occurring at about 90 deg of bank in a level trajectory. Maximum required pitching moment occurs at peak roll rate, and is achieved at AOA above 45 deg. The conditions for maximum rolling moment depend on the value of the roll mode time constant. For a small time constant (fast response) the maximum rolling moment occurs at maximum roll acceleration and zero AOA, largely independent of aircraft orientation; for a large time constant, maximum required rolling moment occurs at maximum roll rate, at maximum AOA, and at 180 deg of bank in level flight. Maximum yawing moment occurs at maximum roll acceleration, maximum AOA, and is largely independent of airplane orientation.

Durham, Wayne C.↗