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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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58 records · Page 4
All sourcesNASA NTRSDOE OSTI
NASA NTRS1992

Effectiveness and duration of intramuscular antimotion sickness medications

Motion sickness inhibits gastric motility, making the oral route ineffective for medications. The intramuscular route is an effective alternative. The rotating chair was used to produce the M 111 level of motion sickness on the Graybiel Symptom Scale. The intramuscular medications given 30 minutes before rotation were compared with placebo (saline, 1 mL) for effectiveness and duration in increasing the number of tolerated head movements. Average placebo number of head movements was 294. Promethazine 25 mg increased head movements by 78% (P < .05), with a duration of 12 hours. Scopolamine 0.2 mg increased head movements by 91% (P < .05), with a duration of 4 hours. The effect of caffeine 250 mg and ephedrine 25 mg was not significant. When combined with scopolamine, ephedrine produced an 32% additive effect. Scopolamine 0.08 mg, 0.1 mg, and 0.2 mg and also promethazine 12.5 mg and 25 mg were significant (P < .05). Promethazine appears to be the drug of choice for intramuscular use because of a longer duration and a high level of effectiveness. Scopolamine was of high effectiveness, but had a duration of 4 hours. It was eight times as potent by the intramuscular as by the oral route.

Non-NASA Center↗
NASA NTRS2011

Application of Laser Mass Spectrometry to Art and Archaeology

REMPI laser mass spectrometry is a combination of resonance enhanced multiphoton ionization spectroscopy and time of flight mass spectrometry, This technique enables the collection of mass specific optical spectra as well as of optically selected mass spectra. Analytes are jet-cooled by entrainment in a molecular beam, and this low temperature gas phase analysis has the benefit of excellent vibronic resolution. Utilizing this method, mass spectrometric analysis of historically relevant samples can be simplified and improved; Optical selection of targets eliminates the need for chromatography while knowledge of a target's gas phase spectroscopy allows for facile differentiation of molecules that are in the aqueous phase considered spectroscopically indistinguishable. These two factors allow smaller sample sizes than commercial MS instruments, which in turn will require less damage to objects of antiquity. We have explored methods to optimize REMPI laser mass spectrometry as an analytical tool to archaeology using theobromine and caffeine as molecular markers in Mesoamerican pottery, and are expanding this approach to the field of art to examine laccaic acid in shellacs.

Gulian, Lase Lisa E.↗
NASA NTRS2015

Validating and Verifying Biomathematical Models of Human Fatigue

Airline pilots experience acute and chronic sleep deprivation, sleep inertia, and circadian desynchrony due to the need to schedule flight operations around the clock. This sleep loss and circadian desynchrony gives rise to cognitive impairments, reduced vigilance and inconsistent performance. Several biomathematical models, based principally on patterns observed in circadian rhythms and homeostatic drive, have been developed to predict a pilots levels of fatigue or alertness. These models allow for the Federal Aviation Administration (FAA) and commercial airlines to make decisions about pilot capabilities and flight schedules. Although these models have been validated in a laboratory setting, they have not been thoroughly tested in operational environments where uncontrolled factors, such as environmental sleep disrupters, caffeine use and napping, may impact actual pilot alertness and performance. We will compare the predictions of three prominent biomathematical fatigue models (McCauley Model, Harvard Model, and the privately-sold SAFTE-FAST Model) to actual measures of alertness and performance. We collected sleep logs, movement and light recordings, psychomotor vigilance task (PVT), and urinary melatonin (a marker of circadian phase) from 44 pilots in a short-haul commercial airline over one month. We will statistically compare with the model predictions to lapses on the PVT and circadian phase. We will calculate the sensitivity and specificity of each model prediction under different scheduling conditions. Our findings will aid operational decision-makers in determining the reliability of each model under real-world scheduling situations.

fatigue↗
NASA NTRS2018

Evaluation of the Validity of Bio-Mathematical Models in Predicting Fatigue in an Operational Environment

During long-duration spaceflight missions, crewmembers and ground-support staff experience irregular sleep schedules, erratic natural light patterns, and high workload due to mission demands. Such conditions can cause circadian misalignment and sleep loss, which in turn cause deficits in cognitive performance. While bio-mathematical models have been implemented within workplace settings to predict fatigue profiles, the accuracy of sleep-wake models under conditions of non-traditional shiftwork is little known. Thus, the present study aims to evaluate the validity of four sleep-wake models (e.g., SAFTE-FAST, the Unified Model of Performance, the Adenosine-Circadian Model, and the State-Space Model) designed to predict human performance and fatigue levels against objective measures of performance in a spaceflight analog. To accomplish this aim, we will collect Psychomotor Vigilance Task (PVT) data from four crews (n=16) in the Human Exploration Research Analog (HERA) over 45 days. HERA is a closed, 3-story habitat at Johnson Space Center where inhabitants are exposed to extreme space exploration scenarios under varying sleep-wake conditions. The PVT is a simple reaction time test that involves minimal learning, making it sensitive to the effects of sleep loss and circadian misalignment. Findings from this study will help inform work scheduling and implementation of effective countermeasures (e.g., caffeine, lighting) to improve work efficiency and combat fatigue, as well as offer valuable insight into the applicability of bio-mathematical fatigue models in future space exploration missions.

fatigue↗