Engineering Papers⌕ Search

SEARCH · Engineering Papers

Results for “TOXICOLOGY”

Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 73 records · Page 4
All sourcesNASA NTRSDOE OSTI
NASA NTRS2010

Lunar Dust Separation for Toxicology Studies

During the Apollo missions, crewmembers were briefly exposed to dust in the lunar module, brought in after extravehicular activity. When the lunar ascent module returned to micro-gravity, the dust that had settled on the floor now floated into the air, causing eye discomfort and occasional respiratory symptoms. Because our goal is to set an exposure standard for 6 months of episodic exposure to lunar dust for crew on the lunar surface, these brief exposures of a few days are not conclusive. Based on experience with industrial minerals such as sandblasting quartz, an exposure of several months may cause serious damage, while a short exposure may cause none. The detailed characteristics of sub-micrometer lunar dust are only poorly known, and this is the size range of particles that are of greatest concern. We have developed a method for extracting respirable dust (<2.5 micron) from Apollo lunar soils. This method meets stringent requirements that the soil must be kept dry, exposed only to pure nitrogen, and must conserve and recover the maximum amount of both respirable dust and coarser soil. In addition, we have developed a method for grinding coarser lunar soil to produce sufficient respirable soil for animal toxicity testing while preserving the freshly exposed grain surfaces in a pristine state.

Cooper, Bonnie L.↗
NASA NTRS2002

Toxicological Assessment of the International Space Station Atmosphere from Mission 5A to 8A

There are many sources of air pollution that can threaten air quality during space missions. The International Space Station (ISS) is an extremely complex platform that depends on a multi-tiered strategy to control the risk of excessive air pollution. During the seven missions surveyed by th is report, the ISS atmosphere was in a safe, steady-state condition; however, there were minor loads added as new modules were attached. There was a series of leaks of octafluoropropane, which is not directly toxic to humans, but did cause changes in air purification operations that disrupted the steady state condition . In addition, off-nominal regeneration of metal oxide canisters used during extravehicular activity caused a serious pollution incident.

James, John T.↗
NASA NTRS2000

Radiation Transport Modeling and Assessment to Better Predict Radiation Exposure, Dose, and Toxicological Effects to Human Organs on Long Duration Space Flights

NASA's long-range plans include possible human exploratory missions to the moon and Mars within the next quarter century. Such missions beyond low Earth orbit will expose crews to transient radiation from solar particle events which include high-energy galactic cosmic rays and high-energy protons. Because the radiation levels in space are high and the missions long, adequate shielding is needed to minimize the deleterious health effects of exposure to radiation. The focus of this study is radiation exposure to the blood-forming organs of the NASA astronauts. NASA/JSC developed the Phantom Torso Experiment for Organ Dose Measurements which housed active and passive dosimeters that would monitor and record absorbed radiation levels at vital organ locations. This experiment was conducted during the STS-9 I mission in May '98 and provided the necessary space radiation data for correlation to results obtained from the current analytical models used to predict exposure to the blood-forming organs. Numerous models (i.e., BRYNTRN and HZETRN) have been developed and used to predict radiation exposure. However, new models are continually being developed and evaluated. The Space Environment Information Systems (SPENVIS) modeling program, developed by the Belgian Institute for Space Aeronomy, is to be used and evaluated as a part of the research activity. It is the intent of this research effort to compare the modeled data to the findings from the STS-9 I mission; assess the accuracy and efficiency of this model; and to determine its usefulness for predicting radiation exposure and developing better guidelines for shielding requirements for long duration manned missions.

Denkins, Pamela↗
NASA NTRS2012

Revised Toxicological Assessment of ISS Air Quality: May 2012 - August 2012

A summary of the analytical results from 12 grab sample containers (GSCs) collected on ISS and returned aboard 30S is shown in Table 1. The average recoveries of the 3 surrogate standards from the GSCs were as follows: 12C-acetone, 115 +/-- 11%; fluorobenzene, 108 +/- 8%; and chlorobenzene, 102 +/- 16%. Shaded rows indicate data that re limited due to low sample pressures. For completeness, previously reported data from the US Lab collected in May 2012 are included here as well. The revised report provides results from one returned sample that was unlabeled and originally assumed to be unused. The sample was prepared and analyzed for the purpose of measuring the surrogate compounds. It was later determined, based on serial number, that this was the HTB3 first ingress sample.

Meyers, Valerie↗
NASA NTRS2013

Toxicological Assessment of ISS Air Quality: September 2012 - October 2012 with Formaldehyde Supplement from May-October 2012

A summary of the analytical results from 6 grab sample containers (GSCs) and 12 pairs of formaldehyde badges collected on ISS and returned aboard 29S or 31 S is shown in an accompanying table. The average recoveries of the 3 surrogate standards from the GSCs were as follows: C-l3-acetone, 128%; fluorobenzene, 114%; and chlorobenzene, 78%. Recoveries of two lab-control formaldehyde badges averaged 95%.

James, John T.↗
NASA NTRS2013

Toxicological Assessment of ISS Air Quality: SpaceX-2 First Ingress

One mini-grab sample container (M-GSC) was collected by crew members onboard ISS during first ingress into SpaceX-2 on March 3, 2013, three days after late cargo loading and a pre-launch clean air purge. Recoveries of the three surrogate standards from the m-GSC were: 13C-acetone, 97%; fluorobenzene, 95%; and chlorobenzene, 68%.

Meyers, Valerie↗
NASA NTRS2013

Toxicological Assessment of ISS Air Quality: Contingency Sampling - February 2013

Two grab sample containers (GSCs) were collected by crew members onboard ISS in response to a vinegar-like odor in the US Lab. On February 5, the first sample was collected approximately 1 hour after the odor was noted by the crew in the forward portion of the Lab. The second sample was collected on February 22 when a similar odor was noted and localized to the end ports of the microgravity science glovebox (MSG). The crewmember removed a glove from the MSG and collected the GSC inside the glovebox volume. Both samples were returned on SpaceX-2 for ground analysis.

Meyers, Valerie↗
NASA NTRS2013

Toxicological Assessment of ISS Air Quality: April - May 2013

A summary of the analytical results from 4 mini-grab sample (mGSCs) collected on ISS and returned aboard 33S is shown in Table 1. Due to the launch delay of the ATV4 resupply mission, monthly samples were reduced in April and May by omitting sampling of the Service Module in order to ensure contingency samplers were available if needed. Complete data tables of all measured concentrations and corresponding T-values based on 180-day SMACs are enclosed. detection limit for all target compounds, except m/p-xylenes and hexachloro-1, 3-butadiene was 0.025 mg/cu m. The detection limit for m/p-xylenes and hexachloro-1, 3-butadiene and all non-target compounds was 0.05 mg/cu m. The average recoveries of the 3 surrogate standards from the mGSCs were as follows: C-13-acetone, 116 +/- 12%; D-5-fluorobenzene, 117 +/- 7%; and D-5-chlorobenzene, 111 +/- 15%. Initial measured sample pressures were between 13.9 and 14.1 psia for all samples, indicating nominal sample collection. A summary of the analytical results from 3 pairs of passive-diffusion formaldehyde badges collected on ISS and returned aboard 33S is also provided in Table 1. In an effort to conserve samples due to the delay of the ATV4 resupply mission, FMK sampling was only conducted in the US Lab in May. Positive control recoveries (1 trip and 2 lab controls) were 79%, 87%, and 116% respectively.

Meyers, Valerie↗
NASA NTRS2014

Toxicological Assessment of ISS Air Quality: June - September 2013 (Increment 36)

Fourteen mini grab sample containers (msGSCs) were collected on ISS between June and September 2013 and were returned on 34S; however, the ATV-4 first ingress mGSC did not contain sufficient sample to report results (initial sample pressure = 1.2 psia). Of the remaining 13 mGSCs, 12 were collected as routine monthly samples in the Russian Service Module (SM), US Laboratory (Lab), and either the Japanese Pressurized Module (JPM) or the Columbus module (Col), and 1 was collected during HTV-4 first ingress. A summary of the analytical results from the 13 valid mGSCs is shown.

Meyers, Valerie↗
NASA NTRS2018

The Importance of Primary Martian Surface and Airfall Dust Sample Return for Toxicological Hazard Evaluations for Human Exploration

Manned missions to the Moon highlight a major hazard for future human exploration of the Moon and beyond: surface dust. Not only did the dust cause mechanical and structural integrity issues with the suits, the dust 'storm' generated upon reentrance into the crew cabin caused "lunar hay fever" and "almost blindness" . It was further reported that the allergic response to the dust worsened with each exposure. Due to the prevalence of these high exposures, the Human Research Roadmap developed by NASA identifies the Risk of Adverse Health and Performance Effects of Celestial Dust Exposure as an area of concern. Extended human exploration will further increase the probability of inadvertent and repeated exposures to celestial dusts. Going forward, hazard assessments of celestial dusts will be determined through sample return efforts prior to astronaut deployment.

Harrington, A. D.↗
NASA NTRS2007

The Lunar Environment: Determining the Health Effects of Exposure to Moon Dusts

The Earth s moon presents a hostile environment in which to live and work. There is no atmosphere to protect its surface from the ravages of solar wind and micrometeorite impacts. As a result, the moon s surface is covered with a thin layer of fine, charged, reactive dust capable of entering habitats and vehicle compartments, where it can result in crewmember health problems. During the Apollo missions, lunar dusts were introduced into the crew vehicle, resulting in direct exposure and occasional reports of respiratory, dermal and ocular irritation. In order to study the toxicological effects of lunar dust, NASA formed the Lunar Airborne Dust Toxicity Advisory Group (LADTAG). This interdisciplinary group is comprised of leading experts in space toxicology, lunar geology, space medicine and biomedical research. LADTAG has demonstrated that lunar soil contains several types of reactive dusts, including an extremely fine respirable component. These dusts have highly reactive surfaces in the lunar environment; the grains contain surface coatings which are generated by vapor phases formed by hypervelocity impact of micrometeorites. This unique class of dusts has surface properties that are unlike any Earth based analog. These distinctive properties are why lunar dusts are of great toxicological interest. Understanding how these reactive components behave "biochemically" in a moisture-rich pulmonary environment will aid in determining how toxic these particles are to humans. The data obtained from toxicological examination of lunar dusts will determine the human risk criteria for lunar dust exposure and produce a lunar health standard. LADTAG s analysis of lunar dusts and lunar dust simulants will include detailed lunar particle characterizations, determining the properties of particle activation, reactivation of lunar dust, the process of dust passivation and discerning the pathology of lunar dust exposure via inhalation, intratracheal instillation, cell culture exposure, dermal exposure and ocular exposure. The resulting health standard will be time-based and will vary by the duration and type of exposure. It may also be necessary to set multiple standards for different types of lunar dust, as well as for dust in its activated form vs. aged & passivated dust. This standard, set to protect the health of our robust astronaut crews, will not only impact NASA medical operations, but engineering designs as well. The data from our multidisciplinary research are vital in developing remediation devices and environmental monitors. Ultimately, the engineering and safety groups will design and develop countermeasures for space vehicles, suits, rovers and habitats that will be sustained within the limits of the health standard.

Khan-Mayberry, Noreen↗
NASA NTRS2008

Pulmonary Toxicity Studies of Lunar Dusts in Rodents

NASA will build an outpost on the lunar surface for long-duration human habitation and research. The surface of the Moon is covered by a layer of fine, reactive dust, and the living quarters in the lunar outpost are expected to be contaminated by lunar dust. NASA established the Lunar Airborne Dust Toxicity Advisory Group (LADTAG) to evaluate the risk of exposure to the dust and to establish safe exposure limits for astronauts working in the lunar habitat. Because the toxicity of lunar dust is not known, LADTAG has recommended investigating its toxicity in the lungs of laboratory animals. After receiving this recommendation, NASA directed the JSC Toxicology Laboratory to determine the pulmonary toxicity of lunar dust in exposed rodents. The rodent pulmonary toxicity studies proposed here are the same as those proposed by the LADTAG. Studies of the pulmonary toxicity of a dust are generally done first in rodents by intratracheal instillation (ITI). This toxicity screening test is then followed by an inhalation study, which requires much more of the test dust and is labor intensive. We succeeded in completing an ITI study on JSC-1 lunar dust simulant in mice (Lam et al., Inhalation Toxicology 14:901-916, 2002, and Inhalation Toxicology 14: 917-928, 2002), and have conducted a pilot ITI study to examine the acute toxicity of an Apollo lunar (highland) dust sample. Preliminary results obtained by examining lung lavage fluid from dust-treated mice show that lunar dust was somewhat toxic (more toxic than TiO2, but less than quartz dust). More extensive studies have been planned to further examine lung lavage fluid for biomarkers of toxicity and lung tissues for histopathological lesions in rodents exposed to aged and activated lunar dust samples. In these studies, reference dusts (TiO2 and quartz) of known toxicities and have industrial exposure limits will be studied in parallel so the relative toxicity of lunar dust can be determined. The ITI results will also be useful for choosing an exposure concentration for the animal inhalation study on a selected lunar dust sample, which is included as a part of this proposal. The animal inhalation exposure will be conducted with lunar dust simulant prior to the study with the lunar dust. The simulant exposure will ensure that the study techniques used with actual lunar dust will be successful. The results of ITI and inhalation studies will reveal the toxicological risk of exposures and are essential for setting exposure limits on lunar dust for astronauts living in the lunar habitat.

Lam, Chiu-wing↗
NASA NTRS2020

Guidelines for Assessing the Toxic Hazard of Spacecraft Chemicals and Test Materials

This document describes the criteria and procedural guidelines used by the NASA/JSC Toxicology Office (JSCSTO), to perform toxicological evaluations. The JSCSTO is responsible for conducting toxicological assessments and assigning toxic hazard levels (THLs) for essentially all chemicals and test materials to be used in or transported to the habitable areas of U.S. spacecraft, non‐U.S. spacecraft inhabitaed by U.S. crew members or habitable areas of off‐Earth habitats where U.S. crew members would be present, including chemicals carried by visiting spacecraft(visiting vehicles) to and from the International Space Station (ISS). Biohazard assessments for biological materials used in payload experiments are performed by the NASA Biosafety Review Board. Radioactive materials are assessed by the Space Radiation Analysis Group for radiation hazards; the flammability rating on flammable materials is assessed by the JSC Materials and Processes Branch, ES4. This document will focus on the assessment of chemically‐induced toxicity hazards. The toxicological assessments, together with assessments on radioactive, biological, physical, and flammability hazards, are incorporated into a mission‐specific Hazardous Materials Summary Table (HMST).

Valerie Elizabeth Ryder↗
NASA NTRS1992

Guidelines for developing spacecraft maximum allowable concentrations for Space Station contaminants

The National Aeronautics and Space Administration (NASA) is preparing to launch a manned space station by the year 1996. Because of concerns about the health, safety, and functioning abilities of the crews, NASA has requested that the National Research Council (NRC) through the Board on Environmental Studies and Toxicology (BEST) provide advice on toxicological matters for the space-station program. The Subcommittee on Guidelines for Developing Spacecraft Maximum Allowable Concentrations for Space Station Contaminants was established by the Committee on Toxicology (COT) to address NASA's concerns. Spacecraft maximum allowable concentrations (SMAC's) are defined as the maximum concentrations of airborne substances (such as gas, vapor, or aerosol) that will not cause adverse health effects, significant discomfort, or degradation in crew performance.

Source record↗
NASA NTRS2007

The Lunar Environment: Determining the Health Effects of Exposure to Moon Dusts

The moon's surface is covered with a thin layer of fine, charged, reactive dust capable of layer of fine, charged, reactive dust capable of capable of entering habitats and vehicle compartments, where it can result in crewmember health problems. NASA formed the Lunar Airborne Dust Toxicity Advisory Group (LADTAG) to study the effects of exposure to Lunar Dust on human health. To date, no scientifically defensible toxicological studies have been performed on lunar dusts, specifically the determination of exposure limits and their affect on human health. The multi-center LADTAG (Lunar Airborne Dust Toxicology center LADTAG (Lunar Airborne Dust Toxicology Advisory Group) was formed in response to the Office of the Chief Health and Medical Office s (OCHMO) request to develop recommendations for defining risk (OCHMO) request to develop recommendations for defining risk defining risk criteria for human lunar dust exposure.

Khan-Mayberry, Noreen↗