Engineering Papers⌕ Search

SEARCH · Engineering Papers

Results for “Neutron Noise”

Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 73 records · Page 4
All sourcesNASA NTRSDOE OSTI
NASA NTRS1987

Outer magnetospheric fluctuations and pulsar timing noise

The Cheng, Ho, and Ruderman (1986) outer-magnetosphere gap model was used to investigate the stability of Crab-type outer magnetosphere gaps for pulsars having the parameter (Omega-square B) similar to that of the Crab pulsar. The Lamb, Pines, and Shaham (1978) fluctuating magnetosphere noise model was applied to the Crab pulsar to examine the type of the equation of state that best describes the structure of the neutron star. The noise model was also applied to other pulsars, and the theoretical results were compared with observational data. The results of the comparison are consistent with the stiff equation of state, as suggested by the vortex creep model of the neutron star interior. The timing-noise observations also contribute to the evidence for the existence of superfluid in the core of the neutron star.

Cheng, K. S.↗
NASA NTRS1995

Propagation of nuclear burning fronts on accreting neutron stars: X-ray bursts and sub-hertz noise

We identify a new regime of time dependent helium burning for high accretion rate neutron stars and suggest that this burning is the origin of the low-level luminosity variations (on timescales of 10-10(exp 4) s, designated the 'very low-frequency noise'(VLFN) by van der Klis and collaborators) always detected in the brightest accreting X-ray sources. Only two nuclear burning regimes were previously recognized. At accretion rates in excess of the Eddington limit (dot-M approximately greater than (1-3) x 10(exp -8) solar mass/yr), the accreted matter fuses steadily. At very low dot-M, the star's entire surface is rapidly (approximately less than 10 s) burned by a fast propagating convective burning front at regular intervals, giving quasi-periodic Type I X-ray bursts. We show that for the observationally interesting range of 5 x 10(exp -10) solar mass/yr approximately less than dot-M approximately less than 10(exp -8) solar mass/yr, parts of the stellar surface burn slowly. At these accretion rates, a local thermonuclear instability starts a fire which propagates horizontally at v approximately 300 cm/s. The fire propagates around the flammable surface in roughly the same time it takes to accrete enough fuel for the next instability (approximately 10(exp 3)-10(exp 4), so that only a few fires are burning at once, giving rise to large luminosity flares. Nuclear burning is always time dependent for sub-Eddington local accretion rates: a local patch undergoes a recurrent cycle, accumulation fuel for hours until it becomes thermally unstable or is 'ignited' by a nearby burning region. The global pattern of burning and the resulting luminosity are thus very dependent on how fast nuclear fires spread around the star. The nuclear burning luminosity is not uniform over the stellar surface and so may provide a handle on measuring, or constraining, the spin periods of these neutron stars.

Bildsten, Lars↗
NASA NTRS2012

Estimation of Orbital Neutron Detector Spatial Resolution by Systematic Shifting of Differential Topographic Masks

We present a method and preliminary results related to determining the spatial resolution of orbital neutron detectors using epithermal maps and differential topographic masks. Our technique is similar to coded aperture imaging methods for optimizing photonic signals in telescopes [I]. In that approach photon masks with known spatial patterns in a telescope aperature are used to systematically restrict incoming photons which minimizes interference and enhances photon signal to noise. Three orbital neutron detector systems with different stated spatial resolutions are evaluated. The differing spatial resolutions arise due different orbital altitudes and the use of neutron collimation techniques. 1) The uncollimated Lunar Prospector Neutron Spectrometer (LPNS) system has spatial resolution of 45km FWHM from approx. 30km altitude mission phase [2]. The Lunar Rennaissance Orbiter (LRO) Lunar Exploration Neutron Detector (LEND) with two detectors at 50km altitude evaluated here: 2) the collimated 10km FWHM spatial resolution detector CSETN and 3) LEND's collimated Sensor for Epithermal Neutrons (SETN). Thus providing two orbital altitudes to study factors of: uncollimated vs collimated and two average altitudes for their effect on fields-of-view.

McClanahan, T. P.↗
NASA NTRS1989

The solar gamma ray and neutron capabilities of COMPTEL on the Gamma Ray Observatory

The imaging Compton telescope COMPTEL on the Gamma Ray Observatory (GRO) has unusual spectroscopic capabilities for measuring solar gamma-ray and neutron emission. The launch of the GRO is scheduled for June 1990 near the peak of the sunspot cycle. With a 30 to 40 percent probability for the Sun being in the COMPTEL field-of-view during the sunlit part of an orbit, a large number of flares will be observed above the 800 keV gamma-ray threshold of the telescope. The telescope energy range extends to 30 MeV with high time resolution burst spectra available from 0.1 to 10 MeV. Strong Compton tail suppression of instrumental gamma-ray interactions will facilitate improved spectral analysis of solar flare emissions. In addition, the high signal to noise ratio for neutron detection and measurement will provide new neutron spectroscopic capabilities. Specifically, a flare similar to that of 3 June 1982 will provide spectroscopic data on greater than 1500 individual neutrons, enough to construct an unambiguous spectrum in the energy range of 20 to 200 MeV. Details of the instrument and its response to solar gamma-rays and neutrons will be presented.

Ryan, James M.↗
DOE OSTI2020

Measurement uncertainty of rossi-alpha neutron experiments

Rossi-alpha neutron experiments are used to estimate the prompt neutron decay constant of a fissile assembly, a quantity of widespread interest in applications including in nuclear nonproliferation and criticality safety. This work develops a mathematical model to efficiently estimate measurement uncertainty of Rossi-alpha neutron experiments inferred from a two-exponential fit model with histogram binning. The derived uncertainty estimates were validated using repeated Rossi-alpha measurements of a subcritical, 4.5-kg sphere of weapons-grade, alpha-phase plutonium with nickel, copper, tungsten, and polyethylene reflectors. The estimates of uncertainty for the histogram data produced by the model were conservative and agree with the reference uncertainties within noise. The estimates of the prompt neutron decay constant uncertainty agreed with the reference uncertainties within one standard deviation. In conclusion, the proposed model will reduce total measurement times, ultimately reducing operational and procedural costs in application.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗
NASA NTRS1986

Vela X-1 pulse timing. I - Determination of the neutron star orbit

Analysis and interpretation of observations of the pulsed X-ray emission from Vela X-1 are presented. The interrelated tasks of determining the neutron-star orbit and calculating pulse emission times in the rest frame of the source are considered, with the underlying motivation to utilize this time series for analysis of fluctuations in the pulse emission frequency, which are interpreted as noise in the neutron-star rotation rate. However, the redness and strength of this noise in Vela X-1 pose a nontrivial complication, because the parameters of the neutron-star orbit are estimated by pulse timing and hence are themselves affected by fluctuations in the pulse emission frequency. A second challenge is presented by substantial fluctuations in the Vela X-1 pulse shape that, if ignored, would significantly reduce both the precision of the orbital solution and the ability to study fluctuations in the rotation rate. The report emphasizes the analysis techniques that have been developed to obtain the most precise orbital solution possible in the face of these difficulties. These techniques are general and may be applied to other pulsars that exhibit substantial fluctuations in pulse shape and frequency, such as Her X-1 and Cen X-3.

Boynton, P. E.↗
DOE OSTI2021

Neutron Transmission Imaging with a Portable D-T Neutron Generator

Fast-neutron transmission imaging provides complementary information to x-ray transmission imaging. While fast neutron imaging resolution is generally below x-ray imaging, 14-MeV neutrons have an advantage over portable x-ray systems. Neutrons have higher transmission through high-Z materials due to a more uniform attenuation as a function of material atomic number Z compared to X-rays, and can therefore image low-Z materials inside high-Z materials. As a result, portable neutron transmission imaging has many applications, including inspection of concrete and welds for corrosion in vehicles, bridges, and other infrastructure, measurement of material levels in containers, and inspection of suspicious packages. Fast-neutron imaging is also more practical for field use than thermal-neutron imaging due to the size and shielding requirements typical of thermal-imaging systems compared to the availability of small 14.1 MeV D-T neutron generators. However, there are limitations in portable fast-neutron imaging systems, including limited neutron output, limited light produced by neutron scintillators, and lower resolution due to neutron source spot size and 2-3 mm scintillator thickness. In addition, digital-panel dark-noise is roughly 100x higher than neutron scintillator light, and variations in noise across the panel and in time is comparable to the imaging signal. Here we discuss recent efforts in developing a portable fast-neutron radiography system, including an improved neutron scintillator, mitigation of panel noise, and new commercial portable D-T neutron generators. We also present MCNP efforts to model neutron imaging, including scintillator resolution and the effects of neutron scattering from the object and surrounding materials.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗
DOE OSTI2026

Upgrade and characterization of the fast-channels of Imaging Neutral Particle Analyzers in the DIII-D tokamak

This publication presents the characterization of the recently upgraded fast (MHz) channels of the DIII-D Imaging Neutral Particle Analyzers. The new system allows for a phase space resolution of < 10 keV and < 10 cm. The main source of noise is due to the background radiation (neutrons and gammas) present in the diagnostic lab during experiments, which can hit the photomultipliers and generate large spikes in signal. Good linear correlations (r 2 > 0.9) are found between the average rate of noise spikes in the fast channels and the average neutron rate. Additional noise is caused by the scintillation of the optical fibers used to guide the signal to the acquisition system, which is induced by neutron and gamma impacts. A correlation factor r 2 > 0.6 between the baseline noise caused by this scintillation and the signals in the neutron diagnostic was found. Possible mitigation strategies, such as the use of shielding and filters, are discussed. These allow to reduce the noise spike rate by an order of magnitude and the noise baseline by a factor 4. Despite the noise, it is shown that the upgraded fast channels provide enough signal-to-noise ratio to observe coherent fluctuations of the energetic particle population.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗
DOE OSTI2025

Welch Method and Bootstrapping Applied to Subcritical Gamma Noise

We measured the prompt neutron decay constant 𝛼 of the CROCUS zero-power reactor at the Swiss Federal Institute of Technology Lausanne using cross-power spectral density (CPSD) analysis of gamma-gamma correlations from two trans-stilbene organic scintillators positioned near the reactor core. We measured critical and subcritical states, with water levels ranging from 960 mm (critical) to 800 mm (𝜌=−1.4 $ subcritical). Our analysis used the Welch method, dividing signal segments for fast Fourier transform (FFT) frequency analysis and applying bootstrapping uncertainty quantification that uses Welch-defined segments. Results demonstrated a clear increase in the measured 𝛼 as reactor reactivity decreased, distinguishing critical from subcritical conditions. At the 960-mm critical level, 𝛼 was estimated at 155.9 ± 0.7 s −1 , and for the 800-mm subcritical level, 𝛼 increased significantly to 367.3 ± 6.9 s –1 . A linear regression of subcritical states yielded a critical estimate of 154.0 ± 3.1 s –1 , aligning with the static 𝛼 estimate at critical. The bootstrapping method produced normally distributed 𝛼 estimates, confirming data consistency. The gamma CPSD 𝛼 estimates clearly distinguish reactor states and improve monitoring of zero-power reactors. The future deployment of modular and microreactors as potential candidates for noise analysis is demonstrated in CROCUS, particularly zero-power mock-ups of new designs. The improvement of noise analysis in the subcritical domain from this work will support experimental data for reactor deployment and procedure.

CROCUS↗
DOE OSTI2022

Feynman-α analysis using BGO gamma-ray detector in UTR-KINKI reactor

In conventional reactor noise measurement based on neutron detection, a neutron detector must be placed as close to a core as possible, to observe a largest possible correlation amplitude. For most of reactors other than critical assemblies, however, the placement is hardly possible. We focused on an alternative reactor noise measurement using prompt gamma-rays having a long flight range, to overcome the above constraint. A Feynman-α analysis using a NaI(Tl) scintillation detector was previously performed in UTR-KINKI, however, white noise originating from radioactivation of the scintillator significantly degraded the correlation amplitude. In this study, another Feynman-α analysis using a BGO gamma-ray detector, which never suffers from any radioactivation, is performed. A series of Feynman-α analyses for a critical state and several subcritical states of UTR-KINKI reactor has been carried out using two BGO detectors and a BF{sub 3} neutron detector to determine prompt-neutron decay constant. In the present analysis, the dead-time effect of these detectors and the delayed-neutron effect are considered. The prompt-neutron decay constant determined from Feynman-α analysis based on gamma-ray detection agrees with that from the analysis based on neutron detection. The Feynman-α analysis based on detecting gamma rays appears to be able to determine prompt-neutron decay constant at least as efficiently as the conventional analysis detecting neutrons.

21 SPECIFIC NUCLEAR REACTORS AND ASSOCIATED PLANTS↗
NASA NTRS1997

Torque Reversal and Spin-Down of the Accretion-Powered Pulsar 4U 1626-67

Over 5 yr of hard X-ray (20-60 keV) monitoring of the 7.66 s accretion-powered pulsar 4U 1626-67 with the Compton Gamma Ray Observatory/BATSE large-area detectors has revealed that the neutron star is now steadily spinning down, in marked contrast to the steady spin-up and spin-down torques differ by only 15% with the neutron star spin changing on a timescale |v/v| approximately equals 5000 yr in both states. The current spin-down rate is itself decreasing on a timescale |v/v| approximately equals 26 yr. The long-term timing history shows small-amplitude variations on a 4000 day timescale, which are probably due to variations in the mass transfer rate. The pulsed 20-60 keV emission from 4U 1626-67 is well-fitted by a power-law spectrum with photon index gamma = 4.9 and a typical pulsed intensity of 1.5 x 10(exp -10) ergs cm (exp -2)s(exp -1). The low count rates with BATSE prohibited us from constraining the reported 42 minute binary orbit, but we can rule out long-period orbits in the range 2 days < or = P(orb) < or = 900 days. We compare the long-term torque behavior of 4U 1626-67 to other disk-fed accreting pulsars and discuss the implications of our results for the various theories of magnetic accretion torques. The abrupt change in the sign of the torque is difficult to reconcile with the extremely smooth spin-down now observed. The strength of the torque noise in 4U 1626-67, approximately 10(exp -22) Hz(exp 2)s(exp -2) Hz(exp -1), is the smallest ever measured for an accreting X-ray pulsar, and it is comparable to the timing noise seen in young radio pulsars. We close by pointing out that the core temperature and external torque (the two parameters potentially relevant to internal sources of timing noise) of an accreting neutron star are also comparable to those of young radio pulsars.

Chakrabarty, Deepto L.↗
DOE OSTI2025

Bayesian Gaussian process inference for neutron spin echo measurement

Neutron spin echo (NSE) spectroscopy provides unique access to microscopic dynamics, but its application is often constrained by low neutron flux, long acquisition times, and significant noise. Here, we present a Bayesian inference approach based on Gaussian process regression (GPR) to reconstruct high-quality spin echo signals from sparse and noisy data by exploiting correlations in reciprocal space. Benchmarks on synthetic datasets and validation with experimental NSE measurements of dendrimers show that GPR suppresses noise, interpolates missing intensity values, and accommodates irregular observations. The method improves accuracy, shortens acquisition times, and enables high-throughput and real-time studies. Beyond NSE, the framework is broadly applicable to other low signal-to-noise ratio scattering techniques, thereby extending the scope of neutron spectroscopy.

Tung, Chi-Huan [Oak Ridge National Laboratory (ORN↗
DOE OSTI2021

Growth and characterization of large (Y,La)TiO 3 and (Y,Ca)TiO 3 single crystals

The Mott-insulating rare-earth titanates ( R TiO 3 , with R being a rare-earth ion) are an important class of materials that encompasses interesting spin-orbital phases as well as ferromagnet-antiferromagnet and insulator-metal transitions. The growth of these materials has been plagued by difficulties related to overoxidation, which arises from a strong tendency of Ti 3 + to oxidize to Ti 4 + . We describe our efforts to grow sizable single crystals of YTiO 3 , Y 1 - x La x TiO 3 ( x ≤ 0.25 ), and Y 1 - y Ca y TiO 3 ( y ≤ 0.35 ) with the optical traveling-solvent floating-zone technique. Finally, we present sample characterization via chemical composition analysis, magnetometry, charge transport, neutron scattering, x-ray absorption spectroscopy, and x-ray magnetic circular dichroism to understand macroscopic physical property variations associated with overoxidation. Furthermore, we demonstrate a good signal-to-noise ratio in inelastic magnetic neutron scattering measurements of spin-wave excitations. A superconducting impurity phase, found to appear in Ca-doped samples at high doping levels, is identified as TiO.

36 MATERIALS SCIENCE↗
DOE OSTI2020

Imaging Based Detector with Efficient Scintillators for Neutron Diffraction Measurements

The Anger Camera developed by the detector group at the Oak Ridge National Laboratory was utilized for the present work for its unique advantage of employing multiple modules to obtain large active measurement area for detecting diffracted/scattered thermal neutrons. Considering the relatively small flux associated with diffracted/scattered neutrons, suitable efficiency with high spatial resolution is a requirement for utilizing two-dimensional imaging detectors. The potential to implement pulse shape (in addition to pulse height) discrimination-based scintillators further enhances the ability to detect diffracted neutrons with improved signal to noise ratio. In this paper, initial results associated with 6Li glass-based scintillator will be presented. The authors explored the feasibility of using this system to detect and quantify diffraction peaks and peak shifts at the Neutron Residual Stress Facility (NRSF2), High Flux Isotope Reactor (HFIR) in the Oak Ridge National Laboratory (ORNL). Suitable camera mounting and shielding had to be developed. Reference measurements using polycrystalline powders with known atomic planar spacing will be discussed along with measurement settings associated with expected resolution for peak shift measurements. Initial results are promising and demonstrate that a suitable scintillation-based neutron detecting system is viable for residual stress-based diffraction measurements. Small area detectors are also feasible with suitable consideration to scattering volume and distance to detector.

Seals, Matthew↗
DOE OSTI2025

Magnetic properties of a staggered S = 1 chain with an alternating single-ion anisotropy direction

Materials composed of spin-1 antiferromagnetic (AFM) chains are known to adopt complex ground states that are sensitive to the single-ion-anisotropy (SIA) energy ( D ), and intrachain ( J 0 ) and interchain ( J 1 , 2 ′ ) exchange energy scales. While theoretical and experimental studies have extended this model to include various other energy scales, the effect of the lack of a common SIA axis is not well explored. Here we investigate the magnetic properties of Ni ( pyrimidine ) ( H 2 O ) 2 ( NO 3 ) 2 , a chain compound where the tilting of Ni octahedra leads to a twofold alternation of the easy-axis directions along the chain. Muon-spin relaxation measurements indicate a transition to long-range order at T N = 2.3 K and the magnetic structure is initially determined to be antiferromagnetic and collinear using elastic neutron diffraction experiments. Inelastic neutron scattering measurements were used to find J 0 = 5.107 ( 7 ) K , D = 2.79 ( 1 ) K , J 1 ′ = 0.00 ( 5 ) K , J 2 ′ = 0.18 ( 3 ) K , and a rhombic anisotropy energy E = 0.19 ( 9 ) K . Mean-field modeling reveals that the ground state structure hosts spin canting of ϕ ≈ 6 . 5 ∘ , which is not detectable above the noise floor of the elastic neutron diffraction data. Monte Carlo simulation of the powder-averaged magnetization, M ( H ) , is then used to confirm these Hamiltonian parameters, while single-crystal M ( H ) simulations provide insight into features observed in the data. Published by the American Physical Society 2025

Vaidya, S. (ORCID:000000033975497X)↗
NASA NTRS1987

Pulse-timing study of Vela X-1 based on Hakucho and Tenma data - 1980-1984

The extensive observations of Vela X-1 acquired from 1980 to 1984 with the Hakucho and Tenma satellites, using a pulse-filtering technique that provides a significant improvement in pulse-timing precision, are reexamined. The details of the preparation of this data base, including the determination of updated orbital parameters based on these and previously published observations covering a 10-yr interval, are reported. Preparatory to estimation of angular-acceleration flux-correlation pairs, substantially improved estimates of the power density of fluctuations in the derivative of the pulse frequency on analysis periods between 0.5 and 80 days are presented. These results support the phenomenological hypothesis that unresolved fluctuations in the angular acceleration of the neutron star, describable as random noise, are responsible for the entire history of the observed variation in pulse frequency of Vela X-1 on all time scales longer than a few days.

Deeter, J. E.↗
DOE OSTI2022

Front-End Design for SiPM-Based Monolithic Neutron Double Scatter Imagers

Neutron double scatter imaging exploits the kinematics of neutron elastic scattering to enable emission imaging of neutron sources. Due to the relatively low coincidence detection efficiency of fast neutrons in organic scintillator arrays, imaging efficiency for double scatter cameras can also be low. One method to realize significant gains in neutron coincidence detection efficiency is to develop neutron double scatter detectors which employ monolithic blocks of organic scintillator, instrumented with photosensor arrays on multiple faces to enable 3D position and multi-interaction time pickoff. Silicon photomultipliers (SiPMs) have several advantageous characteristics for this approach, including high photon detection efficiency (PDE), good single photon time resolution (SPTR), high gain that translates to single photon counting capabilities, and ability to be tiled into large arrays with high packing fraction and photosensitive area fill factor. However, they also have a tradeoff in high uncorrelated and correlated noise rates (dark counts from thermionic emissions and optical photon crosstalk generated during avalanche) which may complicate event positioning algorithms. We have evaluated the noise characteristics and SPTR of Hamamatsu S13360-6075 SiPMs with low noise, fast electronic readout for integration into a monolithic neutron scatter camera prototype. The sensors and electronic readout were implemented in a small-scale prototype detector in order to estimate expected noise performance for a monolithic neutron scatter camera and perform proof-of-concept measurements for scintillation photon counting and three-dimensional event positioning.

47 OTHER INSTRUMENTATION↗
DOE OSTI2024

Neutrons in Structural Biology: Challenges and Opportunities (Workshop Report)

Gaining a thorough understanding of biological systems requires building our knowledge about biological processes from the level of atoms and electrons, and up to whole organisms. Such comprehensive knowledge will allow for a predictive understanding of complex biological systems behavior. It will guide us in the design and development of novel therapeutics and vaccines to tackle existing health threats and to prepare for future pandemics, and it will provide information necessary to create new biomaterials and bio-inspired technologies through manipulation of biological macromolecules, their assemblies, single cells and even microorganisms. Reaching these goals will require a synergistic combination of multiple experimental techniques with molecular calculations and predictive simulations, and the design and development of new techniques and capabilities that bridge current knowledge and technology gaps. Neutron scattering provides unique information about the biomacromolecular structure and function and can play a major role in achieving these goals. A workshop was held to engage the scientific community in identifying pressing challenges in biochemistry, structural biology, enzymology and structure-guided drug design not solved with the current neutron scattering technologies or utilizing other structural biology techniques such as X-ray crystallography, NMR, and cryo-EM. The workshop brought together structural biology, biochemistry and computational experts, as well as early career researchers and students, creating a forum for discussing scientific advancement and collaboration. The workshop included a one-day satellite training workshop where graduate students and postdoctoral researchers were educated in the application of neutron crystallography and small-angle scattering in structural biology. Furthermore, the Instrument Scientific Advisory Board (ISAB) for the development of a macromolecular neutron diffractometer at ORNL’s Second Target Station was introduced at the workshop. The major outcome was that neutrons can provide atomic-level understanding of biomacromolecular structure, function and dynamics which is of paramount importance for addressing the identified challenges. Neutron crystallography, in particular, can resolve long-standing biochemical issues regarding enzyme function by delineating the underlying chemistry and can have a major impact on the design of small-molecule therapeutics, especially in combination with molecular computation (quantum chemistry and molecular dynamics simulations) and the emerging artificial intelligence (AI)-assisted drug design technologies. The unique properties of neutrons, including their high sensitivity to hydrogen and their non-destructive nature, make them ideal probes of biological matter. There is a palpable need in the scientific community to expand and enhance the impact of neutron sciences on biology. Neutron crystallography is the only structural biology method capable of determining positions of all hydrogen atoms in proteins, nucleic acids and their complexes at near-physiological temperatures and of unstable species at cryogenic temperatures. Moreover, neutron analysis is non-ionizing, non-destructive and does not perturb the structure or redox chemistry of active site metal centers and clusters in proteins, which can be invaluable for studying radiation-sensitive metalloprotein complexes. Further, neutron energies used in scattering applications are similar to atomic motions, permitting neutron spectroscopies to characterize the dynamics of biomacromolecules on the picosecond to microsecond timescales. The different sensitivities of neutrons to protium (H) and deuterium (D) isotopes of hydrogen allow enhanced visibility of specific parts of biological complexes through isotopic labeling. The impact of neutrons will be most powerful when neutron scattering is combined with complementary experimental techniques that use photons and electrons, and with high-performance computing. The interconnection and mutuality of the experimental and theoretical capabilities will drive discoveries in biological and health sciences to generate more complete picture of complex biological systems. The major limitation in the field of biological neutron crystallography has been signal-to-noise, demanding large samples that are difficult to produce for the majority of biomacromolecules and limiting the applicability of this technique in biological sciences. A neutron crystallography instrument at the Second Target Station will revolutionize biological science with neutrons by engaging a large scientific community of structural biologists, enabling successful neutron diffraction experiments from radically smaller biomacromolecular crystals, resolving unanswered biochemical questions, and meaningfully contributing to rational drug design. The meeting highlighted 10 grand challenges that will be addressed with this advanced capability over the next decade and beyond, and the recommendations required to help address them are given below.

59 BASIC BIOLOGICAL SCIENCES↗