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At least 73 records · Page 4

Tying the knot in the tetrahydrofolate (THF) riboswitch: A molecular basis for gene regulation

Effective gene regulation by the tetrahydrofolate riboswitch depends not only on ligand affinity but also on the kinetics of ligand association, which involves two cooperative binding sites. Here, we have determined a 1.9-Å resolution crystal structure of the ligand-free THF riboswitch aptamer. The pseudoknot binding site ‘unwinds’ in the absence of ligand, whereby the adjacent helical domains (P1, P2, and P3) become disjointed, resulting in rotation and misalignment of the gene-regulatory P1 helix with respect to P3. In contrast, the second binding site at the three-way junction, which is the first to fold, is structurally conserved between apo and holo forms. This suggests a kinetic role for this site, in which binding of the first ligand molecule to the stably folded three-way junction promotes formation of the regulatory pseudoknot site and subsequent binding of the second molecule. As such, these findings provide a molecular basis for both conformational switching and kinetic control.

59 BASIC BIOLOGICAL SCIENCES↗

An X-ray and optical study of the interaction of the Cygnus Loop supernova remnant with an interstellar cloud

We have used the ROSAT high-resolution imager and optical emission line data to study the structure of a bright optical knot on the southeastern rim of the Cygnus Loop supernova remnant. This knot has been identified as an encounter between the blast wave and a small isolated cloud. The knot appears in projection just behind the blast wave, which is traced by Balmer line filaments which bound the X-ray emission. The knot is a prominent X-ray feature, consisting of a numerb of filaments which are correlated with the optical line emission. These data permit a detailed view of the blast wave interaction. By combining the optical and X-ray data it is possible to trace the blast wave as a continuous surface from its southern edge around the western side of the cloud that then continues on to the north. The southeastern knot is an indentation on the surface of the blast wave. Thus the southeastern knot is not a small cloud that has been overrun by the blast wave, but the tip of a larger cloud. Bright X-ray emission is associated with bright radiative filaments. The location of this emission, upstream of the radiative shocks, implies that the enhanced X-rays come from a reverse shock. The presence of a reverse shock is further evidence that the southeastern knot represents an early stage of a blast wave encountering a large cloud. A consistent picture of the Cygnus Loop as an explosion within a preexisting cavity is emerging. These observations agree with that picture.

Graham, James, R.↗

Structure of the X-Ray Emission from the Jet of 3C 273

We present images from four Chandra observations of the quasar 3C 273. The zeroth order images from two grating observations using the AXAF CCD Imaging Spectrometer (ACIS-S) detector are used to examine the structure and spectrum of the jet. The jet has at least four distinct features which are not resolved in previous observations. Using jet feature nomenclature based on HST observations, we find that knot Al is very bright in X-rays. We have measured the X-ray spectrum of this X-ray knot for the first time, obtaining a photon index of 1.36 +/- 0.11 and a flux density of 37 +/- 4 nJy at 1 keV. Combining this measurement with lower frequency data shows that a pure synchrotron model can fit the spectrum of knot Al from 4 GHz to 5 keV (over nine decades in energy) without a change of spectral slope. Knot A2 is also detected and is somewhat blended with knot B1 but synchrotron emission is not likely to explain the X-ray emission due to the spectral turnover observed in the optical-UV band. No other knots are clearly detected but there is an indication of weak emission from the eastern portion of knot H3. near the "head," which is radio-bright. There is diffuse flux which extends from 14 arcsec to 20 arcsec which shows curvature that is comparable to the optical flux found by Bahcall, et al.

Marshall, H. L.↗

Learning to Unknot

We introduce natural language processing into the study of knot theory, as made natural by the braid word representation of knots. We study the UNKNOT problem of determining whether or not a given knot is the unknot. After describing an algorithm to randomly generate N-crossing braids and their knot closures and discussing the induced prior on the distribution of knots, we apply binary classification to the UNKNOT decision problem. We find that the Reformer and shared-QK Transformer network architectures outperform fully-connected networks, though all perform at 95% accuracy. Perhaps surprisingly, we find that accuracy increases with the length of the braid word, and that the networks learn a direct correlation between the confidence of their predictions and the degree of the Jones polynomial. Finally, we utilize reinforcement learning (RL) to find sequences of Markov moves and braid relations that simplify knots and can identify unknots by explicitly giving the sequence of unknotting actions. Trust region policy optimization (TRPO) performs consistently well, reducing 80% of the unknots with up to 96 crossings we tested to the empty braid word, and thoroughly outperformed other RL algorithms and random walkers. Studying these actions, we find that braid relations are more useful in simplifying to the unknot than one of the Markov moves.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Full scale wind tunnel investigation of a bearingless main helicopter rotor

A stability test program was conducted to determine the effects of airspeed, collective pitch, rotor speed and shaft angle on stability and loads at speeds beyond that attained in the BMR/BO-105 flight test program. Loads and performance data were gathered at forward speeds up to 165 knots. The effect of cyclic pitch perturbations on rotor response was investigated at simulated level flight conditions. Two configuration variations were tested for their effect on stability. One variable was the control system stiffness. An axially softer pitch link was installed in place of the standard BO-105 pitch link. The second variation was the addition of elastomeric damper strips to increase the structural damping. The BMR was stable at all conditions tested. At fixed collective pitch, shaft angle and rotor speed, damping generally increased between hover and 60 knots, remained relatively constant from 60 to 90 knots, then decreased above 90 knots. Analytical predictions are in good agreement with test data up to 90 knots, but the trend of decreasing damping above 90 knots is contrary to the theory.

Source record↗

Flight evaluation of the DEEC secondary control air-start capability

The air-start capability of a secondary engine control (SEC) was tested for a DEEC-equipped F100 engine and installed in an F-15 airplane. Two air-start schedules were tested. The first was referred to as the group I schedule; the second or revised schedule was the group II start schedule. Using the group I start schedule, an airspeed of 300 knots was required to ensure successful 40- and 25-percent SEC-mode air starts. If N2 were less than 40 percent, a stall would occur when the start bleeds closed 40 sec after initiation of the air start. All JFS-assisted air starts were successful with the group start schedule. For the group II schedule, the time between pressurization and start-bleed closure ranged between 50 and 72 sec depending on altitude. All air starts were successful above 225 knots givin a 75-knot reduction in required airspeed for a successful air start. Spooldown air starts of 40 percent were successful at 200 knots at altitudes up to 10,650 m and at 175 knots at altitudes up to 6100 m. Idle rpm was lower than the desired 65 percent for air starts at higher altitudes and lower airspeeds. All JSF-assisted air starts were successful.

Johnson, J. B.↗

Models of the Cartwheel ring galaxy: Spokes and starbursts

Recent observations of this famous ring galaxy, including optical and near-infrared CCD surface photometry, and VLA radio continuum and 21 cm line mapping (Higdon 1992b, in prep.), have inspired a renewed modeling effort. Toomre's (1978, in The Large-scale Structure of the Universe, eds. Longair and Einasto) series of restricted three-body simulations demonstrated how the multiple rings could be produced in a nearly head-on galaxy collision. New models with a halo-dominated potential based on the 21 cm rotation curve are able to reproduce such details as the spacing between rings, ring widths, offset of the nucleus, and several kinematical features, thus providing strong support for the collisional theory. The new observations have shown there are little or no old stars in Cartwheel; it may consist almost entirely of gas and stars produced as a result of compression in the ring wave. To model this process Smooth Particle Hydrodynamics (SPH) simulations of the Cartwheel disk have been performed. Fixed gravitational potentials were used to represent the Cartwheel and a roughly 30 percent mass collision partner. The interaction dynamics was treated as in the usual restricted three-body approximation, and the effects of local self-gravity between disk particles were calculated. We are particularly interested in testing the theory that enhanced star formation in waves is the result of gravitational instability in the compressed region (see e.g. Kennicutt 1989, ApJ 344, 685). The gas surface density in a number of simulations was initialized to a value slightly below the threshold for local gravitational instability throughout most of the disk. The first ring wave produces relatively modest compressions (a factor of order a few), triggering instability in a narrow range of wavelengths. Self-gravity in the disk is calculated over a comparable range of scales. Simulations were run with isothermal, adiabatic, and adiabatic with radiative cooling characterized by a relatively short timescale. The isothermal approximation is good except in the vicinity of the strong second (inner) ring, and several snapshots from one case are shown in the figure below. Flocculent spiral segments are present before the collision, and these are compressed into dense knots in the ring wave. These knots are likely to be sites of vigorous star formation. In the strong rarefaction behind the outer ring most of the knots are radially stretched and sheared, giving rise to spoke-like features. A few dense knots are evidently very tightly bound, because they retain their coherence and are stretched relatively little through the rarefaction. This is in accord with evidence for continuing star formation in some spokes (Marcum, Appleton and Higdon 1992). The number and spacing of spokes is a direct function of the scale of the gravitational instability in the disk. Thus, the gravitational instability theory, together with the hypothesis that massive stars are only formed in dense knots of gas, can account for most of the distinct morphology of the Cartwheel.

Struck-Marcell, Curtis↗

Deep VLA imaging of twelve extended 3CR quasars

A representative sample of 12 extended quasars from the 3CR catalog has been imaged at 4.9 GHz using the Very Large Array (VLA). These full synthesis observations typically achieve an rms noise of 20 micro-Jy per beam. Jets are detected on at least one side of every source. The jets are well collimated compared with those in less powerfull sources, but spreading is detected in most of them. The opening angles of several jets are not constant, but show recollimation after an initial regime of rapid spreading. Many of the jets contain quasiperiodic strings of knots, of which the knot closest to the central feature is usually the brightest (until the jet nears its hot spot). The degrees of linear polarization at the jet knots range from less than 5% to approx. 50%, but show no common trend with distance along the jets. In knots that are elongated in directions close to that of the jet, the E vectors tend to be orthogonal to the jet axis. The prominence of the inner, straighter jet segments relative to the extended lobes correlates significantly with the prominence of the milliarcsecond-scale central features, but the prominence of the more bent jet segments does not. Candidates for counterjet emission are detected in seven sources, but there is no unambiguous, continuous counterjet in any of them. Estimates of the flux density ratios between the straighter jet segments and the counterjets based on these tentative detections range from 1.2:1 to greater than 175:1. There is no evidence in this sample that counterjet detectability correlates with such putative inclination indicators as central feature prominence or projected linear size. There is also no evidence that the prominence of the counterjets anticorrelates with that of the jets as predicted by simple relativistic-beaming models for the jet/counterjet asymmetry. There is, however, strong evidence that large bends in the main jet favor counterjet detection, and there are no counterjet candidates opposite long, uninterrupted straight segments of the main jets. The detectability of the counterjets in these quasars may therefore be strongly influenced by interactions between the underlying beams and inhomogeneities in the surrounding material. We offer a new empirical definition of the term 'hot spot' that is intended to improve the distinction between such features and 'jet knots.' Both the compactness of hot spots and their position in the lobe are affected by whether they are fed by a detectable jet. When the hot spots differ significantly in compactness, the more compact one is always on the jetted side. Jetted hot spots are also more likely to be recessed deeply from the outer edge of their lobes than are their counterjetted counterparts. The jetted hot spot is less prominent relative to other extended emission if the jet bends through a large angle, particularly if a large bend occurs abruptly. The counterjetted hot spot is also less well defined if the jet is more bent. The lobes of several sources show considerable inhomogeneity, including filamentation.

Bridle, Alan H.↗

NGC 5291: Implications for the Formation of Dwarf Galaxies

The possible formation and evolution of dwarf irregular galaxies from material derived from perturbed evolved galaxies is addressed via an H I study of a likely example, the peculiar system NGC 5291. This system, located in the western outskirts of the cluster Abell 3574, contains the lenticular galaxy NGC 5291 which is in close proximity to a disturbed companion and is flanked by an extensive complex of numerous knots extending roughly 4 min north and 4 min south of the galaxy. In an initial optical and radio study, Longmore et al. (1979, MNRAS, 188, 285) showed that these knots have the spectra of vigorous star-forming regions, and suggested that some may in fact be young dwarf irregular galaxies. High resolution 21-cm line observations taken with the VLA are presented here and reveal that the H I distribution associated with this system encompasses not only the entire N-S complex of optical knots, but also forms an incomplete ring or tail that extends approximately 3 min to the west. The H I associated with NGC 5291 itself shows a high velocity range; the Seashell is not detected. The formation mechanism for this unusual system is unclear and two models - a large, low-luminosity ram-swept disk, and a ram-swept interaction-are discussed. The H I in the system contains numerous concentrations, mostly along the N-S arc of the star-forming complexes, which generally coincide with one or more optical knots; the larger H I features contain several x 10(exp 9) solar mass of gas. Each of the knots is compared to a set of criteria designed to determine if these objects are bound against their own internal kinetic energy and are tidally stable relative to the host galaxy. An analysis of the properties of the H I concentrations surrounding the optical star-forming complexes indicates that at least the largest of these is a bound system; it also possesses a stellar component. It is suggested that this object is a genuinely young dwarf irregular galaxy that has evolved from the material associated with the system and that this entire complex contains several proto- or young dwarf irregular galaxies in various stages of development. We are therefore witnessing the early evolution of a number of genuinely young galaxies. Given the evident importance of the NGC 5291 system as a 'nursery' for young galaxies, careful modeling is required if we are to understand this remarkable galaxy.

Malphrus, Benjamin K.↗

NASA/University Joint Venture in Space Science (JOVE)

This system has an immense complex of optical knots that extend several galactic diameters to the north and south of the main optical object. These are star forming regions, some of which are the size of small irregular galaxies. It has a nearby companion called the 'seashell' owing to its disturbed appearance. The data had been reduced and images formed; a figure is attached. The high resolution observations show that the atomic hydrogen (HI) encompasses not only the N-S complex of optical knots but it forms an incomplete ring or tail that extends approximately 3 arcmins to the west. The seashell was not detected, and the HI associated with NGC 5291 itself shows a very large velocity range. The formation mechanism for this disturbed and distorted complex is unclear. X-ray emission suggesting ram sweeping is also observed. This author favors an explanation involving an interaction between the two components, NGC 5291 and the seashell. We are witnessing the formation of tidal tails and bridges between the galaxies and the associated ejecta. Ram sweeping occurs as the system moves bodily through the medium of the cluster of galaxies, Abell 3574, to which NGC 5291 et al. belong. There are numerous concentrations of HI, mostly along the N-S star forming complexes which generally coincide with the optical knots; the larger features contain several x109 solar mass, again the magnitude of a small irregular galaxy. Each knot was compared to a set of criteria designed to test if the feature was stable against its own internal kinetic energy, and stable against the tidal forces of the host galaxy. At least one of the objects (Knot B) appears to be a bound system suggesting that it is a genuinely young dwarf irregular galaxy that has evolved from the material associated with his interacting complex. We conclude that we are witnessing the early evolution of young galaxies and that NGC 5291 and the seashell are a nursery.

Gottesman, Stephen T.↗

STIS Observations of the Ly\Alpha Bright Jet Associated with the Herbig Ae Star HD163296

We present follow-up HST/Space Telescope Imaging Spectrograph (STIS) observations of the Ly-alpha bright jet associated with the near-ZAMS Herbig Ae star HD163296. The proper motions and radial velocities of the knots in the flow are consistent with a collimated outflow inclined by 40 deg relative to the plane of the sky with a flow velocity that varies from 350 to 500 km/s along the jet. A new knot is visible in the jet at a projected distance of 0.33 arcsec (40 AU) from the central star. The knot has a dynamical age of only seven months, making it the youngest HH knot ever observed. We did not detect any emission from the counterjet within 2.5 arcsec of the source, which is consistent with absorption due to a uniform 450 AU radius disk tilted at 50 deg relative to the line of sight. We also present observations made with the Goddard Fabry-Perot Imager which show additional, more distant knots along the blue and red shifted outflow lobes, and discuss the collimation of the jet and implications for a magnetosphere associated with HD 163296. Support for this study was provided by HST STIS GTO funding through support to the NOAO, in response to the NASA A/O OSSA-4-84 through the Hubble Space Telescope Project at GSFC, as well as NASA grant NRA-98-03-UVG-O11. NOAO is operated by the Association of Universities for Research in Astronomy (AURA), Inc., under cooperative agreement with the National Science Foundation. Data analysis facilities were provided by the Laboratory for Astronomy & Solar Physics, NASA/GSFC.

Devine, David↗

Looking Closely at "Medusa": Star Forming Regions in NGC 4194

The "Medusa" (NGC 4194, Mrk 201) is a blue compact galaxy, with strong far infrared and radio emission. Ground-based observations exhibit a distorted image with a tidal tail and regions of strong star formation. A population of massive O and early B stars is evident from the IUE spectra HST survey of Seyfert and starburst galaxies notes NCG 4194 is an HII galaxy with lumpy HII regions and knots. The central starburst is apparently produced by a galaxy merger. As part of an investigation of star formation in interacting galaxies, we have obtained ultraviolet and visible images of the central regions of NGC 4194 with the Space Telescope Imaging Spectrograph on HST. Imaging was obtained in two ultraviolet (FUV-MAMA+F25QTZ, NUV-MAMA+F25CN182) and one visible (CCD+F28X50LP) band. Individual star forming knots (at HST resolution) have been identified. We present sized and luminosities for the individual knots, and the knot luminosity function. We compare our data to current starburst models to constrain stellar ages and populations. Knot characteristics as a function of location in the galaxy will also be discussed.

Weistrop, D.↗

Emission-Line Galaxies from the PEARS Hubble Ultra Deep Field: A 2-D Detection Method and First Results

The Hubble Space Telescope (HST) Advanced Camera for Surveys (ACS) grism PEARS (Probing Evolution And Reionization Spectroscopically) survey provides a large dataset of low-resolution spectra from thousands of galaxies in the GOODS North and South fields. One important subset of objects in these data are emission-line galaxies (ELGs), and we have investigated several different methods aimed at systematically selecting these galaxies. Here we present a new methodology and results of a search for these ELGs in the PEARS observations of the Hubble Ultra Deep Field (HUDF) using a 2D detection method that utilizes the observation that many emission lines originate from clumpy knots within galaxies. This 2D line-finding method proves to be useful in detecting emission lines from compact knots within galaxies that might not otherwise be detected using more traditional 1D line-finding techniques. We find in total 96 emission lines in the HUDF, originating from 81 distinct "knots" within 63 individual galaxies. We find in general that [0 1111 emitters are the most common, comprising 44% of the sample, and on average have high equivalent widths (70% of [0 1111 emitters having rest-frame EW> 100A). There are 12 galaxies with multiple emitting knots; several show evidence of variations in H-alpha flux in the knots, suggesting that the differing star formation properties across a single galaxy can in general be probed at redshifts approximately greater than 0.2 - 0.4. The most prevalent morphologies are large face-on spirals and clumpy interacting systems, many being unique detections owing to the 2D method described here, thus highlighting the strength of this technique.

Gardner, J. P.↗

The Mass-loss History of the Red Hypergiant VY CMa

Imaging and spectroscopy of the knots, clumps, and extended arcs in the complex ejecta of VY CMa confirm a record of high mass-loss events over the past few hundred years. Hubble Space Telescope/Space Telescope Imaging Spectrograph spectroscopy of numerous small knots close to the star allow us to measure their radial velocities from the strong K i emission and determine their separate motions, spatial orientations, and time since ejecta. Their ages concentrate around 70, 120, 200, and 250 yr ago. A K i emission knot only 50 mas from the star ejected as recently as 1985–1995 may coincide with an H{sub 2}O maser. Comparison with VY CMa’s historic light curve from 1800 to the present shows several knots with ejection times that correspond with extended periods of variability and deep minima. The similarity of this correspondence in VY CMa with the remarkable recent dimming of Betelgeuse and an outflow of gas is apparent. The evidence for similar outflows from the surface of a more typical red supergiant suggests that discrete ejections are more common and surface or convective activity is a major source of mass loss for red supergiants.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗