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At least 73 records · Page 4

Mapping and Quantification of Vascular Branching in Plants, Animals and Humans by VESGEN Software

Humans face daunting challenges in the successful exploration and colonization of space, including adverse alterations in gravity and radiation. The Earth-determined biology of humans, animals and plants is significantly modified in such extraterrestrial environments. One physiological requirement shared by humans with larger plants and animals is a complex, highly branching vascular system that is dynamically responsive to cellular metabolism, immunological protection and specialized cellular/tissue function. The VESsel GENeration (VESGEN) Analysis has been developed as a mature beta version, pre-release research software for mapping and quantification of the fractal-based complexity of vascular branching. Alterations in vascular branching pattern can provide informative read-outs of altered vascular regulation. Originally developed for biomedical applications in angiogenesis, VESGEN 2D has provided novel insights into the cytokine, transgenic and therapeutic regulation of angiogenesis, lymphangiogenesis and other microvascular remodeling phenomena. Vascular trees, networks and tree-network composites are mapped and quantified. Applications include disease progression from clinical ophthalmic images of the human retina; experimental regulation of vascular remodeling in the mouse retina; avian and mouse coronary vasculature, and other experimental models in vivo. We envision that altered branching in the leaves of plants studied on ISS such as Arabidopsis thaliana cans also be analyzed.

Parsons-Wingerter, Patricia A.↗

VESGEN Mapping of Bioactive Protection against Intestinal Inflammation: Application to Human Spaceflight and ISS Experiments

Challenges to successful space exploration and colonization include adverse physiological reactions to micro gravity and space radiation factors. Constant remodeling of the microvasculature is critical for tissue preservation, wound healing, and recovery after ischemia. Regulation of the vascular system in the intestine is particularly important to enable nutrient absorption while maintaining barrier function and mucosal defense against micro biota. Although tremendous progress has been made in understanding the molecular circuits regulating neovascularization, our knowledge of the adaptations of the vascular system to environmental challenges in the intestine remains incomplete. This is in part because of the lack of methods to observe and quantify the complex processes associated with vascular responses in vivo. Developed by GRC as a mature beta version, pre-release research software, VESsel GENeration Analysis (VESGEN) maps and quantifies the fractal-based complexity of vascular branching for novel insights into the cytokine, transgenic and therapeutic regulation of angiogenesis, lymphangiogenesis and microvascular remodeling. Here we demonstrate that VESGEN can be used to characterize the dynamic vascular responses to acute intestinal inflammation and mucosal recovery from in vivo confocal microscopic 3D image series. We induced transient intestinal inflammation in mice by DSS treatment and investigated whether the ability of the pro biotic yeast Saccharomyces boulardii (Sb) to protect against intestinal inflammation was due to regulation of vascular remodeling. A primary characteristic of inflammation is excessive neovascularization (angiogenesis) resulting in fragile vessels prone to bleeding. Morphological parameters for triplicate specimens revealed that Sb treatment greatly reduced the inflammatory response of vascular networks by an average of 78%. This resulted from Sb inhibition of vascular endothelial growth factor receptor signaling, a major angiogenesis signaling pathway. It needs to be determined whether pro biotic yeast represents a promising approach to GI protection in space. GRC performed only the VESGEN post-testing analysis.

Parsons-Wingerter, P. A.↗

Mapping and Quantification of Vascular Branching in Plants, Animals and Humans by VESGEN Software

Humans face daunting challenges in the successful exploration and colonization of space, including adverse alterations in gravity and radiation. The Earth-determined biology of plants, animals and humans is significantly modified in such extraterrestrial environments. One physiological requirement shared by larger plants and animals with humans is a complex, highly branching vascular system that is dynamically responsive to cellular metabolism, immunological protection and specialized cellular/tissue function. VESsel GENeration (VESGEN) Analysis has been developed as a mature beta version, pre-release research software for mapping and quantification of the fractal-based complexity of vascular branching. Alterations in vascular branching pattern can provide informative read-outs of altered vascular regulation. Originally developed for biomedical applications in angiogenesis, VESGEN 2D has provided novel insights into the cytokine, transgenic and therapeutic regulation of angiogenesis, lymphangiogenesis and other microvascular remodeling phenomena. Vascular trees, networks and tree-network composites are mapped and quantified. Applications include disease progression from clinical ophthalmic images of the human retina; experimental regulation of vascular remodeling in the mouse retina; avian and mouse coronary vasculature, and other experimental models in vivo. We envision that altered branching in the leaves of plants studied on ISS such as Arabidopsis thaliana cans also be analyzed.

Parsons-Wingerter, P. A.↗

SMAP Data Assimilation at the GMAO

The NASA Soil Moisture Active Passive (SMAP) mission has been providing L-band (1.4 GHz) passive microwave brightness temperature (Tb) observations since April 2015. These observations are sensitive to surface(0-5 cm) soil moisture. Several of the key applications targeted by SMAP, however, require knowledge of deeper-layer, root zone (0-100 cm) soil moisture, which is not directly measured by SMAP. The NASA Global Modeling and Assimilation Office (GMAO) contributes to SMAP by providing Level 4 data, including the Level 4 Surface and Root Zone Soil Moisture(L4_SM) product, which is based on the assimilation of SMAP Tb observations in the ensemble-based NASA GEOS-5 land surface data assimilation system. The L4_SM product offers global data every three hours at 9 km resolution, thereby interpolating and extrapolating the coarser- scale (40 km) SMAP observations in time and in space (both horizontally and vertically). Since October 31, 2015, beta-version L4_SM data have been available to the public from the National Snow and Ice Data Center for the period March 31, 2015, to near present, with a mean latency of approx. 2.5 days.

Land Surface Model↗

An Assessment of New Satellite Data Products for the Development of a Long-Term Global Solar Resource at 10-100 km

A project representing an effort to reprocess the NASA based solar resource data sets is reviewed. The effort represented a collaboration between NASA, NOAA, NREL and the SUNY-Albany and aimed to deliver a 10 km resolution, 3-hourly data set spanning from 1983 through near-present. Part of the project was to transition project capability to NREL for annual processing to extend data set. Due to delays in the key input project called ISCCP, we evaluate only Beta versions of this data set and also introduce the potential use of another NASA Langley based cloud data set for the CERES project. The CERES project uses these cloud properties to compute global top-of-atmosphere and surface fluxes at the 1x1 degree resolution. Here, we also briefly discuss these data sets in potential usage for solar resource benchmarking.

Stackhouse, Paul W., Jr.↗

Online NASA Software Estimating Tools (ONSET): A Suite of Web-Based Cost Analysis Tools

This paper provides an overview of ONSET theOnline NASA Software Estimating Tools suite of web-basedcosts analysis tools. ONSET is comprised of the AnalogySoftware Cost Tool (ASCoT) [1], and the CubeSat Or MicrosatProbabilistic and Analogies Cost Tool (COMPACT) [2]. TheOnline NASA Space Estimation Tool (ONSET) has beendeveloped to provide a standardized platform for hosting webbasedNASA cost estimation tools on NASA ONCE (OneNASA Cost Engineering). It evolved from the BETA version ofASCoT (The NASA Analogy Software Cost Tool) which wasreleased in 2017 and was presented at the 2017 IEEEAerospace Conference. This first release of ONSET contains anew version of ASCoT as well as the first official release ofCOMPACT (CubeSat Or Microsat Probabilistic + AnalogiesCost Tool). In this paper we will provide an overview ofONSET, all its features and a high-level summary of bothASCoT and COMPACT. The heart of both tools arealgorithms for analogy-based estimation based on system levelinputs.

Johnson, James↗

Identifying Hurricane Impacts on Barbuda Using Citizen Science Ground Observations, Drone Photography and Satellite Imagery

Barbuda is a low-lying leeward island in the West Indies. In September 2017 Hurricane Irma battered the island with 185 mph winds. Damage to housing and infrastructure was so extensive that all 1800 residents of the island were immediately evacuated post hurricane to the neighboring island of Antigua. Our research is focused on documenting and analyzing the landscape scale changes that took place on the island as a result of the hurricane using a nested methodology. Ground level observations were recorded using a beta version of the Global Learning and Observation to Benefit the Environment (GLOBE) Observer Land Cover tool. Aerial photographs provide medium scale landscape resolution. Satellite images were processed to provide NDVI values. We describe how nested data at several spatial scales enable detailed description of Hurricane Irma’s impact across the landscape of this 62 sq. mile island. Here we are connecting observations at different spatial scales, using citizen science observations, aerial drone photography and satellite imagery to document and analyze hurricane impacts on the island of Barbuda, eastern Caribbean.

Barbuda↗

Applicability of Fly Neighborly Noise Recommendations to UAM Quadrotors Undergoing Steady Maneuvers

This initial study examines whether the Helicopter Association International (HAI) Fly Neighborly operational recommendations that are based on single main rotor/tail rotor configurations will hold for non-conventional UAM rotorcraft with multiple rotors. The 6-occupant quadrotor concept vehicle designed under the NASA Revolutionary Vertical Lift Technology (RVLT) Project is studied. The tip speed is 550 ft/sec, with three blades per rotor (“550/3”). Predictions are made for three steady maneuvers: level turns, descending turns, and climbing turns. The RVLT Toolchain is exercised using CAMRAD II, pyaaron/AARON/ANOPP2 and a beta version of AMAT (ANOPP2 Mission Analysis Tool). AMAT provides functionality to acoustically model the curved flight paths associated with maneuvers. In addition to quadrotor trim and performance, this study includes analysis of azimuthal variations of the vertical blade loading and its derivative in the form of contour plots on a rotor plane and line plots at one radial location (r/R=0.765). Quadrotor noise trends are analyzed using maximum Overall Sound Pressure Level (OASPL) and Effective Perceived Noise Level (EPNL). The Fly Neighborly guideline that addresses descents (“Level turns are quieter than descending turns”) is predicted to hold for the RVLT Quadrotor as well.

UAM↗

An Assessment of New Satellite Data Products for the Development of a Long-Term Global Solar Resource at 10-100 km

A project representing an effort to reprocess the NASA based solar resource data sets is reviewed. The effort represented a collaboration between NASA, NOAA, NREL and the SUNY-Albany and aimed to deliver a 10 km resolution, 3-hourly data set spanning from 1983 through near-present. Part of the project was to transition project capability to NREL for annual processing to extend data set. Due to delays in the key input project called ISCCP, we evaluate only Beta versions of this data set and also introduce the potential use of another NASA Langley based cloud data set for the CERES project. The CERES project uses these cloud properties to compute global top-of-atmosphere and surface fluxes at the 1x1 degree resolution. Here, we also briefly discuss these data sets in potential usage for solar resource benchmarking.

14 SOLAR ENERGY↗

Tsdat: An Open-Source Data Standardization Framework for Marine Energy and Beyond: Preprint

Many organizations are tasked with the collection and processing of large quantities of data from various measurement devices. Data reported from these sources are often not interoperable with datasets and software used by analysts and other organizations in the same field, introducing barriers for collaboration on large-scale projects. This poses a particular problem for cross-device comparisons and machine learning applications. To address these challenges, the open source Time-Series Data Pipelines (Tsdat) software was developed by a joint collaboration between Pacific Northwest National Laboratory, the National Renewable Energy Laboratory, and Sandia National Laboratories to facilitate collaboration and accelerate advancements in the Marine Energy domain through the development of an open-source ecosystem of tools. This paper will describe the Tsdat software and the data standards within which the framework operates. A beta version of the framework has been released and is currently being used by several projects in marine energy, wind energy, and building energy systems.

big data↗

Developing an Interactive Landscape for Mobility Resources: Preprint

As the world continues to be increasingly driven by data, the ways researchers and professionals sort and collect this data is critical. In the world of mobility data, new levels of data from public transportation systems, location services, and other means are being lost due to how little organization exists. Much of the data is proprietary, and there are few if any de jure or even de facto standards connecting data. There is also little knowledge about the gaps that exist in the data. In this project, we created an interactive landscape where mobility resources are categorized and organized in an easy to use, living document. We made this landscape with open-source code from the CNCF Cloud Native Landscape and repurposed it to the mobility data's needs. Additionally, unlike previous sources that organize mobility data, this document can be updated through GitHub by those in the field to keep its sources relevant. Following the creation of a beta version of the landscape, we conducted several interviews with industry researchers and professionals to ensure the landscape would be useful. The result is an online hub where mobility researchers and resource creators can easily access research and collaborate.

ADVANCED PROPULSION SYSTEMS↗

MISSE 6, 7 and 8 Materials Sample Experiments from the International Space Station Materials and Processes Team

The International Space Station Materials and Processes (ISS M&P) team has multiple material samples on MISSE 6, 7 and 8 to observe Low Earth Orbit (LEO) environmental effects on Space Station materials. Optical properties, thickness/mass loss, surface elemental analysis, visual and microscopic analysis for surface change are some of the techniques employed in this investigation. The ISS M&P team has participated in previous MISSE activities in order to better characterize the LEO effects on Space Station materials. This investigation will further this effort. Results for the following MISSE 6 samples materials will be presented: a comparison of anodize and chemical conversion coatings on various aluminum alloys, electroless nickel; AZ93 white ceramic thermal control coating with and without Teflon; Hyzod(TM) polycarbonate used to temporarily protect ISS windows; Russian quartz window material; reformulated Teflon (TM) coated Beta Cloth (Teflon TM without perfluorooctanoic acid (PFOA)) and a Dutch version of beta cloth. Discussion for current and future MISSE materials experiments will be presented. MISSE 7 samples are: deionized water sealed anodized aluminum Photofoil(TM); indium tin oxide (ITO)- coated Kapton(TM) used as thermo-optical surfaces; mechanically scribed tin-plated beryllium-copper samples for "tin pest" growth ( alpha/Beta transformation); Crew Exploration Vehicle (CEV) parachute soft goods. MISSE 8 sample: exposed "scrim cloth" (fiberglass weave) from the ISS solar array wing material, Davlyn fiberglass sleeve material, Permacel and Intertape protective tapes, and ITO-coated Kapton.

Kravchenko, Michael↗

MCNP6 and SERPENT2 Performances with Unstructured Mesh Geometry

Traditionally, Monte Carlo codes model a nuclear reactor by combinatorial geometry. In this model, volume primitives (e,g, spheres, cylinders, parallelepipeds...) are combined together by Boolean operations (e.g. union, intersection, and complement) and replicated by lattice definitions to build the core geometry. Recently, high performances computing platforms allowed using unstructured mesh geometry in Monte Carlo codes. When this option is chosen, any type of core geometry can be modeled since the restriction of using volume primitives is removed. In an unstructured mesh geometry, Boolean operations and lattice definitions are not used since each volume is defined by triangular surfaces (facets). This study focuses on two Monte Carlo codes: MCNP (version 6.1.1 beta) developed at Los Alamos National Laboratory since 1957 and written in FORTRAN90, C, and C++ (267,000 total source code lines), and SERPENT (version 2.1.27) developed at VTT Technical Research Centre since 2004 and written in C (195,000 total source code lines). These two codes follow different approaches for the unstructured mesh geometry modeling: MCNP uses ABAQUS format, whereas SERPENT uses the STL format. In the STL (STereoLithographic) geometry model only the surfaces of the volume are meshed; the interior part of the volumes is not meshed. In the STL geometry model, the whole geometry is defined by the sequence of SOLID and ENDSOLID sections. Each volume of the geometry must have a SOLID and ENDSOLID section. The STL file contains no information specifying the materials of the volumes. MCNP and SERPENT can model any kind of complicated geometry using unstructured meshes. MCNP and SERPENT use the ABAQUS and STL file formats, respectively. The STL file format does not have tetrahedrons and has only triangular facets on the volumes boundary. This allows SERPENT simulations to run 10 times faster than MCNP. However, if Monte Carlo results have to be coupled to thermal-hydraulics codes, the interior of the geometry volumes must be meshed, which may reduce SERPENT performances.

97 MATHEMATICS AND COMPUTING↗

Assessment of Version 4 of the SMAP Passive Soil Moisture Standard Product

NASAs Soil Moisture Active Passive (SMAP) mission launched on January 31, 2015 into a sun-synchronous 6 am6 pm orbit with an objective to produce global mapping of high-resolution soil moisture and freeze-thaw state every 2-3 days. The SMAP radiometer began acquiring routine science data on March 31, 2015 and continues to operate nominally. SMAPs radiometer-derived standard soil moisture product (L2SMP) provides soil moisture estimates posted on a 36-km fixed Earth grid using brightness temperature observations and ancillary data. A beta quality version of L2SMP was released to the public in October, 2015, Version 3 validated L2SMP soil moisture data were released in May, 2016, and Version 4 L2SMP data were released in December, 2016. Version 4 data are processed using the same soil moisture retrieval algorithms as previous versions, but now include retrieved soil moisture from both the 6 am descending orbits and the 6 pm ascending orbits. Validation of 19 months of the standard L2SMP product was done for both AM and PM retrievals using in situ measurements from global core calval sites. Accuracy of the soil moisture retrievals averaged over the core sites showed that SMAP accuracy requirements are being met.

SMAP↗

Evaluation of the Validated Soil Moisture Product from the SMAP Radiometer

NASA's Soil Moisture Active Passive (SMAP) mission launched on January 31, 2015 into a sun-synchronous 6 am/6 pm orbit with an objective to produce global mapping of high-resolution soil moisture and freeze-thaw state every 2-3 days using an L-band (active) radar and an L-band (passive) radiometer. The SMAP radiometer began acquiring routine science data on March 31, 2015 and continues to operate nominally. SMAP's radiometer-derived soil moisture product (L2_SM_P) provides soil moisture estimates posted on a 36 km fixed Earth grid using brightness temperature observations from descending (6 am) passes and ancillary data. A beta quality version of L2_SM_P was released to the public in September, 2015, with the fully validated L2_SM_P soil moisture data expected to be released in May, 2016. Additional improvements (including optimization of retrieval algorithm parameters and upscaling approaches) and methodology expansions (including increasing the number of core sites, model-based intercomparisons, and results from several intensive field campaigns) are anticipated in moving from accuracy assessment of the beta quality data to an evaluation of the fully validated L2_SM_P data product.

Ocean Salinity↗

Simulation of Auger electron emission from nanometer-size gold targets using the Geant4 Monte Carlo simulation toolkit

We report that a revised atomic deexcitation framework for the Geant4 general purpose Monte Carlo toolkit capable of simulating full Auger deexcitation cascades was implemented in June 2015 release (version 10.2 Beta). An overview of this refined framework and testing of its capabilities is presented for the irradiation of gold nanoparticles (NP) with keV photon and MeV proton beams. The resultant energy spectra of secondary particles created within and that escape the NP are analyzed and discussed. It is anticipated that this new functionality will improve and increase the use of Geant4 in the medical physics, radiobiology, nanomedicine research and other low energy physics fields.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

IBEX: An open infrastructure software platform to facilitate collaborative work in radiomics

Purpose: Radiomics, which is the high-throughput extraction and analysis of quantitative image features, has been shown to have considerable potential to quantify the tumor phenotype. However, at present, a lack of software infrastructure has impeded the development of radiomics and its applications. Therefore, the authors developed the imaging biomarker explorer (IBEX), an open infrastructure software platform that flexibly supports common radiomics workflow tasks such as multimodality image data import and review, development of feature extraction algorithms, model validation, and consistent data sharing among multiple institutions. Methods: The IBEX software package was developed using the MATLAB and C/C++ programming languages. The software architecture deploys the modern model-view-controller, unit testing, and function handle programming concepts to isolate each quantitative imaging analysis task, to validate if their relevant data and algorithms are fit for use, and to plug in new modules. On one hand, IBEX is self-contained and ready to use: it has implemented common data importers, common image filters, and common feature extraction algorithms. On the other hand, IBEX provides an integrated development environment on top of MATLAB and C/C++, so users are not limited to its built-in functions. In the IBEX developer studio, users can plug in, debug, and test new algorithms, extending IBEX’s functionality. IBEX also supports quality assurance for data and feature algorithms: image data, regions of interest, and feature algorithm-related data can be reviewed, validated, and/or modified. More importantly, two key elements in collaborative workflows, the consistency of data sharing and the reproducibility of calculation result, are embedded in the IBEX workflow: image data, feature algorithms, and model validation including newly developed ones from different users can be easily and consistently shared so that results can be more easily reproduced between institutions. Results: Researchers with a variety of technical skill levels, including radiation oncologists, physicists, and computer scientists, have found the IBEX software to be intuitive, powerful, and easy to use. IBEX can be run at any computer with the windows operating system and 1GB RAM. The authors fully validated the implementation of all importers, preprocessing algorithms, and feature extraction algorithms. Windows version 1.0 beta of stand-alone IBEX and IBEX’s source code can be downloaded. Conclusions: The authors successfully implemented IBEX, an open infrastructure software platform that streamlines common radiomics workflow tasks. Its transparency, flexibility, and portability can greatly accelerate the pace of radiomics research and pave the way toward successful clinical translation.

60 APPLIED LIFE SCIENCES↗

Simulations of stellar collapses to black holes: Influence of hyperons

Stellar core collapse to a black hole is an event where extremely high temperatures and densities are reached. It is then expected that additional particles to nucleons and electrons appear, as hyperons. We present numerical simulations of the collapse of massive stars to black holes, with an equation of state based on the Lattimer-Swesty one, but allowing for the presence of Λ hyperons. A feature of these equations of state is that its cold and beta-equilibrium version allows for neutrons stars with almost two solar masses, marginally compatible with recent observations. Spherically symmetric simulations, under some conditions, may show the effect of a phase transition to hyperonic matter before the appearance of the black hole. We show axisymmetric simulations, too, where this phase transition would be smoothed, but where gravitational waves show clear imprint of the presence of hyperons.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗