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At least 721 records · Page 40

The effects of orbital spaceflight on bone histomorphometry and messenger ribonucleic acid levels for bone matrix proteins and skeletal signaling peptides in ovariectomized growing rats

A 14-day orbital spaceflight was performed using ovariectomized Fisher 344 rats to determine the combined effects of estrogen deficiency and near weightlessness on tibia radial bone growth and cancellous bone turnover. Twelve ovariectomized rats with established cancellous osteopenia were flown aboard the space shuttle Columbia (STS-62). Thirty ovariectomized rats were housed on earth as ground controls: 12 in animal enclosure modules, 12 in vivarium cages, and 6 killed the day of launch for baseline measurements. An additional 18 ovary-intact rats were housed in vivarium cages as ground controls: 8 rats were killed as baseline controls and the remaining 10 rats were killed 14 days later. Ovariectomy increased periosteal bone formation at the tibia-fibula synostosis; cancellous bone resorption and formation in the secondary spongiosa of the proximal tibial metaphysis; and messenger RNA (mRNA) levels for the prepro-alpha2(1) subunit of type 1 collagen, osteocalcin, transforming growth factor-beta, and insulin-like growth factor I in the contralateral proximal tibial metaphysis and for the collagen subunit in periosteum pooled from tibiae and femora and decreased cancellous bone area. Compared to ovariectomized weight-bearing rats, the flight group experienced decreases in periosteal bone formation, collagen subunit mRNA levels, and cancellous bone area. The flight rats had a small decrease in the cancellous mineral apposition rate, but no change in the calculated bone formation rate. Also, spaceflight had no effect on cancellous osteoblast and osteoclast perimeters or on mRNA levels for bone matrix proteins and signaling peptides. On the other hand, spaceflight resulted in an increase in bone resorption, as ascertained from the diminished retention of a preflight fluorochrome label. This latter finding suggests that osteoclast activity was increased. In a follow-up ground-based experiment, unilateral sciatic neurotomy of ovariectomized rats resulted in cancellous bone loss in the unloaded limb in excess of that induced by gonadal hormone deficiency. This additional bone loss was arrested by estrogen replacement. We conclude from these studies that estrogen alters the expression of signaling peptides believed to mediate skeletal adaptation to changes in mechanical usage and likewise modifies the skeletal response to mechanical unloading.

NASA Program Space Physiology and Countermeasures↗

Targeted sulfur(VI) fluoride exchange-mediated covalent modification of a tyrosine residue in the catalytic pocket of tyrosyl-DNA phosphodiesterase 1

Abstract Developing effective inhibitors of the DNA repair enzyme tyrosyl-DNA phosphodiesterase 1 (TDP1) has been challenging because of the enzyme shallow catalytic pocket and non-specific substrate binding interactions. Recently, we discovered a quinolone-binding hot spot in TDP1’s active site proximal to the evolutionary conserved Y204 and F259 residues that position DNA. Sulfur (VI) fluoride exchange (SuFEx) is a biocompatible click chemistry reaction that enables acylation of protein residues, including tyrosine. Selective protein modifications can provide insights into the biological roles of proteins and inform ligand design. As we report herein, we used SuFEx chemistries to prepare covalent TDP1-bound binders showing site-specific covalent bonds with Y204. Our work presents the first application of SuFEx chemistries to TDP1 ligands. It validates the ability to covalently modify specific TDP1 residues by designed targeting and adds to the chemical biology resource toolbox for studying TDP1.

Chemistry↗

Biospheric traumas caused by large impacts and predicted relics in the sedimentary record

When a large asteroid or comet impacts the Earth the supersonic plume ejected on impact causes severe shock heating and chemical reprocessing of the proximal atmosphere. The resultant NO is converted rapidly to NO2, foliage damage due to exposure to NO2 and HNO3, toxicosis resulting from massive mobilization of soil trace metals, and faunal asphyxiation due to exposure to NO2. One class of relic evidence for the above effects arises because extinction of species caused by these chemically induced traumas would be selective. A second class of relic evidence arises because the acid rain will cause massive weathering of continental rocks and soils characterized by large ratios of the relatively insoluble metals, to the more soluble metals. This weathering would be best recorded in fossils in unperturbed deltaic, neritic, or limnetic sediments and for metals with very long oceanic residence times in deep ocean sediments as well. This evidence is discussed.

Prinn, R. G.↗

Noachian Martian Volcanics a Water Source

H2O was supplied to the Noachian atmosphere by eruptions, or in association with large impacts. Most water outgassed into an extremely cold atmosphere, and condensate deposits were inevitable. High heat flow could lead to subglacial melting only if ice thicknesses were greater than 500-1000m, which is extremely unlikely. Subareal melting and flow is contingent upon temperatures periodically exceeding 273 K, and retarding evaporative loss of the flow. In still air, evaporation into a dry atmosphere is in the free convection regime, and a stream with 2 cu m/s discharge, flowing 1 m/s could persist for hundreds of days and cover distances greater than any valley reach. The zero-wind-shear condition is considered implausible however. We investigate the possibility that evaporation rates were suppressed because the atmosphere was regionally charged with H2O as it moved over snow/ice fields. Our initial concern is precipitation from volcanic plumes. A Kilauea-style eruption on the martian surface would cover a 10km circular deposit with 10cm of H2O, if all H2O could be precipitated near the vent. The characteristics of the eruption at the vent, (vent size, temperature, H2O content, etc.) are independent of the environmental conditions. The subsequent behavior of the plume, including precipitation of ash and H2O condensate depends strongly on the environment. Hence, the proximal fate of volcanic H2O is amenable to treatment in a model. A simple bulk thermodynamic model of the rise of an H2O plume through a stably stratified CO2 atmosphere, with only adiabatic cooling, produces runaway plume rise. A more complex treatment includes the effects of latent heat release, wind shear along the plume, divergence of ash and H2O, and will yield more realistic estimates of H2O transport in eruptive plumes. Results of these simulations will be presented.

Zent, A. P.↗

On Structural Design of a Mobile Lunar Habitat with Multi-Layered Environmental Shielding

The future human lunar missions are expected to undertake far more ambitious activities than those of the Apollo program with the possibility of some missions lasting up to several months. Such extended missions require the use of large-size lunar outposts to accommodate living quarters for the astronauts as well as indoor laboratory facilities. The greatest obstacle to the prolonged human presence on the Moon is the threat posed by the harsh lunar environment that is plagued with multi-source high-energy radiation exposure as well as frequent barrage of meteoroids. Hence, for such extended missions to succeed, it is vital that the future lunar outposts be designed to provide a safe habitat for the astronauts. Over the past few years, a variety of ideas and concepts for future lunar outposts and bases have been proposed. With shielding as the primary concern, some have suggested the use of natural structures such as lava tubes while others have taken a more industrial approach and suggested the construction of fixed structures in the form of inflatable, inflatable with rigid elements, and tent-style membrane. For evaluation of these structural design concepts, Drake and Richter1 have proposed a rating system based on such factors as effectiveness, importance, and timing. While all of these designs, in general, benefit from in-situ resource utilization (i.e., lunar regolith) for shielding, they share a common disadvantage of being fixed to one particular location that would limit exploration to the region in close proximity of the outpost.

Rais-Rohani, Masoud↗

Technical Report Series on Global Modeling and Data Assimilation: Estimates of AOD Trends (2002 - 2012) Over the World's Major Cities Based on the MERRA Aerosol Reanalysis - Volume 32

NASA's Global Modeling and Assimilation Office has extended the Modern-Era Retrospective Analysis for Research and Application (MERRA) tool with five atmospheric aerosol species (sulfates, organic carbon, black carbon, mineral dust and sea salt). This inclusion of aerosol reanalysis data is now known as MERRAero. This study analyses a ten-year period (July 2002 - June 2012) MERRAero aerosol reanalysis applied to the study of aerosol optical depth (AOD) and its trends for the aforementioned aerosol species over the world's major cities (with a population of over 2 million inhabitants). We found that a proportion of various aerosol species in total AOD exhibited a geographical dependence. Cities in industrialized regions (North America, Europe, central and eastern Asia) are characterized by a strong proportion of sulfate aerosols. Organic carbon aerosols are dominant over cities which are located in regions where biomass burning frequently occurs (South America and southern Africa). Mineral dust dominates other aerosol species in cities located in proximity to the major deserts (northern Africa and western Asia). Sea salt aerosols are prominent in coastal cities but are dominant aerosol species in very few of them. AOD trends are declining over cities in North America, Europe and Japan, as a result of effective air quality regulation. By contrast, the economic boom in China and India has led to increasing AOD trends over most cities in these two highly-populated countries. Increasing AOD trends over cities in the Middle East are caused by increasing desert dust.

AOD↗

Fully Distributed Multi-Material Magnetic Sensing Structures for Multiparameter DAS Applications

This dissertation demonstrates the first of its kind distributed magnetic field sensor based on a fiber optic distributed acoustic sensing (DAS) scheme. Ferromagnetic nickel and Metglas® were dispersed internally within a fiber optic preform and then drawn on an in-house fiber optic draw tower to lengths in the kilometers. Due to the close proximity of the ferromagnetic metals and fiber optic core, the magnetostrictive strain response of the ferromagnetic materials when exposed to a magnetic field would perturbate within the fiber cladding and transfer that strain, internally, to the fiber optic core. Strain resulting from the magnetostrictive effect allows the DAS based sensor to accurately translate strain into readable magnetic field data. Due to the high sensitivity seen in this sensor design, multiparameter sources, acoustic and magnetic fields, were tested and validated and a three dimensional magnetic-field vector sensor was proposed. Numerical analysis of the novel sensor design was first implemented using COMSOL Multiphysics, where inputs such as magnetostrictive element shape, size, distance, and number were first investigated. Upon optimizing system constraints, the sensor design was further modified such that single mode operation was consistent across multiple fiber draws while retaining high strain transfer from the ferromagnetic elements to the fiber optic core. Ferromagnetic material selection was evaluated as a function of the saturation magnetostriction constants and a total of 4 modules were used to fully characterize the complex physics involved in this sensor design. All fabrication and testing were performed in-house using a full scale 3-story fiber draw tower and custom environmental testing stations to imitate naturally occurring events such as magnetic or acoustic point sources. A unique stacking method was used to embed ferromagnetic nickel and Metglas® into a fiber optic preform which when combined with a custom fiber draw process resulted in consistent multi-material fibers drawn to lengths of 1-km. In-house testing facilities included different types of electromagnetic generators, in addition to a soil test bed, and an outdoor test bed which allowed 100 meters of fiber to be tested simultaneously. All tested sensors demonstrated high strain transfer capabilities on the order of 0.01-10 μϵ depending on the materials used, ferromagnetic rod number, and core to metal spacing. Due to the sensitivity of the system the difference between AC and DC was distinct, and directional magnetostriction was studied. Transverse and longitudinal magnetic wave propagation was controlled through a solenoid and rectangular Helmholtz coil, both built in-house. A three-dimensional magnetic field vector sensor was proposed due to the success of the magnetic field sensor, and a design was proposed and initially tested to validate direction as a function of field strength and distance. To summarize, this dissertation explores the first fully distributed magnetic field sensor using DAS based techniques and one of the first multi-material fiber draw processes which can produce consistent single mode fiber up to 1-km. Due to extensive FEA modeling, multiple iterations of the magnetic sensor were fully characterized and an equation describing the relationship between sensor design and strain transfer has been created and validated experimentally. Multi-parameter tests including acoustic and magnetic fields were implemented and an algorithm was developed to separate the mixed signals. Finally, a test was performed to demonstrate the feasibility of sensing magnetic fields directionally. Cumulative results demonstrate a high-quality sensor alternative to current designs which may surpass other magnetic sensors due to innate multi-parameter capabilities, in addition to the inexpensive production cost and extremely long operating lengths.

02 PETROLEUM↗

Partial Loss of Anabolic Effect of Prostaglandin E(sub 2) on Bone After Its Withdrawal in Rats

The object of this study was to determine the fate of PGE(sub 2)-induced new bone mass after withdrawal of PGE(sub 2) administration. Seven-month-old male Sprague-Dawley rats were given subcutaneous injections of 1, 3, and 6 mg PGE(sub 2),/kg/d for 60 days and then withdrawn for 60 and 120 days. Histomorphometric analyses were performed on double fluorescent labeled undecalcified proximal tibial bone specimens. After 60 days of PGE(sub 2) treatment, a new steady state of increased trabecular bone area (+67% and +81% with 3 and 6 mg PGE(sub 2)/kg/d) from woven bone and stimulated lamellar bone formation, elevated bone turnover, and shortened remodeling periods were achieved compared to age-matched controls. In contrast, after 60 and 120 days withdrawal of PGE(sub 2), a new steady state characterized by less trabecular bone area (+40% to +60% of controls with 3 and 6 mg/kg/d doses), normal lamellar bone formation, no woven bone formation from controls, and eroded surface greater than those seen in controls and previously in 60-day PGE(sub 2) treated rats. The decrease in new bone mass after withdrawal of PGE(sub 2), was due to a further elevation of bone resorption above that induced by the PGE(sub 2) treatment and a reduction in PGE(sub 2), stimulated bone formation activities. Although there is more trabecular bone than in controls after 120 days withdrawal of PGE(sub 2), we postulate that the skeletal adaptation to mechanical usage will eventually reduce the bone mass to control levels. Thus, it is conservative to conclude that the anabolic effect of PGE(sub 2) was dependent upon continuous daily administration of PGE(sub 2) in these older rats.

Ke, H. Z.↗

Photosynthetic characteristics and estimated growth rates indicate grazing is the proximate control of primary production in the equatorial Pacific

Macronutrients persist in the surface layer of the equatorial Pacific because the production of phytoplankton is limited; the nature of this limitation has yet to be resolved. Measurements of photosynthesis as a function of irradiance (P-I) provide information on the control of primary productivity, a question of great biogeochemical importance. Accordingly, P-I was measured in the equatorial Pacific along 150 deg W, during February-March 1988. Diel variability of P-I showed a pattern consistent with nocturnal vertical mixing in the upper 20 m followed by diurnal stratification, causing photoinhibition near the surface at midday. Otherwise, the distribution of photosynthetic parameters with depth and the stability of P-I during simulated in situ incubations over 2 days demonstrated that photoadaptation was nearly complete at the time of sampling: photoadaptation had not been effectively countered by upwelling or vertical mixing. Measurements of P-I and chlorophyll during manipulations of trace elements showed that simple precautions to minimize contamination were sufficient to obtain valid rate measurements and that the specific growth rates of phytoplankton were fairly high in situ, a minimum of 0.6/d. Diel variability of beam attenuation also indicated high specific growth rates of phytoplankton and a strong coupling of production with grazing. It appears that grazing is the proximate control on the standing crop of phytoplankton. Nonetheless, the supply of a trace nutrient such as iron might ultimately regulate productivity by influencing species composition and food-web structure.

Cullen, John J.↗

Land Use and Land Cover Change, Urban Heat Island Phenomenon, and Health Implications: A Remote Sensing Approach

Land use and land cover maps of Atlanta Metropolitan Area in Georgia were produced from Landsat MSS and TM images for 1973,1979,1983,1987,1992, and 1997, spanning a period of 25 years. Dramatic changes in land use and land cover have occurred with loss of forest and cropland to urban use. In particular, low-density urban use, which includes largely residential use, has increased by over 119% between 1973 and 1997. These land use and land cover changes have drastically altered the land surface characteristics. An analysis of Landsat images revealed an increase in surface temperature and a decline in NDVI from 1973 to 1997. These changes have forced the development of a significant urban heat island effect and an increase in ground level ozone production to such an extent, that Atlanta has violated EPA's ozone level standard in recent years. The urban heat island initiated precipitation events that were identified between 1996 and 2000 tended to occur near high-density urban areas but outside the I-285 loop that traverses around the Central Business District, i.e. not in the inner city area, but some in close proximity to the highways. The health implications were investigated by comparing the spatial patterns of volatile organic compounds (VOC) and nitrogen oxides (NOx) emissions, the two ingredients that form ozone by reacting with sunlight, with those of rates of cardiovascular and chronic lower respiratory diseases. A clear core-periphery pattern was revealed for both VOC and NOx emissions, but the spatial pattern was more random in the cases of rates of cardiovascular and chronic lower respiratory diseases. Clearly, factors other than ozone pollution were involved in explaining the rates of these diseases. Further research is therefore needed to understand the health geography and its relationship to land use and land cover change as well as urban heat island effect. This paper illustrates the usefulness of a remote sensing approach for this purpose.

Lo, C. P.↗

Fabrication of Piezoelectric Polymer and Metal–Organic Framework Composite Thin Films Using Solution Shearing

Polymer-metal–organic framework (polymer-MOF) composites have garnered significant interest as polymers can enhance the processability and industrial applicability of MOFs. Thin films of these composites are particularly attractive for applications in sensing, separations, and flexible electronics. Solution shearing, a meniscus-guided coating technique, has emerged as a scalable process for fabricating thin films of MOFs, and can produce large-area films within minutes. In this study, we utilized solution shearing to fabricate composite thin films of a MOF UiO-66 and a piezoelectric polymer poly(vinylidene fluoride-trifluoroethylene) (P(VDF-TrFE)), investigating how polymer concentration during MOF synthesis and composite formation influences thin film properties, including crystallinity, surface coverage, and piezoelectric performance. Additionally, solid-state NMR spectroscopy was utilized to probe the interactions between P(VDF-TrFE) and UiO-66 in the composite. Evidence from solid-state NMR indicated polymer-MOF interactions, suggesting that the polymer strands are in close proximity to the UiO-66 pores, supporting a mixed surface coating and pore infiltration model. Furthermore, incorporating P(VDF-TrFE) enhanced the film’s areal coverage from 70% to 100%. While the thermal conductivity remained essentially unchanged, the composite film showed an improved piezoelectric effect. The composite with 91 wt % P(VDF-TrFE) exhibited the highest output voltage of 9.1 V and a sensitivity of 0.26 V/N under applied pressure. This work demonstrates the potential of solution shearing as a scalable technique for fabricating polymer-MOF composite thin films.

P(VDF-TrFE)↗

Supercapacitance and superinductance of TiN and NbTiN films in the vicinity of superconductor-to-insulator transition

We investigate the low-temperature complex impedance of disordered insulating thin TiN and NbTiN films in the frequency region 400 Hz–1 MHz in close proximity to the superconductor–insulator transition (SIT). The frequency, temperature, and magnetic field dependencies of the real and imaginary parts of the impedance indicate that in full accord with the theoretical predictions and earlier observations, the films acquire self-induced electronic granularity and become effectively random arrays of superconducting granules coupled via Josephson links. Accordingly, the inductive component of the response is due to superconducting droplets, while the capacitive component results from the effective Josephson junctions capacitances. The impedance crosses over from capacitive to inductive behavior as films go across the transition.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗

Effects of dilution in ionic liquid supercapacitors

Room-temperature ionic liquids (RTILs) are synthetic electrolytes that have a large electrochemical stability window, making them attractive candidates for electric double-layer capacitor (EDLC) applications. Due to their high viscosities and low ionic conductivities, RTILs are often diluted with organic solvent for practical use. Here, we study the effects of dilution on the performance of RTIL EDLCs using a simple mean-field model. We find that dilution diminishes the unfavorable hysteresis that results from a spontaneous surface charge separation (SSCS). As a result, the RTIL concentration can be used to modulate the proximity to the SSCS transition, and maximize capacitance. The interplay between the concentration and the correlation strength gives rise to complex zero-potential phase behavior, including a tricritical point and a λ-line, very similar to the Blume–Capel dilute Ising model. Additionally, electrodes that are solvophilic aid in the prevention of SSCS by drawing solvent molecules to the electrode and displacing ions. Solvophilic electrodes give rise to a phase transition at finite potential where the surface charge rapidly increases with a small increase in potential, leading to a substantial increase in capacitance and energy storage.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Hydrokinetic Turbines in Yawed Conditions: Toward Synergistic Fluvial Installations

Laboratory experiments were performed in critical mobility conditions to study the effects of an in-stream horizontal axis turbine in yawed conditions. The misalignment between the rotor axis and the incoming flow velocity is observed to alter the near and far wake of the turbine, as well as the scour and deposition patterns in the proximity of the monopile support tower. Various hydraulic conditions may lead to such misalignment, e.g., as a result of complex fluvial bathymetries distorting the flow or as a strategy to steer the wake away from downstream units and maximize energy production in a turbine array. The research first investigates the simplest case of a single turbine deployed along the channel centerline and oriented at different yaw angles to study the wake deflection and the turbine performance. A second set of experiments is performed moving the turbine relatively close to a nonerodible lateral wall to explore a potential passive yaw control strategy devoted to protect the banks from erosion by steering the wake toward the channel center and favor deposition along the bank.

42 ENGINEERING↗

Multi-channel, multi-template event reconstruction for SuperCDMS data using machine learning

SuperCDMS SNOLAB uses kilogram-scale germanium and silicon detectors to search for dark matter. Each detector has Transition Edge Sensors (TESs) patterned on the top and bottom faces of a large crystal substrate, with the TESs electrically grouped into six phonon readout channels per face. Noise correlations are expected among a detector's readout channels, in part because the channels and their readout electronics are located in close proximity to one another. Moreover, owing to the large size of the detectors, energy deposits can produce vastly different phonon propagation patterns depending on their location in the substrate, resulting in a strong position dependence in the readout-channel pulse shapes. Both of these effects can degrade the energy resolution and consequently diminish the dark matter search sensitivity of the experiment if not accounted for properly. We present a new algorithm for pulse reconstruction, mathematically formulated to take into account correlated noise and pulse shape variations. This new algorithm fits N readout channels with a superposition of M pulse templates simultaneously - hence termed the N$\times$M filter. We describe a method to derive the pulse templates using principal component analysis (PCA) and to extract energy and position information using a gradient boosted decision tree (GBDT). We show that these new N$\times$M and GBDT analysis tools can reduce the impact from correlated noise sources while improving the reconstructed energy resolution for simulated mono-energetic events by more than a factor of three and for the 71Ge K-shell electron-capture peak recoils measured in a previous version of SuperCDMS called CDMSlite to $<$ 50 eV from the previously published value of $\sim$100 eV. These results lay the groundwork for position reconstruction in SuperCDMS with the N$\times$M outputs.

Albakry, M. F. [British Columbia U.; TRIUMF]↗

Energy spectrum and current-phase relation of a nanowire Josephson junction close to the topological transition

A semiconducting nanowire proximitized by an $\textit{s}$-wave superconductor can be tuned into a topological state by an applied magnetic field. This quantum phase transition is marked by the emergence of Majorana zero modes at the ends of the wire. The fusion of Majorana modes at a junction between two nanowires results in a 4π-periodic Josephson effect. Here, we elucidate how the 4π periodicity arises across the topological phase transition in a highly-transparent short nanowire junction. Owing to a high transmission coefficient, Majorana zero modes coming from different wires are strongly coupled, with an energy scale set by the proximity-induced, field-independent pairing potential. At the same time, the topological spectral gap—defined by competition between superconducting correlations and Zeeman splitting—becomes narrow in the vicinity of the transition point. The resulting hybridization of the fused Majorana states with the spectral continuum strongly affects the electron density of states at the junction and its Josephson energy. We study the manifestations of this hybridization in the energy spectrum and phase dependence of the Josephson current. We pinpoint the experimentally observable signatures of the topological phase transition, focusing on junctions with weak backscattering.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗

Matrix Completion for Improved Observability in Low-Voltage Distribution Grids

This paper considers the problem of recovering missing entries in a partially observed matrix from relatively few measurements (i.e., the so-called matrix completion problem) with the aim of increasing the presently limited observability of low-voltage distribution grids. To this end, the partially observed matrix is formed using scarce voltage magnitude measurements while accounting for their spatial information. Voltage readings are assumed to be collected from distribution utility sensors and/or geographically-distributed cable television network sensors located in immediate proximity to distribution grid nodes. A matrix completion approach built on the parameter-less singular value shrinkage technique is used to estimate voltage magnitudes at otherwise non-observable low-voltage nodes using a small number of single- or multiple-snapshot data. The effectiveness of the proposed approach is demonstrated using a U.S.-style distribution test system from the synthetic SMART- DS data set under very low- to moderate-observability conditions.

low-rank matrix completion↗

A Computational Study to Investigate the Effect of Defect Geometries on the Fatigue Crack Driving Forces in Powder-Bed AM Materials

Powder-bed additive manufacturing (AM) processes are associated with the formation of multiple types of process-specific pores, including but not limited to lack-of-fusion (LoF) and keyhole pores. The performance of an AM component is dependent on the type of pores, their density and their proximity to the free surface, and other heterogeneities in the microstructure. In order to characterize the influence of porosity on the mechanical behavior of AM materials, it is imperative to quantitatively analyze the heterogeneous strain accumulation in the vicinity of porosity. Process-specific microstructure models are generated using SPPARKS, an open-source process simulation code. Spherical keyhole or irregular LoF pores are embedded into the microstructure models, which are meshed and input into a finite element code, ScIFEN, to solve for the heterogeneous strain localization in the vicinity of the pores. Given the non-smooth geometries of LoF pores, they readily promote strain accumulation in their vicinity thereby increasing the propensity of initiating fatigue cracks.

Saikumar R Yeratapally↗