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At least 73 records · Page 4
All sourcesNASA NTRSDOE OSTI
DOE OSTI2015

MO-D-213-05: Sensitivity of Routine IMRT QA Metrics to Couch and Collimator Rotations

Purpose: To assess the sensitivity of gamma index and other IMRT QA metrics to couch and collimator rotations. Methods: Two brain IMRT plans with couch and/or collimator rotations in one or more of the fields were evaluated using the IBA MatriXX ion chamber array and its associated software (OmniPro-I’mRT). The plans were subjected to routine QA by 1) Creating a composite planar dose in the treatment planning system (TPS) with the couch/collimator rotations and 2) Creating the planar dose after “zeroing” the rotations. Plan deliveries to MatriXX were performed with all rotations set to zero on a Varian 21ex linear accelerator. This in effect created TPS-created planar doses with an induced rotation error. Point dose measurements for the delivered plans were also performed in a solid water phantom. Results: The IMRT QA of the plans with couch and collimator rotations showed clear discrepancies in the planar dose and 2D dose profile overlays. The gamma analysis, however, did pass with the criteria of 3%/3mm (for 95% of the points), albeit with a lower percentage pass rate, when one or two of the fields had a rotation. Similar results were obtained with tighter criteria of 2%/2mm. Other QA metrics such as percentage difference or distance-to-agreement (DTA) histograms produced similar results. The point dose measurements did not obviously indicate the error due to location of dose measurement (on the central axis) and the size of the ion chamber used (0.6 cc). Conclusion: Relying on Gamma analysis, percentage difference, or DTA to determine the passing of an IMRT QA may miss critical errors in the plan delivery due to couch/collimator rotations. A combination of analyses for composite QA plans, or per-beam analysis, would detect these errors.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2016

Modification and validation of an analytical source model for external beam radiotherapy Monte Carlo dose calculations

Purpose: A dose calculation tool, which combines the accuracy of the dose planning method (DPM) Monte Carlo code and the versatility of a practical analytical multisource model, which was previously reported has been improved and validated for the Varian 6 and 10 MV linear accelerators (linacs). The calculation tool can be used to calculate doses in advanced clinical application studies. One shortcoming of current clinical trials that report dose from patient plans is the lack of a standardized dose calculation methodology. Because commercial treatment planning systems (TPSs) have their own dose calculation algorithms and the clinical trial participant who uses these systems is responsible for commissioning the beam model, variation exists in the reported calculated dose distributions. Today’s modern linac is manufactured to tight specifications so that variability within a linac model is quite low. The expectation is that a single dose calculation tool for a specific linac model can be used to accurately recalculate dose from patient plans that have been submitted to the clinical trial community from any institution. The calculation tool would provide for a more meaningful outcome analysis. Methods: The analytical source model was described by a primary point source, a secondary extra-focal source, and a contaminant electron source. Off-axis energy softening and fluence effects were also included. The additions of hyperbolic functions have been incorporated into the model to correct for the changes in output and in electron contamination with field size. A multileaf collimator (MLC) model is included to facilitate phantom and patient dose calculations. An offset to the MLC leaf positions was used to correct for the rudimentary assumed primary point source. Results: Dose calculations of the depth dose and profiles for field sizes 4 × 4 to 40 × 40 cm agree with measurement within 2% of the maximum dose or 2 mm distance to agreement (DTA) for 95% of the data points tested. The model was capable of predicting the depth of the maximum dose within 1 mm. Anthropomorphic phantom benchmark testing of modulated and patterned MLCs treatment plans showed agreement to measurement within 3% in target regions using thermoluminescent dosimeters (TLD). Using radiochromic film normalized to TLD, a gamma criteria of 3% of maximum dose and 2 mm DTA was applied with a pass rate of least 85% in the high dose, high gradient, and low dose regions. Finally, recalculations of patient plans using DPM showed good agreement relative to a commercial TPS when comparing dose volume histograms and 2D dose distributions. Conclusions: A unique analytical source model coupled to the dose planning method Monte Carlo dose calculation code has been modified and validated using basic beam data and anthropomorphic phantom measurement. While this tool can be applied in general use for a particular linac model, specifically it was developed to provide a singular methodology to independently assess treatment plan dose distributions from those clinical institutions participating in National Cancer Institute trials.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2015

Synthesis, characterization, crystal structure, and thermal analysis of 2-chloro-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl) acetamide

The title compound, C{sub 13}H{sub 14}O{sub 2}N{sub 3}Cl, has been synthesized by the reaction of chloroacetyl chloride with 4-aminoantipyrine in basic media and characterized by FT-IR, CHN elemental analysis, UV-Vis, TGA, DTA, DSC and single crystal X-ray diffraction. crystals are monoclinic, sp. gr. P2{sub 1}/c, a = 6.9994(6), b = 12.4035(13), c = 15.836(2) Å, β = 100.367(9)°, Z = 4. The crystal structure is stabilized by N–H···O and C–H···O interactions, the former interactions result in the formation of dimers corresponding to R{sub 2}{sup 2} (10) graphset motif and the dimers are further connected by C–H···O hydrogen bonding forming chains. In addition, the thermal stability of the compound was determined by TGA, DTA, DSC analysis, and absorption at λ{sub max} = 298 nm was determined by UV-Vis spectrophotometer.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗
DOE OSTI2018

Peptide Fragmentation Modeller

The Peptide Fragmentation Modeller is a command-line utility reads that reads in a text file of peptide sequences and generates the theoretical fragmentation pattern for each, outputting the results in a single concatenated DTA file, or in separate .Dta files. The ion intensity values are not predicted values; instead, b, c, y, and z ions are assigned an intensity of 100; while a ions and neutral loss ions receive an intensity of 20.

Monroe, Matthew↗
DOE OSTI2018

Creation of a Robust and Generalizable Machine Learning Classifier for Patient Ventilator Asynchrony

Background: As healthcare increasingly digitizes, streaming waveform data is being made available from an variety of sources, but there still remains a paucity of performant clinical decision support systems. For example, in the intensive care unit (ICU) existing automated alarm systems typically rely on simple thresholding that result in frequent false positives. Recurrent false positive alerts create distrust of alarm mechanisms that can be directly detrimental to patient health. To improve patient care in the ICU, we need alert systems that are both pervasive, and accurate so as to be informative and trusted by providers. Objective: We aimed to develop a machine learning-based classifier to detect abnormal waveform events using the use case of mechanical ventilation waveform analysis, and the detection of harmful forms of ventilation delivery to patients. We specifically focused on detecting injurious subtypes of patient-ventilator asynchrony (PVA).Methods: Using a dataset of breaths recorded from 35 different patients, we used machine learning to create computational models to automatically detect, and classify two types of injurious PVA, double trigger asynchrony (DTA), breath stacking asynchrony (BSA). We examined the use of synthetic minority over-sampling technique (SMOTE) to overcome class imbalance problems, varied methods for feature selection, and use of ensemble methods to optimize the performance of our model. Results: We created an ensemble classifier that is able to accurately detect DTA at a sensitivity/specificity of 0.960/0.975, BSA at sensitivity/specificity of 0.944/0.987, and non-PVA events at sensitivity/specificity of .967/.980. Conclusions: Our results suggest that it is possible to create a high-performing machine learning-based model for detecting PVA in mechanical ventilator waveform data in spite of both intra-patient, and inter-patient variability in waveform patterns, and the presence of clinical artifacts like cough and suction procedures. Our work highlights the importance of addressing class imbalance in clinical data sets, and the combined use of statistical methods and expert knowledge in feature selection.

97 MATHEMATICS AND COMPUTING↗
DOE OSTI2019

Formation, Stability and Magnetism of New Gd 3 TAl 3 Ge 2 Quaternary Compounds (T = Mn, Cu)

A study on the formation and stability of new quaternary compounds with the general chemical formula Gd 3 TAl 3 Ge 2 (T = Mn, Cu) has been undertaken by experimental investigations (SEM-EDX, DTA and XRD) and density functional theory (DFT) calculations. These compounds crystallize in the hexagonal Y 3 NiAl 3 Ge 2 -type structure (hP9, P–62m, Z = 1) (an ordered, quaternary derivative of the ternary ZrNiAl or of the binary Fe 2 P prototypes), with lattice parameters values a = 7.0239(2) Å and c = 4.2580(1) Å for Gd 3 MnAl 3 Ge 2 and a = 7.0434(1) Å and c = 4.2089(1) Å for Gd 3 CuAl 3 Ge 2 . DTA suggests a peritectic reaction for the formation of these compounds (at 1245°C for Gd 3 CuAl 3 Ge 2 ). The existence and stability of these phases has been explained on the basis of DFT calculations, and a comparison of ground state properties of the studied compounds with the earlier known Gd 3 CoAl 3 Ge 2 phase is outlined. The negative formation energies in all three cases govern the stability of compounds from theory as well, predicting Gd 3 MnAl 3 Ge 2 as the most stable phase with highest formation energy (–13.01 eV/f.u.). The total DOS are generic in nature and suggest the robust magnetism, with the Gd-f moments of ≈7 μ B . An antiparallel coupling among Gd-f and T-d states is observed for all compounds, as usually seen in rare earth (R) - transition metal (T) compounds. Preliminary magnetization measurements on Gd 3 MnAl 3 Ge 2 show two ferromagnetic/ferrimagnetic (FM/FIM) like transitions at T C1 = 142 K and T C2 = 97 K, with another anomaly seen at ≈15 K. Isothermal magnetization data show no hysteresis even at 5 K, and the magnetization does not saturate up to 50 kOe, further suggesting a possible FIM behavior.

36 MATERIALS SCIENCE↗
NASA NTRS1971

Differential thermal analysis and gas release studies of Apollo 11 samples.

The liquidus-solidus behavior of Apollo 11 lunar fines and the evolution characteristics of CO, nitrogen, He, Ne, and Ar were investigated by use of the combined techniques of high-vacuum differential thermal analysis (DTA) and mass spectrometry between 100 and 1500 C. The DTA thermogram has shown that the lunar fines undergo partial melting over a broad range of temperature from about 915 to 1300 C, with a significant initial melting of glassy and crystalline components within the fines at about 1140 C. The lunar material becomes a homogeneous melt at about 1300 C.

Wachi, F. M.↗
NASA NTRS1974

Study of recrystallization and devitrification of lunar glass

The technique of differential thermal analysis (DTA) was applied to the study of the Apollo 17 orange soil (74220,63) and the Apollo 16 glass coated anorthite (64455,21). These glasses show accentuated exotherms of strain relief in the annealing range which is indicative of rapid cooling. These are amenable to interpretation by comparison to the known history of synthetic glasses. Synthetic glasses were prepared whose similarity in behavior between the lunar glasses and their synthetic analogs is striking. Approximate rates of cooling of the lunar glasses were determined from comparative DTA of lunar and synthetic glasses and from the determination of the relation of strain relief in the annealing range to quench rate. At higher temperatures the glasses show exotherms of crystallization. The crystallization products associated with the exothermic reactions have been identified by X-ray diffraction and the surface morphologies developed by strain relief and crystallization have been characterized with scanning electron microscopy.

Ulrich, D. R.↗
NASA NTRS1978

Determination of liquid-phase immiscibility in the lead-zinc system

A number of different techniques in the past have yielded inconsistent equilibrium measurements of immiscibility in the Pb-Zn system above 600 C. Accurate differential thermal analysis (DTA) measurements were performed on well-homogenized samples of high-purity Pb-Zn, and they indicate that the immiscibility curve is higher than previously accepted for Zn compositions between 20 and 70 at. %. The maximum deviations observed correspond to about 20 C. Below 600 C the DTA results agree with previous results.

Trahan, J. F.↗
NASA NTRS1980

On the barrier to crystal nucleation in lunar glasses

The paper describes an analytical method for calculating in detail the size distributions of small crystallites and nuclei in supercooled liquids as they are being quenched to form a glass and subsequently reheated above the glass transition to produce crystallization. This method is applied to experiments performed using differential thermal analysis (DTA) to estimate the barriers to crystal nucleation and the cooling rates required to form glasses or bodies with various degrees of crystallinity. DTA data and derived nucleation barriers are reported for anorthite and for the following lunar compositions: 15498, 15418, matrix and intrusion compositions of breccia 15286, Apollo 15 green glass, Luna 24 highland basalt, and 65016.

Yinnon, H.↗
NASA NTRS1982

Characteristics of the handling and positioning aid

The handling and positioning aid which (HPA) provides a wide range of adjustable work stations both inboard and outboard of the cargo bay is discussed. It can assist with berthing and docking, it is robust, stiff, has a simple control system, and is modular. An articulated arm version of HPA employed in a typical servicing mission is shown. Mounted on a base frame that spans the Orbiter cargo bay, the 6 m arm is long enough to hold the satellite being serviced and keep its solar array clear of the Orbiter radiators. By adjusting the length and angle of the support platform mast, and rotating the tip of the HPA arm, almost every item on the satellite can be reached. Spares and change-out units can be brought to and from the work site by the RMS, which is controlled from the aft flight deck. The fore and aft position of the base frame can be changed between Orbiter flights and this, together with the 5 degrees of freedom (DOF) of the long arm, allows work sites to be chosen that meet the clearance, reach and vision requirements of many missions. Flight article activities are shown are shown above the dashed horizontal line and Development Test Article (DTA) work below. Flight article requirements and concepts and the design of the DTA are developed.

Goodwin, C. J.↗
NASA NTRS1984

Experimental results for the rapid determination of the freezing point of fuels

Two methods for the rapid determination of the freezing point of fuels were investigated: an optical method, which detected the change in light transmission from the disappearance of solid particles in the melted fuel; and a differential thermal analysis (DTA) method, which sensed the latent heat of fusion. A laboratory apparatus was fabricated to test the two methods. Cooling was done by thermoelectric modules using an ice-water bath as a heat sink. The DTA method was later modified to eliminate the reference fuel. The data from the sample were digitized and a point of inflection, which corresponds to the ASTM D-2386 freezing point (final melting point), was identified from the derivative. The apparatus was modifified to cool the fuel to -60 C and controls were added for maintaining constant cooling rate, rewarming rate, and hold time at minimum temperature. A parametric series of tests were run for twelve fuels with freezing points from -10 C to -50 C, varying cooling rate, rewarming rate, and hold time. Based on the results, an optimum test procedure was established. The results showed good agreement with ASTM D-2386 freezing point and differential scanning calorimetry results.

Mathiprakasam, B.↗
NASA NTRS1988

Crystallization kinetics of BaO-Al2O3-SiO2 glasses

Barium aluminosilicate glasses are being investigated as matrix materials in high-temperature ceramic composites for structural applications. Kinetics of crystallization of two refractory glass compositions in the barium aluminosilicate system were studied by differential thermal analysis (DTA), X-ray diffraction (XRD), and scanning electron microscopy (SEM). From variable heating rate DTA, the crystallization activation energies for glass compositions (wt percent) 10BaO-38Al2O3-51SiO2-1MoO3 (glass A) and 39BaO-25Al2O3-35SiO2-1MoO3 (glass B) were determined to be 553 and 558 kJ/mol, respectively. On thermal treatment, the crystalline phases in glasses A and B were identified as mullite (3Al2O3-2SiO2) and hexacelsian (BaO-Al2O3-2SiO2), respectively. Hexacelsian is a high-temperature polymorph which is metastable below 1590 C. It undergoes structural transformation into the orthorhombic form at approximately 300 C accompanied by a large volume change which is undesirable for structural applications. A process needs to be developed where stable monoclinic celsian, rather than hexacelsian, precipitates out as the crystal phase in glass B.

Bansal, Narottam P.↗
NASA NTRS1989

Crystallization kinetics of BaO-Al2O3-SiO2 glasses

Barium aluminosilicate glasses are being investigated as matrix materials in high-temperature ceramic composites for structural applications. Kinetics of crystallization of two refractory glass compositions in the barium aluminosilicate system were studied by differential thermal analysis (DTA), X-ray diffraction (XRD), and scanning electron microscopy (SEM). From variable heating rate DTA, the crystallization activation energies for glass compositions (wt percent) 10BaO-38Al2O3-51SiO2-1MoO3 (glass A) and 39BaO-25Al2O3-35SiO2-1MoO3 (glass B) were determined to be 553 and 558 kJ/mol, respectively. On thermal treatment, the crystalline phases in glasses A and B were identified as mullite (3Al2O3-2SiO2) and hexacelsian (BaO-Al2O3-2SiO2), respectively. Hexacelsian is a high-temperature polymorph which is metastable below 1590 C. It undergoes structural transformation into the orthorhombic form at approximately 300 C accompanied by a large volume change which is undesirable for structural applications. A process needs to be developed where stable monoclinic celsian, rather than hexacelsian, precipitates out as the crystal phase in glass B.

Bansal, Narottam P.↗
NASA NTRS1990

Determining the nucleation rate curve for lithium disilicate glass by differential thermal analysis

The crystallization of lithium disilicate (Li2O+2SiO2) glass nucleated at various temperatures was studied by differential thermal analysis (DTA). A plot of the DTA crystallization peak height versus nucleation temperature closely resembles the classical nucleation rate curve for lithium disilicate glass whose maximum is at 453 C. The glass becomes saturated with internal nuclei when heated at 453 C for 10 h. The activation energy for crystallization and the heat of crystallization are independent of the concentration of nuclei and are 249 + or - 10 and 67 + or - 3 kJ/mol, respectively. The Avrami exponent, n, depends strongly on the concentration of nuclei in the glass.

Ray, Chandra S.↗
NASA NTRS1990

The position of the magnetotail neutral sheet in the near-earth region

The position of the near-earth neutral sheet throughout the nightside region between R = 5 R(E) and R = 8.8 R(E) is examined statistically using magnetic field data from AMPTE/CCE. As has been demonstrated previously, the latitudinal position of the neutral sheet is primarily controlled by the dipole tilt angle. The position also depends on local time, radial distance, and magnetic activity. These dependencis may be represented by the empirical formula MLAT = - (0.14 Kp + 0.69) /cos(Phi)/exp 1/3 (0.065 R exp 0.8 - 0.16) DTA, where MLAT is the position in degrees of the neutral sheet relative to the magnetic equator, Kp is the 3-hourly magnetic activity index, Phi is the magnetic local time in degrees (midnight = 0 deg), R is the radius in R(E), and DTA is the dipole tilt angle in degrees.

Lopez, Ramon E.↗
NASA NTRS1989

A study of microstructural characteristics and differential thermal analysis of Ni-based superalloys

The objective of this work is to correlate the mechanical properties of the Ni-based superalloy MAR M246(Hf) used in the Space Shuttle Main Engine with its structural characteristics by systematic study of optical photomicrographs and differential thermal analysis. The authors developed a method of predicting the liquidus and solidus temperature of various nickel based superalloys (MAR-M247, Waspaloy, Udimet-41, polycrystalline and single crystals of CMSX-2 and CMSX-3) and comparing the predictions with the experimental differential thermal analysis (DTA) curves using Perkin-Elmer DTA 1700. The method of predicting these temperatures is based on the additive effect of the components dissolved in nickel. The results were compared with the experimental values.

Aggarwal, M. D.↗
NASA NTRS1991

Nucleation and crystallization of Na2O-2CaO-3SiO2 glass by differential thermal analysis

DTA is presently used to characterize the nucleation and crystallization processes of the Na2O-2CaO-3SiO2 glass. A nucleation rate-temperaturelike curve is obtained by plotting either the reciprocal of the temperature corresponding to the crystallization peak maximum, or the height of the crystallization peak, as a function of nucleation temperature. The nucleation-temperature range for this glass composition, 550-650 C, and the maximum nucleation temperature of 600 + or - 5 C, are found to be in excellent agreement with those associated with the classical nucleation technique, followed by isothermal crystallization. It is noted that when most of the nucleation occurs during the DTA measurements, a modified Kissinger equation must be used to calculate the crystallization energy.

Xu, Xiaojie J.↗