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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 739 records · Page 41
All sourcesNASA NTRSDOE OSTI
DOE OSTI2025

Cross-species analysis of FcγRIIa/b (CD32a/b) polymorphisms at position 131: structural and functional insights into the mechanism of IgG- mediated phagocytosis in human and macaque

Introduction Antibodies play a critical role in immunity in part by mediating clearance of pathogens and infected cells by antibody-dependent cellular phagocytosis (ADCP) through engagement of Fc gamma receptors (FcγRs) on innate immune cells. Among these, FcγRIIa (CD32a) is a key activating receptor expressed on macrophages, dendritic cells, and other antigen-presenting cells. Its affinity for IgG and ability to mediate ADCP is influenced by allelic polymorphisms. In humans, a single amino acid polymorphism at position 131, where histidine (H) is substituted with arginine (R), leads to decreased IgG1 and IgG2 subclass binding affinity and, consequently, lower efficiency of phagocytic responses. Rhesus macaques ( Macaca mulatta ), which are widely used as nonhuman primate models, exhibit a similar polymorphism at position 131 of FcγRIIa, but with arginine replaced by proline (P). Here, we investigated structure-function relationships associated with the FcγRIIa polymorphism at position 131 in both species, specifically with respect to IgG1 and IgG2. Methods We determined the structures of complexes formed by each variant with IgG1 Fc and those formed by the higher affinity variant with IgG2 Fc for both species by x-ray crystallography and linked these structures to affinity and activity using SPR and an ADCP assay. We also determined the structure of human inhibitory FcγRIIb (CD32b) in complex with IgG1 Fc by x-ray crystallography. Results Through analysis of these structures, our studies reveal that FcγRIIa engagement is minimally influenced by Fc glycan composition, distinguishing it from FcγRIIIa whose affinity is strongly influenced by glycan-composition. Comparative structures of human and macaque FcγRIIa variants demonstrate species- and allele-specific differences in Fc binding, but our functional assays showed only minimal allele-specific effects in humans. In contrast, allele-specific effects in macaques were highly significant; the macaque P 131 variant showing uniformly reduced IgG affinity. Conclusion These insights highlight fundamental interspecies and allelic distinctions that are critical for interpreting FcγRIIa-mediated effector functions in macaque models and for optimizing translational antibody and vaccine design.

Tolbert, William D.↗
DOE OSTI2024

Vehicle Position Detection Based on Machine Learning Algorithms in Dynamic Wireless Charging

Dynamic wireless charging (DWC) has emerged as a viable approach to mitigate range anxiety by ensuring continuous and uninterrupted charging for electric vehicles in motion. DWC systems rely on the length of the transmitter, which can be categorized into long-track transmitters and segmented coil arrays. The segmented coil array, favored for its heightened efficiency and reduced electromagnetic interference, stands out as the preferred option. However, in such DWC systems, the need arises to detect the vehicle’s position, specifically to activate the transmitter coils aligned with the receiver pad and de-energize uncoupled transmitter coils. This paper introduces various machine learning algorithms for precise vehicle position determination, accommodating diverse ground clearances of electric vehicles and various speeds. Through testing eight different machine learning algorithms and comparing the results, the random forest algorithm emerged as superior, displaying the lowest error in predicting the actual position.

47 OTHER INSTRUMENTATION↗
DOE OSTI2024

Intensified Positive Arctic–Methane Feedback under IPCC Climate Scenarios in the 21st Century

The positive Arctic–methane (CH 4 ) feedback forms when more CH 4 is released from the Arctic tundra to warm the climate, further stimulating the Arctic to emit CH 4 . This study utilized the CLM-Microbe model to project CH 4 emissions across five distinct Arctic tundra ecosystems on the Alaska North Slope, considering three Shared Socioeconomic Pathway (SSP) scenarios using climate data from three climate models from 2016 to 2100. Employing a hyper-resolution of 5 m × 5 m within 40,000 m 2 domains accounted for the Arctic tundra’s high spatial heterogeneity; three sites were near $Utqia\dot{g}vik$ (US-Beo, US-Bes, and US-Brw), with one each in Atqasuk (US-Atq) and Ivotuk (US-Ivo). Simulated CH 4 emissions substantially increased by a factor of 5.3 to 7.5 under the SSP5–8.5 scenario compared to the SSP1–2.6 and SSP2–4.5 scenarios. The projected CH 4 emissions exhibited a stronger response to rising temperature under the SSP5–8.5 scenario than under the SSP1–2.6 and SSP2–4.5 scenarios, primarily due to strong temperature dependence and the enhanced precipitation-induced expansion of anoxic conditions that promoted methanogenesis. The CH 4 transport via ebullition and plant-mediated transport is projected to increase under all three SSP scenarios, and ebullition dominated CH 4 transport by 2100 across five sites. Projected CH 4 emissions varied in temperature sensitivity, with a Q 10 range of 2.7 to 60.9 under SSP1–2.6, 3.8 to 17.6 under SSP2–4.5, and 5.7 to 17.2 under SSP5–8.5. Compared with the other three sites, US-Atq and US-Ivo were estimated to have greater increases in CH 4 emissions due to warmer temperatures and higher precipitation. The fact that warmer sites and warmer climate scenarios had higher CH 4 emissions suggests an intensified positive Arctic–CH 4 feedback in the 21st century. Microbial physiology and substrate availability dominated the enhanced CH 4 production. The simulated intensified positive feedback underscores the urgent need for a more mechanistic understanding of CH 4 dynamics and the development of strategies to mitigate CH 4 across the Arctic.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2024

Measuring Fiber Positioning Accuracy and Throughput with Fiber Dithering for the Dark Energy Spectroscopic Instrument

Highly multiplexed, fiber-fed spectroscopy is enabling surveys of millions of stars and galaxies. The performance of these surveys depends on accurately positioning fibers in the focal plane to capture target light. We describe a technique to measure the positioning accuracy of fibers by dithering fibers slightly around their ideal locations. This approach also enables measurement of the total system throughput and point-spread function delivered to the focal plane. We then apply this technique to observations from the Dark Energy Survey Instrument (DESI), and demonstrate that DESI positions fibers to within 0farcs08 of their targets (5% of a fiber diameter) and achieves a system throughput within about 7% of expectations.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗
DOE OSTI2017

INFLUENCE OF THE GALACTIC GRAVITATIONAL FIELD ON THE POSITIONAL ACCURACY OF EXTRAGALACTIC SOURCES

We investigate the influence of random variations of the Galactic gravitational field on the apparent celestial positions of extragalactic sources. The basic statistical characteristics of a stochastic process (first-order moments, an autocorrelation function and a power spectral density) are used to describe a light ray deflection in a gravitational field of randomly moving point masses as a function of the source coordinates. We map a 2D distribution of the standard deviation of the angular shifts in positions of distant sources (including reference sources of the International Celestial Reference Frame) with respect to their true positions. For different Galactic matter distributions the standard deviation of the offset angle can reach several tens of μ as (microarcsecond) toward the Galactic center, decreasing down to 4–6 μ as at high galactic latitudes. The conditional standard deviation (“jitter”) of 2.5 μ as is reached within 10 years at high galactic latitudes and within a few months toward the inner part of the Galaxy. The photometric microlensing events are not expected to be disturbed by astrometric random variations anywhere except the inner part of the Galaxy as the Einstein–Chvolson times are typically much shorter than the jittering timescale. While a jitter of a single reference source can be up to dozens of μ as over some reasonable observational time, using a sample of reference sources would reduce the error in relative astrometry. The obtained results can be used for estimating the physical upper limits on the time-dependent accuracy of astrometric measurements.

79 ASTRONOMY AND ASTROPHYSICS↗
NASA NTRS1962

Application of Statistical Filter Theory to the Optimal Estimation of Position and Velocity on Board a Circumlunar Vehicle

Concepts from statistical filter theory are applied to the problem of in-flight determination of the position and velocity of a space vehicle for the purposes of midcourse guidance. The source of information is assumed to be an arbitrary sequence of measurements of any desired set of "observables" (e.g., space angles), the measurements being corrupted by additive errors so that the position and velocity are never known perfectly. A state transition approach is employed which leads naturally to a computational scheme that is readily implemented by a digital computer. The scheme can be regarded as a dynamical time-varying filter which weights the incoming observations in an optimal sense for use in producing an up-to-date optimal estimate of position and velocity. The advantages of the scheme are (1) it provides the best possible estimate (minimum error) based upon ensemble statistics of injection conditions and measurement errors; (2) it is extremely versatile, not requiring adherence to a predetermined observation schedule or reference trajectory; and (3) the computations are sufficiently simple to be practical in an on-board computer. A digital computer simulation of the proposed system is employed to demonstrate the feasibility of an all on-board system and to illustrate the performance attainable in a hypothetical physical situation.

SPACE VEHICLE↗
NASA NTRS1966

Thermal motor positions magnetometer sensors

Reversing, thermal, motor-driven device positions magnetometer sensors for checking zero offset. The device alternately positions two sensors at fixed positions 90 degrees apart. The thermal motor is fabricated completely of nonmagnetic materials.

Kerwin, W. J.↗
NASA NTRS1971

VHF Ranging and Position Fixing Experiment Using ATS Satellites: Final Report on Phases 1 and 2, 25 November 1968 - 1 May 1971

The testing program with the ATS-1 and ATS-3 spacecraft showed that geostationary satellites can provide superior communications and position surveillance for mobile craft. Inexpensive modifications to conventional mobile communications equipment aboard the craft can provide reliable, high quality voice and digital communications with distant ground stations and other vehicles, and automatic surveillance of the positions of all the craft by a ground facility. The tests also demonstrated the location and automatic readout of remote data collection platforms. Frequency modulation signals with the narrow audio and radio frequency bandwidths of terrestrial mobile radio communications were relayed through the VHF transponders of the geostationary satellites. The voice and digital communications were far superior in reliability and quality to long-distance mobile communications by other means. It was shown that one satellite can provide nearly uniform high quality performance over approximately one-third of the earth's surface. Position fixes by range measurement from the two satellites were accurate to approximately one nautical mile, except near the equator and the poles.

Source record↗
NASA NTRS1972

Thermal positive ions in the outer ionosphere and magnetosphere from Ogo 1.

Study of the positive thermal ion densities measured with a spherical electrostatic analyzer aboard OGO 1 between September and October, 1964. A high variability of charged-particle distributions is established within and beyond the plasmapause boundary. The density gradient was in an inverse relation to the plasmapause L position and was consistently about one order of magnitude higher for the afternoon sector orbits than for the nightside orbits. Irregularities of different types were observed in the positive thermal ion densities within the plasmasphere and outside it, showing no correlation with the magnetic activity level. A delay of 3 to 9 hr was observed in the movement of the plasmapause following an increase in the magnetic activity level on the nightside.

Ahmed, M.↗
NASA NTRS1972

Resonance scattering of the first positive system of N2 in the dayglow.

Rocket measurements of the differential photoelectron flux and the volume emission rate of the N2(0, 0) second positive band are used to calculate the daytime concentration of metastable A(super 3)Sigma(sub u)+ molecules, and consequently the resonance scattering contribution to the N2 first positive emission in the dayglow. The dominant source of N2 first positive emission is found to be photoelectron impact, with resonance scattering contributing only 10-20 per cent the total emission.

Feldman, P. D.↗
NASA NTRS1973

Positive ions in the mesosphere.

Positive ions have been measured using the parachute borne blunt probe, a subsonic system launched on meteorological rockets, which measures polar electrical conductivities in the 30 to 80 km altitude range. A central feature of the daytime positive conductivity profiles is a sharp break occurring between 60 and 70 km which indicates the transition from galactic cosmic ray to solar ultraviolet ionization, and, hence provides information about the nitric oxide density. In the 50-60 km region the positive ion conductivity is relatively constant with altitude and correlates well with atmospheric temperature down to 35 km. Using temperature and pressure profiles and a reduced mobility, the conductivity profiles may be converted to density profiles. The average mid-latitude daytime profile at intermediate solar zenith angles showed a minimum at 63.5 km.

Hale, L. C.↗
NASA NTRS1973

Algebraic criteria for positive realness relative to the unit circle.

A definition is presented of the circle positive realness of real rational functions relative to the unit circle in the complex variable plane. The problem of testing this kind of positive reality is reduced to the algebraic problem of determining the distribution of zeros of a real polynomial with respect to and on the unit circle. Such reformulation of the problem avoids the search for explicit information about imaginary poles of rational functions. The stated algebraic problem is solved by applying the polynomial criteria of Marden (1966) and Jury (1964), and a completely recursive algorithm for circle positive realness is obtained.

Siljak, D. D.↗
NASA NTRS1974

Target Acquisition and Positioning Study (TAPS)

The Scientific Instruments for the Large Space Telescope (LST) require a high degree of accuracy for positioning targets within their respective entrance apertures. The acquisition, verification of position, and guidance during an experiment must be accomplished with a minimum loss of observing time for the maximum effectiveness of the total mission. This study evaluates several viable concepts and modes of operation that are applicable for a Target Acquisition and Positioning System (TAPS) that is responsive to the LST instrument requirements.

Source record↗
NASA NTRS1974

Acoustic field positioning for containerless processing

The non-contact positioning of materials in a space processing chamber is accomplished using a new type of acoustic levitator. Liquid and solid materials are positioned using a single source of sound. Fine control of position may be obtained by motion of an acoustical reflector. Electrical power required is usually less than 100 watts. The system operates satisfactorily at high and low temperatures and is adaptable as an add-on feature to existing space experiments. Containerless melting and solidification can be performed and a freely suspended liquid can be shaped to the contour of the sound field. Experiments are described in which aluminum, glass and plastic materials are melted and solidified in the containerless state. The system has applications to containerless crystal growth, melting and related processes.

Whymark, R. R.↗
NASA NTRS1974

Acoustic chamber for weightless positioning

The objective of this work is to perfect and extend the acoustic position technique that was developed at JPL for use in the future Space Processing Laboratory in Space. The main effort is centered on design of a position device for processing of molten materials. Namely, a resonator has the capability of positioning in an extreme temperature gradient and a frequency servo loop to maintain it there as the temperature varies.

Wang, T. G.↗
NASA NTRS1974

Intrathoracic and venous pressure relationships during responses to changes in body position

Simultaneous end-expiratory pressures, referred to midthoracic level, in the superior and abdominal venae cavae, pericardial space, and right and left heart, were recorded without thoracotomy in three anesthetized dogs during sudden changes from supine to vertical head-up or head-down body positions. Intrathoracic and dependent great vein pressures referred to midchest level (sixth thoracic vertebra) decreased and showed simple hydrostatic gradients in either vertical position. However, a discontinuity in the large vein hydrostatic gradient occurred just distal to the superior margin of the thorax in either body position and was resumed again above this level. It is concluded that, just as the cerebrospinal fluid and intraperitoneal pressures minimize the effects of gravitational and inertial forces on the cerebral and visceral circulations, the pericardial and pleural pressures have a similar role for the heart proper.

Avasthey, P.↗
NASA NTRS1974

Continuous-output terminal-shock-position sensor for mixed-compression inlets evaluated in wind tunnel tests of YF-12 aircraft inlet

An electronic sensor was built to measure the position of the terminal shock in a supersonic inlet. The sensor uses several static-pressure taps in the inlet wall. The sensor output is continuously proportional to shock position. When the sensor was installed in a YF-12 aircraft flight inlet during wind tunnel tests, it indicated shock position within + or - 5 percent of the total distance covered by the static-pressure-tap region. The maximum error caused by an angle of attack change of 4 deg was less than 25 percent. In the region of normal inlet operation, the angle of attack error is negligible. Frequency-response tests show the amplitude ratio is constant out to 60 Hz, and decreases to about 50 percent at 100 Hz, with a phase lag of 50 deg.

Dustin, M. O.↗
NASA NTRS1976

Position error propagation in the simplex strapdown navigation system

The results of an analysis of the effects of deterministic error sources on position error in the simplex strapdown navigation system were documented. Improving the long term accuracy of the system was addressed in two phases: understanding and controlling the error within the system, and defining methods of damping the net system error through the use of an external reference velocity or position. Review of the flight and ground data revealed error containing the Schuler frequency as well as non-repeatable trends. The only unbounded terms are those involving gyro bias and azimuth error coupled with velocity. All forms of Schuler-periodic position error were found to be sufficiently large to require update or damping capability unless the source coefficients can be limited to values less than those used in this analysis for misalignment and gyro and accelerometer bias. The first-order effects of the deterministic error sources were determined with a simple error propagator which provided plots of error time functions in response to various source error values.

Source record↗