The effects of carbon dioxide on hypothalamic self-stimulation during hypoxia.
Carbon dioxide effects on hypothalamic self stimulation in hypoxia, noting role in maintaining functional neuronal population
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Carbon dioxide effects on hypothalamic self stimulation in hypoxia, noting role in maintaining functional neuronal population
Chemoreceptor stimulation and control of breathing during hypoxia
Hypoxia effects on physiological parameters of oxygen consumption and body thermoregulation
Oxygen supply and acclimatization of dogs with anemia and circulatory hypoxia in mountain air
Renal effects of moderate hypoxia exposure in mice as reflected in urine volume and electrolyte excretion patterns during four days at simulated altitude
Hypoxia exposure effect on RNA synthesis in rat anterior pituitary cultured in vitro
Hypoxia tolerances in nitrogen dilution chamber of chickens at sea level and high altitudes, discussing role of hematocrit and heart mass
Hyperoxia and hypoxia effects on mitotic activity in regenerating and normal rat liver exposed to environmental conditions
Erythropoietic response in anesthetized dogs subjected to sublethal whole-body proton irradiation followed by hypoxic hypoxia, discussing test procedure and results
Chronic hypoxia exposure effect on development and maintenance of renal hypertension in rats
Hypoxia affecting circulatory responses in dogs, such as cardiac output, left ventricular dp/dt, and stroke volume
Dynamic respiratory and circulatory responses to hypoxia in anesthetized dogs, recording oxygen partial pressures, heart rate, blood pressure, blood flows, respiratory rate, etc
Chronic hypoxia effects on blood oxygen and carbon dioxide tensions and pH changes in unanesthetized chickens at high altitude compared to sea level control
The effects upon range of accommodation and color vision of reduced atmospheric pressure, at partial and complete elimination of nitrogen, of hypoxia, and of exposure for varying periods of time to restricted visual environment, have been studied alone or in various combinations. Measurements were made on the electroretinogram, the electrooculogram, and the diameter of the retinal vessels as an indicator of blood flow to the retina at the time of total elimination of nitrogen. An objective method was used to test range of accommodation. In the color vision test the flicker colors of a Benham's top were matched with a colorimeter.
The dynamics of basic functional systems and behavioral reactions depend on the oxygen regime of the human body when confined in pressurized compartments during space flight. Permissible concentrations of oxygen, carbon dioxide and other gases to avoid symptoms of hypoxia, hyperoxia and hypercapnia are discussed in relation to numerous human tolerance studies.
Three series of experiments were simultaneously carried on rats with the purpose of studying the action of different stimulants on the blood system; rats were subjected to immobilization, hypoxic hypoxia and erythropoietin administration. Changes in various cellular forms in the bone marrow, the thymus and the spleen were studied. A unitypical reaction, as in stress, was noted during the first hours; a reduction of the cell count in the lymphoid organs, a reduction of granulocytes and an increase of lymphoid cells in the bone marrow. The differences were chiefly quantitative. This was followed by stimulation of myelo and erythropoiesis determined by the specific features of the action applied. Nonspecific blood reaction was apparently due to activation of the adaptation mechanisms.
Six male subjects were exposed on two separate occasions to simulated microgravity with 28 deg head-down tilt (HD) for 1 h with baseline followed by recovery at + 17 deg head-up. Pulmonary ventilation, gas exchange, spirometry, and central and cerebral blood flow characteristics were compared while breathing ambient air and reduced F(I)O2 equivalent to 14,828 ft. With hypoxia (HY), the increased tidal volume served to attenuate the drop in arterial saturation by reducing deadspace ventilation. Arterial and mixed venous PO2, values, estimated from peripheral venous samples and cardiac output (CO), were both maintained during HD in HY. Mixed venous PO2 was elevated by an increase in CO associated with a reduction in systemic resistance. Changes in spirometric indices during HD were not accentuated by HY, making the presence of interstitial edema unlikely. Cerebral flow and resistance showed minor reductions with HD. Tissue oxygenation and cardiopulmonary function were not notably effected by HD during HY, but a combination of these two stressors may predispose subjects to subsequent orthostatic intolerance during initial recovery.