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At least 73 records · Page 4
All sourcesNASA NTRSDOE OSTI
NASA NTRS1975

On hemispheric differences in evoked potentials to speech stimuli

Confirmation is provided for the belief that evoked potentials may reflect differences in hemispheric functioning that are marginal at best. Subjects were right-handed and audiologically normal men and women, and responses were recorded using standard EEG techniques. Subjects were instructed to listen for the targets while laying in a darkened sound booth. Different stimuli, speech and tone signals, were used. Speech sounds were shown to evoke a response pattern that resembles that to tone or clicks. Analysis of variances on peak amplitude and latency measures showed no significant differences between hemispheres, however, a Wilcoxon test showed significant differences in hemispheres for certain target tasks.

Galambos, R.↗
NASA NTRS1975

On hemispheric differences in evoked potentials to speech stimuli

Subjects were asked to count the number of times a 'target' sound occurred in lists of speech sounds (pa or ba) or pure tones (250 or 600 c/sec) in which one of the sounds (the 'frequent') appeared about four times as often as the target. The response to both targets and frequents were separately averaged from electrodes at vertex at symmetrical left and right parietal locations. The expected sequence of deflections, including P3 waves with about 350 msec latency, was found in the responses to target stimuli. Very little difference was found between the right and left hemispheric responses to speech or pure tones, either frequent or target.

Galambos, R.↗
NASA NTRS1982

Interaction of gravitic and mechanical stimuli in tropic and nastic responses in beans

Experiments designed to explore the interaction of gravity and mechanical stimuli in the tropic and nastic movements of Cherokee Bush bean plants were summarized. When 10-day-old plants were rubbed just prior to presentation of the gravitic stimulus (by placing them on their sides), they displayed much less geotropic curvature than did nonrubbed controls. Geotropism could also be inhibited by rubbing even after it had been progressing for two hours. Wind from a fan could also inhibit geotropism, suggesting that this phenomenon also occurs in nature.

Jaffe, M. J.↗
NASA NTRS1984

Far-field brainstem responses evoked by vestibular and auditory stimuli exhibit increases in interpeak latency as brain temperature is decreased

The effect of decreasing of brain temperature on the brainstem auditory evoked response (BAER) in rats was investigated. Voltage pulses, applied to a piezoelectric crystal attached to the skull, were used to evoke stimuli in the auditory system by means of bone-conducted vibrations. The responses were recorded at 37 C and 34 C brain temperatures. The peaks of the BAER recorded at 34 C were delayed in comparison with the peaks from the 37 C wave, and the later peaks were more delayed than the earlier peaks. These results indicate that an increase in the interpeak latency occurs as the brain temperature is decreased. Preliminary experiments, in which responses to brief angular acceleration were used to measure the brainstem vestibular evoked response (BVER), have also indicated increases in the interpeak latency in response to the lowering of brain temperature.

Hoffman, L. F.↗
NASA NTRS1988

Efficient use of bit planes in the generation of motion stimuli

The production of animated motion sequences on computer-controlled display systems presents a technical problem because large images cannot be transferred from disk storage to image memory at conventional frame rates. A technique is described in which a single base image can be used to generate a broad class of motion stimuli without the need for such memory transfers. This technique was applied to the generation of drifting sine-wave gratings (and by extension, sine wave plaids). For each drifting grating, sine and cosine spatial phase components are first reduced to 1 bit/pixel using a digital halftoning technique. The resulting pairs of 1-bit images are then loaded into pairs of bit planes of the display memory. To animate the patterns, the display hardware's color lookup table is modified on a frame-by-frame basis; for each frame the lookup table is set to display a weighted sum of the spatial sine and cosine phase components. Because the contrasts and temporal frequencies of the various components are mutually independent in each frame, the sine and cosine components can be counterphase modulated in temporal quadrature, yielding a single drifting grating. Using additional bit planes, multiple drifting gratings can be combined to form sine-wave plaid patterns. A large number of resultant plaid motions can be produced from a single image file because the temporal frequencies of all the components can be varied independently. For a graphics device having 8 bits/pixel, up to four drifting gratings may be combined, each having independently variable contrast and speed.

Mulligan, Jeffrey B.↗
NASA NTRS1989

Halftoning method for the generation of motion stimuli

This paper describes a novel computer-graphic technique for the generation of a broad class of motion stimuli for vision research, which uses color table animation in conjunction with a single base image. Using this technique, contrast and temporal frequency can be varied with a negligible amount of computation, once a single-base image is produced. Since only two-bit planes are needed to display a single drifting grating, an eight-bit/pixel display can be used to generate four-component plaids, in which each component of the plaid has independently programmable contrast and temporal frequency. Because the contrast and temporal frequencies of the various components are mutually independent, a large number of two-dimensional stimulus motions can be produced from a single image file.

Mulligan, Jeffrey B.↗
NASA NTRS1990

Processing of form stimuli presented unilaterally in humans, chimpanzees (Pan troglodytes), and monkeys (Macaca mulatta)

Visual forms were unilaterally presented using a video-task paradigm to ten humans, chimpanzees, and two rhesus monkeys to determine whether hemispheric advantages existed in the processing of these stimuli. Both accuracy and reaction time served as dependent measures. For the chimpanzees, a significant right hemisphere advantage was found within the first three test sessions. The humans and monkeys failed to show a hemispheric advantage as determined by accuracy scores. Analysis of reaction time data revealed a significant left hemisphere advantage for the monkeys. A visual half-field x block interaction was found for the chimpanzees, with a significant left visual field advantage in block two, whereas a right visual field advantage was found in block four. In the human subjects, a left visual field advantage was found in block three when they used their right hands to respond. The results are discussed in relation to recent reports of hemispheric advantages for nonhuman primates.

Hopkins, William D.↗
NASA NTRS1989

Behavior of human horizontal vestibulo-ocular reflex in response to high-acceleration stimuli

The horizontal vestibulo-ocular reflex (VOR) during transient, high-acceleration (1900-7100 deg/sec-squared) head rotations was studied in four human subjects. Such stimuli perturbed the angle of gaze and caused illusory movement of a viewed target (oscillopsia). The disturbance of gaze could be attributed to the latency of the VOR (which ranged from 6-15 ms) and inadequate compensatory eye rotations (median VOR gain ranged from 0.61-0.83).

Maas, E. F.↗
NASA NTRS1992

Beta-endorphin and arginine vasopressin following stressful sensory stimuli in man

This experimentation partially defines, for the first time, the response of beta-endorphin (ENDO) in man during tests designed to elicit nausea and motion sickness. These responses are similar to those associated with arginine vasopressin (AVP) and adreno-corticotropin (ACTH) to the extent that all hormones rise in response to motion sickness (p less than 0.003). Repeated exposure diminished motion-induced release of ENDO (p less than 0.005) and AVP (p less than 0.004) despite a three-fold increase in resistance to motion stimuli. Higher post-stress levels of AVP (p less than 0.04) and ACTH (p less than 0.02) were correlated with greater resistance to motion sickness. These data support the hypothesis that release of AVP is a significant link between stressful motion and motion-induced nausea and other autonomic system changes. Further, resistant individual apparently can tolerate higher peripheral levels of AVP before nausea results. Peripheral release of ENDO and ACTH may follow release of AVP; however, given the extensive and complex functional interactions that exist between AVP and the opiate systems, it is not yet possible to define a clear role for ENDO in the etiology of motion sickness.

Kohl, Randall L.↗
NASA NTRS1992

Catecholaminergic responses to stressful motion stimuli, scopolamine plus amphetamine, and dexamethasone

Peripheral levels of epinephrine (EPI) and neoepinephrine (NE) generally rise following stressful motion stimuli. Effective anti-motion sickness drugs, scopolamine plus, d-amphetamine (S/D) and dexamthasone (DEX) modulate release of EPI and NE. This modulation may be of etiological relevance. Methods: Severe nausea was induced by exposure to coriolis simulation using a rotating chair. Chronic administration of S/D (0.4 and 5 mg/da) DEX (3 mg/day) and placebo preceded coriolis simulation. EPI and NE were measured immediately before and after simulation. A double-blind crossover design was used. Results: Nausea-induced elevations of EPI (2.5 fold, p less than .01) and NE were not diminished upon repeated exposure and adaptation to the stressor. Subjects with more pronounced elevations of EPI following simulation displayed higher resistance to stressful motion (p less .05). Alteration of peripheral catechlomaine levels following drug suggested that motion sickness was not mediated by peripheral catechlolamine receptor simulation. EPI and NE levels were 2.8 and 3.6-fold higher (p less than .03 and .01) after nausea without DEX treatment. DEX loading halved pre-stress levels of EPI and NE (p less than .05). Conclusions: Marked differences were noted in individual responses to drug and systematic responses of EPI and NE. It is possible that the responses of EPI to motion sickness may predict resistance to stressful motion and represent a peripheral manifestation of some as yet unknown central event of etiologic relevance.

Kohl, R. L.↗
NASA NTRS1999

Effects of Space Flight-Associated Stimuli on Development of Murine and Medaka Sensory-Motor Systems

The major goal of these studies was to continue investigations into the influence of altered gravitational fields on the development and function of the vertebrate brain and nervous system. Of major focus during the 18-month finding period of this award was the maintenance of the animals used in the experimental mouse and medaka model paradigms. The experiments focused on characterization of stress-sensitive periods in neural development and immediate or delayed effects on gene expression, physiology and behavior. The hypothesis under investigation was that the environment of space will have biologically significant effects on the development and function of the vertebrate nervous system. We have postulated that these effects will be more significant on certain neural compartments, such as the vestibular-motor system, and that these effects will have greater impact at particular stages of embryonic and post-natal development of the animal. Development of the central nervous system is well known for its vulnerability and sensitivity to environmental stimuli, although the effects of gravitational influences are poorly understood. The long-term goals of this research effort, initiated previously and continued in limited capacity during this interim period, were to provide important new information on the effects of altered environments during these critical periods.

Wolgemuth, Debra J.↗
NASA NTRS1996

Macular Preprocessing of Linear Acceleratory Stimuli: Implications for the Clinic

Three-dimensional reconstructions of innervation patterns in rat maculae were carried out using serial section images sent to a Silicon Graphics workstation from a transmission electron microscope. Contours were extracted from mosaicked sections, then registered and visualized using Biocomputation Center software. Purposes were to determine innervation patterns of type II cells and areas encompassed by vestibular afferent receptive fields. Terminals on type II cells typically are elongated and compartmentalized into parts varying in vesicular content; reciprocal and serial synapses are common. The terminals originate as processes of nearby calyces or from nerve fibers passing to calyces outside the immediate vicinity. Thus, receptive fields of the afferents overlap in unique ways. Multiple processes are frequent; from 4 to 6 afferents supply 12-16 terminals on a type II cell. Processes commonly communicate with two type II cells. The morphology indicates that extensive preprocessing of linear acceleratory stimuli occurs peripherally, as is true also of visual and olfactory systems. Clinically, this means that loss of individual nerve fibers may not be noticed behaviorally, due to redundancy (receptive field overlap). However, peripheral processing implies the presence of neuroactive agents whose loss can acutely or chronically alter normal peripheral function and cause balance disorders. (Platform presentation preferred - Theme 11)

Ross, M. D.↗
NASA NTRS1997

The Search for Optimal Visual Stimuli

In 1983, Watson, Barlow and Robson published a brief report in which they explored the relative visibility of targets that varied in size, shape, spatial frequency, speed, and duration (referred to subsequently here as WBR). A novel aspect of that paper was that visibility was quantified in terms of threshold contrast energy, rather than contrast. As they noted, this provides a more direct measure of the efficiency with which various patterns are detected, and may be more edifying as to the underlying detection machinery. For example, under certain simple assumptions, the waveform of the most efficiently detected signal is an estimate of the receptive field of the visual system's most efficient detector. Thus one goal of their experiment Basuto search for the stimulus that the 'eye sees best'. Parenthetically, the search for optimal stimuli may be seen as the most general and sophisticated variant of the traditional 'subthreshold summation' experiment, in which one measures the effect upon visibility of small probes combined with a base stimulus.

Watson, Andrew B.↗
NASA NTRS2002

Effect of 3-Day Bed Rest on the Basal Sympathetic Activity and Responsiveness of this System to Physiological Stimuli In Athletes and Sedentary Subjects

The aims of this study were: (1) to examine the effect of three days of bed rest (BR) on basal plasma epinephrine [E] and norepinephrine [NE] and the catecholamine responses to various physiological stimuli, and (2) to find out whether previous physical activity modifies effects of BR. In the first series, 29 young men (11 sedentary students, 8 endurance and 10 strength trained athletes) were submitted to oral glucose tolerance test in supine position and to active orthostatic test before and after 3 days of BR. Plasma [E] and [NE] were measured after overnight fast (basal condition), at 60, 120 and 180 min after glucose ingestion (70 a), and at the 8th min of unsupported standing. In the second series, other 22 subjects (12 sedentary students, 10 endurance and 10 strength trained athletes) were submitted to 2 min cold pressor test (CPT) and exercise. Plasma E and NE were determined in the supine position after overnight fast and at 60th and 120th s of hand cooling. Then, after breakfast followed by 2-3 hour sitting, the subjects performed cycle ergometer exercise with workload increasing until volitional exhaustion. Plasma [E] and [NE] were determined at the end of each load. Plasma catecholamines were determined made radioenzymatically. After BR, basal plasma [NE] was decreased in endurance and strength athletes (p<0.01) but not in sedentary subjects. In neither group BR affected the basal [E]. Responses of both catecholamines to glucose load were diminished after BR in all three groups (p<0.05) but the effect was most pronounced in the endurance athletes. All subjects tolerated well 8-min standing although their heart rate response was increased after BR. Plasma catecholamine responses standing were not significantly affected by BR in either group but the plasma [NE] and [E] during standing were lowered after BR in endurance athletes (p<0.01). BR did not affect blood pressure and catecholamine responses to CPT. The pre- and post-exercise plasma catecholamines were similar before and after BR although the subjects achieved lower maximal loads after BR. In endurance athletes the threshold for plasma NA rise occurred at lower work intensity after than before BR (p<0.05).

Smorawinski, Jerzy↗
NASA NTRS1992

Response of pontomedullary reticulospinal neurons to vestibular stimuli in vertical planes. Role in vertical vestibulospinal reflexes of the decerebrate cat

1. To investigate the neural substrate of vestibulospinal reflexes in decerebrate cats, we studied the responses of pontomedullary reticulospinal neurons to natural stimulation of the labyrinth in vertical planes. Our principal aim was to determine whether reticulospinal neurons that terminate in, or are likely to give off collaterals to, the upper cervical segments had properties similar to those of the vestibulocollic reflex (VCR). 2. Antidromic stimulation was used to determine whether the neurons projected to the neck, lower cervical, thoracic, or lumbar levels. Dynamics of the responses of spontaneously firing neurons were studied with sinusoidal stimuli delivered at 0.05-1 Hz and aligned to the plane of body rotation, that produced maximal modulation of the neuron (response vector orientation). Each neuron was assigned a vestibular input classification of otolith, vertical canal, otolith + canal, or spatial-temporal convergence (STC). 3. We found, in agreement with previous studies, that the largest fraction of pontomedullary reticulospinal neurons projected to the lumbar cord, and that only a small number ended in the neck segments. Neurons projecting to all levels of the spinal cord had similar responses to labyrinth stimulation. 4. Reticulospinal neurons that received only vertical canal inputs were rare (1 of 67 units). Most reticulospinal neurons (48%) received predominant otolith inputs, 18% received otolith + canal input, and only 9% had STC behavior. These data are in sharp contrast to the results of our previous studies of vestibulospinal neurons. A considerable portion of vestibulospinal neurons receives vertical canal input (38%), fewer receive predominantly otolith input (22%), whereas the proportion that have otolith + canal input or STC behavior is similar to our present reticulospinal data. 5. The response vector orientations of our reticulospinal neurons, particularly those with canal inputs (canal, otolith + canal, STC) were predominantly in the roll quadrants. There was no evidence of convergence of inputs from like canals across the midline (e.g., right anterior + left anterior). 6. Two characteristics of the VCR, STC behavior and bilateral input from symmetric vertical canals (in some muscles), cannot be accounted for by the reticulospinal neurons that we studied. Because these characteristics are also not seen in vestibulocollic neurons, they are likely to be the result of the appropriate convergence of vestibular signals in the spinal cord. 7. Pontomedullary reticulospinal neurons seem particularly well suited to play a role in gravity-dependent postural reflexes of neck and limbs.

NASA Discipline Neuroscience↗
NASA NTRS2009

Spatial Cognitive Performance During Adaptation to Conflicting Tilt-Translation Stimuli as a Sensorimotor Spaceflight Analog

The need to resolve new patterns of sensory feedback in altered gravitoinertial environments requires cognitive processes to develop appropriate reference frames for spatial orientation awareness. The purpose of this study was to examine deficits in spatial cognitive performance during adaptation to conflicting tilt-translation stimuli. Fourteen subjects were tilted within a lighted enclosure that simultaneously translated at one of 3 frequencies. Tilt and translation motion was synchronized to maintain the resultant gravitoinertial force aligned with the longitudinal body axis, resulting in a mismatch analogous to spaceflight in which the canals and vision signal tilt while the otoliths do not. Changes in performance on different spatial cognitive tasks were compared 1) without motion, 2) with tilt motion alone (pitch at 0.15, 0.3 and 0.6 Hz or roll at 0.3 Hz), and 3) with conflicting tilt-translation motion. The adaptation paradigm was continued for up to 30 min or until the onset of nausea. The order of the adaptation conditions were counter-balanced across 4 different test sessions. There was a significant effect of stimulus frequency on both motion sickness and spatial cognitive performance. Only 3 of 14 were able to complete the full 30 min protocol at 0.15 Hz, while 7 of 14 completed 0.3 Hz and 13 of 14 completed 0.6 Hz. There were no changes in simple visual-spatial cognitive tests, e.g., mental rotation or match-to-sample. There were significant deficits during 0.15 Hz adaptation in both accuracy and reaction time during a spatial reference task in which subjects are asked to identify a match of a 3D reoriented cube assemblage. Our results are consistent with antidotal reports of cognitive impairment that are common during sensorimotor adaptation with G-transitions. We conclude that these cognitive deficits stem from the ambiguity of spatial reference frames for central processing of inertial motion cues.

Kayanickupuram, A. J.↗
NASA NTRSDate not supplied

Generation of Precision Stimuli for Web-based and At-home Psychophysics

This oral presentation will present methods for “linearizing” a display to enable the delivery of precisely controlled stimuli in vision experiments, performing colorimetric calibrations using common objects, and testing for spatial and temporal nonlinearities.

visual display calibration↗