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At least 73 records · Page 4

Cancer Risk-Assessment of Radiation Damage in Ataxia Telangiectasia Heterozygous Human Breast Epithelial Cell Cultures

This paper describes the study of the markers of cellular changes that are found during the onset of carcinogenesis. Several of the biological factors are markers of stress response, oncoprotein expression, and differentiation factors. Oxidative stress response agents such as heat shock proteins (HSPs) protect cells from oxidative stresses such as ionizing radiation. The onocoprotein HER-2/neu, a specific breast cancer marker, indicates early onset of cancer. Additional structural and morphogenetic markers of differentiation were considered in order to determine initial cellular changes at the initial onset of cancer. As an additional consideration, all-trans retinoic acid (RA), a differentiation agent, was considered because of its known role in regulating normal differentiation and inhibiting tumor proliferation via specific nuclear receptors. This paper discusses study and results of the preliminary analyses of gamma irradiation of AT heterozygous human breast epithelial cells (WH). Comparisons are also made of the effects various RA concentrations post-irradiation.

Lisa C. Applewhite↗

Integration of environmental and spectral data for sunflower stress determination

Stress in sunflowers was assessed in western and northwestern Minnesota. Weekly ground observations (acquired in 1980 and 1981) were analyzed in concert with large scale aerial photography and concurrent LANDSAT data. Using multidate supervised and unsupervised classification procedures, it was found that all crops grown in association with sunflowers in the study area are spectrally separable from one another. Under conditions of extreme drought, severely stressed plants were differentiable from those not severely stressed, but between-crop separation was not possible. Initial regression analyses to estimate sunflower seed yield showed a sensitivity to environmental stress during the flowering and seed development stages. One of the most important biological factors related to sunflower production in the Red River Valley area was found to be the extent and severity of insect infestations.

Lillesand, T.↗

High-burnup fuel stress analysis prior to and during a LOCA transient

High-burnup fuel fragmentation and pulverization have been experimentally observed during simulated loss-of-coolant accident (LOCA) transient testing of high-burnup (>62 GWd/tU) nuclear fuel. The cause of this phenomenon is generally accepted to be the formation of stresses arising from the off-normal conditions. However, the primary mechanism(s) contributing to the stress formation is/are still being debated. Leading hypotheses suggest that the concurrence of fission gas bubbles and high burnup structure on the pellet periphery (i.e., the rim) leave the fuel susceptible to pulverization. Other hypotheses suggest that pulverization is artificially inflated during externally heated tests that do not reproduce prototypic fuel stresses and radial temperature profiles as the fuel transitions from full-power nuclear heating to decay heating. This work performs finite element analyses of fuel pellet temperatures and macroscopic stresses prior to and during a LOCA transient to identify (1) operating conditions that may exacerbate the fuel pellet stress state, (2) differences in predicted stresses with nuclear vs. furnace heating, and (3) how fuel cracking impacts the subsequent stress state in the pellet fragments. Analyses predict that macroscopic transient fuel stresses resulting from constrained thermal expansion will remain below the fracture stress of fresh UO 2 once the fragment size reaches ~4 mm or less. Calculated fuel stresses from simulated LOCA tests performed with representative nuclear vs. electrical heating rates are shown to be equal within 5% and essentially unchanged for all times after the first 27 seconds of the transients. Because the fuel stresses do not change once the temperature profile becomes uniform, macroscopic transient stresses would be no different than those following a normal shutdown. Because pulverization of high burnup fuel does not occur prior to a LOCA test, pulverization of high burnup UO 2 cannot be initiated by differential thermal stresses.

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗

Influence of stress, weightlessness, and simulated weightlessness on differentiation of preosteoblasts

The effects of 18.5 days of weightlessness aboard a satellite, stress of restricted feeding, stress of noise and vibration to simulate space flight and 21 days of head down suspension via the Morey-Holton model for simulated weightlessness was studied. Nuclear size of fibroblastlike cells in PDL on the anterior surface of maxillary first molars was classified as: (1) A-cells, self perpetuating precursors with a nuclear volume 80 micron B-cells, nonosteogenic fibroblasts with a nuclear volume of 80-119 micron 3, C-cells, preosteoblasts that are in G1 stage of the cell cycle with a nuclear size of 120-170 micro, and D-cells, preosteoblasts that are in G2 stage of the cell cycle with a nuclear size 170 micro.

Roberts, W. E.↗

Adaptive Stress Testing: Finding Likely Failure Events with Reinforcement Learning

Finding the most likely path to a set of failure states is important to the analysis of safety-critical systems that operate over a sequence of time steps, such as aircraft collision avoidance systems and autonomous cars. In many applications such as autonomous driving, failures cannot be completely eliminated due to the complex stochastic environment in which the system operates.As a result, safety validation is not only concerned about whether a failure can occur, but also discovering which failures are most likely to occur. This article presents adaptive stress testing (AST), a framework for finding the most likely path to a failure event in simulation. We consider a general black box setting for partially observable and continuous-valued systems operating in an environment with stochastic disturbances. We formulate the problem as a Markov decision process and use reinforcement learning to optimize it. The approach is simulation-based and does not require internal knowledge of the system, making it suitable for black-box testing of large systems. We present different formulations depending on whether the state is fully observable or partially observable. In the latter case, we present a modified Monte Carlo tree search algorithm that only requires access to the pseudorandom number generator of the simulator to overcome partial observability. We also present an extension of the framework, called differential adaptive stress testing (DAST), that can find failures that occur in one system but not in another. This type of differential analysis is useful in applications such as regression testing, where we are concerned with finding areas of relative weakness compared to a baseline. We demonstrate the effectiveness of the approach on an aircraft collision avoidance application, where a prototype aircraft collision avoidance system is stress tested to find the most likely scenarios of near mid-air collision.

Verification and Validation↗

Testing of Helium Cooled Metal Molybdenum Disk Target System

NorthStar Medical Radioisotopes LLC is planning to produce the important medical radioisotope molybdenum-99 (Mo-99) through a photonuclear reaction on molybdenum-100 (Mo-100). In this approach, multiple thin disks of enriched molybdenum metal will be bombarded with a 40-MeV electron beam. Because enriched Mo-100 is expensive, we intend to use as much beam power as possible to achieve maximum production yield and minimize the size of the target. This requirement leads to very high beam power density (heat deposition in the target), which sets challenging requirements for cooling. Together with scientists at Los Alamos National Laboratory, a team at Argonne National Laboratory has developed and demonstrated a cooling approach using pressurized helium, which allows for efficient heat removal. One of the challenges in this approach is the management of the heat load on the target window. The target window separates the high-pressure helium atmosphere inside the target from the vacuum in the beamline, so it is constantly under stress from differential pressure. Also, the window is cooled only by the helium gas flow from one side, making the window design challenging. High heat deposition in the target disks also imposes a strict requirement on performance of the helium cooling system and thickness of the target disks. The target disks are produced from metal powder via a press-and-sinter process. The resulting disks do not possess as high a tensile strength as solid molybdenum and might not survive the vibration from the high-velocity helium coolant and the high thermal stress from beam heating.

42 ENGINEERING↗

Testing of Helium-Cooled Metal Molybdenum Disk Target

NorthStar Medical Radioisotopes LLC is planning to produce an important medical radioisotope, molybdenum-99 (Mo-99), through photonuclear reaction on molybdenum-100 (Mo-100). In this approach, molybdenum metal will be bombarded with a 40-MeV electron beam. Because enriched Mo-100 is expensive, it is desired to use as much beam power as possible to achieve maximum production yield and minimize target mass. This objective leads to very high beam power density (heat deposition in the target), which sets challenging requirements for cooling. Together with scientists at Los Alamos National Laboratory, a team at Argonne National Laboratory has developed and demonstrated a cooling approach using pressurized helium, which allows for efficient heat removal. One of the main challenges in this approach is the management of the heat load on the target window. The target window separates the high-pressure helium inside the target from the vacuum in the beamline, so it is constantly under stress from differential pressure. Also, the window is cooled only by the helium gas flowing on one side, making the window cooling even more challenging. High heat deposition in the target disks also imposes a strict requirement on performance of the helium cooling system and thickness of the target disks. The target disks are produced from metal powder via a press-and-sinter process. The resulting disks do not possess tensile strength as high as solid molybdenum and might not survive the vibration from the high-velocity helium coolant and high thermal stress from beam heating. An Argonne team of scientists performed a series of tests at Argonne’s Low Energy Accelerator Facility (LEAF) [3-7]. This report describes two series of tests for scale down production target designs that utilize full-scale 29 millimeters diameter, 0.75 mm thick press-and-sintered disks. We performed two thermal tests with different beam parameters and configurations of the disk laminations. We compared the results of the window temperature measurements and cooling system parameters obtained in the experiments with those predicted by analytical calculations and Computation Flow Dynamic (CFD) simulations. Results of the experiments and calculations are presented below.

36 MATERIALS SCIENCE↗

Technical and economic feasibility of molten chloride salt thermal energy storage systems

A techno-economic study is performed to assess the feasibility of molten chloride salt thermal energy storage (TES) systems for next generation concentrating solar power. Refractory liners internally insulate tanks to allow tank shells to be constructed from carbon steel. The liner must not be wetted by salt to maintain predictable thermal properties and manageable heat loss out of the tank. The commercial scale tank liner is an anchored brick and mortar design with expansion joints to accommodate thermal expansion. Furthermore, finite element analysis is performed to optimize the thermal and mechanical profile of the tank. Equalizing the shell temperature between the water-cooled foundation and the shell wall is necessary to minimize differential thermomechanical stress and lower overall stress values below industrial allowable limits. The cost of the TES system is estimated to be $60/kWhth, which is four times greater than Department of Energy targets. Solutions to reduce system cost and overall risk are proposed.

14 SOLAR ENERGY↗

EGS Collab Experiment 2: 4100 Foot Level Elastic Property Data

Static and dynamic elastic properties (Young's modulus, Shear Modulus, P-wave Modulus, and Poisson's Ratio) of amphibolites and rhyolites from the TV4100 and TH4100 boreholes at the Sanford Underground Research Laboratory (SURF). Elastic properties include Young's modulus, Poisson's ratio, shear modulus, and p-wave modulus. Raw data from the experiments and slides describing the experimental procedure and a summary of results are included, along with a readme file with additional definitions and information.

15 GEOTHERMAL ENERGY↗

Free-standing thin film Ge single crystals grown by plasma-enhanced chemical vapor deposition

The films, which are approximately 10 microns in thickness, are grown epitaxially on polished (100) NaCl substrates at 450 C by plasma enhanced chemical vapor deposition. Upon cooling, the films are separated from the substrate by differential shear stress, leaving free-standing films of Ge which can be handled. Growths are attained by nucleating at minimum plasma power for very brief intervals and then raising the power to 65 W to increase the growth rate to approximately 10 microns/h. It is found that substrate exposure to the plasma at too high a power for too long a time sputters and erodes the surface, thereby substantially degrading the nucleation process and the ultimate growths. It is noted that the free-standing films are visually specular and exhibit a high degree of crystalline order when examined by X-ray diffraction. Auger electron spectroscopy and energy dispersive analysis of X-rays reveal no detectable bulk contamination.

Outlaw, R. A.↗

Growth of high-quality thin-film Ge single crystals by plasma-enhanced chemical vapor deposition

Thin-film Ge single crystals (approx. 10 microns) have been epitaxially grown on polished NaCl(100) substrates at 450C by using plasma-enhanced chemical vapor deposition. Films on approximately 1 sq cm and larger were separated from the NaCl by either melting the salt or by differential shear stress upon cooling to room temperature. The ordered growth of the Ge was found to be most sensitive to the initial plasma power and to the continuum flow dynamics within the carbon susceptor. The films were visually specular and exhibited a high degree of crysalline order when examined by X-ray diffraction. The films were found to be p-type with a carrier concentration of approximately 3 x 10 to the 16th power/cu cm, a resistivity of 0.11 ohm-cm, and a Hall hole mobility of 1820 sq cm/v/s at room temperature. Vacuum firing minimized the primary contaminant, Na, and corresponding lowered the carrier concentration to 4 x 10 to the 14th power/cu cm.

Outlaw, R. A.↗

Constitutive modeling of cyclic plasticity and creep, using an internal time concept

Using the concept of an internal time as related to plastic strains, a differential stress-strain relation for elastoplasticity is rederived, such that (1) the concept of a yield-surface is retained; (2) the definitions of elastic and plastic processes are analogous to those in classical plasticity theory; and (3) its computational implementation, via a 'tangent-stiffness' finite element method and a 'generalized-midpoint-radial-return' stress-integration algorithm, is simple and efficient. Also, using the concept of an internal time, as related to both the inelastic strains as well as the Newtonian time, a constitutive model for creep-plasticity interaction, is discussed. The problem of modeling experimental data for plasticity and creep, by the present analytical relations, as accurately as desired, is discussed. Numerical examples which illustrate the validity of the present relations are presented for the cases of cyclic plasticity and creep.

Watanabe, O.↗

Turbulence and stall in plane diffusers - Computational study

The effect of free-stream turbulence level on stall conditions in plane diffusers is investigated with a finite-volume numerical method which utilizes a k-epsilon turbulence model or a differential Reynolds stress model for closure. Computed results show qualitative agreement with measured data. The ability to eliminate stall and thereby increase pressure recovery in diffusers at large included angles by utilizing high free-stream turbulence is correctly predicted.

Demuren, A. O.↗

Second-Moment RANS Model Verification and Validation Using the Turbulence Modeling Resource Website (Invited)

The implementation of the SSG/LRR-omega differential Reynolds stress model into the NASA flow solvers CFL3D and FUN3D and the DLR flow solver TAU is verified by studying the grid convergence of the solution of three different test cases from the Turbulence Modeling Resource Website. The model's predictive capabilities are assessed based on four basic and four extended validation cases also provided on this website, involving attached and separated boundary layer flows, effects of streamline curvature and secondary flow. Simulation results are compared against experimental data and predictions by the eddy-viscosity models of Spalart-Allmaras (SA) and Menter's Shear Stress Transport (SST).

Eisfeld, Bernhard↗