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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 73 records · Page 4
All sourcesNASA NTRSDOE OSTI
NASA NTRS1988

Space station functional relationships analysis

A systems engineering process is developed to assist Space Station designers to understand the underlying operational system of the facility so that it can be physically arranged and configured to support crew productivity. The study analyzes the operational system proposed for the Space Station in terms of mission functions, crew activities, and functional relationships in order to develop a quantitative model for evaluation of interior layouts, configuration, and traffic analysis for any Station configuration. Development of the model involved identification of crew functions, required support equipment, criteria of assessing functional relationships, and tools for analyzing functional relationship matrices, as well as analyses of crew transition frequency, sequential dependencies, support equipment requirements, potential for noise interference, need for privacy, and overall compatability of functions. The model can be used for analyzing crew functions for the Initial Operating Capability of the Station and for detecting relationships among these functions. Note: This process (FRA) was used during Phase B design studies to test optional layouts of the Space Station habitat module. The process is now being automated as a computer model for use in layout testing of the Space Station laboratory modules during Phase C.

Tullis, Thomas S.↗
NASA NTRS1989

A unique problem of muscle adaptation from weightlessness: The deceleration deficiency

Decelerator problems of the knee are emphasized since the lower leg musculature is known to atrophy in response to weightlessness. However, other important decelerator functions are served by the shoulder muscles, in particular the rotator cuff muscles. Problems in these muscles often result in tears and dislocations as seen in baseball pitchers. It is noteworthy that at least one device currently exists that can measure concentric and eccentric muscle loading including a submaximal simulated free weight exercise (i.e., force-controlled) and simultaneously record integrated EMG analysis appropriate for assessment of all muscle functional activities. Studies should be undertaken to provide information as to the performance of maximal and submaximal exercise in space travelers to define potential problems and provide rationale for prevention.

Stauber, William T.↗
NASA NTRS1991

Using HST: From proposal to science

The following subject areas are covered: a short history; uses of network STSCII (general communication, science collaboration, functional activities, internal data management, and external data access); proposal/observation handling; DMF access; and future uses and requirements.

Shames, P.↗
NASA NTRS1993

Specification and testing for power by wire aircraft

A power by wire aircraft is one in which all active functions other than propulsion are implemented electrically. Other nomenclature are 'all electric airplane,' or 'more electric airplane.' What is involved is the task of developing and certifying electrical equipment to replace existing hydraulics and pneumatics. When such functions, however, are primary flight controls which are implemented electrically, new requirements are imposed that were not anticipated by existing power system designs. Standards of particular impact are the requirements of ultra-high reliability, high peak transient bi-directional power flow, and immunity to electromagnetic interference and lightning. Not only must the electromagnetic immunity of the total system be verifiable, but box level tests and meaningful system models must be established to allow system evaluation. This paper discusses some of the problems, the system modifications involved, and early results in establishing wiring harness and interface susceptibility requirements.

Hansen, Irving G.↗
NASA NTRS1994

CINDOC, CSIC, and Spanish R and D

The organizational structure and functional activities of the Spanish Center for Scientific Information and Documentation (CINDOC) are discussed. The library holds 8,500 journals, including all the Spanish scientific journals; 16,000 books and 20 CD-ROM data bases. CINDOC creates and distributes its own data bases that include all the articles published in Spanish scientific journals.

Delaviesca, Rosa↗
NASA NTRS1999

Expression of Novel Gene Products Upregulated by Disuse is Normalized by an Osteogenic Mechanical Stimulus: Evidence for the Molecular Basis of a Low Level Biomechanical Countermeasure for Osteoporosis?

The National Research Council's report entitled: A Strategy for Space Biology and Medical Science, highlighted several areas of fundamental scientific investigation which must be addressed to make long-term space exploration not only feasible, but safe. This "Goldberg Strategy," as well as several subsequent reports published by the NRC's Space Studies Board (e.g., Assessment of Programs in Space Biology and Medicine, Smith et. al., 1991), suggests that the principal hurdle to man's extended presence in space is the osteopenia which parallels reduced gravity. Ironically, the most significant risk to the skeleton may only be realized on return to normal gravitational fields, and full recovery of bone mass may never occur. Effective counter-measures to this microgravity induced bone loss are thus essential. Considering the similarities of space and aging induced osteopenia, an indisputable benefit of such a prophylaxis would be its potential as a treatment for the bone loss which plagues over 25 million people in the U.S. The osteogenic potential of mechanical strain is strongly frequency dependent, with sensitivity increasing up through at least 60 Hz (cycles per second). One hundred seconds per day of a 1 Hz cyclic loading will inhibit disuse osteopenia only if sufficient in magnitude to engender 1000 microstrain (mu(epsilon)) in the tissue. When loading is applied at 30 Hz, however, mechanical strains on the order of 5O mu(epsilon) (approx. 1% of the peak strains which occur in bone during vigorous functional activity), can stimulate bone formation in a duration dependent manner. In longer term animal studies, strains of less than 10 mu(epsilon), induced non-invasively via a whole body vibration, will stimulate bone formation on the surfaces of trabeculae, increase bone density, and improve strength. Finally, preliminary results from a double blind prospective clinical trial shows promise in inhibiting the bone loss which parallels the menopause. Based on these observations, we propose that these high frequency, low magnitude, mechanical strains effectively serve as a "surrogate" for musculoskeletal ground reaction forces, and thus represent an ideal countermeasure to the osteopenia which parallels microgravity conditions. The specific goal of this NASA funded work is to identify genes in bone upregulated by disuse, and to determine the efficacy of an osteogenic mechanical stimulus to downregulate their expression.

Rubin, C.↗
NASA NTRS2000

Overexpression of Human Bone Alkaline Phosphatase in Pichia Pastoris

The Pichiapastoris expression system was utilized to produce functionally active human bone alkaline phosphatase in gram quantities. Bone alkaline phosphatase is a key enzyme in bone formation and biomineralization, yet important questions about its structural chemistry and interactions with other cellular enzymes in mineralizing tissues remain unanswered. A soluble form of human bone alkaline phosphatase was constructed by deletion of the 25 amino acid hydrophobic C-terminal region of the encoding cDNA and inserted into the X-33 Pichiapastoris strain. An overexpression system was developed in shake flasks and converted to large-scale fermentation. Alkaline phosphatase was secreted into the medium to a level of 32mgAL when cultured in shake flasks. Enzyme activity was 12U/mg measured by a spectrophotometric assay. Fermentation yielded 880mgAL with enzymatic activity of 968U/mg. Gel electrophoresis analysis indicates that greater than 50% of the total protein in the fermentation is alkaline phosphatase. A purification scheme has been developed using ammonium sulfate precipitation followed by hydrophobic interaction chromatography. We are currently screening crystallization conditions of the purified recombinant protein for subsequent X-ray diffraction analyses. Structural data should provide additional information on the role of alkaline phosphatase in normal bone mineralization and in certain bone mineralization anomalies.

Karr, Laurel↗
NASA NTRS1996

Cloning and characterization of the murine homolog of the sno proto-oncogene reveals a novel splice variant

The cellular function(s) of the SNO protein remain undefined. To gain a better understanding of possible developmental roles of this cellular proto-oncogene, we have cloned two murine sno cDNAs and have investigated their expression patterns in embryonic and postnatal tissues. A single major transcript of 7.5 kb is detected in multiple tissues by Northern blot. However, reverse transcriptase polymerase chain reaction (RT-PCR) and RNAse protection assays revealed a novel splice variant in every tissue examined. Two isoforms, termed sno N and sno-dE3 (dE3, deletion within exon 3), were identified. The sno-dE3 isoform employs a novel 5' splice site located within the coding region of the third exon and deletes potential kinase recognition motifs. Transcripts of both sno isoforms accumulate ubiquitously but are most abundant in the developing central nervous system. The in situ hybridization patterns of sno expression during murine development suggest potential roles in tissues with a high degree of cellular proliferation. Expression in terminally differentiated tissues such as muscle and neurons indicates that SNO may have multiple functional activities.

Non-NASA Center↗
NASA NTRS2012

Functional Near Infrared Spectroscopy: Watching the Brain in Flight

Functional Near Infrared Spectroscopy (fNIRS) is an emerging neurological sensing technique applicable to optimizing human performance in transportation operations, such as commercial aviation. Cognitive state can be determined via pattern classification of functional activations measured with fNIRS. Operational application calls for further development of algorithms and filters for dynamic artifact removal. The concept of using the frequency domain phase shift signal to tune a Kalman filter is introduced to improve the quality of fNIRS signals in realtime. Hemoglobin concentration and phase shift traces were simulated for four different types of motion artifact to demonstrate the filter. Unwanted signal was reduced by at least 43%, and the contrast of the filtered oxygenated hemoglobin signal was increased by more than 100% overall. This filtering method is a good candidate for qualifying fNIRS signals in real time without auxiliary sensors

Harrivel, Angela↗
NASA NTRS2012

Functional Near Infrared Spectroscopy: Watching the Brain in Flight

Functional Near Infrared Spectroscopy (fNIRS) is an emerging neurological sensing technique applicable to optimizing human performance in transportation operations, such as commercial aviation. Cognitive state can be determined via pattern classification of functional activations measured with fNIRS. Operational application calls for further development of algorithms and filters for dynamic artifact removal. The concept of using the frequency domain phase shift signal to tune a Kalman filter is introduced to improve the quality of fNIRS signals in real-time. Hemoglobin concentration and phase shift traces were simulated for four different types of motion artifact to demonstrate the filter. Unwanted signal was reduced by at least 43%, and the contrast of the filtered oxygenated hemoglobin signal was increased by more than 100% overall. This filtering method is a good candidate for qualifying fNIRS signals in real time without auxiliary sensors.

Harrivel, Angela↗
NASA NTRSDate not supplied

Towards Surrogate Modeling of Subgrid Turbulent Transport for 3D Radiative Hydrodynamic Simulations of the Quiet Sun

In this work, we investigate the use of deep learn-ing techniques as surrogate models, to enhance the estimationof effects of subgrid turbulent transport for 3D radiatuve hy-drodynamic simulations of the quiet Sun. We develop two dis-tinct 3D Convolutional Neural Networks (3DCNNs) to capturespatio-temporal dependencies in 3D velocity fields, leveragingdifferent activation functions and architectural designs. Thesemodels integrate both averaged velocity vector components andscalar features such as plasma density to enhance predictionaccuracy. Additionally, a Multilayer Perceptron (MLP) modelis employed to approximate complex nonlinear relationships,offering a comparison in performance between convolutionaland fully connected architectures. Logarithmic transformationis applied to the targets to handle heavily skewed data, im-proving model performance. All models are compared againsta physics-based Gradient Model. Results show that the 3DCNNmodels excel at approximating Reynolds stress tensors, makingthem a candidate for assisting in producing reduced resolutionsimulations, and thereby reducing computational overheadwhile maintaining higher accuracy than the baseline. Thesefindings demonstrate the potential of deep learning, particu-larly CNNs, to advance scalable and accurate simulations ofsolar dynamics, offering a promising alternative to traditionalturbulence models.

Heliophysics↗
NASA NTRS2006

The Solar Wind and Geomagnetic Activity as a Function of Time Relative to Corotating Interaction Regions

Corotating interaction regions during the declining phase of the solar cycle are the cause of recurrent geomagnetic storms and are responsible for the generation of high fluxes of relativistic electrons. These regions are produced by the collision of a high-speed stream of solar wind with a slow-speed stream. The interface between the two streams is easily identified with plasma and field data from a solar wind monitor upstream of the Earth. The properties of the solar wind and interplanetary magnetic field are systematic functions of time relative to the stream interface. Consequently the coupling of the solar wind to the Earth's magnetosphere produces a predictable sequence of events. Because the streams persist for many solar rotations it should be possible to use terrestrial observations of past magnetic activity to predict future activity. Also the high-speed streams are produced by large unipolar magnetic regions on the Sun so that empirical models can be used to predict the velocity profile of a stream expected at the Earth. In either case knowledge of the statistical properties of the solar wind and geomagnetic activity as a function of time relative to a stream interface provides the basis for medium term forecasting of geomagnetic activity. In this report we use lists of stream interfaces identified in solar wind data during the years 1995 and 2004 to develop probability distribution functions for a variety of different variables as a function of time relative to the interface. The results are presented as temporal profiles of the quartiles of the cumulative probability distributions of these variables. We demonstrate that the storms produced by these interaction regions are generally very weak. Despite this the fluxes of relativistic electrons produced during those storms are the highest seen in the solar cycle. We attribute this to the specific sequence of events produced by the organization of the solar wind relative to the stream interfaces. We also show that there are large quantitative differences in various parameters between the two cycles.

McPherron, Robert L.↗
NASA NTRS1989

Motion sickness and gastric myoelectric activity as a function of speed of rotation of a circular vection drum

Motion sickness symptoms and electrogastrograms (EGGs) were obtained from 60 healthy subjects while they viewed an optokinetic drum rotated at one of four speeds: 15, 30, 60 or 90 deg/s. All subjects experienced vection, illusory self-motion. Motion sickness symptoms increased as drums speed increased up to 60 deg/s. Power, spectral intensity, of the EGG at the tachygastria frequencies (4-9 cpm) was calculated at each drum rotation speed. The correlation between the motion sickness symptoms and the power at 4-9 cpm was significant. Thus, drum rotation speed influenced the spectral power of the EGG at 4-9 cpm, tachygastria, and the intensity of motion sickness symptoms.

Hu, Senqi↗