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At least 73 records · Page 4

Chromosome Model reveals Dynamic Redistribution of DNA Damage into Nuclear Sub-domains

Several proteins involved in the response to DNA double strand breaks (DSB) form microscopically visible nuclear domains, or foci, after exposure to ionizing radiation. Radiation-induced foci (RIF) are believed to be located where DNA damage is induced. To test this assumption, we analyzed the spatial distribution of 53BP1, phosphorylated ATM and gammaH2AX RIF in cells irradiated with high linear energy transfer (LET) radiation. Since energy is randomly deposited along high-LET particle paths, RIF along these paths should also be randomly distributed. The probability to induce DSB can be derived from DNA fragment data measured experimentally by pulsed-field gel electrophoresis. We used this probability in Monte Carlo simulations to predict DSB locations in synthetic nuclei geometrically described by a complete set of human chromosomes, taking into account microscope optics from real experiments. As expected, simulations produced DNA-weighted random (Poisson) distributions. In contrast, the distributions of RIF obtained as early as 5 min after exposure to high LET (1 GeV/amu Fe) were non-random. This deviation from the expected DNA-weighted random pattern can be further characterized by relative DNA image measurements. This novel imaging approach shows that RIF were located preferentially at the interface between high and low DNA density regions, and were more frequent in regions with lower density DNA than predicted. This deviation from random behavior was more pronounced within the first 5 min following irradiation for phosphorylated ATM RIF, while gammaH2AX and 53BP1 RIF showed very pronounced deviation up to 30 min after exposure. These data suggest the existence of repair centers in mammalian epithelial cells. These centers would be nuclear sub-domains where DNA lesions would be collected for more efficient repair.

Costes, Sylvain V.↗

Note on the Optimum Search Strategy for Uniformly Distributed CW Transmitters

The relative probability of detecting randomly distributed CW transmitters as a function of the fraction of the sky which is searched (in a fixed time) is given. It is shown that the probability of detecting such a class of transmitters with a given receiving system is a maximum if the entire sky is searched. The particular case of a search in which the number of directions searched is equal to the telescope gain and the integration time per beam element is equal to the reciprocal of the channel bandwidth is discussed.

Gulkis, S.↗

A model of the galactic tidal interaction with the Oort comet cloud

A model of the in situ Oort cloud which is isotropic with a random distribution of perihelia directions and angular momenta is considered. The energy distribution adopted has a continuous range of values appropriate for long-period (greater than 200 yr) comets. The evolution of 1,000,000 comets are tracked as they are made observable by the galactic tidal torque. Detailed results are obtained for the predicted distribution of new comets. Predictions of observed distributions are presented and compared with the random in situ results as well as with the actual observed distributions of class I comets. The predictions are in reasonable agreement with actual observations and, in many cases, are significantly different from random when perihelia directions are separated into galactic northern and southern hemispheres.

Matese, John J.↗

Apparent associations between bright galaxies and quasi-stellar objects.

A comparison of the spatial distribution of the 47 identified QSOs in the 3C and 3CR catalogs with the small-redshift galaxies contained in the Reference Catalog of Bright Galaxies shows that four QSOs with redshift in the range 0.5-1.4 are much closer to bright galaxies than would be expected if the 47 QSOs were distributed randomly. An extensive analysis of the distributions shows that the probability that this is a chance occurrence is less than 0.005. It is also shows that the radio-quiet QSO PHL 1226 lies very close to IC 1746 to which it appears to have a physical connection.

Burbidge, E. M.↗

Gravitational microlensing and gamma-ray bursts

Models of gravitational microlensing at small and large optical depth are presented, with a special emphasis on the time delays between microimages. The time distribution of microimage arrival times is random when the microobjects responsible for the lensing are randomly distributed. If the microobjects are clustered in space, then microimages are clustered in time. In some models there are many pairs of microimages with a very small time separation. It is proposed that the recently discovered recurrent soft gamma-ray burster GB 790107, for which more than 50 bursts were detected, is a single event multiply imaged due to gravitational microlensing by an ensemble of nonrandomly distributed microobjects, perhaps a rich cluster of galaxies. Some observational tests of this hypothesis are proposed. If correct, the hypothesis requires the burster to be at a cosmological distance, perhaps farther away than the most distant quasars.

Paczynski, Bohdan↗

Statistical analysis of mesoscale rainfall: Dependence of a random cascade generator on large-scale forcing

Under the theory of independent and identically distributed random cascades, the probability distribution of the cascade generator determines the spatial and the ensemble properties of spatial rainfall. Three sets of radar-derived rainfall data in space and time are analyzed to estimate the probability distribution of the generator. A detailed comparison between instantaneous scans of spatial rainfall and simulated cascades using the scaling properties of the marginal moments is carried out. This comparison highlights important similarities and differences between the data and the random cascade theory. Differences are quantified and measured for the three datasets. Evidence is presented to show that the scaling properties of the rainfall can be captured to the first order by a random cascade with a single parameter. The dependence of this parameter on forcing by the large-scale meteorological conditions, as measured by the large-scale spatial average rain rate, is investigated for these three datasets. The data show that this dependence can be captured by a one-to-one function. Since the large-scale average rain rate can be diagnosed from the large-scale dynamics, this relationship demonstrates an important linkage between the large-scale atmospheric dynamics and the statistical cascade theory of mesoscale rainfall. Potential application of this research to parameterization of runoff from the land surface and regional flood frequency analysis is briefly discussed, and open problems for further research are presented.

Over, Thomas, M.↗

Amyloplasts that sediment in protonemata of the moss Ceratodon purpureus are nonrandomly distributed in microgravity

Little is known about whether or how plant cells regulate the position of heavy organelles that sediment toward gravity. Dark-grown protonemata of the moss Ceratodon purpureus displays a complex plastid zonation in that only some amyloplasts sediment along the length of the tip cell. If gravity is the major force determining the position of amyloplasts that sediment, then these plastids should be randomly distributed in space. Instead, amyloplasts were clustered in the subapical region in microgravity. Cells rotated on a clinostat on earth had a roughly similar non-random plastid distribution. Subapical clusters were also found in ground controls that were inverted and kept stationary, but the distribution profile differed considerably due to amyloplast sedimentation. These findings indicate the existence of as yet unknown endogenous forces and mechanisms that influence amyloplast position and that are normally masked in stationary cells grown on earth. It is hypothesized that a microtubule-based mechanism normally compensates for g-induced drag while still allowing for regulated amyloplast sedimentation.

Non-NASA Center↗

High-accuracy computation of Delta V magnitude probability densities - Preliminary remarks

This paper describes an algorithm for the high accuracy computation of some statistical quantities of the magnitude of a random trajectory correction maneuver (TCM). The trajectory correction velocity increment Delta V is assumed to be a three-component random vector with each component being a normally distributed random scalar having a possibly nonzero mean. Knowledge of the statitiscal properties of the magnitude of a random TCM is important in the planning and execution of maneuver strategies for deep-space missions such as Galileo. The current algorithm involves the numerical integration of a set of differential equations. This approach allows the computation of density functions for specific Delta V magnitude distributions to high accuracy without first having to generate large numbers of random samples. Possible applications of the algorithm to maneuver planning, planetary quarantine evaluation, and guidance success probability calculations are described.

Chadwick, C.↗

The correlation function for density perturbations in an expanding universe. III The three-point and predictions of the four-point and higher order correlation functions

Higher-order correlation functions for the large-scale distribution of galaxies in space are investigated. It is demonstrated that the three-point correlation function observed by Peebles and Groth (1975) is not consistent with a distribution of perturbations that at present are randomly distributed in space. The two-point correlation function is shown to be independent of how the perturbations are distributed spatially, and a model of clustered perturbations is developed which incorporates a nonuniform perturbation distribution and which explains the three-point correlation function. A model with hierarchical perturbations incorporating the same nonuniform distribution is also constructed; it is found that this model also explains the three-point correlation function, but predicts different results for the four-point and higher-order correlation functions than does the model with clustered perturbations. It is suggested that the model of hierarchical perturbations might be explained by the single assumption of having density fluctuations or discrete objects all of the same mass randomly placed at some initial epoch.

Mcclelland, J.↗

Analysis of two-dimensional incompressible flows by a subsurface panel method

A new approach to panel methods is explored for two-dimensional steady incompressible flows. The method uses linear distributions of sources and vortices on straight-line panels, but satisfies boundary conditions on the actual body surface, at nodes that are also end points of the panels. The result is continuity in body-surface velocity distribution, without recourse to numerical quadrature for the velocity influence coefficients. The method is unusually sensitive to the distribution of the nodes. For example, it almost always fails to give acceptable results when the nodes are distributed randomly. However, the continuity of the velocity distribution makes possible a unique node redistribution scheme, which may be iterated to give accurate results reliably.

Moran, J.↗

Far field beam pattern of one MW combined beam of laser diode array amplifiers for space power transmission

The far-field beam pattern and the power-collection efficiency are calculated for a multistage laser-diode-array amplifier consisting of about 200,000 5-W laser diode arrays with random distributions of phase and orientation errors and random diode failures. From the numerical calculation it is found that the far-field beam pattern is little affected by random failures of up to 20 percent of the laser diodes with reference of 80 percent receiving efficiency in the center spot. The random differences in phases among laser diodes due to probable manufacturing errors is allowed to about 0.2 times the wavelength. The maximum allowable orientation error is about 20 percent of the diffraction angle of a single laser diode aperture (about 1 cm). The preliminary results indicate that the amplifier could be used for space beam-power transmission with an efficiency of about 80 percent for a moderate-size (3-m-diameter) receiver placed at a distance of less than 50,000 km.

Kwon, Jin H.↗

Optimal partitioning of random programs across two processors

The optimal partitioning of random distributed programs is discussed. It is concluded that the optimal partitioning of a homogeneous random program over a homogeneous distributed system either assigns all modules to a single processor, or distributes the modules as evenly as possible among all processors. The analysis rests heavily on the approximation which equates the expected maximum of a set of independent random variables with the set's maximum expectation. The results are strengthened by providing an approximation-free proof of this result for two processors under general conditions on the module execution time distribution. It is also shown that use of this approximation causes two of the previous central results to be false.

Nicol, D. M.↗

Optimal partitioning of random programs across two processors

The optimal partitioning of random-distributed programs is discussed. It is concluded that the optimal partitioning of a homogeneous random program over a homogeneous distributed system either assigns all modules to a single processor, or distributes the modules as evenly as possible among all processors. The analysis rests heavily on the approximation which equates the expected maximum of a set of independent random variables with the set's maximum expectation. The results are strengthened by providing an approximation-free proof of this result for two processors under general conditions on the module execution time distribution. It is also shown that use of this approximation causes two of the previous central results to be false.

Nicol, David M.↗

High Entropy Protected Sharp Magnetic Transitions in Highly Disordered Spinel Ferrites

How disorder affects magnetic ordering is always an intriguing question, and it becomes even more interesting in the recently rising high entropy oxides due to the extremely high disorder density. However, due to the lack of high-quality single crystal samples, the strong compositional disorder effect on magnetic transition has not been deeply investigated. In this work, we have successfully synthesized high-quality single crystalline high entropy spinel ferrites (Mg 0.2 Mn 0.2 Fe 0.2 Co 0.2 Ni 0.2 ) x Fe 3-x O 4 . Our findings from high-temperature magnetization and neutron diffraction experiments showed ferrimagnetic transitions at 748, 694, and 674 K for x values of 1, 1.5, and 1.8, respectively. Notably, the magnetic transition almost showed no broadening for x values of 1 and 1.5, compared to Fe 3 O 4 . Extended X-ray absorption fine structure measurements provided insights into the elemental distribution among the octahedral and tetrahedral sites. The random distribution of elements across these sites reduced the formation of local clusters and short-range orders, enhancing sample homogeneity and preserving the sharpness of the magnetic transition, despite bond length variation. Here, our study not only marks the first successful synthesis of an HEO bulk single crystal exhibiting long-range magnetic order but also sheds light on the interaction between high configurational entropy and magnetic orderings. This opens new avenues for future research and applications of magnetic high entropy oxides.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Remote Sensing of Earth Terrain

Theoretical models that are useful and practical in relating remote sensing data to the important physical parameters characterizing Earth terrain are developed. The development of models that are useful in data analysis and interpretation, scene simulation, and developing new remote sensing approaches and techniques is discussed. Numerous theoretical models that are applicable to the active and passive remote sensing of plowed fields, atmospheric precipitation, vegetation, and snow fields were developed. The radiative transfer theory is used to interpret the active and passive data as a function of rain rate. Both the random medium model and the discrete scatterer model is used to study the remote sensing of vegetation fields. Due to the non-spherical geometry of the scatterers there is strong azimuthal dependence in the observed data. Thus, the anisotropic random medium model and the discrete scatterer model with nonspherical particles was developed. In order to relate the remote sensing data to the actual physical parameters, the scattering of electromagnetic waves from randomly distributed dielectric scatterers was studied. Both the rigorous random discrete scatterer theory and the strong fluctuation theory are used to derive the backscattering cross section in terms of the actual physical parameters and the results agree well with the data obtained from the snow fields.

Kong, J. A.↗

Distribution and moments of radial error

An investigation of the moments and probability distribution of the resultant of two normally distributed random variables is presented. This is the so-called generalized Rayleigh distribution which has many applications in the study of wind shear, random noise, and radar. The most general formula was derived, and two special cases were considered for which tables of the moments and probability distribution functions are included as an appendix. One of the special cases was generalized to n-dimensions.

White, R. G.↗

Classical trajectory study of internal energy distributions in unimolecular processes

Energy flow in a molecular system such as CD3Cl or CD3H representing a chemical activation experiment is studied by the method of classical trajectories. A correlation function method is used to obtain energy distributions before and after the breakup of the activated molecule. The energy distribution in the final product is found to be randomly distributed for a surface with no exit channel barrier or strong intermode couplings. Nonrandom energy distributions result when these special forces are present. Product channel barriers result in an excess of translational energy and exit channel intermode couplings result in nonrandom vibrational distributions.

Mcdonald, J. D.↗