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At least 73 records · Page 4

Damage to the photoreceptor cells of the rabbit retina from 56Fe ions: effect of age at exposure, 1

Optic and proximate tissues of New Zealand white (NZW) rabbits at ages (approximately 3.5 years) near the middle of their median lifespan (5-7 years) were given 0.5-3.5 Gy of 465 MeV u-1 56Fe ions in the Bragg plateau region of energy deposition at a linear energy transfer (LET infinity) of 220 +/- 31 keV micrometer-1. Dose-dependent losses of retinal photoreceptor cells (rods) occurred until 1-2 years after irradiation, the period of this interim report. Similar cumulative losses of photoreceptor cells were seen during the period 1-2 years post-irradiation for rabbits given comparable exposures when young (6-9 weeks old). Since losses of photoreceptor cells at early times had not been determined previously, the current experiment, which was designed to simulate the responses of mature astronauts, redressed that deficiency.

NASA Program NSCORT↗

Mapping by VESGEN of Blood Vessels in the Retinas of ISS Crew Members and Bed Rest Subjects for Increased Understanding of VIIP

Research by NASA has established that significant risks for visual impairment in association with increased intracranial pressure (VIIP) are incurred by microgravity spaceflight, especially long-duration missions. Impairments include decreased near visual acuity, posterior globe flattening, choroidal folds, optic disc edema, and cotton wool spots. Much remains to be learned about the etiology of VIIP before effective countermeasures can be developed. Contributions of retinal vascular remodeling to the etiology of VIIP have not yet been investigated, primarily due to the current lack of ophthalmic tools for precisely measuring progressive pathophysiological remodeling of the retinal microvasculature. Although ophthalmic science and clinical practice are now highly sophisticated at detecting indirect, secondary signs of vascular remodeling such as cotton wool spots that arise during the progression of retinal vascular diseases, methods for quantifying direct, primary vascular changes are not yet established. To help develop insightful analysis of retinal vascular remodeling for aerospace medicine, we will map and quantify by our innovative VESsel GENeration Analysis (VESGEN) software the remodeling status of retinal blood vessels in crew members before and after ISS missions, and in healthy human subjects before and after head-down tilt bed rest. For this proof-of-concept study, we hypothesize that pathophysiological remodeling of retinal blood vessels occurs in coordination with microgravity-induced fluid shifts prior to development of visual impairments. VESGEN analysis in previous research supported by the US National Institutes of Health identified surprising new opportunities to regenerate retinal vessels during early-stage progression of the visually impairing, potentially blinding disease, diabetic retinopathy.

ISS Crew↗

An "artificial retina" processor for track reconstruction at the full LHC crossing rate

Here, we present the latest results of an R&D; study for a specialized processor capable of reconstructing, in a silicon pixel detector, high-quality tracks from high-energy collision events at 40 MHz. The processor applies a highly parallel pattern-recognition algorithm inspired to quick detection of edges in mammals visual cortex. After a detailed study of a real-detector application, demonstrating that online reconstruction of offline-quality tracks is feasible at 40 MHz with sub-microsecond latency, we are implementing a prototype using common high-bandwidth FPGA devices.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

The artificial retina processor for track reconstruction at the LHC crossing rate

We present results of an R&D study for a specialized processor capable of precisely reconstructing, in pixel detectors, hundreds of charged-particle tracks from high-energy collisions at 40 MHz rate. We apply a highly parallel pattern-recognition algorithm, inspired by studies of the processing of visual images by the brain as it happens in nature, and describe in detail an efficient hardware implementation in high-speed, high-bandwidth FPGA devices. This is the first detailed demonstration of reconstruction of offline-quality tracks at 40 MHz and makes the device suitable for processing Large Hadron Collider events at the full crossing frequency.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Projections of scan patterns on human retina

Fundus camera tracks eye movements by using camera optics with the aid of an inverted system. Camera provides a flying-spot circular scanning light source in the normal film plane and a broadband photodetector in position normally occupied by light source.

Kelly, D. H.↗

Direct stimulation of the retina by the method of virtual-quanta for heavy cosmic-ray nuclei

The contribution to the frequency of visual sensations induced in the dark-adapted eye by the virtual photon field was calculated, this field is associated with the heavy nuclei that exist in space beyond the geomagnetic field. In order to determine the probability that the virtual photon field induces a light flash, only the portion of the virtual photon spectrum that corresponds to the known frequency dependence of the sensitivity of human rods to visible light was utilized. The results can be expressed as a curve of the mean frequency of light flashes induced by the absorption of at least R virtual photons versus the threshold number R. The contribution to the light flash frequency from the virtual photon field of heavy cosmic ray nuclei is smaller than that from Cerenkov photons. The flux and energy spectra of galactic cosmic ray nuclei helium to iron were used.

Mcnulty, P. J.↗

Visual perception of accelerated nitrogen nuclei interacting with the human retina.

Visual phenomena have now been observed in high-energy nitrogen beams produced at the Berkeley Bevatron. Using a nitrogen beam deflected at about 266 MeV/nucleon, three scientifically trained subjects made a series of observations. These observations confirm earlier hypotheses and argue for electronic excitation in or near the outer segments as the important mechanism. A picture showing a simplified anatomy of the left eye in horizontal section is presented. Three regions where various beam positions intercepted visual nervous structures are indicated.

Budinger, T. F.↗

Visual response time to colored stimuli in peripheral retina - Evidence for binocular summation

Simple onset response time (RT) experiments, previously shown to exhibit binocular summation effects for white stimuli along the horizontal meridian, were performed for red and green stimuli along 5 oblique meridians. Binocular RT was significantly shorter than monocular RT for a 45-min-diameter spot of red, green, or white light within eccentricities of about 50 deg from the fovea. Relatively large meridian differences were noted that appear to be due to the degree to which the images fall on corresponding retinal areas.

Haines, R. F.↗

Spectral consequences of photoreceptor sampling in the rhesus retina

Optical transforms were used to compute the power spectra of rhesus cones treated as arrays of image sampling points. Spectra were obtained for the central fovea, parafovea, periphery, and far periphery. All were consistent with a novel spatial sampling principle that introduces minimal noise for spatial frequencies below the Nyquist limits implied by local receptor densities, while frequencies above the nominal Nyquist limits are not converted into conspicuous moiree patterns, but instead are scattered into broadband noise. This sampling scheme allows the visual system to escape aliasing distortion despite a large mismatch between retinal image bandwidth and the Nyquist limits implied by extrafoveal cone densities.

Yellott, J. I., Jr.↗

The effect of a hyperdynamic environment on the development of the rat retina

The effects of a 2 G field on the retinal development of the layers in the rat and central visual system nuclei are investigated. The thickness of the retinal layers, ganglion cells, and brains of male and female Wistar rats suspended from an 18 foot diameter centrifuge creating a 2 G field are evaluated and compared with a control group. A decrease in the thickness of the outer nuclear layer (ONL) of 37.1 percent, of 58.5 percent in the inner nuclear layer (INL), and of 28.8 percent in the inner plexiform layer (IPL), and a reduction in body weight are observed in the 2-G rats. The data reveal that the ganglion cells and visual system nuclei activity correspond well with the control data; however, the medial terminal nucleus (MTN) activity is inhibited in the 2-G rats. It is concluded that the differences in ONL and IPL are attributed to body weight reduction, but the INL and MTN are affected by the 2-G conditions.

Murakami, D. M.↗

Relative Terrain Imaging Navigation (RETINA) Tool for the Asteroid Redirect Robotic Mission (ARRM)

As a part of the NASA initiative to collect a boulder off of an asteroid and return it to Lunar orbit, the Satellite Servicing Capabilities Office (SSCO) and NASA GSFC are developing an on-board relative terrain imaging navigation algorithm for the Asteroid Redirect Robotic Mission (ARRM). After performing several flybys and dry runs to verify and refine the shape, spin, and gravity models and obtain centimeter level imagery, the spacecraft will descend to the surface of the asteroid to capture a boulder and return it to Lunar Orbit. The algorithm implements Stereophotoclinometry methods to register landmarks with images taken onboard the spacecraft, and use these measurements to estimate the position and orientation of the spacecraft with respect to the asteroid. This paper will present an overview of the ARRM GN&C system and concept of operations as well as a description of the algorithm and its implementation. These techniques will be demonstrated for the descent to the surface of the proposed asteroid of interest, 2008 EV5, and preliminary results will be shown.

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