Transit shapes and self-organizing maps as a tool for ranking planetary candidates: application to Kepler and K2
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D. J. Armstrong↗
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Results for “K2”
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Microbial vitamin biosynthesis links gut microbiota dynamics to chemotherapy toxicity
ABSTRACT Dose-limiting toxicities pose a major barrier to cancer treatment. While preclinical studies show that the gut microbiota influences and is influenced by anticancer drugs, data from patients paired with careful side effect monitoring remains limited. Here, we investigate capecitabine (CAP)-microbiome interactions through longitudinal metagenomic sequencing of stool from 56 advanced colorectal cancer patients. CAP significantly altered the gut microbiome, enriching for menaquinol (vitamin K2) biosynthesis genes. Transposon library screens, targeted gene deletions, and media supplementation revealed that menaquinol biosynthesis protectsEscherichia colifrom drug toxicity. Stool menaquinol gene and metabolite levels were associated with decreased peripheral sensory neuropathy. Machine learning models trained in this cohort predicted toxicities in an independent cohort. Taken together, these results suggest treatment-associated increases in microbial vitamin biosynthesis serve a chemoprotective role for bacterial and host cells. Further, our findings provide a foundation for in-depth mechanistic dissection, human intervention studies, and extension to other cancer treatments. IMPORTANCE Side effects are common during the treatment of cancer. The trillions of microbes found within the human gut are sensitive to anticancer drugs, but the effects of treatment-induced shifts in gut microbes for side effects remain poorly understood. We profiled gut microbes in colorectal cancer patients treated with capecitabine and carefully monitored side effects. We observed a marked expansion in genes for producing vitamin K2 (menaquinone). Vitamin K2 rescued gut bacterial growth and was associated with decreased side effects in patients. We then used information about gut microbes to develop a predictive model of drug toxicity that was validated in an independent cohort. These results suggest that treatment-associated increases in bacterial vitamin production protect both bacteria and host cells from drug toxicity, providing new opportunities for intervention and motivating the need to better understand how dietary intake and bacterial production of micronutrients like vitamin K2 influence cancer treatment outcomes.
Microbiology↗
High resolution spectroscopy of the disk chromosphere. II - Time sequence observations of Ca II H and K emissions.
Two independent sets of high resolution time series spectra of the Ca II H and K emission obtained at the Solar Tower and at the Big Dome of the Sacramento Peak Observatory on September 11th, 1971 are reported. The evolutionary behavior of the emission first reported by Wilson and Evans is confirmed, but the detail of the evolution is found to be more complex. In one case, a doubly peaked feature showing some K3 emission evolves into a single K2 (red) peak with no K3 emission. Coincidentally, a neighboring doubly peaked feature evolves to a very strong blue peak. In an entirely independent sequence a doubly peaked feature evolves into a single red peak. The K2 emission then fades completely although the continuum threads are still strong. Finally a strong K2 blue peak appears. It is concluded that the observed evolution of the K2 emission is due to temporal variations in the physical conditions which give rise to them.
Wilson, P. R.↗
The First Year of KOKEE12M-WETTZ13S VGOS Intensive Scheduling: Status and Efforts Towards Improvement
The KOKEE12M-WETTZ13S (K2-Ws) Intensive series began on January 4, 2021. Evaluation of the first year of schedules has shown that the series is performing reasonably weel, but the schedules could be improved. For example, the number of scheduled observations in a typical 2021 K2-Ws session is approximately half that of the first few MACGO12M-WETTZ13S Intensive sessions, and scheduling fewer observations negatively impats UT1 results. Also, preliminary analysis of the scheduled and achieve SNRs of the K2-Ws observations and the SNRs' ratios shows examples where the achieved SNRs are either too high, indicating long observations that could have been replaced by a greater number of shorter observations, or too low, indicating a lack of robustness that could lead to observation loss. In this poster, we describe key aspects of how the K2-Ws Intensives have been scheduled in 2021. Then we discuss the areas of concern and the status of efforts to make improvements in these areas.
Karen Baver↗
Kinetics of the reactions of ClO with O and with NO
The rate constants k1, k2, and k3 for the reactions Cl + O3 yields ClO + O2 (1), ClO + O yields Cl + O2 (2), and ClO + NO yields Cl + NO2 (3), respectively, were measured by the discharge-flow technique, in which chlorine atoms are added to a flow of O3 and either O or NO in a helium carrier gas. The conditions of the experiment were such that the steady-state concentration ratios of Cl to ClO are simply interpretable in terms of the rate constant ratios k2/k3 or k3/k1. These rate constant ratios were measured over the range 220 to 298 K and combined with the directly determined k1 value to yield k2 and k3. The results are: k1 = 2.12 x 10 to the -11th exp(-157/T); k2 = 3.38 x 10 to -11th exp(75 plus or minus 40/T); and k3 = 1.13 x 10 to the -11th exp(200 plus or minus 30/T) cu cm/sec.
Zahniser, M. S.↗
Determination of stress intensity factors for interface cracks under mixed-mode loading
A simple technique was developed using conventional finite element analysis to determine stress intensity factors, K1 and K2, for interface cracks under mixed-mode loading. This technique involves the calculation of crack tip stresses using non-singular finite elements. These stresses are then combined and used in a linear regression procedure to calculate K1 and K2. The technique was demonstrated by calculating three different bimaterial combinations. For the normal loading case, the K's were within 2.6 percent of an exact solution. The normalized K's under shear loading were shown to be related to the normalized K's under normal loading. Based on these relations, a simple equation was derived for calculating K1 and K2 for mixed-mode loading from knowledge of the K's under normal loading. The equation was verified by computing the K's for a mixed-mode case with equal and normal shear loading. The correlation between exact and finite element solutions is within 3.7 percent. This study provides a simple procedure to compute K2/K1 ratio which has been used to characterize the stress state at the crack tip for various combinations of materials and loadings. Tests conducted over a range of K2/K1 ratios could be used to fully characterize interface fracture toughness.
Naik, Rajiv A.↗
Nonlocal effects on thermal transport in hydrodynamic simulations of unmagnetized MagLIF-relevant gaspipes on NIF
We present simulations of heat flow relevant to gaspipe experiments on the National Ignition Facility to investigate kinetic effects on transport phenomena. D 2 and neopentane (C 5 H 12 ) filled targets are used to study the laser preheat stage of a MagLIF scheme where an axial magnetic field is sometimes applied to the target. Simulations were done with the radiation-MHD code HYDRA with a collision-dominated fluid model and the SNB nonlocal electron thermal conduction model. Using the SNB model to evolve the electron temperature increased the heat front propagation of neopentane gas targets compared to a local model by limiting radial heat flow. This increases electron temperature near the axis, which decreases laser absorption. We find that the effect of heat flow models on temperature profiles and laser propagation is modest. Beyond the SNB model, we utilize HYDRA to initialize plasma conditions for the Vlasov–Fokker–Planck K2 code. We run K2 until a quasi-steady state is reached and examine the impact of kinetic effects on heat transport. Although axial heat flow is well predicted by fluid models, the fluid model consistently overpredicts radial heat flow up to 150% in regions with the largest temperature gradient of D 2 filled gaspipes. On the other hand, the SNB nonlocal electron conduction model is found to be adequate for capturing kinetic heat flow in gaspipes.
Lau, Ryan Y. [Univ. of Colorado, Boulder, CO (Unit↗
Tidal perturbations on the orbits of GEOS-1 and GEOS-2
Analysis of the luni-solar tidal perturbations of the inclination of GEOS-1 (1965-89A) and GEOS-2 (1968-002A) yielded the values k2 = 0.22 (sigma = 0.02) and 0.31 (sigma = 0.01) respectively for the second degree Love number. For GEOS-1 a new, purely numerical method involving osculating elements was employed. For GEOS-2 it was necessary to analyze the variations of the mean elements because of the very long period (450d) of the dominant solar tidal perturbation. An additional analysis of the variation of the mean elements of GEOS-1 confirmed the value of k2 obtained from the osculating elements.
Douglas, B. C.↗
The Apsidal-motion test for models of main-sequence stars
Apsidal-motion constants, k2, have been determined for models of homogeneous main-sequence stars constructed with the new 'Thomas-Fermi' opacities of Carson. These models are similar to those constructed with the 'hydrogenic' opacities of Cox and Stewart up to about 7 solar masses, but yield smaller values of k2 at higher masses. Nevertheless, the new theoretical constants are still systematically too large compared with most of the empirical constants known for members of well-observed binary systems. Uniform rotation is found to lower the theoretical constants only slightly. The effect of normal evolution during core hydrogen burning, however, produces good detailed agreement with observations. The primary of alpha Vir is probably evolving normally if Carson's opacities are adopted.
Stothers, R.↗
Ultraviolet observations of cool stars. IV - Intensities of Lyman-alpha and Mg II in epsilon Pegasi and epsilon Eridani, and line width-luminosity correlations
A spectrometer on the Copernicus satellite has been used to confirm the existence of a line width-luminosity relation for the Ly-alpha and Mg II 2800-A chromospheric emission lines in K-type stars by observation of a K2 dwarf (epsilon Eri) and a K2 supergiant (epsilon Peg). Combined with previously reported observations of lines in three K giants (alpha Boo, alpha Tau, and beta Gem), the data are consistent with an identical dependence of line width on absolute visual magnitude for the Ca II K, Ly-alpha, and Mg II 2795-A lines. Surface fluxes of Ly-alpha, Mg II 2800-A, and O V 1218-A (upper limit) for epsilon Eri, and of Mg II 2800-A for epsilon Peg are also compared with values reported previously for the three giant stars.
Mcclintock, W.↗
Effect of the reaction HO2 + O3 yields OH + 2O2 on stratospheric ozone
It is noted that recent measurements of large values of the rate coefficient for the reaction NO + HO2 yields NO2 + OH lead to model predictions of excessive amounts of stratospheric ozone. This letter shows that a recent measurement of the rate coefficient (k2) for the reaction HO2 + O3 yields OH + 2O2 largely resolves these problems of excessive stratospheric ozone in models. A two-dimensional model of stratospheric trace constituents is used to calculate the concentrations of 35 constituents; the results are compared with experimental measurements of ozone column densities. It is found that the model predictions of excess ozone abundances diminish significantly when the measured value of k2 is employed.
Whitten, R. C.↗
Jovian electron propagation out of the solar equatorial plane - Pioneer 11 observations
Jovian electron intensity in the energy range 2-7 MeV was measured along the trajectory of Pioneer 11 up to 16 deg heliographic latitude. These electrons have crossed the average direction of the interplanetary magnetic field, propagating normal to the solar equatorial plane, and their intensity continues to be modulated by corotating interaction regions over this latitude range. From these data, the electron diffusion coefficient perpendicular to the equatorial plane (K2 = 2 x 10 to the 20th sq cm/s) was derived to within a factor 2 using a three-dimensional diffusion-convection model and the values of the parallel and perpendicular diffusion coefficients in the solar equatorial plane (Ky = 5 x 10 to the 22nd sq cm/s, K2 = 10 to the 21st sq cm/s, respectively), which had previously successfully described Jovian electron propagation near the equatorial plane from 1 to about 10 AU. These results indicate that the Jovian electron intensity may be very low at high solar latitudes.
Hamilton, D. C.↗
Axions and SN 1987A: Axion trapping
If an axion of mass between about 10(exp -3) eV and 1 eV exists, axion emission would have significantly affected the cooling of the nascent neutron star associated with SN 1987A. For an axion of mass less than about 10(exp -2) eV, axions produced deep inside the neutron star simply stream out; in a previous paper this case has been addressed. Remarkably, for an axion of mass greater than about 10(exp -2) eV axions would, like neutrinos, have a mean-free path that is smaller than the size of a neutron star, and thus would become 'trapped' and radiated from an axion sphere. In this paper the trapping regime is treated by using numerical models of the initial cooling of a hot neutron star that incorporate a leakage approximation scheme for axion-energy transport. The axion opacity is computed due to inverse nucleon-nucleon, axion bremsstrahlung, and numerical models are used to calculate the integrated axion luminosity, the temperature of the axion sphere, and the effect of axion emission on the neutrino bursts detected by the Kamiokande 2 (K2) and Irvine-Michigan-Brookhaven (IMB) water-Cherenkov detectors. The larger the axion mass, the stronger the trapping and the smaller the axion luminosity. The earlier estimate is confirmed and refined of the axion mass above which trapping is so strong that axion emission does not significantly affect the neutrino burst. Based upon the neutrino-burst duration--the most sensitive barometer of axion cooling--it is concluded that for an axion mass of greater than about 0.3 eV, axion emission would not have had a significant effect on the neutrino bursts detected by K2 and IMB. The present work, together with the previous work, strongly suggests that an axion with mass in the interval 10(exp -3) eV to 0.3 eV is excluded by SN 1987A.
Burrows, Adam↗
Inference in fuzzy rule bases with conflicting evidence
Inference based on fuzzy 'If ... then' rules has played a very important role since when Zadeh proposed the Compositional Rule of Inference and, especially, since the first successful application presented by Mamdani. From the mid-1980's when the 'fuzzy boom' started in Japan, numerous industrial applications appeared, all using simplified techniques because of the high levels of computational complexity. Another feature is that antecedents in the rules are distributed densely in the input space, so the conclusion can be calculated by some weighted combination of the consequents of the matching (fired) rules. The CRI works in the following way: If R is a rule and A* is an observation, the conclusion is computed by B* = R o A* (o stands for the max-min composition). Algorithms implementing this idea directly have an exponential time complexity (maybe the problem is NP-hard) as the rules are relations in X x Y, a k1 x k2 dimensional space, if X is k1, Y is k2 dimensional. The simplified techniques usually decompose the relation into k1 projections in X(sub i) and measure in some way the degree of similarity between observation and antecedent by some parameter of the overlapping. These parameters are aggregated to a single value in (0,1) which is applied as a resulting weight for the given rule. The projections of rules in dimensions Y(sub i) are weighted by these aggregated values and then they are combined in order to obtain a resulting conclusion separately in every dimension. This method is unapplicable with sparse bases as there is no guarantee that an arbitrary observation matches with any of the antecedents. Then, the degree of similarity is 0 and all consequents are weighted by 0. Some considerations for such a situation are summarized in the next sections.
Koczy, Laszlo T.↗
The SOHO-Stellar Connection
I discusses practical aspects of the so-called "solar-stellar" connection; namely, the fundamental principles, the tools at the disposal of the stellar astronomer, and a few recent examples of the connection in action. I provide an overall evolutionary context for coronal activity, calling attention to the very different circumstances of low mass main sequence stars like the Sun, which are active mainly early in their lives; compared with more massive stars, whose coronally active phase occurs near the end of their lives, during their brief incursion into the cool half of the Hertzsprung-Russell diagram as yellow and then red giants. On the instrumental slide, I concentrate primarily on spectroscopy, in the ultraviolet and X-ray bands where coronae leave their most obvious signatures. I present an early glimpse of the type of moderate resolution spectra we can expect from the recently launched Chandra observatory, and contemporaneous HST STIS high-resolution UV measurements of the CXO calibration star Capella (alpha Aur; G8 III + G1 III). I compare STIS spectra of solar-type dwarfs-zeta Dor (F7 V), an active coronal source; and alpha Cen A (G2 V), a near twin of the Sun-to a trace obtained with the SOHO SUMER imaging UV spectrometer. I also compare STIS line profiles of the active coronal dwarf to the corresponding features in the mixed-activity "hybrid-chromosphere" bright giant alpha TrA (K2 II) and the archetype "noncoronal" red giant Arcturus (alpha Boo; K2 III). The latter shows dramatic evidence for a "cool absorber" in its outer atmosphere that is extinguishing the "hot lines" (like Si IV lambda1393 and N V lambda1238) below about 1500 A, probably through absorption in the Si I lambda1525 and C I lambda1240 photoionization continua. The disappearance of coronae across the "Linsky-Haisch" dividing line near K1 III thus apparently is promoted by a dramatic overturning in the outer atmospheric structure, namely the coronae of the red giants seem to lie beneath their extended chromospheres, rather than outside as in the Sun. I then discuss an intriguing long-slit STIS low-resolution observation of an X-ray active late-A dwarf in the nearby Hyades cluster: the spatially resolved UV spectroscopy clearly shows that a previously unseen close companion (a dKe or dMe) likely is responsible for the coronal activity, rather than some unexplained departure of the A dwarf from its expected state of X-ray dormancy. Finally, I describe early results from a joint observing campaign involving SOHO SUMER, TRACE, and the Kitt Peak Infrared Imaging Spectrometer, conducted May 1999, to explore the dynamics of the quiet solar atmosphere through the key "magnetic transition zone" that separates the kinetically dominated deep photosphere from the magnetically dominated coronal regime. Linking spatially and temporally resolved solar properties to aspects of the averaged lineshapes (for example: widths, asymmetries, intensity ratios, and Doppler shifts) is a crucial step in carrying any physical wisdom we develop in the solar setting to the distant stars.
Ayres, Thomas R.↗
Finding New Math Identities by Computer
Recently a number of interesting new mathematical identities have been discovered by means of numerical searches on high performance computers, using some newly discovered algorithms. These include the following: pi = ((sup oo)(sub k=0))(Sigma) (1 / 16) (sup k) ((4 / 8k+1) - (2 / 8k+4) - (1 / 8k+5) - (1 / 8k+6)) and ((17 pi(exp 4)) / 360) = ((sup oo)(sub k=1))(Sigma) (1 + (1/2) + (1/3) + ... + (1/k))(exp 2) k(exp -2), zeta(3, 1, 3, 1, ..., 3, 1) = (2 pi(exp 4m) / (4m+2)! where m = number of (3,1) pairs. and where zeta(n1,n2,...,nr) = (sub k1 (is greater than) k2 (is greater than) ... (is greater than) kr)(Sigma) (1 / (k1 (sup n1) k2 (sup n2) ... kr (sup nr). The first identity is remarkable in that it permits one to compute the n-th binary or hexadecimal digit of pu directly, without computing any of the previous digits, and without using multiple precision arithmetic. Recently the ten billionth hexadecimal digit of pi was computed using this formula. The third identity has connections to quantum field theory. (The first and second of these been formally established; the third is affirmed by numerical evidence only.) The background and results of this work will be described, including an overview of the algorithms and computer techniques used in these studies.
Bailey, David H.↗
Lunar Rotation and the Lunar Interior
Variations in rotation and orientation of the Moon are sensitive to solid-body tidal dissipation, dissipation due to relative motion at the fluid-core/ solid-mantle boundary, and tidal Love number k2. There is weaker sensitivity to flattening of the core-mantle boundary (CMB) and fluid core moment of inertia. Accurate Lunar Laser Ranging (LLR) measurements of the distance from observatories on the Earth to four retroreflector arrays on the Moon are sensitive to lunar rotation and orientation variations and tidal displacements. Past solutions using the LLR data have given results for dissipation due to solid-body tides and fluid core plus Love number. Past detection of CMB flattening has been marginal but is improving, while direct detection of the core moment has not yet been achieved. Three decades of Lunar Laser Ranging (LLR) data are analyzed using a weighted least-squares approach. The lunar solution parameters include dissipation at the fluid-core/solid-mantle boundary, tidal dissipation, dissipation-related coefficients for rotation and orientation terms, potential Love number k2, a correction to the constant term in the tilt of the equator to the ecliptic which is meant to approximate the influence of core-mantle boundary flattening, and displacement Love numbers h2 and l2. Several solutions, with different combinations of solution parameters and constraints, are considered.
Williams, J. G.↗
Fluid core size of Mars from detection of the solar tide
The solar tidal deformation of Mars, measured by its k2 potential Love number, has been obtained from an analysis of Mars Global Surveyor radio tracking. The observed k2 of 0.153 +/- 0.017 is large enough to rule out a solid iron core and so indicates that at least the outer part of the core is liquid. The inferred core radius is between 1520 and 1840 kilometers and is independent of many interior properties, although partial melt of the mantle is one factor that could reduce core size. Ice-cap mass changes can be deduced from the seasonal variations in air pressure and the odd gravity harmonic J3, given knowledge of cap mass distribution with latitude. The south cap seasonal mass change is about 30 to 40% larger than that of the north cap.
Mars↗