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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 73 records · Page 4
All sourcesNASA NTRSDOE OSTI
DOE OSTI2025

Development of emerging model microorganisms: Megasphaera elsdenii for biomass and organic acid upgrading to fuels and chemicals

The metabolic diversity of microorganisms in nature represents a largely untapped source of valuable compounds that are difficult or impossible to produce in the limited number of available model systems. Efforts to produce longer-chain alcohols, such as hexanol, in organisms like Escherichia coli have met with limited success; production of C6 and larger products remains low, highlighting the challenges of extending chain elongation pathways beyond a single cycle. Megasphaera elsdenii naturally condenses acetyl-CoA to efficiently generate C4–C8 organic acids, making it a promising candidate for producing fuels and chemicals from lactate and plant-derived carbohydrates. This high native flux through the chain elongation pathway offers the potential for higher yields and titers of medium-chain products, such as hexanol, compared to conventional hosts. Recent advances—most notably the development of a transformation method for M. elsdenii—have further opened the organism to detailed physiological studies and bioengineering. While full development of M. elsdenii as a hexanol-producing platform was not achieved, significant progress was made in understanding its metabolism and building foundational genetic tools for future engineering.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2026

Development of Biofuel and Bioenergy Processes for Photosynthetic CO 2 Assimilation (CRADA Final Report)

In order to fully exploit algae carbon assimilation for fuels, a preqrequisite is high photosynthetic efficiency and carbon conversion to fuel precursors. In the context of this collaborative project between NLR and EMRE we aim to address aspects of both the biological constraints around photosynthesis-driven carbon assimilation flux as well as elements that bridge the gap between laboratory cultivation and meaningful outdoor deployment, building on the unique capabilities of NLR and EMRE’s algae bioengineering teams. The goal of this work is to improve our understanding of key cellular biochemistry, mass cultivation, and biomass conversion constraints that presently limit the potential bio-oil yield. The proposed first phase of this work will focus on biomass growth improvements by testing hypotheses for alleviating identified metabolic and photophysiological bottlenecks. The results of this work could inform decisions by stakeholders (e.g., industry, community, investors) on the design and deployment of a sustainable biofuel supply chain from algae.

09 BIOMASS FUELS↗
DOE OSTI2024

DNA parts and gene constructs for plant biodesign

Plant biodesign requires the knowledge of DNA parts (e.g., genes, promoters, terminators), along with their combinations (as gene constructs) linked to engineered traits. DNA parts with validated or predicted functions in plants have been deposited in various online databases. However, these existing databases focus on basic biological functions of individual DNA parts, leaving a gap between basic knowledge and bioengineering applications. To fill this knowledge gap, we have created a user-friendly, open-ended database as a knowledge graph linking DNA parts to gene constructs to traits. This database contains experimentally validated DNA parts and gene constructs documented in peer-reviewed publications. The DNA parts include 1) molecular components with biological functions, such as genes involved in various biological processes (e.g., metabolic and signal transduction pathways) and 2) molecular components with technical functions, such as gene expression, genome engineering and sequence splicing. The gene constructs deposited in this database include both single-gene and multi-gene constructs. This database allows users to submit DNA parts and gene construct compositions linked to engineered traits described in peer-reviewed publications, providing a public digital repository for sharing the biodesign information among the researchers in the fields of plant biotechnology and plant synthetic biology.

plant biodesign synthetic biology gene constructs ↗
DOE OSTI2024

Artificial Intelligence Transforming Post-Translational Modification Research

Post-Translational Modifications (PTMs) are covalent changes to amino acids that occur after protein synthesis, including covalent modifications on side chains and peptide backbones. Many PTMs profoundly impact cellular and molecular functions and structures, and their significance extends to evolutionary studies as well. In light of these implications, we have explored how artificial intelligence (AI) can be utilized in researching PTMs. Initially, rationales for adopting AI and its advantages in understanding the functions of PTMs are discussed. Then, various deep learning architectures and programs, including recent applications of language models, for predicting PTM sites on proteins and the regulatory functions of these PTMs are compared. Finally, our high-throughput PTM-data-generation pipeline, which formats data suitably for AI training and predictions is described. We hope this review illuminates areas where future AI models on PTMs can be improved, thereby contributing to the field of PTM bioengineering.

59 BASIC BIOLOGICAL SCIENCES↗
NASA NTRS1973

Transducer technology transfer to bio-engineering applications

The results of a technology transfer of a miniature unidirectional stress transducer, developed for experimental stress analysis in the aerospace field, to applications in bioengineering are reported. By modification of the basic design and innovations in attachment techniques, the transducer was successfully used in vivo on the myocardium of large dogs to record the change in contractile force due to coronary occlusion, reperfusion, and intervention.

Duran, E. N.↗
NASA NTRS1974

Technical evaluation of the Aerospace Medical Panel Specialists Meeting on Escape Problems and Manoeuvres in Combat Aircraft

A technical evaluation of the papers presented at a conference on escape systems for helicopters and V/STOL aircraft was made. The subjects discussed include the following: (1) bioengineering aspects of spinal injury during ejection, (2) aerodynamic forces acting on crewman during escape, (3) operational practicality of fly away ejection seats, (4) helicopter survivability requirements, (5) ejection experience from V/STOL aircraft, and (6) research projects involving escape and retrieval systems.

Jones, W. L.↗
NASA NTRS1974

Summer Institute in Biomedical Engineering, 1973

Bioengineering of medical equipment is detailed. Equipment described includes: an environmental control system for a surgical suite; surface potential mapping for an electrode system; the use of speech-modulated-white-noise to differentiate hearers and feelers among the profoundly deaf; the design of an automatic weight scale for an isolette; and an internal tibial torsion correction study. Graphs and charts are included with design specifications of this equipment.

Deloatch, E. M.↗
NASA NTRS1974

Rehabilitation and the Veterans' Administration

The Veteran's Administration health care system provides prosthetic and sensory aids for the rehabilitation of neurologically handicapped veterans. Research and development centers include prosthetic clinic teams, orthopedic shops, restoration clinics, bioengineering services, orthotics, etc.

Meister, F.↗
NASA NTRS1976

A perceptual channel for information transfer over kilometer distances Historical perspective and recent research

For more than 100 years, scientists have attempted to determine the truth or falsity of claims for the existence of a perceptual channel whereby certain individuals are able to perceive and describe remote data not presented to any known sense. This paper presents an outline of the history of scientific inquiry into such so-called paranormal perception and surveys the current state of the art in parapsychological research in the United States and abroad. The nature of this perceptual channel is examined in a series of experiments carried out in the Electronics and Bioengineering Laboratory of Stanford Research Institute. The perceptual modality most extensively investigated is the ability of both experienced subjects and inexperienced volunteers to view, by innate mental processes, remote geographical or technical targets including buildings, roads, and laboratory apparatus. The accumulated data indicate that the phenomenon is not a sensitive function of distance, and Faraday cage shielding does not in any apparent way degrade the quality and accuracy of perception. On the basis of this research, some areas of physics are suggested from which a description or explanation of the phenomenon could be forthcoming.

Puthoff, H. E.↗
NASA NTRS1981

Space transportation system flight 2 OSTA-1 scientific payload data management plan

The Shuttle Imaging Radar-A (SIR-A), Shuttle Multispectral Infrared Radiometer (SMIRR), Future Identification and Location Experiment (FILE), Measurement of Air Pollution from Satellites (MAPS), Ocean Color Experiment (OCE), the Night/Day Optical Survey of Lightning (NOSL), and the Heflex Bioengineering Test (HBT) experiments are described.

Source record↗
NASA NTRS1982

OSTA-1 - Shuttle's first scientific and applications payload

The Office of Space and Terrestrial Applications' OSTA-1 scientific and applications payload will be carried by the second Space Shuttle flight and be concerned primarily with the remote sensing of land resources, atmospheric phenomena and ocean conditions. Incorporated by the OSTA-1 payload are the Shuttle Multispectral IR Radiometer, the Feature Identification and Location Experiment, the Measurement of Air Pollution from Satellites experiment, the Ocean Color Experiment, the Night/Day Optical Survey of Lightning, and the Heflex Bioengineering Test.

Demas, L. J.↗
NASA NTRS1982

Life science research in space - The Spacelab era

The events leading up to Spacelab mission 4, which is to be dedicated exclusively to life sciences experimentation in 1984-85, are described. Out of 400 experiment proposals initially received and assessed, 87 candidates were chosen for definition studies to identify the resources which would be required. These proposals addressed such problems encountered in previous space flights as space motion sickness, cardiovascular deconditioning and muscle wasting, calcium loss, and red cell mass reduction. Additional experiments were selected from bioengineering, plant physiology, and cell biology. Human subjects will consist of a Mission Specialist Astronaut and up to four Payload Specialists. Equipment to be used in experimentation includes biotelemetry systems, microscopes, cameras, centrifuges and refrigerators, all of which have been designed for use in weightless conditions. The 87 candidate experiments will be further reduced to about 20.

Farrell, R. M.↗
NASA NTRS1982

The OSTA-1 mission - Overview of the goals, mission parameters and instrumentation for the first Shuttle scientific payload

Aspects of the second Space Shuttle flight, which carried the first payload of scientific instruments for remote sensing of the earth's atmosphere, oceans, and land areas, are discussed. The development and integration of the payload, the mission simulations and end-to-end testing, the launch, the payload mission operations, the landing, data removal, and payload removal, the scientific results, and some planned experiments using the Shuttle are addressed. Summaries of the experimental results are presented, including those for the imaging radar, infrared radiometer, ocean color experiment, air pollution measurements, feature identification and location experiment, night/day optical lightning survey, and bioengineering test. The availability of data and science reports is also covered.

Taranik, J. V.↗
NASA NTRS1984

System for the Management of Trauma and Emergency Surgery in Space

The need to develop a systems approach to the management of trauma and other major clinical medical events in space along with appropriate development and evaluation of surgical techniques and required hardware was investigated. A prototype zero gravity surgical module was constructed and tested aboard a KC-135 aircraft during parabolic arc zero G flight. To insure parity of quality care to that available on Earth, it was recommended that a clinical medical and bioengineering advisory committee define and help develop the necessary components of the clinical medical care system for the space station and lunar base. Key components of the system are aerospace surgical training, medical equipment development, including support hardware and software, rapid access to a network of specialty expertise, and continued research and development.

Houtchens, B.↗
NASA NTRS1983

ECUT: Energy Conversion and Utilization Technologies program. Industry, university and research interest in the US Department of Energy ECUT biocatalysis research activity

The results of a Research Opportunity Notice (RON) disseminated by the Jet Propulsion Laboratory for the U.S. Department of Energy Conversion and Utilization Technologies (ECUT) Program's Biocatalysis Research Activity are presented. The RON was issued in late April of 1983 and solicited expressions of interest from petrochemical and chemical companies, bioengineering firms, biochemical engineering consultants, private research laboratories, and universities for participating in a federal research program to investigate potential applications of biotechnology in producing chemicals. The RON results indicate that broad interest exists within the nation's industry, universities, and research institutes for the Activity and its planned research and development program.

Wilcox, R. E.↗
NASA NTRS1982

OSTA-1 lessons learned and recommendations for future payloads

Five remote sensing experiments, together with one air pollution and one bioengineering experiment, were incorporated into the first Space Shuttle scientific payload of the NASA Office of Space and Terrestrial Applications (OSTA-1). The instrument package, experimental procedures, and specialized personnel teams all performed satisfactorily. Attention is presently given to the lessons learned during the OSTA-1-incorporating mission, STS-2 of November 12, 1981. Payload test and integration teams should never take unfamiliar facilities for granted. Training, especially if it employs hands-on experience with full-scale mockups and mission simulations, is found to be highly effective. Ephemeris data is too important to trust to table-top calculators, since errors propagate in repeated calculations. Terminal access to an off-line computer is required.

Baldwin, R. R.↗