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At least 739 records · Page 41

Charged-hadron identification at Belle II

The Belle II experiment’s ability to identify particles critically affects the sensitivity of its measurements. We describe Belle II’s algorithms for identifying charged particles and evaluate their performance in separating pions, kaons, and protons using $426\,\text {fb}^{-1}$ of data collected at the energy-asymmetric $e^{+}e^{-}$ collider SuperKEKB in 2019–2022 at center-of-mass energies at and near the mass of the $\Upsilon$ (4S).

Adachi, I. (ORCID:0000000322870173)↗

A continuous calibration of the ATLAS flavour-tagging classifiers via optimal transportation maps

A calibration of the ATLAS flavour-tagging algorithms using a new calibration procedure based on optimal transportation maps is presented. Simultaneous, continuous corrections to the b-jet, c-jet, and light-flavour jet classification probabilities from jet-tagging algorithms in simulation are derived for b-jets using $t\bar{t} \rightarrow e\mu \nu \nu bb$ data. After application of the derived calibration maps, closure between simulation and observation is achieved for jet flavour observables used in ATLAS analyses of Large Hadron Collider (LHC) Run 2 proton-proton collision data. This continuous calibration opens up new possibilities for the future use of jet flavour information in LHC analyses and also serves as a guide for deriving high-dimensional corrections to simulation via transportation maps, an important development for a broad range of inference tasks.

Aad, G. [Aix-Marseille Université] (ORCID:00000002↗

Measurement of high-mass $t\bar{t}\ell ^{+}\ell ^{-}$ production and lepton flavour universality-inspired effective field theory interpretations at $\sqrt{s}=13$ $\text {T}\text {e}\hspace{-1.00006pt}\text {V}$ with the ATLAS detector

Measurements of $t\bar{t}\ell ^{+}\ell ^{-}$ production in the region of high dilepton invariant mass with effective field theory (EFT) interpretations are presented. They are performed using final states with three isolated leptons (electrons or muons) and are based on $\sqrt{s} = 13$ TeV proton–proton collision data with an integrated luminosity of $140\,\textrm{fb}^{-1}$, recorded from 2015 to 2018 with the ATLAS detector at the Large Hadron Collider. Measurements of the $t\bar{t}\ell ^{+}\ell ^{-}$ signal strength and cross-section upper-limits are performed inclusively in lepton flavour and separately for electrons and muons. The study also aims to probe anomalous four-fermion interactions including to test for possible lepton flavor universality violation. No significant deviations from the Standard Model predictions are observed and the measurements are interpreted through the EFT formalism to provide new constraints on the relevant operators.

Aad, G. [CNRS/IN2P3] (ORCID:0000000266654934)↗

Search for electroweak production of vector-like leptons in $\tau$-lepton and b-jet final states in pp collisions at $\sqrt{s}$ = 13 TeV with the ATLAS detector

A search for pair-production of vector-like leptons is presented, considering their decays into a third-generation Standard Model (SM) quark and a vector leptoquark ( U 1 ) as predicted by an ultraviolet-complete extension of the SM, referred to as the ‘4321’ model. Given the assumed decay of U 1 into third-generation SM fermions, the final state can contain multiple τ-leptons and b-quarks. This search is based on a dataset of pp collisions at $\sqrt{s}=13$ TeV recorded with the ATLAS detector during Run 2 of the Large Hadron Collider, corresponding to an integrated luminosity of up to $140~\textrm{fb}^{-1}$. No significant excess above the SM background prediction is observed, and 95% confidence level limits on the cross-section times branching ratio are derived as a function of the vector-like lepton mass. A lower observed (expected) limit of 910 GeV (970 GeV) is set on the vector-like lepton mass. Additionally, the results are interpreted for a supersymmetric model with an R-parity violating coupling to the third-generation quarks and leptons. Lower observed (expected) limits are obtained on the higgsino mass at 880 GeV (940 GeV) and on the wino mass at 1170 GeV (1170 GeV).

Aad, G. [CPPM, Aix-Marseille Université, CNRS/IN2P↗

Measurements of Higgs boson production via gluon–gluon fusion and vector-boson fusion using $H\rightarrow WW^*\rightarrow \ell \nu \ell \nu$ decays in pp collisions with the ATLAS detector and their effective field theory interpretations

Higgs boson production cross-sections via gluon–gluon fusion and vector-boson fusion in proton–proton collisions are measured in the $H\rightarrow WW^*\rightarrow \ell \nu \ell \nu$ decay channel. The Large Hadron Collider delivered proton–proton collisions at a centre-of-mass energy of 13 TeV between 2015 and 2018, which were recorded by the ATLAS detector, corresponding to an integrated luminosity of $140\,\text {fb}^{-1}.$ The total cross-sections for Higgs boson production by gluon–gluon fusion and vector-boson fusion times the $H\rightarrow WW^*$ branching ratio are measured to be $12.4^{+1.3}_{-1.2}\,\text {pb}$ and $0.79^{+0.18}_{-0.16}\,\text {pb},$ respectively, in agreement with the Standard Model predictions. Higgs boson production is further characterised through measurements of Simplified Template Cross-Sections in a total of fifteen kinematic fiducial regions. A new scheme of kinematic fiducial regions has been introduced to enhance the sensitivity to CP-violating effects in Higgs boson interactions. Both schemes are used to constrain CP-even and CP-odd dimension-six operators in the Standard Model effective field theory.

Aad, G. [CPPM, Aix-Marseille Université, CNRS/IN2P↗

Estimation of backgrounds from jets misidentified as τ-leptons using the Universal Fake Factor method with the ATLAS detector

Processes with τ$$\tau $$-leptons in the final state are important for Standard Model measurements and searches for physics beyond the Standard Model. The ATLAS experiment at the Large Hadron Collider observes τ$$\tau $$-leptons produced in proton–proton collisions only through their decay products. Data analyses involving hadronically decaying τ$$\tau $$-leptons face challenges due to backgrounds from jets misidentified as τ$$\tau $$-leptons that are not modelled reliably by Monte Carlo simulations. Data-driven methods such as the fake-factor method allow such misidentified backgrounds to be predicted by measuring transfer factors, known as fake factors, in data from dedicated regions. This paper describes a refined technique for determining the fake factors, the Universal Fake Factor method. It evaluates the fake factors for a signal region by using fake factors from samples enriched in different sources of jets misidentified as τ$$\tau $$-leptons (light-quark, gluon, b-quark, and pile-up jets). Each fake factor is calculated as a linear combination of fake factors measured in these different enriched samples. For the full Run 2 data set, the systematic uncertainty of the calculated fake factors, evaluated using W(μν)$$W(\mu u )$$ enriched event sample, ranges from 15 to 35% depending on the τ$$\tau $$-lepton’s transverse momentum and charged-particle decay multiplicity.

Aad, G↗

Search for squarks and gluinos in pp collisions at $\sqrt{s} = 13$ TeV and 13.6 TeV in events with $\tau$-leptons, jets and missing transverse momentum using the ATLAS detector

A search for R-parity-conserving supersymmetry in events with large missing transverse momentum, jets and at least one hadronically decaying $\tau$-lepton is presented. Both gluino and squark pair production are considered, with the cascade decay of each gluino or squark producing either a $\tau$-slepton or a $\tau$-sneutrino. Three channels are examined, requiring either exactly one hadronically decaying $\tau$-lepton and no other leptons, exactly one hadronically decaying $\tau$-lepton and at least one other lepton, or two or more hadronically decaying $\tau$-leptons. Analyses in the three channels are optimised independently and combined statistically. Two separate analysis strategies, either a cut-and-count or machine-learning approach, are used. The search uses 140 and 51.8 of pp collision data recorded by the ATLAS detector at the Large Hadron Collider during 2015–2018 at TeV and 2022–2023 at TeV, respectively. Gluino masses below 2.25 TeV and squark masses up to 1.7 TeV are excluded

Aad, G. [CNRS/IN2P3] (ORCID:0000000266654934)↗

The environmental impact, carbon emissions and sustainability of computing in the ATLAS experiment

ATLAS, a general-purpose experiment at the Large Hadron Collider (LHC), makes use of a large internationally-distributed computing infrastructure, including over 10 6 TB of managed data on disk and tape and almost one million simultaneously running CPU cores. Upgrades for the High-Luminosity LHC (HL-LHC) will increase the required computing resources by a factor of 3–4 by the beginning of the 2030s, and by an order of magnitude before the conclusion of data taking at the beginning of the 2040s. These resources are spread over around 100 computing sites worldwide. Efforts are underway within the experiment to evaluate and mitigate various aspects of the environmental impact of the sites, with the additional long-term goal of making recommendations to the sites that will significantly reduce the total expected environmental impact in the HL-LHC era. These efforts take several forms: building awareness in the experiment community, adjusting aspects of the computing policy, and modifications of data center configurations, either in ways that take advantage of particular features of ATLAS workloads or in generic ways that reduce the environmental impact of the computing resources. This paper describes the ongoing investigations and approaches that have already provided useful and actionable outcomes.

Aad, G. [CNRS/IN2P3] (ORCID:0000000266654934)↗

Search for heavy neutral leptons in decays of W bosons produced in 13 TeV pp collisions using prompt signatures in the ATLAS detector

The existence of right-handed neutrinos with Majorana masses below the electroweak scale could help address the origins of neutrino masses, the matter–antimatter asymmetry, and dark matter. In this paper, leptonic decays of W bosons from 140 fb-1$$^{-1}$$ of 13 TeV proton–proton collisions at the LHC, reconstructed in the ATLAS experiment, are used to search for heavy neutral leptons produced through their mixing with muon or electron neutrinos in a scenario with lepton number violation. The search is conducted using prompt leptonic decay signatures. The considered final states require two same-charge leptons or three leptons, while vetoing three-lepton same-flavour topologies. No significant excess over the expected Standard Model backgrounds is found, leading to constraints on the heavy neutral lepton’s mixing with muon and electron neutrinos for heavy-neutral-lepton masses. The analysis excludes |Ue|2$$|U_{e}|^2$$ values above 8×10-5$$8\times 10^{-5}$$ and |Uμ|2$$|U_{\mu }|^2$$ values above 5.0×10-5$$5.0 \times 10^{-5}$$ in the full mass range of 8–65 GeV. The strongest constraints are placed on heavy-neutral-lepton masses in the range 15–30 GeV of |Ue|2<1.1×10-5$$|U_{e}|^2 < 1.1 \times 10^{-5}$$ and |Uμ|2<5×10-6$$|U_{\mu }|^2 < 5 \times 10^{-6}$$.

Aad, G↗

Search for Beyond the Standard Model physics with anomaly detection in multilepton final states in pp collisions at s=13TeV with the ATLAS detector

A model-agnostic search for Beyond the Standard Model physics is presented, targeting final states with at least four light leptons (electrons or muons). The search regions are separated by event topology and unsupervised machine learning is used to identify anomalous events in the full 140 fb-1$$^{-1}$$ of proton–proton collision data collected with the ATLAS detector during Run 2. No significant excess above the Standard Model background expectation is observed. Model-agnostic limits are presented in each topology, along with limits on several benchmark models including vector-like leptons, wino-like charginos and neutralinos, or smuons. Limits are set on the flavourful vector-like lepton model for the first time.

Aad, G↗

Measurement of the W-boson angular coefficients and transverse momentum in pp collisions at s=13 TeV with the ATLAS detector

The angular distributions of Drell–Yan lepton pairs provide sensitive probes of the underlying dynamics of quantum chromodynamics (QCD) effects in vector-boson production. This paper presents for the first time the measurement of the full set of angular coefficients together with the differential cross-section as a function of the transverse momentum of the W boson, in the full phase space of the decay leptons. The measurements are performed separately for the W-$$W^-$$ and W+$$W^+$$ channels. The analysis uses proton–proton collision data recorded by the ATLAS experiment at the Large Hadron Collider in 2017 and 2018, during special low-luminosity runs with a reduced number of interactions per bunch crossings (pile-up). The data correspond to an integrated luminosity of 338 pb-1$$^{-1}$$ at a centre-of-mass energy of s=13$$\sqrt{s} = 13$$ TeV. The low pile-up environment provides excellent experimental conditions for high-precision measurements of W-boson production. All results agree with theoretical predictions incorporating finite-order QCD corrections up to order αS2$$\alpha _S^2$$.

Aad, G↗

Precise measurement of the tt¯ production cross-section and lepton differential distributions in eμ dilepton events from s=13TeVpp collisions with the ATLAS detector

The inclusive top quark pair (tt¯$$t\bar{t}$$) cross-section σtt¯$$\sigma _{t\bar{t}}$$ has been measured in proton–proton collisions at s=13TeV$$\sqrt{s}=13\,\text {TeV}$$, using 140fb-1$$140\,{\text {fb}^{-1}} $$ of data collected by the ATLAS experiment at the Large Hadron Collider. Using events with an opposite-charge eμ$$e\mu $$ pair and b-tagged jets, the cross-section is measured to be: σtt¯=829.3±1.3(stat)±8.0(syst)±7.3(lumi)±1.9(beam)pb,$$\begin{aligned} \sigma _{t\bar{t}} & = 829.3\pm 1.3\,\mathrm {(stat)}\ \pm 8.0\,\mathrm {(syst)}\ \pm 7.3\,\mathrm {(lumi)}\ \\ & \quad \pm 1.9\,\mathrm {(beam)}\,\textrm{pb}, \end{aligned}$$where the uncertainties reflect the limited size of the data sample, experimental and theoretical systematic effects, the integrated luminosity, and the proton beam energy, giving a total uncertainty of 1.3%. The result is used to determine the top quark pole mass via the dependence of the predicted cross-section on mtpole$${m_{t}^\textrm{pole}}$$, giving mtpole=172.8-1.7+1.5$${m_{t}^\textrm{pole}}=172.8^{+1.5}_{-1.7}$$ GeV$$\text {GeV}$$. The same event sample is used to measure absolute and normalised differential cross-sections for the tt¯→eμνν¯bb¯$$t\bar{t} \rightarrow e\mu u \bar{ u }b\bar{b} $$ process as a function of single-lepton and dilepton kinematic variables. Complementary measurements of eμbb¯$$e\mu b\bar{b} $$ production, treating both tt¯$$t\bar{t}$$ and Wt events as signal, are also provided. Both sets of differential cross-sections are compared to the predictions of various Monte Carlo event generators, demonstrating that the state-of-the-art generators Powheg MiNNLO and Powhegbb4l describe the data better than Powheghvq.

Aad, G↗

Considerations for three-dimensional image reconstruction from experimental data in coherent diffractive imaging

The Datasets folder contains 3 datasets, corresponding to the datasets mentioned in the article with 670, 2691 and 586 images. The Runs folder has all the runs used. Besides the images itself it also contains tags for each image under `/entry_1/image_1/detector_and_photon_corrected/tags`. The `headings` attribute gives the name of each tag. The `Jonas Strict` tag corresponds to the 670 images, the `Redflamingo` tag to the 2691 images and the `Redflamingo_Ida_subset` tag to the 586 images. The final dataset with 260 images can be obtained from `Datasets/amoc6914-Redflamingo-manual-586.h5` and use the `/model/diameterNM` group to select the 260 images with size closest to 214 nm.

AMO↗

Potentially adaptive SARS-CoV-2 mutations discovered with novel spatiotemporal and explainable AI models

Abstract Background A mechanistic understanding of the spread of SARS-CoV-2 and diligent tracking of ongoing mutagenesis are of key importance to plan robust strategies for confining its transmission. Large numbers of available sequences and their dates of transmission provide an unprecedented opportunity to analyze evolutionary adaptation in novel ways. Addition of high-resolution structural information can reveal the functional basis of these processes at the molecular level. Integrated systems biology-directed analyses of these data layers afford valuable insights to build a global understanding of the COVID-19 pandemic. Results Here we identify globally distributed haplotypes from 15,789 SARS-CoV-2 genomes and model their success based on their duration, dispersal, and frequency in the host population. Our models identify mutations that are likely compensatory adaptive changes that allowed for rapid expansion of the virus. Functional predictions from structural analyses indicate that, contrary to previous reports, the Asp 614 Gly mutation in the spike glycoprotein (S) likely reduced transmission and the subsequent Pro 323 Leu mutation in the RNA-dependent RNA polymerase led to the precipitous spread of the virus. Our model also suggests that two mutations in the nsp13 helicase allowed for the adaptation of the virus to the Pacific Northwest of the USA. Finally, our explainable artificial intelligence algorithm identified a mutational hotspot in the sequence of S that also displays a signature of positive selection and may have implications for tissue or cell-specific expression of the virus. Conclusions These results provide valuable insights for the development of drugs and surveillance strategies to combat the current and future pandemics.

59 BASIC BIOLOGICAL SCIENCES↗

Circularization of 23S rRNA but not 16S rRNA within archaeal ribosomes

Background Processing of archaeal 16S and 23S rRNAs is believed to involve excision of individual rRNAs from polycistronic precursors, circularization of excised rRNAs, and re-linearization before the incorporation into ribosomes. However, all the knowledge is derived from several isolated species, leaving open the possibility that different processes may occur in other archaeal groups. Results Here, we investigate rRNAs from diverse and mostly uncultivated archaea. Sequencing of total cellular RNA from eight phylum-level lineages indicates that archaeal circular 23S rRNA transcript abundances vastly exceed those of linear counterparts, and linear versions are often undetectable. As the majority of rRNAs derive from mature ribosomes, the data suggest that ribosomes contain circular 23S rRNAs. Thus, we directly sequence RNA extracted from isolated ribosomes of a model archaeon, Methanosarcina acetivorans, and confirm that the 23S rRNAs in the ribosomes are circular. Structural modeling places the 5′ and 3′ ends of the linear precursors of archaeal 23S rRNAs in close proximity to form a GNRA tetraloop (in which N is A, C, G, or U and R is A or G), consistent with their existence as circular molecules. We also confirm the existence of circular 16S rRNA intermediates in transcriptomes of most archaea, yet a circular form is not evident in some distinct archaeal groups, suggesting that certain archaea do not circularize 16S rRNA during processing. Conclusions Our findings uncover unexpected variations in the processing required to generate mature rRNAs and the conformation of functional molecules in archaeal ribosomes.

Archaea↗

Interactions between terminal ribosomal RNA helices stabilize the E. coli large ribosomal subunit

The ribosome is a large ribonucleoprotein assembly that uses diverse and complex molecular interactions to maintain proper folding. In vivo assembled ribosomes have been isolated using MS2 tags installed in either the 16S or 23S ribosomal RNAs (rRNAs), to enable studies of ribosome structure and function in vitro. RNA tags in the Escherichia coli 50S subunit have commonly been inserted into an extended helix H98 in 23S rRNA, as this addition does not affect cellular growth or in vitro ribosome activity. Here, we find that E. coli 50S subunits with MS2 tags inserted in H98 are destabilized compared to wild-type (WT) 50S subunits. We identify the loss of RNA–RNA tertiary contacts that bridge helices H1, H94, and H98 as the cause of destabilization. Using cryogenic electron microscopy (cryo-EM), we show that this interaction is disrupted by the addition of the MS2 tag and can be restored through the insertion of a single adenosine in the extended H98 helix. This work establishes ways to improve MS2 tags in the 50S subunit that maintain ribosome stability and investigates a complex RNA tertiary structure that may be important for stability in various bacterial ribosomes.

59 BASIC BIOLOGICAL SCIENCES↗