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At least 739 records · Page 41

Laser-induced modification of structure and shape of cartilage in otolaryngology and orthopaedics

We present the results of basic research in laser modification of tissues in otolaryngology (correcting the shape of nasal septum and larynx cartilages), cosmetology (correcting ear and nose shape), orthopaedics and spinal surgery (treatment of diseases of spine disc and joints). The physical processes and mechanisms of laser-induced relaxation of stresses and regeneration of tissues are considered. New results of studies in this fast-developing field of laser surgery are presented, in particular, the results of laser correction of costal cartilage shape in the process of making implants for the treatment of larynx stenosis and controlled regeneration of the hyaline articular cartilage. (laser medicine)

62 RADIOLOGY AND NUCLEAR MEDICINE↗

Laser-induced modification of graphene in the presence of ethanol on a graphene – substrate interface

We have studied the effect that the substitution of an organic substance (ethanol) for water adsorbate on a CVD graphene–SiO{sub 2}/Si interface has on the laser-induced modification of graphene and graphene structures on the SiO{sub 2} film. Scanning probe microscopy has been used to analyse changes in the electronic properties of graphene structures on a hydrophilic substrate in the presence of ethanol and as a result of a laser-induced spatial redistribution of a water–alcohol adsorbate on the interface. It has been demonstrated experimentally that ethanol substitution for water adsorbate leads to an increase in the surface potential of the graphene, which is equivalent to a reduction in its work function with respect to the original level under normal conditions at a relative humidity of air from 30% to 60%. In the laser irradiation zone, we observe an additional increase in surface potential by 30–50 mV. Thus, ethanol makes it possible to tune the laser-induced electronic properties of graphene on a substrate. In addition, it has been shown that the intercalation of ethanol molecules leads to severe temporal instability of the physical properties of graphene structures produced by local laser irradiation. We have demonstrated the possibility of information ‘rewriting’ by low-intensity laser pulses in microregions with a changed surface potential in the presence of ethanol. (interaction of laser radiation with matter. laser plasma)

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Analysis of laser-induced modification of collagen structure using nonlinear optical microscopy

Nonlinear optical microscopy is used to monitor changes in the collagen structure of patellar ligament after IR laser heating up to a temperature of 60 °C. Pre-denaturation modification of the tissue matrix exhibits specific properties and consists in splitting of initially parallel fibre bundles into array of divergent fibres. Image processing employing Fast Fourier transform analysis is used for characterising images of the fibre structure and determining the collagen orientation index. An increase in manifestation of laser-induced disordering with an increase in IR laser radiation power from 0.3 to 2 W is accompanied by a decrease in the collagen orientation index. The specific disorganisation of the collagen tissue structure during laser heating is supposed to be due to fast speed and local action of the laser heating, which leads to mechanical distortions of the structural elements of tissue matrix. (paper)

36 MATERIALS SCIENCE↗

Host target modification as a strategy to counter pathogen hijacking of the jasmonate hormone receptor

Significance Pathogen infections can cause significant crop losses worldwide and major disturbances in natural ecosystems. Understanding the molecular basis of plant disease susceptibility is important for the development of new strategies to prevent disease outbreaks. Recent studies have identified the plant jasmonate (JA) hormone receptor as one of the common targets of pathogen virulence factors. In this study, we modified the JA receptor and showed that transgenic Arabidopsis plants with the modified JA receptor gained resistance to bacterial pathogens that secrete a potent JA-mimicking toxin to promote infection. Our results suggest that host target modification may be developed as a new strategy to protect the disease-vulnerable components of the susceptible plant against highly evolved pathogens.

59 BASIC BIOLOGICAL SCIENCES↗

Modification of Wool Fibers via Base/Cationic Detergent Pretreatment and Transglutaminase-mediated Reaction of Keratin

The surface modification of wool fibers is an important part of the textile industry to add functionality and stability to wool products. In this study, we developed a process utilizing a base/cationic surfactant solution pretreatment followed by an enzyme-mediated keratin crosslinking reaction to modify the wool fibers. Changes in water contact angle demonstrated the successful transformation of the hydrophobic wool surface to a more hydrophilic one after soaking in sodium carbonate solution containing hexadecyltrimethylammonium bromide (CTAB). The treated fabrics were further characterized by colorimetry and fluorescent spectrometry. Results showed that the pretreatment increased the yellowness of fabrics and caused some structural changes among certain amino acids, such as tryptophan and cystine. Keratin extracted from coarse wool fibers was further applied on pretreated fabrics through a microbial transglutaminase (mTGase) mediated reaction under mild conditions. Morphological characterization via SEM demonstrated the effective coverage of keratin on the scales of wool. The current method may provide an alternative processing protocol to modify wool fibers and improve the quality and performance of wool products.

36 MATERIALS SCIENCE↗

Elimination of MHD current sheets by modifications to the plasma wall in a fixed boundary model

Models of magnetohydrodynamic (MHD) equilibia that for computational convenience assume the existence of a system of nested magnetic flux surfaces tend to exhibit singular current sheets. These sheets are located on resonant flux surfaces that are associated with rational values of the rotational transform. We study the possibility of eliminating these singularities by suitable modifications of the plasma boundary, which we prescribe in a fixed boundary setting. We find that relatively straightforward iterative procedures can be used to eliminate weak current sheets that are generated at resonant flux surfaces by the nonlinear interactions of resonating wall harmonics. These types of procedures may prove useful in the design of fusion devices with configurations that enjoy improved stability and transport properties.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Cosmological perturbations and structure formation in nonlocal infrared modifications of general relativity

We study the cosmological consequences of a recently proposed nonlocal modification of general relativity, obtained by adding a term m{sup 2}R □{sup −2}R to the Einstein-Hilbert action. The model has the same number of parameters as ΛCDM, with m replacing Ω{sub Λ}. At the background level, after fixing m so to reproduce the observed value of Ω{sub M}, we get a pure prediction for the equation of state of dark energy as a function of redshift, w{sub DE}(z), with w{sub DE}(0) in the range [−1.165,−1.135] as Ω{sub M} varies over the broad range Ω{sub M} element of [0.20,0.36]. We find that the cosmological perturbations are well-behaved, and the model fully fixes the dark energy perturbations as a function of redshift z and wavenumber k. The nonlocal model provides a good fit to supernova data and predicts deviations from General Relativity in structure formation and in weak lensing at the level of 3-4%, therefore consistent with existing data but readily detectable by future surveys. For the logarithmic growth factor we obtain γ ≅ 0.53, to be compared with γ ≅ 0.55 in ΛCDM. For the Newtonian potential on subhorizon scales our results are well fitted by Ψ(a;k) = [1+μ{sub s}a{sup s}]Ψ{sub GR}(a;k) with a scale-independent μ{sub s} ≅ 0.09 and s ≅ 2, while the anisotropic stress is negligibly small.

79 ASTRONOMY AND ASTROPHYSICS↗

Just enough inflation: power spectrum modifications at large scales

We show that models of 'just enough' inflation, where the slow-roll evolution lasted only 50- 60 e-foldings, feature modifications of the CMB power spectrum at large angular scales. We perform a systematic analytic analysis in the limit of a sudden transition between any possible non-slow-roll background evolution and the final stage of slow-roll inflation. We find a high degree of universality since most common backgrounds like fast-roll evolution, matter or radiation-dominance give rise to a power loss at large angular scales and a peak together with an oscillatory behaviour at scales around the value of the Hubble parameter at the beginning of slow-roll inflation. Depending on the value of the equation of state parameter, different pre-inflationary epochs lead instead to an enhancement of power at low ℓ, and so seem disfavoured by recent observational hints for a lack of CMB power at ℓ∼< 40. We also comment on the importance of initial conditions and the possibility to have multiple pre-inflationary stages.

79 ASTRONOMY AND ASTROPHYSICS↗

Modification of the magneto-hydrodynamic equilibrium by the lower-hybrid wave driven fast electrons on the TST-2 spherical tokamak

Presence of a large population of fast particles may qualitatively modify the tokamak equilibrium from the one that can be described by standard magneto-hydrodynamics (MHD). The kinetic modification of the MHD equilibrium was studied for a lower-hybrid (LH) wave driven plasma on the TST-2 spherical tokamak. The analysis was performed using an equilibrium reconstruction method based on an extended MHD model that considers a two-component plasma of bulk MHD fluid and kinetic fast electrons. Scrape-off-layer current appeared naturally in the extended MHD analysis because of the finite electron orbit excursion from the flux surfaces. This reduced the bulk pressure contribution to the toroidal current substantially. Furthermore, the resulting poloidal flux profile was more consistent with that inferred from the Thomson scattering measurement.

extended magneto-hydrodynamics↗

Plasma modification through boron particulate injection in the full tungsten environment of WEST

Recent experiments have confirmed the compatibility of extended boron particulate injections with high performance plasma discharges in the full tungsten (W) environment of WEST. Utilizing an impurity powder dropper (IPD) equipped with boron (B) powders a series of extended experimental programs providing controlled injections have quantified plasma response to varying levels of injection rate and total injection quantity. Calibration of injection quantities confirmed through post-situ testing of the IPD and cross-correlated with both high-speed camera illumination and spectroscopic measurement have allowed for the first time a fine scale determination of the effects of powder introduction on plasma performance. Plasma enhancement, consistent with turbulence reduction through profile modification, has been observed with sustained increases in the stored energy (WMHD), by 18%, electron temperature (T e ) by 35%, and neutron rate (N n ) by up to 200%, all of which scale positively with increasing powder injection rates. These injections have also resulted in both prompt and extended reductions in native impurity content, decreases in post injection radiated power, and strong decreases in divertor deuterium signatures signifying a reduction in recycling suggesting enhanced boron layer formation which provides a reduction of source terms and leads to enhanced gettering of main ion and impurity sources.

Lunsford, R. [Princeton Plasma Physics Laboratory ↗

Modification of the MTS model for high strain-rate behavior of TI-6AL-4V

The Mechanical Threshold Stress (MTS) model provides excellent predictive capabilities for the material constitutive response for a wide range of temperatures and strain rates. However, the MTS model fails to capture the rapidly increasing yield stress at high strain rate behavior as the deformation controlling mechanism transitions from thermal activation to drag mechanisms, only capturing the linear behavior. Further, the model typically over predicts the flow stress behavior at yield and post yield due to its use of a constant work hardening rate parameter derived from the stress–strain response at constant saturation stress. An alternative approach to fitting portions of the MTS model is investigated and mathematical models are developed to address these issues. The results show that with appropriate experimental data, the mechanical threshold stress and work hardening rate parameters within the MTS model can quite easily and accurately be modified to extend applicability to high strain rate behavior and more accurately model the initial flow stress behavior at early work hardening rates without modification of the functions core to the MTS model itself.

36 MATERIALS SCIENCE↗

Effect Modification by Age on the Benefit or Harm of Antihypertensive Treatment for Elderly Hypertensives: A Systematic Review and Meta-analysis

Abstract BACKGROUND The influence of age on balance of benefit vs. potential harm of blood pressure (BP)-lowering therapy for elderly hypertensives is unclear. We evaluated the modifying effects of age on BP lowering for various adverse outcomes in hypertensive patients older than 60 years without specified comorbidities. METHODS All relevant randomized controlled trials (RCTs) were systematically identified. Coronary heart disease, stroke, heart failure (HF), cardiovascular death, major adverse cardiovascular events (MACE), renal failure (RF), and all-cause death were assessed. Meta-regression analysis was used to explore the relationship between achieved systolic BP (SBP) and the risk of adverse events. Random-effects meta-analysis was used to pool the estimates. RESULTS Our study included 18 RCTs (n = 53,993). Meta-regression analysis showed a lower achieved SBP related with a lower risk of stroke and cardiovascular death, but an increased risk of RF. The regression slopes were comparable between populations stratifying by age 75 years. In subgroup analysis, the relative risks of a more aggressive BP lowering strategy were similar between patients aged older or less than 75 years for all outcomes except for RF (P for interaction = 0.02). Compared to treatment with final achieved SBP 140–150 mm Hg, a lower achieved SBP (<140 mm Hg) was significantly associated with decreased risk of stroke (relative risk = 0.68; 95% confidence interval = 0.55–0.85), HF (0.77; 0.60–0.99), cardiovascular death (0.68; 0.52–0.89), and MACE (0.83; 0.69–0.99). CONCLUSIONS To treat hypertension in the elderly, age had trivial effect modification on most outcomes, except for renal failure. Close monitoring of renal function may be warranted in the management of elderly hypertension.

Huang, Chi-Jung↗

Interpretation of the BRITE oscillation data of the hybrid pulsator ν Eridani: a call for the modification of stellar opacities

The analysis of the BRIght Target Explorer (BRITE) oscillation spectrum of the main-sequence early B-type star ν Eridani is presented in this paper. Only models with the modified mean opacity profile can account for the observed frequency ranges as well as for the values of some individual frequencies. The number of the κ-modified seismic models is constrained by the non-adiabatic parameter f, which is very sensitive to the opacity changes in the subphotospheric layers, where the pulsations are driven. We present an example of the model that satisfies all the above conditions. It seems that the OPLIB opacities are preferred over those from the OPAL and OP projects. Finally and moreover, we discuss additional consequences of the opacity modification, namely, an enhancement of the efficiency of convection in the Z bump as well as an occurrence of close radial modes which is a kind of avoided-crossing phenomenon common for non-radial modes in standard main-sequence models.

79 ASTRONOMY AND ASTROPHYSICS↗

Cryo-EM structures of DNA-free and DNA-bound BsaXI: architecture of a Type IIB restriction–modification enzyme

Abstract We have determined multiple cryogenic electron microscopy (cryo-EM) structures of the Type IIB restriction–modification enzyme BsaXI. Such enzymes cleave DNA on both sides of their recognition sequence and share features of Types I, II, and III restriction systems. BsaXI forms a heterotrimeric (RM)2S assemblage in the presence and absence of bound DNA. Two unique structural motifs—a multi-helical “knob” and a long antiparallel double-helical “paddle”—are involved in DNA binding and cleavage. Binding of the DNA target triggers a large conformational change from an ‘open’ to ‘closed’ configuration, resulting in a mixture of two different conformations with respect to the positioning of the S subunit and its target recognition domains on the enzyme’s bipartite DNA target site. Structure-guided mutagenesis studies implicated two clusters of residues in the RM subunit as being critical for DNA cleavage, both are located proximal to a DNA cleavage site. One corresponds to a canonical PD-(D/E)xK endonuclease site in the N-terminal endonuclease domain, while the other corresponds to residues clustered within the paddle motif (near to the C-terminal end of the RM subunit). This analysis facilitates a comparison of three potential mechanisms by which such enzymes cleave DNA on each side of the bound target.

Shen, Betty W.↗

g -factor modification in a bulk InGaAs epilayer by an in-plane electric field

We report on the modification of the g factor by an in-plane electric field in an In 0.026 Ga 0.974 As epilayer. We performed external magnetic field scans of the Faraday rotation of the InGaAs film in order to independently determine the g factor and the spin-orbit fields. The g factor increases from –0.4623 ± 0.0001 at 0 V/cm to –0.4570 ± 0.0001 at 40 V/cm applied along the [11¯0] crystal axis. Lastly, the change in g factor with electric field can have a large effect on the determination of the internal spin-orbit and nuclear fields from Larmor precession frequency measurements.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗

Linear Boltzmann transport for jet propagation in the quark-gluon plasma: Inelastic processes and jet modification

A linear Boltzmann transport (LBT) Monte Carlo model has been developed to describe jet propagation and interaction with the quark-gluon plasma (QGP) in relativistic heavy-ion collisions. A complete set of elastic-scattering processes and medium-induced gluon emissions based on the higher-twist formalism are incorporated for both jet shower and medium recoil partons. It has been employed to describe experimental data on large transverse momentum hadron and jet spectra, correlation and jet substructures in high-energy heavy-ion collisions. Here, we document in detail the structure of the model and validation of the Monte Carlo implementations of the physics processes in LBT, in particular, the inelastic process of medium-induced gluon radiation. We carry out a comprehensive examination of the jet-medium interaction as implemented in LBT through energy loss and momentum broadening of a single hard parton, the energy and transverse momentum transfer from leading partons to medium-induced gluons and jet-induced medium excitation, and medium modification of reconstructed jets in a static and uniform medium. With realistic and event-by-event hydrodynamic medium in heavy-ion collisions, we compute and compare with experimental data on the jet cone-size dependence of the single inclusive jet suppression at both the BNL Relativistic Heavy-Ion Collider (RHIC) and the CERN Large Hadron Collider (LHC), the dijet asymmetry at the LHC and γ-jet correlation at RHIC. Effects of medium-induced gluon emissions and jet-induced medium excitation on jet observables are systematically examined. Rescatterings of the radiated gluons and recoil partons with the QGP are found essential to account for the enhancement of soft particle yield toward the edge of the jet cone.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

Mass depletion: A new parameter for quantitative jet modification

In this paper, we propose an extension to classify jet modification in heavy-ion collisions by including the jet mass along with its energy. The mass of a jet, as measured by jet reconstruction algorithms, is constrained by the jet's virtuality, which in turn has a considerable effect on such observables as the fragmentation function and jet shape observables. The leading parton, propagating through a dense medium, experiences substantial virtuality (or mass) depletion along with energy loss. Meaningful comparisons between surviving jets and jets produced in p-p collisions require mass depletion to be taken into account. Using a vacuum event generator, we show the close relationship between the actual jet mass and that after applying a jet reconstruction algorithm. Using an in-medium event generator, we demonstrate the clear difference between the mass of a surviving parton exiting a dense medium and a parton with a similar energy formed in a hard scattering event. Effects of this difference on jet observables are discussed.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Multistage Monte Carlo simulation of jet modification in a static medium

In this work, the modification of hard jets in an extended static medium held at a fixed temperature is studied using three different Monte Carlo event generators: linear Boltzmann transport (LBT), modular all twist transverse-scattering elastic-drag and radiation (MATTER), and modular algorithm for relativistic treatment of heavy-ion interactions (MARTINI). Each event generator contains a different set of assumptions regarding the energy and virtuality of the partons within a jet versus the energy scale of the medium and, hence, applies to a different epoch in the space-time history of the jet evolution. Here modeling is developed where a jet may sequentially transition from one generator to the next, on a parton-by-parton level, providing a detailed simulation of the space-time evolution of medium modified jets over a much broader dynamic range than has been attempted previously in a single calculation. Comparisons are carried out for different observables sensitive to jet quenching, including the parton fragmentation function and the azimuthal distribution of jet energy around the jet axis. The effect of varying the boundary between different generators is studied and a theoretically motivated criterion for the location of this boundary is proposed. Lastly, the importance of such an approach with coupled generators to the modeling of jet quenching is discussed.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗