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At least 73 records · Page 4
All sourcesNASA NTRSDOE OSTI
NASA NTRS2000

T Lymphocyte Activation Threshold is Increased in Reduced Gravity

There have been substantial advances in molecular and cellular biology that have provided new insight into the biochemical and genetic basis of lymphocyte recognition, activation and expression of distinct functional phenotypes. It has now become evident that for both T and B cells, stimuli delivered through their receptors can result in either clonal expansion or apoptosis. In the case of T cells, clonal expansion of helper cells is accompanied by differentiation into two major functional subsets which regulate the immune response. The pathways between the membrane and the nucleus and their molecular components are an area of very active investigation. This meeting will draw together scientists working on diverse aspects of this problem, including receptor ligand interactions, intracellular pathways that transmit receptor mediated signals and the effect of such signal transduction pathways on gene regulation. The aim of this meeting is to integrate the information from these various experimental approaches into a new synthesis and molecular explanation of T cell activation, differentiation and death.

Adams, Charley L.↗
NASA NTRS2003

Cardiac myofilaments: mechanics and regulation

The mechanical properties of the cardiac myofilament are an important determinant of pump function of the heart. This report is focused on the regulation of myofilament function in cardiac muscle. Calcium ions form the trigger that induces activation of the thin filament which, in turn, allows for cross-bridge formation, ATP hydrolysis, and force development. The structure and protein-protein interactions of the cardiac sarcomere that are responsible for these processes will be reviewed. The molecular mechanism that underlies myofilament activation is incompletely understood. Recent experimental approaches have been employed to unravel the mechanism and regulation of myofilament mechanics and energetics by activator calcium and sarcomere length, as well as contractile protein phosphorylation mediated by protein kinase A. Central to these studies is the question whether such factors impact on muscle function simply by altering thin filament activation state, or whether modulation of cross-bridge cycling also plays a part in the responses of muscle to these stimuli.

Review, Tutorial↗
NASA NTRS2003

Effect Of Simulated Microgravity On Activated T Cell Gene Transcription

Studies of T lymphocytes under the shear stress environment of clinorotation have demonstrated an inhibition of activation in response to TCR mediated signaling. These results mimic those observed during space flight. This work investigates the molecular signaling events of T lymphocyte activation with clinorotation. Purified human T lymphocytes and the T cell clone Jurkat exhibit an uncoupling of signaling as mediated through the TCR. Activation of the transcription factor AP-1 is inhibited while activation of NFAT occurs. NFAT dephosphorylation and activation is dependent on sustained Ca(++) influx. Alternatively, AP-1, which consists of two transcription factors, jun and fos, is activated by PKC and Ras mediated pathways. TCR signaling is known to be dependent on cytoskeletal rearrangements, in particular, raft aggregation is critical. Raft aggregation, as mediated through GM, crosslinking, overcomes the inhibition of T lymphocyte activation with clinorotation, indicating that the block is occurring upstream of raft aggregation. Clinorotation is shown to have an effect similar to a weak TCR signal.

Morrow, Maureen A.↗
NASA NTRS1990

CO mapping of the nuclear region of NGC 6946 and IC 342 with Nobeyama millimeter array

CO observations of nearby galaxies with nuclear active star forming regions (and starburst galaxies) with angular resolutions around 7 seconds revealed that molecular bars with a length of a few kiloparsecs have been formed in the central regions of the galaxies. The molecular bar is interpreted as part of shock waves induced by an oval or barred potential field. By shock dissipation or dissipative cloud-cloud collisions, the molecular gas gains an infall motion and the nuclear star formation activity is fueled. But the distribution and kinematics of the molecular gas in the nuclear regions, which are sites of active star formation, remain unknown. Higher angular resolutions are needed to investigate the gas in the nuclear regions. Researchers made aperture synthesis observations of the nuclear region of the late-type spiral galaxies NGC 6946 and IC 342 with resolutions of 7.6 seconds x 4.2 seconds (P.A. = 147 deg) and 2.4 seconds x 2.3 seconds (P.A. = 149 deg), respectively. The distances to NGC 6496 and IC 342 are assumed to be 5.5 Mpc and 3.9 Mpc, respectively. Researchers have found 100-300 pc nuclear gas disk and ring inside a few kpc molecular gas bars. Researchers present the results of the observations and propose a possible mechanism of active star formation in the nuclear region.

Ishizuki, Sumio↗
NASA NTRS2022

Structural and Dynamical Analysis of the Quiescent Molecular Ridge in the Large Magellanic Cloud

We present a comparison of low-J13CO and CS observations of four different regions in the LMC—the quiescent Molecular Ridge, 30 Doradus, N159, and N113, all at a resolution of ∼3 pc. The regions 30 Dor, N159, and N113 are actively forming massive stars, while the Molecular Ridge is forming almost no massive stars, despite its large reservoir of molecular gas and proximity to N159 and 30 Dor. We segment the emission from each region into hierarchical structures using dendrograms and analyze the sizes, masses, and line widths of these structures. We find that the Ridge has significantly lower kinetic energy at a given size scale and also lower surface densities than the other regions, resulting in higher virial parameters. This suggests that the Ridge is not forming massive stars as actively as the other regions because it has less dense gas and not because collapse is suppressed by excess kinetic energy. We also find that these physical conditions and energy balance vary significantly within the Ridge and that this variation appears only weakly correlated with distance from sites of massive-star formation such as R136 in 30 Dor, which is ∼1 kpc away. These variations also show only a weak correlation with local star formation activity within the clouds.

Molly K Finn↗
NASA NTRS1982

Comet Bowell /1980b/ - An active-looking dormant object

The absence of molecular emissions in the spectrum of Comet Bowell, a nearly constant amount of dust in its coma, a slow expansion rate of the coma and implied low particle velocities, a tail width that does not increase with increasing distance from the nucleus, the absence of tail particles less than 0.5 mm in diameter, and the development of an elongated coma, lead to the conclusion that the solid particles in the coma and tail are not recent ejecta, and that the comet has probably been dormant. It is speculated that 10 to the 13th g of observed coma and tail particles is either a leftover pristine material that has never contacted the nucleus surface, or a product of erratic activity associated with chemical instability, at temperatures below 40 K, stimulated by cosmic ray and/or UV irradiation of the surface layer during the comet's Oort cloud stay. It remains possible that the comet may temporarily become active near perihelion.

Sekanina, Z.↗
NASA NTRS2017

4BMS-X Design and Test Activation

In support of the NASA goals to reduce power, volume and mass requirements on future CO2 (Carbon Dioxide) removal systems for exploration missions, a 4BMS (Four Bed Molecular Sieve) test bed was fabricated and activated at the NASA Marshall Space Flight Center. The 4BMS-X (Four Bed Molecular Sieve-Exploration) test bed used components similar in size, spacing, and function to those on the flight ISS flight CDRA system, but were assembled in an open framework. This open framework allows for quick integration of changes to components, beds and material systems. The test stand is highly instrumented to provide data necessary to anchor predictive modeling efforts occurring in parallel to testing. System architecture and test data collected on the initial configurations will be presented.

Peters, Warren T.↗
NASA NTRS2021

Anion-Assisted Delivery of Multivalent Cations to Inert Electrodes

To understand and control key electrochemical processes - metal plating, corrosion, intercalation, etc. requires molecular-scale details of the active species at electrochemical interfaces and their mechanisms for de-solvation from the electrolyte. Using free energy sampling techniques we reveal the interfacial speciation of divalent cations in ether-based electrolytes and mechanisms for their delivery to an inert graphene electrode interface. Surprisingly, we find that anion solvophobicity drives a high population of anion-containing species to the interface that facilitate the delivery of divalent cations, even to negatively charged electrodes. Our simulations indicate that cation desolvation is greatly facilitated by cation-anion coupling. We propose anion solvophobicity as a molecular-level descriptor for rational design of electrolytes with increased efficiency for electrochemical processes limited by multivalent cation desolvation.

Electrochemical interfaces↗
NASA NTRS1985

Disuse Induced Changes in the Cholinergic System of Sciatic Nerve and Slow and Fast Twitch Muscle of Rats

Hindlimb suspension was used as a model of disuse in experiments studing the effects of reduced muscle activity on AChE and its molecular forms, choline acetyltransferase and nicotinic receptor binding in innervated slow and fast muscle. The weight of SOL was reduced to 64% within one week and continued to decrease progressively up to the third week when the weight was reduced to 40% as compared to controls. EDL showed a significant decrease in its weight only at the end of three weeks hypokinesia when it was reduced to 71% of control. Biochemical and histochemical findings are summarized. From these data and from morphological findings it is evident that some properties of skeletal muscles are strongly dependent on patterns and level of loadbearing and on motor unit activiy. With suspension-induced disuse, the usually slow SOL appeared to change its characteristics such as fiber type distribution and AChE activity to one that more resembled a faster muscle. It is important to note that hypokinesia induced changes either physiological, biochemical or morphological, are totally reversible as the induced changes returned to control levels within a week after cessation of disuse.

Dettbarn, W. D.↗
NASA NTRS1995

Double-Knudsen-Cell Apparatus Measures Alloy-Component Activities

Double-Knudsen-cell apparatus provides molecular beam from selected one of two Knudsen cells. Both cells maintained at same temperature. Molecular beam directed into mass spectrometer for measurement of vapor pressure of selected material component. Designed to minimize undesired thermal gradients, provides appropriate translation to place selected cell in position for sampling, and minimizes mixing of molecular beams from cells.

Jacobson, Nathan S.↗
NASA NTRS1983

A revised thermospheric model based on mass spectrometer and incoherent scatter data - MSIS-83

It is noted that the model presented here extends the previous description of neutral parameters to the base of the thermosphere in a continuous manner while maintaining the basic structure of the MSIS model at higher altitudes. As the altitude decreases, the composition approaches lower atmosphere values, whereas yearly, and to a lesser extent daily, variations in temperature and density are in reasonable agreement with earlier results for the lower thermosphere. An alternate description is given of magnetic storm variations on the basis of the three hour ap indices and an 8- to 10-hour exponential decay in thermospheric density and temperature response after a heating event. Additional coefficients are included for the time independent and magnetic activity terms, among them a longitudinally dependent seasonal magnetic activity effect. The description of molecular oxygen derives from mass spectrometer and EUV absorption measurements rather than ion chemistry.

Hedin, A. E.↗
NASA NTRS1985

The thermal structure of the dayside upper atmosphere of Venus above 125 km

A one-dimensional model of the Venus thermosphere has been constructed which includes computation of the heating efficiency of solar ultraviolet radiation, heat loss by radiation to space of infrared-active species, thermal transport by molecular and eddy conduction, and viscous dissipation. By comparing model predictions with results obtained from the Pioneer Venus Orbiter spacecraft, the results indicate that energy transport parameterized by eddy heat conduction plays a dominant role in determining thermospheric temperature. It is suggested that there exists a feedback mechanism linking heating and thermospheric circulation such that eddy cooling maintains an asymptotic temperature of about 300 K for both solar-maximum and solar-minimum conditions. The variation in thermospheric temperature with solar zenith angle, atomic oxygen-mixing ratio, rate of vibrational excitation of CO2 by ground-state O atoms, and the assumed transfer of O(1D) electronic energy to CO2 vibrational energy are also studied.

Hollenbach, D. J.↗
NASA NTRS1991

Aerothermodynamics of a 1.6-m-diameter sphere in hypersonic rarefied flow

Results of a numerical study using the direct simulation Monte Carlo (DSMC) method are presented for hypersonic rarefied flow about a 1.6-m-diameter sphere. The flow conditions considered are those experienced by a typical satellite in orbit or by a space vehicle during entry. The altitude range considered is that from 90 to 200 km, which encompasses the near continuum, transitional and free-molecular flow regimes. A freestream velocity of 7.5 km/s is assumed in the simulations. The results show that transitional effects are significant at all altitudes below 200 km, but at 200 km the flow about the sphere attains the free-molecular limit. Very little chemical activity is present above 120 km. Both the stagnation point heat transfer and the sphere drag approach their respective free molecule values at 200 km. Results highlight the thermal and chemical nonequilibrium nature of the flowfield. Nonequilibrium effects on the surface heating and body drag are also investigated.

Dogra, Virendra K.↗
NASA NTRS1991

All-optical photochromic spatial light modulators based on photoinduced electron transfer in rigid matrices

A single material (not a multi-element structure) spatial light modulator may be written to, as well as read out from, using light. The device has tailorable rise and hold times dependent on the composition and concentration of the molecular species used as the active components. The spatial resolution of this device is limited only by light diffraction as in volume holograms. The device may function as a two-dimensional mask (transmission or reflection) or as a three-dimensional volume holographic medium. This device, based on optically-induced electron transfer, is able to perform incoherent to coherent image conversion or wavelength conversion over a wide spectral range (ultraviolet, visible, or near-infrared regions).

Beratan, David N.↗
NASA NTRS1992

Materials dispersion and biodynamics project research

The Materials Dispersion and Biodynamics Project (MDBP) focuses on dispersion and mixing of various biological materials and the dynamics of cell-to-cell communication and intracellular molecular trafficking in microgravity. Research activities encompass biomedical applications, basic cell biology, biotechnology (products from cells), protein crystal development, ecological life support systems (involving algae and bacteria), drug delivery (microencapsulation), biofilm deposition by living organisms, and hardware development to support living cells on Space Station Freedom (SSF). Project goals are to expand the existing microgravity science database through experiments on sounding rockets, the Shuttle, and COMET program orbiters and to evolve,through current database acquisition and feasibility testing, to more mature and larger-scale commercial operations on SSF. Maximized utilization of SSF for these science applications will mean that service companies will have a role in providing equipment for use by a number of different customers. An example of a potential forerunner of such a service for SSF is the Materials Dispersion Apparatus (MDA) 'mini lab' of Instrumentation Technology Associates, Inc. (ITA) in use on the Shuttle for the Commercial MDAITA Experiments (CMIX) Project. The MDA wells provide the capability for a number of investigators to perform mixing and bioprocessing experiments in space. In the area of human adaptation to microgravity, a significant database has been obtained over the past three decades. Some low-g effects are similar to Earth-based disorders (anemia, osteoporosis, neuromuscular diseases, and immune system disorders). As new information targets potential profit-making processes, services and products from microgravity, commercial space ventures are expected to expand accordingly. Cooperative CCDS research in the above mentioned areas is essential for maturing SSF biotechnology and to ensure U.S. leadership in space technology. Currently, the MDBP conducts collaborative research with investigators at the Rockefeller University, National Cancer Institute, and the Universities of California, Arizona, and Alabama in Birmingham. The growing database from these collaborations provides fundamental information applicable to development of cell products, manipulation of immune cell response, bone cell growth and mineralization, and other processes altered by low-gravity. Contacts with biotechnology and biopharmaceutical companies are being increased to reach uninformed potential SSF users, provide access through the CMDS to interested users for feasibility studies, and to continue active involvement of current participants. We encourage and actively seek participation of private sector companies, and university and government researchers interested in biopharmaceuticals, hardware development and fundamental research in microgravity.

Lewis, Marian L.↗
NASA NTRS1997

Characteristics of an Electron Cyclotron Resonance Plasma Source for the Production of Active Nitrogen Species in III-V Nitride Epitaxy

A simple analysis is provided to determine the characteristics of an electron cyclotron resonance (ECR) plasma source for the generation of active nitrogen species in the molecular beam epitaxy of III-V nitrides. The effects of reactor geometry, pressure, power, and flow rate on the dissociation efficiency and ion flux are presented. Pulsing the input power is proposed to reduce the ion flux.

Meyyappan, Meyya↗