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At least 73 records · Page 4
All sourcesNASA NTRSDOE OSTI
NASA NTRS1995

Dynamic properties of helium ions in the solar wind

We characterize the dynamic properties of He ions of the solar wind. Because of the non-negligible abundance and the significant fraction of momentum flux inherent in helium ions, this species has an influence on the state of turbulence. Especially, we analyze the helium dynamic properties of different solar wind types. After a discussion of the influence of measurement errors on the statistical analysis of He bulk velocities, we investigate the structure function dependency on the solar wind state. We find a self-similar sealing in the range of minutes to days with characteristic structure function slopes deviating from the canonical Kolmogorov values. For comparison with previous studies, we also analyze H structure functions of the same time periods and discuss differences of coinciding He and H structure functions in the framework of the concept of intermittency.

Zurbuchen, Th.↗
NASA NTRS1992

Effects of a simulated microgravity model on cell structure and function in rat testis and epididymis

The effect of simulated microgravity on the structure and function of the testis and epididymis cells was investigated in rats subjected to 7 days of tail suspension. Results of a histological examination revealed presence of disorganized seminiferous tubules and accumulation of large multinucleated cells and spermatids in the lumen of the epididymis. In addition, decreases in the content of testis protein and in testosterone levels in the testis, the interstitial fluid, and the epididymis were observed.

Hadley, Jill A.↗
NASA NTRS1995

Molecular dynamics studies of simple membrane-water interfaces: Structure and functions in the beginnings of cellular life

Molecular dynamics computer simulations of the structure and functions of a simple membrane are performed in order to examine whether membranes provide an environment capable of promoting protobiological evolution. Our model membrane is composed of glycerol 1-monooleate. It is found that the bilayer surface fluctuates in time and space, occasionally creating thinning defects in the membrane. These defects are essential for passive transport of simple ions across membranes because they reduce the Born barrier to this process by approximately 40%. Negative ions are transferred across the bilayer more readily than positive ions due to favorable interactions with the electric field at the membrane-water interface. Passive transport of neutral molecules is, in general, more complex than predicted by the solubility-diffusion model. In particular, molecules which exhibit sufficient hydrophilicity and lipophilicity concentrate near membrane surfaces and experience 'interfacial resistance' to transport. The membrane-water interface forms an environment suitable for heterogeneous catalysis. Several possible mechanisms leading to an increase of reaction rates at the interface are discussed. We conclude that vesicles have many properties that make them very good candidates for earliest protocells. Some potentially fruitful directions of experimental and theoretical research on this subject are proposed.

Pohorille, Andrew↗
NASA NTRS2016

Comparison of Structural and Functional Ocular Outcomes Between 14- and 70 Day Bed Rest

Purpose: To compare structural and functional ocular outcomes in healthy human subjects undergoing 14- and/or 70-day head-down-tilt bed rest (HDTBR). We hypothesized the amount of HDTBR-induced ocular changes be affected by the HDTBR duration. Methods: The studies were conducted at the NASA Flight Analogs Research Unit, The University of Texas Medical Branch at Galveston, Galveston, TX. Participants were selected using NASA standard screening procedures. Standardized NASA screening procedures and bed rest conditions (e.g., strict sleep-wake cycle, standardized diet, continuous video monitoring) were implemented in both studies. Participants maintained a 6deg HDTBR position for 14 and/or 70 consecutive days and did not engage in exercise. Weekly ophthalmological examinations were conducted in the sitting (pre/post-bed rest only) and HDT positions. Ocular outcomes of interest included: near best-corrected visual acuity (BCVA); spherical equivalent, as determined by cycloplegic autorefraction; Goldmann applanation tonometry and iCare (Icare Finland Oy, Espoo, Finland) intraocular pressure (IOP) measurement; color vision; red dot test; modified Amsler grid test; confrontational visual field; stereoscopic color fundus photography; Spectralis OCT (Heidelberg Engineering, GmbH, Heidelberg, Germany) retinal nerve fiber layer thickness (RNFLT), peripapillary and macular retinal thicknesses. Mixed-effects linear models were used to compare pre- and post-HDTBR observations between 14- and 70-day HDTBR for our continuously scaled outcomes.

Cromwell, R. L.↗
NASA NTRS1989

Design of a structural and functional hierarchy for planning and control of telerobotic systems

Hierarchical structures offer numerous advantages over conventional structures for the control of telerobotic systems. A hierarchically organized system can be controlled via undetailed task assignments and can easily adapt to changing circumstances. The distributed and modular structure of these systems also enables fast response needed in most telerobotic applications. On the other hand, most of the hierarchical structures proposed in the literature are based on functional properties of a system. These structures work best for a few given functions of a large class of systems. In telerobotic applications, all functions of a single system needed to be explored. This approach requires a hierarchical organization based on physical properties of a system and such a hierarchical organization is introduced. The decomposition, organization, and control of the hierarchical structure are considered, and a system with two robot arms and a camera is presented.

Acar, Levent↗
NASA NTRS1975

Applications of a quadratic extended interior penalty function for structural optimization

A quadratic extended interior penalty function formulation especially well suited for second-order unconstrained optimization procedures is presented. Analytical derivatives of constraints and an approximate analysis technique are used. Minimum-mass design results are presented which indicate that the combination of these procedures can help make mathematical programming a useful optimization tool for large-order structural design problems with a large number of design variables and multiple constraints. Examples include statically loaded high- and low-aspect-ratio wings simultaneously subjected to stress, displacement, minimum gage and, in some cases, maximum strain constraints.

Haftka, R. T.↗
NASA NTRS1996

Towards an understanding of the structural and functional properties of MscL, a mechanosensitive channel in bacteria

Whether it be to sense a touch, arterial pressure, or an osmotic gradient across a cell membrane, essentially all living organisms require the capability of detecting mechanical force. Electrophysiological evidence has suggested that mechanosensitive ion channels play a major role in many systems where mechanical force is detected. But, despite their biological importance, determination of the most basic structural and functional features of mechanosensitive channels has only recently become possible. A gene called mscL, which was isolated from Escherichia coli, was the first gene shown to encode a mechanosensitive channel activity. This channel directly responds to tension in the membrane; no other proteins are required. MscL appears to be a homohexamer of a 136 amino acid polypeptide that is highly alpha helical, contains two transmembrane domains, and has both the amino and carboxyl termini in the cytoplasm. The study of the MscL protein remains, to date, one of the most viable options for understanding the structural and functional characteristics of a mechanosensitive channel.

NASA Discipline Cell Biology↗
NASA NTRS1997

The Structure and Function of Non-Collagenous Bone Proteins

The long-term goal for this program is to determine the structural and functional relationships of bone proteins and proteins that interact with bone. This information will used to design useful pharmacological compounds that will have a beneficial effect in osteoporotic patients and in the osteoporotic-like effects experienced on long duration space missions. The first phase of this program, funded under a cooperative research agreement with NASA through the Texas Medical Center, aimed to develop powerful recombinant expression systems and purification methods for production of large amounts of target proteins. Proteins expressed in sufficient'amount and purity would be characterized by a variety of structural methods, and made available for crystallization studies. In order to increase the likelihood of crystallization and subsequent high resolution solution of structures, we undertook to develop expression of normal and mutant forms of proteins by bacterial and mammalian cells. In addition to the main goals of this program, we would also be able to provide reagents for other related studies, including development of anti-fibrotic and anti-metastatic therapeutics.

Hook, Magnus↗
NASA NTRS2011

Using Dark Matter Haloes to Learn about Cosmic Acceleration: A New Proposal for a Universal Mass Function

Structure formation provides a strong test of any cosmic acceleration model because a successful dark energy model must not inhibit or overpredict the development of observed large-scale structures. Traditional approaches to studies of structure formation in the presence of dark energy or a modified gravity implement a modified Press-Schechter formalism, which relates the linear overdensities to the abundance of dark matter haloes at the same time. We critically examine the universality of the Press-Schechter formalism for different cosmologies, and show that the halo abundance is best correlated with spherical linear overdensity at 94% of collapse (or observation) time. We then extend this argument to ellipsoidal collapse (which decreases the fractional time of best correlation for small haloes), and show that our results agree with deviations from modified Press-Schechter formalism seen in simulated mass functions. This provides a novel universal prescription to measure linear density evolution, based on current and future observations of cluster (or dark matter) halo mass function. In particular, even observations of cluster abundance in a single epoch will constrain the entire history of linear growth of cosmological of perturbations.

Prescod-Weinstein, Chanda↗
NASA NTRS1987

Diagnosis and sensor validation through knowledge of structure and function

The liquid oxygen expert system 'LES' is proposed as the first capable of diagnostic reasoning from sensor data, using model-based knowledge of structure and function to find the expected state of all system objects, including sensors. The approach is generally algorithmic rather than heuristic, and represents uncertainties as sets of possibilities. Functional relationships are inverted to determine hypothetical values for potentially faulty objects, and may include conditional functions not normally considered to have inverses.

Scarl, Ethan A.↗
NASA NTRS1987

Sensor-based diagnosis using knowledge of structure and function

A system for fault detection and isolation called LES, developed at the Kennedy Space Center for the Space Shuttle's Launch Processing System, is a well-developed diagnostic system that is simultaneously model-based and sensor-based. This experiment has led to a surprising result: the failure of a sensor can not only be handled in precisely the same way as the failure of any other object, but may present an especially easy case. Classical rule-based diagnostic systems need to find out whether or not their sensors are telling them the truth before they can safely draw inferences from them. By contrast, while LES does treat sensors as a special case, it does so only because there may exist a short cut that allows them to be handled more simply than other objects. LES uses both structural and functional knowledge, and has found cases in which the structural knowledge can be economically replaced by the judicious use of functional relationships; LES' functional relationships are stored in exactly one place, so they must be inverted to determine hypothetical values for possibly faulty objects. The inversion process has been extended to include conditional functions not normally considered to have inverses.

Scarl, Ethan A.↗
NASA NTRS2003

Use of GTE, Mozaic, Sonex, and UARS-MLS Data in Understanding Tropospheric Processes Critical to Model Development

During the first year we focused on the analysis of data collected on over 7600 commercial aircraft flights (the MOZAIC program). The aim was to further our understanding of the fundamental dynamical processes that drive mesoscale phenomena in the upper troposphere and lower stratosphere, and their effects on the advection of passive scalars. Through these studies we made the following findings. 2001]: We derived the Kolmogorov equation for the third-order velocity structure function on an f-plane. We showed how the sign of the function yields the direction of the energy cascade. The remarkable linearity of the measured off diagonal third-order structure function was studied. We suggested that the Coriolis term, which appears explicitly in this equation, may be crucial in understanding the observed kinetic energy spectra at scales larger than 100 km, instead of the nonlinear advection term as previously assumed. Also, we showed that decreases with latitude for mid- to high-latitudes, and tabulated the values. Ozone concentration structure functions were calculated by restricting the data points to approximately isentropic pairings. In this way we were able to make comparisons with scalar advection theories. We found that, at even the largest scales, there was no evidence for the simple scaling predicted for smooth advection/diffusion.

Newell, Reginald E.↗
NASA NTRS2005

The Effects of Instrumental Elliptical Polarization on Stellar Point Spread Function Fine Structure

We present procedures and preliminary results from a study on the effects of instrumental polarization on the fine structure of the stellar point spread function (PSF). These effects are important to understand because the the aberration caused by instrumental polarization on an otherwise diffraction-limited will likely have have severe consequences for extreme high contrast imaging systems such as NASA's planned Terrestrial Planet Finder (TPF) mission and the proposed NASA Eclipse mission. The report here, describing our efforts to examine these effects, includes two parts: 1) a numerical analysis of the effect of metallic reflection, with some polarization-specific retardation, on a spherical wavefront; 2) an experimental approach for observing this effect, along with some preliminary laboratory results. While the experimental phase of this study requires more fine-tuning to produce meaningful results, the numerical analysis indicates that the inclusion of polarization-specific phase effects (retardation) results in a point spread function (PSF) aberration more severe than the amplitude (reflectivity) effects previously recorded in the literature.

high angular resolution↗
NASA NTRS2008

Arterial Structure and Function in Women and Men Following Long Duration Bed Rest

Orthostatic intolerance is a well-recognized consequence of space flight and bed rest (BR), with a greater incidence reported in women. We hypothesized that leg, but not arm, arterial structure and function would be altered following prolonged BR, as a model of space flight, and that women would be more susceptible to BR-induced deconditioning than men. METHODS: Ten volunteers (5 males, 5 females) completed 90 d of 6 head-down BR. Subjects participated in tests of brachial (BA) and anterior tibial (AT) artery endothelium-dependent (flow mediated dilation [FMD] following 5-7 min of arterial occlusion) and endothelium-independent (0.4 mg sublingual nitroglycerin [SN]) vasodilation before BR (PRE) and on days 7 (BR7), 21 (BR21), and 90 (BR90) of BR. Vessel diameter and intimal medial thickness (IMT) were measured by ultrasound. IMT, baseline diameter, and percent change in diameter from baseline during FMD and SN tests were compared across BR and between genders using repeated measures two-way ANOVA with Bonferroni post-hoc tests in which PRE and women were control conditions. RESULTS: Baseline vessel diameter was lower in women than in men in both the BA (p=0.005) and AT (p=0.01) across all days. Baseline AT diameter decreased during BR (p=0.01) and tended to be more profound in women (interaction, p=0.06). AT diameter was reduced in women at BR21 and BR90 (p<0.01) but not in men. In contrast, there was no BR effect on baseline BA diameter. IMT also decreased in the AT (p<0.001) but not in the BA during BR; AT IMT was reduced by BR21 (p<0.05). As a group, there was no effect of BR on AT FMD, BA FMD, and AT SN-dilation, although BA SN-dilation was significantly reduced on BR21 (p=0.01). Across all BR days, women exhibited higher AT FMD (p=0.03), BA FMD (p=0.02), and BA SN-dilation (p=0.01) and tended to demonstrate greater AT SN-dilation (p=0.11). CONCLUSIONS: These preliminary results suggest that arterial remodeling occurs during BR in the leg (decreased diameter and IMT), but not in the arm, and that women appear to be more responsive to BR than men. These changes in the leg, coupled with larger responses to direct and indirect stimulation of the arterial smooth muscle, may be related to the greater incidence of orthostatic intolerance in women after BR and space flight.

Lee, Stuart M. C.↗
NASA NTRS2016

ERRATUM: 'MAPPING THE GAS TURBULENCE IN THE COMA CLUSTER: PREDICTIONS FOR ASTRO-H'

The published version of this paper contained an error in Figure 5. This figure is intended to show the effect on the structure function of subtracting the bias induced by the statistical and systematic errors on the line shift. The filled circles show the bias-subtracted structure function. The positions of these points in the left panel of the original figure were calculated incorrectly. The figure is reproduced below (with the original caption) with the correct values for the bias-subtracted structure function. No other computations or figures in the original manuscript are affected.

galaxies: clusters: intracluster medium- methods: ↗
NASA NTRS1984

The influence of gravity on structure and function of animals

Gravity is the only environmental parameter that has remained constant during the period of evolution of living matter on earth. Thus, it must have been a major force in shaping living things. The influence of gravitational loading on evolution of the vertebrate skeleton is well recognized, and scale effects have been studied. This paper, however, considers in addition four pivotal events in early evolution that would seem to have been significant for the later success and diversifcation of animal life. These are evolution of the cytoskeleton, cell motility (flagellae and cilia), gravity detecting devices (accelerometers), and biomineralization. All are functionally calcium dependent in eukaryotes and all occurred or were foreshadowed in prokaryotes. A major question is why calcium was selected as an ion of great importance to the structure and function of living matter; another is whether gravity played a role in its selection.

Ross, M. D.↗
NASA NTRS2012

First-and Second-Order Displacement Transfer Functions for Structural Shape Calculations Using Analytically Predicted Surface Strains

New first- and second-order displacement transfer functions have been developed for deformed shape calculations of nonuniform cross-sectional beam structures such as aircraft wings. The displacement transfer functions are expressed explicitly in terms of beam geometrical parameters and surface strains (uniaxial bending strains) obtained at equally spaced strain stations along the surface of the beam structure. By inputting the measured or analytically calculated surface strains into the displacement transfer functions, one could calculate local slopes, deflections, and cross-sectional twist angles of the nonuniform beam structure for mapping the overall structural deformed shapes for visual display. The accuracy of deformed shape calculations by the first- and second-order displacement transfer functions are determined by comparing these values to the analytically predicted values obtained from finite element analyses. This comparison shows that the new displacement transfer functions could quite accurately calculate the deformed shapes of tapered cantilever tubular beams with different tapered angles. The accuracy of the present displacement transfer functions also are compared to those of the previously developed displacement transfer functions.

Ko, William L.↗
NASA NTRS1978

Structural and Functional Organization of the Vestibular Apparatus in Rats Subjected to Weightlessness for 19.5 Days Aboard the Kosmos-782 Satellite

The vestibular apparatus was investigated in rats subjected to weightlessness for 19.5 days. The vestibular apparatus was removed and its sections were fixed in a glutaraldehyde solution for investigation by light and electron microscopes. Structural and functional charges were noted in the otolith portions of the ear, with the otolith particles clinging to the utricular receptor surface and with the peripheral arrangement of the nucleolus in the nuclei of the receptor cells. It is possible that increased edema of the vestibular tissue resulted in the destruction of some receptor cells and in changes in the form and structure of the otolith. In the horizontal crista, the capula was separated.

Vinnikov, Y. A.↗