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At least 739 records · Page 41

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DOE OSTI2020

A dynamic charge-charge interaction modulates PP2A:B56 substrate recruitment

The recruitment of substrates by the ser/thr protein phosphatase 2A (PP2A) is poorly understood, limiting our understanding of PP2A-regulated signaling. Recently, the first PP2A:B56 consensus binding motif, LxxIxE, was identified. However, most validated LxxIxE motifs bind PP2A:B56 with micromolar affinities, suggesting that additional motifs exist to enhance PP2A:B56 binding. Here, we report the requirement of a positively charged motif in a subset of PP2A:B56 interactors, including KIF4A, to facilitate B56 binding via dynamic, electrostatic interactions. Using molecular and cellular experiments, we show that a conserved, negatively charged groove on B56 mediates dynamic binding. We also discovered that this positively charged motif, in addition to facilitating KIF4A dephosphorylation, is essential for condensin I binding, a function distinct and exclusive from PP2A-B56 binding. Together, these results reveal how dynamic, charge-charge interactions fine-tune the interactions mediated by specific motifs, providing a new framework for understanding how PP2A regulation drives cellular signaling.

59 BASIC BIOLOGICAL SCIENCES↗

DOE OSTI2021

FRET-based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices

Single-molecule FRET (smFRET) has become a mainstream technique for studying biomolecular structural dynamics. The rapid and wide adoption of smFRET experiments by an ever-increasing number of groups has generated significant progress in sample preparation, measurement procedures, data analysis, algorithms and documentation. Several labs that employ smFRET approaches have joined forces to inform the smFRET community about streamlining how to perform experiments and analyze results for obtaining quantitative information on biomolecular structure and dynamics. The recent efforts include blind tests to assess the accuracy and the precision of smFRET experiments among different labs using various procedures. These multi-lab studies have led to the development of smFRET procedures and documentation, which are important when submitting entries into the archiving system for integrative structure models, PDB-Dev. This position paper describes the current ‘state of the art’ from different perspectives, points to unresolved methodological issues for quantitative structural studies, provides a set of ‘soft recommendations’ about which an emerging consensus exists, and lists openly available resources for newcomers and seasoned practitioners. To make further progress, we strongly encourage ‘open science’ practices.

59 BASIC BIOLOGICAL SCIENCES↗

NASA NTRS1969

Proceedings of the Second Workshop on Voltage Breakdown in Electronic Equipment at Low Air Pressure

The Second Workshop on Voltage Breakdown in Electronic Equipment at Low Air Pressure was sponsored by the Jet Propulsion Laboratory, Pasadena, California. It has been three and one-half years since the convening of the first workshop on voltage breakdown. In this interval, gains are evidenced in the progress and sophistication in solving voltage breakdown problems affecting electronic equipment operating at high altitudes or other low air pressure environments. Although space applications predominate the area of concern, other projects such as the SST are becoming increasingly involved with voltage breakdown. High-voltage breakdown in spacecraft continues; however, the incidences of occurrence appear to have decreased in spite of an increase in the number of missions flown. This, it is felt, is due to many project managers now requiring all equipment with voltage in excess of 270-V peak to be designed to operate in the critical pressure region without damage, even though its normal functional environment is sea level pressure and the hard vacuum of space. In addition, designers are becoming more aware of the principle of good high-voltage design by selecting void-free components, proper spacing of conductors, isolating high-voltage circuitry from lower voltage areas, etc. The consensus seems to be that the slight increase in cost to achieve a provable corona-free design is more than offset by the increase in confidence that the equipment will survive accidental loss of vacuum during high-vacuum tests, inadvertent turn on while passing through the critical air-pressure region of earth after launch or outgassing in flight pressurizing the enclosure into the critical pressure region.

E. R. Bunker, Jr.↗

NASA NTRS1972

Post-workshop models of Jupiter's radiation belts

Models for the charged particle populations of Jupiter's trapped radiation belts were derived at the Jupiter Radiation Belt Workshop on the basis of several assumptions which represented a consensus of opinion. It was possible to improve the models on the basis of work performed after the workshop concluded. These improvements affect the models in two ways. The effects of special relativity on the particle energy and flux dependences in the magnetosphere were included in a derivation based on L-shell diffusion with conservation of the magnetic moment. Quantitative conclusions are available for the limit which ion cyclotron instability places on the proton population. A set of models which incorporates these developments in a way consistent with the original workshop assumptions and conclusions is described.

Divine, N.↗

NASA NTRS1972

Effects of n-dominance and group composition on task efficiency in laboratory triads.

Task-oriented triads were formed into various homogeneous and heterogeneous combinations according to their scores on the n-dominance personality trait of the Edwards Personal Preference Schedule. Five group categories were used. The group task required a consensus decision on each trial. High cooperation and interdependence were reinforced by partially restricting the communication network. Results showed heterogeneous groups significantly better at organizing their group communication processes. They consequently performed the task more efficiently than homogeneous triads.

Lampkin, E. C.↗

NASA NTRS1970

An experiment with interactive planning models

Experiments on decision making in planning problems are described. Executives were tested in dealing with capital investments and competitive pricing decisions under conditions of uncertainty. A software package, the interactive risk analysis model system, was developed, and two controlled experiments were conducted. It is concluded that planning models can aid management, and predicted uses of the models are as a central tool, as an educational tool, to improve consistency in decision making, to improve communications, and as a tool for consensus decision making.

Beville, J.↗

NASA NTRS1973

Agricultural applications of ERTS-1 data

In an attempt to evaluate the usefulness of ERTS imagery for the production of land use stratifications as a preliminary step in the crop inventory process, all land within San Joaquin County was delineated into broad land use and crop category classes based on their appearance on the ERTS-1 Color composite image. The stratification of the agricultural land use categories proved to be a relatively simple task, taking each of three interpreters approximately 30 minutes to complete. The three interpretations were quite similar requiring only minor revisions to produce a consensus stratification. A total of 13 different agricultural strata were recognized, differing both in general field size and relative proportions of crop types and degree of irrigation. Upon comparing these interpretations, it was concluded that nearly all boundaries were truly representative of differing cropping practices. In a number of cases, the stratifications agreed almost exactly with soil type boundaries as drawn by earlier soils surveys.

Draeger, W. C.↗

NASA NTRS1974

A review of surface-crack fracture testing

A brief historical review of surface-crack testing and analysis is given together with some examples of service failures due to surface cracks. The factors which complicate the analysis and interpretation of surface-crack fracture data are discussed. Current efforts to develop consensus recommendations for tensile testing of surface-crack specimens are summarized.

Orange, T. W.↗

NASA NTRS1974

Study plan to identify long term national telecommunications need and priorities applying Delphi techniques (handbook)

A handbook that explains the basic Delphi methodology and discusses modified Delphi techniques is presented. The selection of communications experts to participate in a study, the construction of questionnaires on potential communications developments, and requisite technology is treated. No two modified Delphi studies were the same, which reflects the flexibility and adaptability of the technique. Each study must be specifically tailored to a particular case, and consists of seeking a consensus of opinion among experts about a particular subject and attendant conditions that may prevail in the future.

Source record↗

NASA NTRS1975

Quantification of Geologic Lineaments by Manual and Machine Processing Techniques

The effect of operator variability and subjectivity in lineament mapping and methods to minimize or eliminate these problems by use of several machine preprocessing methods was studied. Mapped lineaments of a test landmass were used and the results were compared statistically. The total number of fractures mapped by the operators and their average lengths varied considerably, although comparison of lineament directions revealed some consensus. A summary map (785 linears) produced by overlaying the maps generated by the four operators shows that only 0.4 percent were recognized by all four operators, 4.7 percent by three, 17.8 percent by two, and 77 percent by one operator. Similar results were obtained in comparing these results with another independent group. This large amount of variability suggests a need for the standardization of mapping techniques, which might be accomplished by a machine aided procedure. Two methods of machine aided mapping were tested, both simulating directional filters.

Podwysocki, M. H.↗

NASA NTRS1974

A review of surface-crack fracture testing

Orange, T. W.↗

NASA NTRS1975

Quantification of geologic lineaments by manual and machine processing techniques

A study was conducted to investigate the effect of operator variability and subjectivity in lineament mapping and to examine methods to minimize or eliminate these problems by use of several machine preprocessing methods. LANDSAT scenes from the Anadarko Basin of Oklahoma and the Colorado Plateau were analyzed as test cases. Four geologists mapped lineaments on an Anadarko Basin scene, using transparencies of MSS bands 4-7, and their results are compared statistically. The total number of fractures mapped by the operators and their average lengths varied considerably, although comparison of lineament directions revealed some consensus. A summary map (785 linears) produced by overlaying the maps generated by the four operators showed that only 0.4% were recognized by all four operators, 4.7% by three, 17.8% by two and 77% by one operator. Two methods of machine aided mapping were tested, both simulating directional filters. One consists of computer (digital) processing of CCTs using edge enhancement algorithms, the other employs a television (analog) scanning of an image transparency which superimposes the original image and one offset in the direction of the scan line.

Podwysocki, M. H.↗

NASA NTRS1977

Accomplishments in ride quality research: Present and near future

Areas of research in the field of ride quality were categorized into generic subdivisions. The following generic areas were identified: single degree of freedom simulations, multiple degrees of freedom simulations, field simulations, field experiments, surveys/reviews, and modeling techniques. From this review a consensus was reached on the projection of needs for future research efforts, including a prioritization, as well as time and cost estimates of ride quality studies.

Source record↗

NASA NTRS1976

Summary of studies for a solar optical telescope in space: 1968-1976

The primary objective of this review is to tabulate the basic recommendations of several solar telescope studies. A primary matrix, listing some of the basic optical parameters, was compiled and forms the basis for a table. From this table it is apparent that a strong consensus exists on the configuration of the telescope and on its fundamental dimensionless parameters. Other tables presented in this document address the basic approach of each study to the telescope design as well as to the design of critical subsystems. These subsystem problems include the material, coating, configuration, mounting, launch locks, and thermal control of the primary mirror, the structure of the main telescope and the instrument bay, the mechanisms for radiation rejection, thermal control, and meteoroid shielding, and methods of maintaining image quality by proper alignment and by image motion compensation.

Bremer, J.↗

NASA NTRS1979

Recommendations

Significant progress was made in the development of remote sensing techniques for estimating soil moisture, and some useful applications for soil moisture information was demonstrated. However, there is an array of questions that must be answered before an operational program is appropriate. A substantial research-oriented program is justified. A summary of recommendations made by participants in the workshop concerning future research and development is presented. These recommendations represent a consensus of opinions from the Workshop participants, but are not necessarily unanimous views.

Source record↗

NASA NTRS1980

Study of research and development requirements of small gas-turbine combustors

A survey is presented of the major small-engine manufacturers and governmental users. A consensus was undertaken regarding small-combustor requirements. The results presented are based on an evaluation of the information obtained in the course of the study. The current status of small-combustor technology is reviewed. The principal problems lie in liner cooling, fuel injection, part-power performance, and ignition. Projections of future engine requirements and their effect on the combustor are discussed. The major changes anticipated are significant increases in operating pressure and temperature levels and greater capability of using heavier alternative fuels. All aspects of combustor design are affected, but the principal impact is on liner durability. An R&D plan which addresses the critical combustor needs is described. The plan consists of 15 recommended programs for achieving necessary advances in the areas of liner thermal design, primary-zone performance, fuel injection, dilution, analytical modeling, and alternative-fuel utilization.

Demetri, E. P.↗

NASA NTRS1981

Rotorcraft aviation icing research requirements: Research review and recommendations

The status of rotorcraft icing evaluation techniques and ice protection technology was assessed. Recommendations are made for near and long term icing programs that describe the needs of industry. These recommended programs are based on a consensus of the major U.S. helicopter companies. Specific activities currently planned or underway by NASA, FAA and DOD are reviewed to determine relevance to the overall research requirements. New programs, taking advantage of current activities, are recommended to meet the long term needs for rotorcraft icing certification.

Peterson, A. A.↗

NASA NTRS1980

United Nations principles on remote sensing - Report on developments, 1970-1980

The paper deals with the efforts of the United Nations Committee on the Peaceful Uses of Outer Space (COPUOS) to reach a consensus on legal principles governing the international use of remote sensing of the earth from space. The proceedings of the Working Group from 1971 to 1974 and the Legal Subcommittee from 1973 to 1980 are presented. Though the Committee has reached agreement on certain points, some key questions remain unresolved relative to dissemination of data and to the need for or method of classifying remote sensing data based on spatial resolution. An appendix of texts and draft principles worked out by COPUOS is also presented.

Mossinghoff, G. J.↗