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NASA NTRS2005

Calcium Kinetics During Space Flight

Bone loss during space flight is one of the most critical challenges to astronaut health on space exploration missions. Defining the time course and mechanism of these changes will aid in developing means to counteract bone loss during space flight, and will have relevance for other clinical situations that impair weight-bearing activity. Bone health is a product of the balance between bone formation and bone resorption. Early space research could not clearly identify which of these was the main process altered in bone loss, but identification of the collagen crosslinks in the 1990s made possible a clear understanding that the impact of space flight was greater on bone resorption, with bone formation being unchanged or only slightly decreased. Calcium kinetics data showed that bone resorption was greater during flight than before flight (668 plus or minus 130 vs. 427 plus or minus 153 mg/d, p less than 0.001), and clearly documented that true intestinal calcium absorption was lower during flight than before flight (233 plus or minus 87 vs. 460 plus or minus 47 mg/d, p less than 0.01). Weightlessness had a detrimental effect on the balance in bone turnover: the difference between daily calcium balance during flight (-234 plus or minus 102 mg/d) and calcium balance before flight (63 plus or minus 75 mg/d) approached 300 mg/d (p less than 0.01). These data demonstrate that the bone loss that occurs during space flight is a consequence of increased bone resorption and decreased intestinal calcium absorption. Examining the changes in bone and calcium homeostasis in the initial days and weeks of space flight, as well as at later times on missions longer than 6 months, is critical to understanding the nature of bone adaptation to weightlessness. To increase knowledge of these changes, we studied bone adaptation to space flight on the 16-day Space Shuttle Columbia (STS-107) mission. When the brave and talented crew of Columbia were lost during reentry on the tragic morning of February 1, 2003, in a much smaller matter, the scientific products of this experiment, successfully obtained on orbit, were lost as well. As we begin to plan for missions back to the Moon, and even off to Mars, many questions remain to be answered. Counteracting bone loss is one of the greatest challenges. Calcium kinetics studies provide a valuable tool for assessing this loss, and evaluating countermeasures.

Smith, Scott M.↗
NASA NTRS2024

NASA Marshall Space Flight Center In-Space Cryogenic Propulsion Capabilities and Applications to Human Exploration

The current focus on lunar exploration and future human missions to Mars is driving in-space propulsion system requirements toward higher performance cryogenic systems with long-duration storage and operational capabilities. Not only do these systems offer higher performance than storable propellant options, but they also enable the potential for in-situ propellant production. Future Mars transit systems are envisioned to utilize either high-thrust nuclear thermal propulsion (with liquid hydrogen propellant), or hybrid systems with both cryogenic chemical systems (likely LOX/CH4) for high acceleration maneuvers and nuclear electric systems for long duration high Isp maneuvers. Exploration architectures based on either of these options require the use of high-performance cryogenic propellants with long-duration storage capabilities for both in-space transportation as well as planetary descent and ascent functions. Current efforts focusing on lunar exploration also rely on cryogenic propellants (either LOX/LCH4 or LOX/LH2) for lunar transit and descent/ascent transportation functions. In-space cryogenic propulsion systems pose numerous technology challenges with respect to long-duration propellant storage and usage, including advanced insulation, tank stratification and pressure management, cryogenic refrigeration to reduce propellant loss through boil off, low leakage cryogenic valves, low temperature liquid acquisition, and cryogenic propellant transfer. NASA has invested in technology development efforts, demonstrating individual technologies and systems-level operations. NASA Marshal Space Flight Center has also invested in multiple test facilities and modular test rigs that allow ground demonstration of numerous integrated technologies and systems concepts of operations. Additional investments have been made to mature analytical capabilities and design tools. These capabilities, both test/demonstration & engineering design/analysis, are available to support internal efforts and industrial partners in the development of exploration and science mission systems. With this increased interest, it is critical to understand the current state of in-space cryogenic propulsion technology, determine risks to its successful application to human exploration, and prepare the engineering, test, and evaluation capabilities to support the ambitious plans for future systems. This paper provides a survey of recent developments in in-space cryogenic propulsion and cryogenic propellant management technologies, as well as facilities and engineering/analytical capabilities ready to support current and future exploration efforts.

Cryogenic propulsion, cryogenic fluid management, ↗
NASA NTRS2024

NASA Marshall Space Flight Center In-Space Cryogenic Propulsion Capabilities and Applications to Human Exploration

The current focus on lunar exploration and future human missions to Mars is driving in-space propulsion system requirements toward higher performance cryogenic systems with long-duration storage and operational capabilities. Not only do these systems offer higher performance than storable propellant options, but they also enable the potential for in-situ propellant production. Future Mars transit systems are envisioned to utilize either high-thrust nuclear thermal propulsion (with liquid hydrogen propellant), or hybrid systems with both cryogenic chemical systems (likely LOX/CH4) for high acceleration maneuvers and nuclear electric systems for long duration high Isp maneuvers. Exploration architectures based on either of these options require the use of high-performance cryogenic propellants with long-duration storage capabilities for both in-space transportation as well as planetary descent and ascent functions. Current efforts focusing on lunar exploration also rely on cryogenic propellants (either LOX/LCH4 or LOX/LH2) for lunar transit and descent/ascent transportation functions. In-space cryogenic propulsion systems pose numerous technology challenges with respect to long-duration propellant storage and usage, including advanced insulation, tank stratification and pressure management, cryogenic refrigeration to reduce propellant loss through boil off, low leakage cryogenic valves, low temperature liquid acquisition, and cryogenic propellant transfer. NASA has invested in technology development efforts, demonstrating individual technologies and systems-level operations. NASA Marshal Space Flight Center has also invested in multiple test facilities and modular test rigs that allow ground demonstration of numerous integrated technologies and systems concepts of operations. Additional investments have been made to mature analytical capabilities and design tools. These capabilities, both test/demonstration & engineering design/analysis, are available to support internal efforts and industrial partners in the development of exploration and science mission systems. With this increased interest, it is critical to understand the current state of in-space cryogenic propulsion technology, determine risks to its successful application to human exploration, and prepare the engineering, test, and evaluation capabilities to support the ambitious plans for future systems. This paper provides a survey of recent developments in in-space cryogenic propulsion and cryogenic propellant management technologies, as well as facilities and engineering/analytical capabilities ready to support current and future exploration efforts.

Cryogenic propulsion, cryogenic fluid management, ↗
NASA NTRS2024

NASA Marshall Space Flight Center In-Space Cryogenic Propulsion Capabilities and Applications to Human Exploration

The current focus on lunar exploration and future human missions to Mars is driving in-space propulsion system requirements toward higher performance cryogenic systems with long-duration storage and operational capabilities. Not only do these systems offer higher performance than storable propellant options, but they also enable the potential for in-situ propellant production. Future Mars transit systems are envisioned to utilize either high-thrust nuclear thermal propulsion (with liquid hydrogen propellant), or hybrid systems with both cryogenic chemical systems (likely LOX/CH 4 ) for high acceleration manoeuvres and nuclear electric systems for long duration high Isp manoeuvres. Exploration architectures based on either of these options require the use of high-performance cryogenic propellants with long-duration storage capabilities for both in-space transportation as well as planetary descent and ascent functions. Current efforts focusing on lunar exploration also rely on cryogenic propellants (either LOX/LCH 4 or LOX/LH 2 ) for lunar transit and descent/ascent transportation functions. In-space cryogenic propulsion systems pose numerous technology challenges with respect to long-duration propellant storage and usage, including advanced insulation, tank stratification and pressure management, cryogenic refrigeration to reduce propellant loss through boil off, low leakage cryogenic valves, low temperature liquid acquisition, and cryogenic propellant transfer. NASA has invested in technology development efforts, demonstrating individual technologies and systems-level operations. NASA Marshal Space Flight Center has also invested in multiple test facilities and modular test rigs that allow ground demonstration of numerous integrated technologies and systems concepts of operations. Additional investments have been made to mature analytical capabilities and design tools. These capabilities (both test/demonstration & engineering design/analysis) are available to support both internal efforts and industrial partners in the development of exploration and science mission systems. With this increased interest, it is critical to understand the current state of in-space cryogenic propulsion technology, determine risks to its successful application to human exploration, and prepare the engineering, test, and evaluation capabilities to support the ambitious plans for future systems. This paper provides a survey of recent developments in in-space cryogenic propulsion and cryogenic propellant management technologies, as well as facilities and engineering/analytical capabilities ready to support current and future exploration efforts.

Cryogenic propulsion↗
NASA NTRS2024

NASA Marshall Space Flight Center In-Space Cryogenic Propulsion Capabilities and Applications to Human Exploration

The current focus on lunar exploration and future human missions to Mars is driving in-space propulsion system requirements toward higher performance cryogenic systems with long-duration storage and operational capabilities. Not only do these systems offer higher performance than storable propellant options, but they also enable the potential for in-situ propellant production. Future Mars transit systems are envisioned to utilize either high-thrust nuclear thermal propulsion (with liquid hydrogen propellant), or hybrid systems with both cryogenic chemical systems (likely LOX/CH 4 ) for high acceleration manoeuvres and nuclear electric systems for long duration high Isp manoeuvres. Exploration architectures based on either of these options require the use of high-performance cryogenic propellants with long-duration storage capabilities for both in-space transportation as well as planetary descent and ascent functions. Current efforts focusing on lunar exploration also rely on cryogenic propellants (either LOX/LCH 4 or LOX/LH 2 ) for lunar transit and descent/ascent transportation functions. In-space cryogenic propulsion systems pose numerous technology challenges with respect to long-duration propellant storage and usage, including advanced insulation, tank stratification and pressure management, cryogenic refrigeration to reduce propellant loss through boil off, low leakage cryogenic valves, low temperature liquid acquisition, and cryogenic propellant transfer. NASA has invested in technology development efforts, demonstrating individual technologies and systems-level operations. NASA Marshal Space Flight Center has also invested in multiple test facilities and modular test rigs that allow ground demonstration of numerous integrated technologies and systems concepts of operations. Additional investments have been made to mature analytical capabilities and design tools. These capabilities (both test/demonstration & engineering design/analysis) are available to support both internal efforts and industrial partners in the development of exploration and science mission systems. With this increased interest, it is critical to understand the current state of in-space cryogenic propulsion technology, determine risks to its successful application to human exploration, and prepare the engineering, test, and evaluation capabilities to support the ambitious plans for future systems. This paper provides a survey of recent developments in in-space cryogenic propulsion and cryogenic propellant management technologies, as well as facilities and engineering/analytical capabilities ready to support current and future exploration efforts.

Cryogenic propulsion↗
NASA NTRS2010

Custom Gradient Compression Stockings May Prevent Orthostatic Intolerance in Astronauts After Space Flight

Orthostatic intolerance after space flight is still an issue for astronauts as no in-flight countermeasure has been 100% effective. NASA astronauts currently wear an inflatable anti-gravity suit (AGS) during re-entry, but this device is uncomfortable and loses effectiveness upon egress from the Shuttle. We recently determined that thigh-high, gradient compression stockings were comfortable and effective after space flight, though to a lesser degree than the AGS. We also recently showed that addition of splanchnic compression to this thigh-high compression stocking paradigm improved orthostatic tolerance to a level similar to the AGS, in a ground based model. Purpose: The purpose of this study was to evaluate a new, three-piece breast-high gradient compression garment as a countermeasure to post-space flight orthostatic intolerance. Methods: Eight U.S. astronauts have volunteered for this experiment and were individually fitted for a three-piece, breast-high compression garment to provide 55 mmHg compression at the ankle which decreased to approximately 20 mmHg at the top of the leg and provides ~15 mmHg over the abdomen. Orthostatic testing occurred 30 days pre-flight (w/o garment) and ~2 hours after flight (w/ garment) on landing day. Blood pressure (BP), Heart Rate (HR) and Stroke Volume (SV) were acquired for 2 minutes while the subject lay prone and then for 3.5 minutes after the subject stands up. To date, two astronauts have completed pre- and post-space flight testing. Data are mean SD. Results: BP [pre (prone to stand): 137+/-1.6 to 129+/-2.5; post: 130+/-2.4 to 122+/-1.6 mmHg] and SV [pre (prone to stand): 61+/-1.6 to 38+/-0.2; post: 58+/-6.4 to 37+/-6.0 ml] decreased with standing, but no differences were seen post-flight w/ compression garments compared to pre-flight w/o garments. HR [pre (prone to stand): 66+/-1.6 to 74+/-3.0, post: 67+/-5.6 to 78+/-6.8 bpm] increased with standing, but no differences were seen pre- to post-flight. Conclusion: After space flight, blood pressure and stroke volume are normally decreased and heart rate is usually elevated to compensate. In this small group of subjects, breast-high gradient compression stockings seem to have prevented these negative effects of spaceflight.

Stenger, Michael B.↗
NASA NTRS2017

Marshall Space Flight Center Technology Capabilities for Use in Space Situational Awareness Activities

Marshall performs research, integrates information, matures technologies, and enhances science to bring together a diverse portfolio of products and services of interest for Space Situational Awareness (SSA) and Space Asset Management (SAM), all of which can be accessed through partnerships with Marshall. Integrated Space Situational Awareness and Asset Management (ISSAAM) is an initiative of NASA's Marshall Space Flight Center to improve space situational awareness and space asset management through technical innovation, collaboration, and cooperation with U.S. Government agencies and the global space community. Marshall Space Flight Center provides solutions for complex issues with in-depth capabilities, a broad range of experience, and expertise unique in the world, and all available in one convenient location. NASA has longstanding guidelines that are used to assess space objects. Specifically, Marshall Space Flight Center has the capabilities, facilities and expertise to address the challenges that space objects, such as near-Earth objects (NEO) or Orbital Debris pose. ISSAAM's three pronged approach brings together vital information and in-depth tools working simultaneously toward examining the complex problems encountered in space situational awareness. Marshall's role in managing, understanding and planning includes many projects grouped under each prong area: Database/Analyses/Visualization; Detection/Tracking/ Mitigation/Removal. These are not limited to those listed below.

Gagliano, Larry↗
NASA NTRS2013

Movable Ground Based Recovery System for Reuseable Space Flight Hardware

A reusable space flight launch system is configured to eliminate complex descent and landing systems from the space flight hardware and move them to maneuverable ground based systems. Precision landing of the reusable space flight hardware is enabled using a simple, light weight aerodynamic device on board the flight hardware such as a parachute, and one or more translating ground based vehicles such as a hovercraft that include active speed, orientation and directional control. The ground based vehicle maneuvers itself into position beneath the descending flight hardware, matching its speed and direction and captures the flight hardware. The ground based vehicle will contain propulsion, command and GN&C functionality as well as space flight hardware landing cushioning and retaining hardware. The ground based vehicle propulsion system enables longitudinal and transverse maneuverability independent of its physical heading.

Sarver, George L.↗
NASA NTRS2010

Acute and Chronic Exposure to CO2 in Space Flight

Spacecraft and space stations, similar to other habitable confined spaces such as submarines, need to provide a breathable atmosphere for their inhabitants. The inevitable production of CO2 during respiration necessitates life support systems that "scrub" the atmosphere and lower CO2 levels. Due to operational limitations associated with space flight (limited mass, volume, power, and consumables) CO2 is not scrubbed down to its terrestrial equivalent of 0.03% CO2 (ppCO2 of 0.23 mmHg), but is kept below 0.7% (ppCO2 of 5.3 mmHg), a level established in NASA s 180-day mission Spacecraft Maximum Allowable Concentration (SMAC) to be safe and unlikely to cause symptoms. Reports of space flight crewmembers becoming symptomatic with headaches, fatigue, and malaise at levels below those known to cause such symptoms terrestrially has prompted studies measuring the levels of CO2 on both the space shuttle and the space station. Data from cabin atmosphere sampling were collected on space shuttle missions STS-113, STS-122, STS-123, and International Space Station Expeditions 12-15 and 17, and the measured CO2 levels were then correlated to symptoms reported by the crew. The results indicate that a correlation exists between CO2 levels and symptomatology, however causality cannot be established at this time. While the short-term effects of elevated CO2 exposure are well known terrestrially, less is known regarding potential long-term effects of prolonged exposure to a CO2-rich environment or how the physiological changes caused by microgravity may interact with such exposures. Other challenges include limitations in the CO2 monitors used, lack of convection in the microgravity environment, and formation of localized CO2 pockets. As it is unclear if the unique environment of space increases sensitivity to CO2 or if other confounding factors are present, further research is planned to elucidate these points. At the same time, efforts are underway to update the SMAC to a lower level

Alexander, D.↗
NASA NTRS2010

Vestibular-Somatosensory Convergence in Head Movement Control During Locomotion after Long-Duration Space Flight

Exposure to the microgravity conditions of space flight induces adaptive modification in the control of vestibular-mediated reflexive head movement during locomotion after space flight. Space flight causes astronauts to be exposed to somatosensory adaptation in both the vestibular and body load-sensing (BLS) systems. The goal of these studies was to examine the contributions of vestibular and BLS-mediated somatosensory influences on head movement control during locomotion after long-duration space flight. Subjects were asked to walk on a treadmill driven at 1.8 m/s while performing a visual acuity task. Data were collected using the same testing protocol from three independent subject groups; 1) normal subjects before and after exposure to 30 minutes of 40% bodyweight unloaded treadmill walking, 2) bilateral labyrinthine deficient (LD) patients and 3) astronauts who performed the protocol before and after long duration space flight. Motion data from head and trunk segmental motion data were obtained to calculate the angular head pitch (HP) movements during walking trials while subjects performed the visual task, to estimate the contributions of vestibular reflexive mechanisms in HP movements. Results showed that exposure to unloaded locomotion caused a significant increase in HP movements, whereas in the LD patients the HP movements were significantly decreased. Astronaut subjects results showed a heterogeneous response of both increases and decreases in the amplitude of HP movement. We infer that BLS-mediated somatosensory input centrally modulates vestibular input and can adaptively modify head-movement control during locomotion. Thus, space flight may cause a central adaptation mediated by the converging vestibular and body load-sensing somatosensory systems.

Mulavara, Ajitkumar↗
NASA NTRS2004

Human Space Flight

The first human space flight, in the early 1960s, was aimed primarily at determining whether humans could indeed survive and function in micro-gravity. Would eating and sleeping be possible? What mental and physical tasks could be performed? Subsequent programs increased the complexity of the tasks the crew performed. Table 1 summarizes the history of U.S. space flight, showing the projects, their dates, crew sizes, and mission durations. With over forty years of experience with human space flight, the emphasis now is on how to design space vehicles, habitats, and missions to produce the greatest returns to human knowledge. What are the roles of the humans in space flight in low earth orbit, on the moon, and in exploring Mars?

Woolford, Barbara↗
NASA NTRS1993

Capabilities and constraints of typical space flight hardware

The Space Experiments Division is in the business of performing ground based low gravity testing and designing experiment hardware for space flight on the Space Shuttle and in the future, Space Station Freedom. As witnessed in combustion work, the reduction of gravity brings forward previously negligible processes and parameters. In a similar manner, the design of experiments for microgravity operation aboard the Space Shuttle must consider parameters that are often not factors for laboratory hardware.

Koudelka, John M.↗
NASA NTRS2000

Earth Science Microwave Remote Sensing at NASA's Goddard Space Flight Center

The Goddard Space Flight Center (GSFC) was established as NASA's first space flight center in 1959. Its 12,000 personnel are active in the Earth and space sciences, astronomy, space physics, tracking and communications. GSFC's mission is to expand our knowledge of the Earth and its environment, the solar system, and the universe through observations from space. The main Goddard campus is located in Greenbelt, Maryland, USA, just north of Washington, D.C. The Wallops Flight Facility (operational since 1945), located on the Atlantic coast of Virginia was consolidated with the Goddard Space Flight Center in 1982. Wallops is now NASA's principal facility for management and implementation of suborbital research programs, and supports a wide variety of airborne science missions as well. As the lead Center for NASA's Earth Science Enterprise (ESE)--a long-term, coordinated research effort to study the Earth as a global environmental system--GSFC scientists and engineers are involved in a wide range of Earth Science remote sensing activities. Their activities range from basic geoscience research to the development of instruments and technology for space missions, as well as the associated Calibration/Validation (Cal/Val) work. The shear breadth of work in these areas precludes an exhaustive description here. Rather, this article presents selected brief overviews of microwave-related Earth Science applications and the ground-based, airborne, and space instruments that are in service, under development, or otherwise significantly involving GSFC. Likewise, contributing authors are acknowledged for each section, but the results and projects they describe represent the cumulative efforts of many persons at GSFC as well as at collaborating institutions. For further information, readers are encouraged to consult the listed websites and references.

Kim, Edward↗
NASA NTRS2003

Effects of the space flight environment on the immune system

Space flight conditions have a dramatic effect on a variety of physiologic functions of mammals, including muscle, bone, and neurovestibular function. Among the physiological functions that are affected when humans or animals are exposed to space flight conditions is the immune response. The focus of this review is on the function of the immune system in space flight conditions during actual space flights, as well as in models of space flight conditions on the earth. The experiments were carried out in tissue culture systems, in animal models, and in human subjects. The results indicate that space flight conditions alter cell-mediated immune responses, including lymphocyte proliferation and subset distribution, and cytokine production. The mechanism(s) of space flight-induced alterations in immune system function remain(s) to be established. It is likely, however, that multiple factors, including microgravity, stress, neuroendocrine factors, sleep disruption, and nutritional factors, are involved in altering certain functions of the immune system. Such alterations could lead to compromised defenses against infections and tumors.

NASA Discipline Regulatory Physiology↗