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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 703 records · Page 39
All sourcesNASA NTRSDOE OSTI
DOE OSTI2020

Adaptive model tuning studies for non-invasive diagnostics and feedback control of plasma wakefield acceleration at FACET-II

Beam-driven plasma wakefield acceleration (PWFA) achieves the same energy gain in a single meter, for which conventional accelerators require several kilometers, however much work is still required to match the beam quality of conventional accelerators. The PWFA processes to be studied at the FACET-II facility will utilize extremely short (down to a few fs) high energy (10 GeV), high charge (few nC) electron and eventually positron bunches. The PWFA process is extremely sensitive to the detailed longitudinal current profiles of these bunches and it would be of great benefit to have precise measurement and control of these profiles. We present an adaptive model tuning technique for FACET-II to adaptively tune online models based on real time accelerator and beam data to continuously provide a non-invasive diagnostic which predicts the longitudinal phase space (LPS) of extremely short and highly compressed electron beams, which otherwise require destructive X-band transverse deflecting cavity (XTCAV)-based measurements. Based on simulation studies, our method has the potential for: (1). The development of a non-invasive longitudinal phase space diagnostic by adaptively tuning models based on non-invasive measurements such as energy spread spectra which could be recorded at all of the bunch compressors in the facility. (2). Utilize these diagnostic to perform model-independent feedback-based to achieve desired longitudinal phase space distributions. (3). Utilize the model-independent feedback approach to maximize energy gain while minimizing emittance growth and energy gain variance of the PWFA process by tuning accelerator parameters, while monitoring what longitudinal phase space the algorithm has found, information that will be useful for further analytical and simulation studies.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗
DOE OSTI2013

Negative feedback regulation of Homer 1a on norepinephrine-dependent cardiac hypertrophy

Homers are scaffolding proteins that modulate diverse cell functions being able to assemble signalling complexes. In this study, the presence, sub-cellular distribution and function of Homer 1 was investigated. Homer 1a and Homer 1b/c are constitutively expressed in cardiac muscle of both mouse and rat and in HL-1 cells, a cardiac cell line. As judged by confocal immunofluorescence microscopy, Homer 1a displays sarcomeric and peri-nuclear localization. In cardiomyocytes and cultured HL-1 cells, the hypertrophic agonist norepinephrine (NE) induces α{sub 1}-adrenergic specific Homer 1a over-expression, with a two-to-three-fold increase within 1 h, and no up-regulation of Homer 1b/c, as judged by Western blot and qPCR. In HL-1 cells, plasmid-driven over-expression of Homer 1a partially antagonizes activation of ERK phosphorylation and ANF up-regulation, two well-established, early markers of hypertrophy. At the morphometric level, NE-induced increase of cell size is likewise and partially counteracted by exogenous Homer 1a. Under the same experimental conditions, Homer 1b/c does not have any effect on ANF up-regulation nor on cell hypertrophy. Thus, Homer 1a up-regulation is associated to early stages of cardiac hypertrophy and appears to play a negative feedback regulation on molecular transducers of hypertrophy. -- Highlights: • Homer 1a is constitutively expressed in cardiac tissue. • In HL-1 cells, norepinephrine activates signaling pathways leading to hypertrophy. • Homer 1a up-regulation is an early event of norepinephrine-induced hypertrophy. • Homer 1a plays a negative feedback regulation modulating pathological hypertrophy. • Over-expression of Homer 1a per se does not induce hypertrophy.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2021

PGC1α regulates mitochondrial oxidative phosphorylation involved in cisplatin resistance in ovarian cancer cells via nucleo-mitochondrial transcriptional feedback

Mitochondria play an important role in effective cell energy production and cell survival under stress conditions, such as treatment with chemotherapeutic drugs. Mitochondrial biogenesis is increased in ovarian cancer tissues, which is accompanied by alteration of mitochondrial energy metabolism, structure, and dynamics. These factors are involved in tumorigenesis and apoptosis resistance, highlighting the role of mitochondria in resisting cisplatin toxicity. Cisplatin-resistant ovarian cancer cells are dependent on mitochondrial OXPHOS for energy supply, and intracellular PGC1α-mediated mitochondrial biogenesis levels are increased in this cell line, indicating the important role of mitochondrial oxidative phosphorylation in cisplatin resistance. As PGC1α is a key molecule for integrating and coordinating nuclear DNA and mitochondrial DNA transcriptional machinery, an investigation into the regulatory mechanism PGC1α in mitochondrial energy metabolism via transcription may provide new clues for solving chemotherapy resistance. In the present study, it was demonstrated that inhibiting the expression of PGC1α decreased nuclear and mitochondrial DNA transcription factor expression, leading to increased lactic acid production and decreased cellular oxygen consumption and mitochondrial oxidative phosphorylation. Furthermore, mitochondrial stress-induced ROS production, as a feedback signal from mitochondria to the cell nucleus, increased PGC1α expression in SKOV3/DDP cells, which was involved in mitochondrial oxidative phosphorylation regulation. Collectively, the present study provides evidence that PGC1α-mediated nuclear and mitochondrial transcription feedback regulates energy metabolism and is involved in ovarian cancer cells escaping apoptosis during cisplatin treatment.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2018

Reduction of Feedback Inhibition in Homoserine Kinase (ThrB) of Corynebacterium glutamicum Enhances L -Threonine Biosynthesis

L -Threonine is an important supplement in the food industry. It is currently produced through fermentation of Escherichia coli but requires additional purification steps to remove E. coli endotoxin. To avoid these steps, it is desirable to use Corynebacterium glutamicum , a microorganism generally regarded as safe. Engineering of C. glutamicum to increase production of l -threonine has mainly focused on gene regulation as well as l -threonine export or carbon flux depletion. In this study, we focus on the negative feedback inhibition produced by L -threonine on the enzyme homoserine kinase (ThrB). Although L -threonine binds to allosteric sites of aspartate kinase (LysC) and homoserine dehydrogenase (Hom), serving as a noncompetitive inhibitor, it acts as a competitive inhibitor on ThrB. This is problematic when attempting to engineer enzymes that are nonresponsive to increasing cellular concentrations of L -threonine. Using primary structure alignment as well as analysis of the Methanocaldococcus jannaschii ThrB ( Mja ThrB) active site in complex with L -threonine (inhibitor of ThrB) and L -homoserine (substrate of ThrB), a conserved active-site alanine residue (A20) in C. glutamicum ThrB ( Cgl ThrB) was predicted to be important for differential interactions with L -threonine and L -homoserine. Through site-directed mutagenesis, we show that one variant of C. glutamicum ThrB, Cgl ThrB-A20G, retains wild-type enzymatic activity, with dramatically decreased feedback inhibition by L -threonine. Additionally, by solving the first Corynebacterium X-ray crystal structure of homoserine kinase, we can confirm that the changes in L -threonine affinity to the Cgl ThrB-A20G active site derive from loss of van der Waals interactions.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
DOE OSTI2020

Observational Evidence of State‐Dependent Positive and Negative Land Surface Feedback on Afternoon Deep Convection Over the Southern Great Plains

Abstract The detection of soil moisture‐precipitation feedback is complicated by the dependence of feedback sign on atmospheric state and cloud types. We evaluated responses of convective clouds to changes in surface evaporative fraction (EF) from satellite and ground‐based measurements over the Southern Great Plains in summer months. Strong responses to EF were inferred only after accounting for tropospheric states supporting systematically positive or negative responses. State dependence (inferred from controlled model experiments) explains the weak response found in previous studies. The probability of transitions from shallow to deep cumulus, and subsequent precipitation onset, increases by 58% over drier surfaces in weakly stratified environments having deeper boundary layers. Boundary layer dynamics play a more important role than low‐level relative humidity in these environments. Wetter surfaces yield increased deep convection in moist and thermally stratified environments. The distinct pathways of convective initiation over dry and wet land surfaces can play important roles in drought onset and termination.

Qiu, Shaoyue↗
DOE OSTI2021

Warm Phase of AMV Damps ENSO Through Weakened Thermocline Feedback

Abstract Interactions between ocean basins affect El Niño–Southern Oscillation (ENSO), altering its impacts on society. Here, we explore the effect of Atlantic Multidecadal Variability (AMV) on ENSO behavior using idealized experiments performed with the NCAR‐CESM1 model. Comparing warm (AMV+) to cold (AMV−) AMV conditions, we find that ENSO sea surface temperature (SST) anomalies are reduced by ∼10% and ENSO precipitation anomalies are shifted to the west during El Niño and east during La Niña. Using the Bjerknes stability index, we attribute the reduction in ENSO variability to a weakened thermocline feedback in boreal autumn. In AMV+, the Walker circulation and trade winds strengthen over the tropical Pacific, increasing the background zonal SST gradient. The background changes shift ENSO anomalies westwards, with wind stress anomalies more confined to the west. We suggest the changes in ENSO‐wind stress decrease the strength of the thermocline feedback in the east, eventually reducing ENSO growth rate.

Trascasa‐Castro, Paloma↗
DOE OSTI2023

The Role of Mesoscale Cloud Morphology in the Shortwave Cloud Feedback

A supervised neural network algorithm is used to categorize near-global satellite retrievals into three mesoscale cellular convective (MCC) cloud morphology patterns. At constant cloud amount, morphology patterns differ in brightness associated with the amount of optically thin cloud features. Environmentally driven transitions from closed MCC to other morphology patterns, typically accompanied by more optically thin cloud features, are used as a framework to quantify the morphology contribution to the optical depth component of the shortwave cloud feedback. A marine heat wave is used as an out-of-sample test of closed MCC occurrence predictions. Morphology shifts in optical depth between 65°S and 65°N under projected environmental changes (i.e., from an abrupt quadrupling of CO 2 ) assuming constant cloud cover contributes between 0.04 and 0.07 W m -2 K -1 (aggregate of 0.06) to the global mean cloud feedback.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2024

The Shortwave Cloud-SST Feedback Amplifies Multi-Decadal Pacific Sea Surface Temperature Trends: Implications for Observed Cooling

Climate models struggle to produce sea surface temperature (SST) gradient trends in the tropical Pacific comparable to those seen recently in nature. Here, we find that the magnitude of the cloud-SST feedback in the subtropical Southeast Pacific is correlated across models with the magnitude of Eastern Pacific multi-decadal SST variability. A heat-budget analysis reveals coupling between cloud-radiative effects, circulation, and SST gradients in driving multi-decadal variability in the Eastern Pacific. Using this relationship and observed feedback estimates, we find that internal Eastern Pacific SST variability is underestimated in most models. Adjusting for model bias increases the likelihood of generating a cooling trend at least as large as observations in preindustrial control simulations by ~56% on average. If models underestimate climate “noise,” as our results suggest, this bias should be accounted for when attributing the relative importance of forced versus unforced changes in the climate.

58 GEOSCIENCES↗
DOE OSTI2017

Climate mitigation from vegetation biophysical feedbacks during the past three decades

The surface air temperature response to vegetation changes has been studied for the extreme case of land-cover change; yet, it has never been quantified for the slow but persistent increase in leaf area index (LAI) observed over the past 30 years (Earth greening). We isolate the fingerprint of increasing LAI on surface air temperature using a coupled land–atmosphere global climate model prescribed with satellite LAI observations. Furthermore, we found that the global greening has slowed down the rise in global land-surface air temperature by 0.09 ± 0.02 °C since 1982. This net cooling effect is the sum of cooling from increased evapotranspiration (70%), changed atmospheric circulation (44%), decreased shortwave transmissivity (21%), and warming from increased longwave air emissivity (-29%) and decreased albedo (-6%). The global cooling originated from the regions where LAI has increased, including boreal Eurasia, Europe, India, northwest Amazonia, and the Sahel. Increasing LAI did not, but, significantly change surface air temperature in eastern North America and East Asia, where the effects of large-scale atmospheric circulation changes mask local vegetation feedbacks. Overall, the sum of biophysical feedbacks related to the greening of the Earth mitigated 12% of global land-surface warming for the past 30 years.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2022

Diminishing seasonality of subtropical water availability in a warmer world dominated by soil moisture–atmosphere feedbacks

Global warming is expected to cause wet seasons to get wetter and dry seasons to get drier, which would have broad social and ecological implications. However, the extent to which this seasonal paradigm holds over land remains unclear. Here we examine seasonal changes in surface water availability (precipitation minus evaporation, P–E) from CMIP5 and CMIP6 projections. While the P–E seasonal cycle does broadly intensify over much of the land surface, ~20% of land area experiences a diminished seasonal cycle, mostly over subtropical regions and the Amazon. Using land–atmosphere coupling experiments, we demonstrate that 63% of the seasonality reduction is driven by seasonally varying soil moisture (SM) feedbacks on P–E. Declining SM reduces evapotranspiration and modulates circulation to enhance moisture convergence and increase P–E in the dry season but not in the wet season. Our results underscore the importance of SM–atmosphere feedbacks for seasonal water availability changes in a warmer climate.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2023

Skin-integrated stretchable actuators toward skin-compatible haptic feedback and closed-loop human-machine interactions

Abstract Skin-integrated haptic interfaces that can relay a wealth of information from the machine to the human are of great interest. However, existing haptic devices are not yet able to produce haptic cues that are compatible with the skin. In this work, we present the stretchable soft actuators for haptic feedback, which can match the perception range, spatial resolution, and stretchability of the skin. Pressure-amplification structures are fabricated using a scalable self-assembly process to ensure an output pressure beyond the skin perception threshold. Due to the minimized device size, the actuator array can be fabricated with a sufficiently high spatial resolution, which makes the haptic device applicable for skin locations with the highest spatial acuity. A haptic feedback system is demonstrated by employing the developed soft actuators and highly sensitive pressure sensors. Two proof-of-concept applications are developed to illustrate the capability of transferring information related to surface textures and object shapes acquired at the robot side to the user side.

Chen, Si↗
DOE OSTI2022

Multichannel haptic feedback unlocks prosthetic hand dexterity

Abstract Loss of tactile sensations is a major roadblock preventing upper limb-absent people from multitasking or using the full dexterity of their prosthetic hands. With current myoelectric prosthetic hands, limb-absent people can only control one grasp function at a time even though modern artificial hands are mechanically capable of individual control of all five digits. In this paper, we investigated whether people could precisely control the grip forces applied to two different objects grasped simultaneously with a dexterous artificial hand. Toward that end, we developed a novel multichannel wearable soft robotic armband to convey artificial sensations of touch to the robotic hand users. Multiple channels of haptic feedback enabled subjects to successfully grasp and transport two objects simultaneously with the dexterous artificial hand without breaking or dropping them, even when their vision of both objects was obstructed. Simultaneous transport of the objects provided a significant time savings to perform the deliveries in comparison to a one-at-a-time approach. This paper demonstrated that subjects were able to integrate multiple channels of haptic feedback into their motor control strategies to perform a complex simultaneous object grasp control task with an artificial limb, which could serve as a paradigm shift in the way prosthetic hands are operated.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2017

Albedo feedbacks to future climate via climate change impacts on dryland biocrusts

Drylands represent the planet’s largest terrestrial biome and evidence suggests these landscapes have large potential for creating feedbacks to future climate. Recent studies also indicate that dryland ecosystems are responding markedly to climate change. Biological soil crusts (biocrusts) - soil surface communities of lichens, mosses, and/or cyanobacteria - comprise up to 70% of dryland cover and help govern fundamental ecosystem functions, including soil stabilization and carbon uptake. Drylands are expected to experience significant changes in temperature and precipitation regimes, and such alterations may impact biocrust communities by promoting rapid mortality of foundational species. In turn, biocrust community shifts affect land surface cover and roughness—changes that can dramatically alter albedo. We tested this hypothesis in a full-factorial warming (+4 °C above ambient) and altered precipitation (increased frequency of 1.2 mm monsoon-type watering events) experiment on the Colorado Plateau, USA. We quantified changes in shortwave albedo via multi-angle, solar-reflectance measurements. Warming and watering treatments each led to large increases in albedo (>30%). This increase was driven by biophysical factors related to treatment effects on cyanobacteria cover and soil surface roughness following treatment-induced moss and lichen mortality. A rise in dryland surface albedo may represent a previously unidentified feedback to future climate.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2014

Effects of stratospheric ozone depletion, solar UV radiation, and climate change on biogeochemical cycling: interactions and feedbacks

Climate change modulates the effects of solar UV radiation on biogeochemical cycles in terrestrial and aquatic ecosystems, particularly for carbon cycling, resulting in UV-mediated positive or negative feedbacks on climate. Possible positive feedbacks discussed in this assessment include: (i) enhanced UV-induced mineralisation of above ground litter due to aridification; (ii) enhanced UV-induced mineralisation of photoreactive dissolved organic matter (DOM) in aquatic ecosystems due to changes in continental runoff and ice melting; (iii) reduced efficiency of the biological pump due to UV-induced bleaching of coloured dissolved organic matter (CDOM) in stratified aquatic ecosystems, where CDOM protects phytoplankton from the damaging solar UV-B radiation. Mineralisation of organic matter results in the production and release of CO 2 , whereas the biological pump is the main biological process for CO 2 removal by aquatic ecosystems. This research also assesses the interactive effects of solar UV radiation and climate change on the biogeochemical cycling of aerosols and trace gases other than CO 2 , as well as of chemical and biological contaminants. Lastly,, interacting effects of solar UV radiation and climate change on biogeochemical cycles are particularly pronounced at terrestrial-aquatic interfaces.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2023

Limited impact of jet-induced feedback in the multi-phase nuclear interstellar medium of 4C12.50

4C12.50 (IRAS 13451+1232) at z = 0.122 is an ultraluminous infared radio galaxy that has often been proposed as a prime candidate for the link between ultraluminous infared galaxies and young radio galaxies. It is also an interesting target to investigate whether and how radio-induced feedback affects the evolution of galaxies in the early phases of radio activity. We study, in detail for the first time, the hot (≥1500 K) molecular gas in 4C12.50. The potential impact of the radio jet on this gas phase, as well as on the star formation activity, are investigated. We also study the ionised (including coronal) gas as traced by the near-infrared lines. Using near-infrared long slit spectroscopy obtained with EMIR on GTC and X-shooter on VLT, we analyse the emission line spectrum of the ionised, coronal, and, specially, the hot molecular gas in the western nucleus hosting the compact radio jet. Based on high spatial resolution ALMA CO(2–1) data, we also revise the location of 4C12.50 in the Kennicutt-Schmidt diagram in order to investigate whether star formation is suppressed. 4C12.50 hosts (2.1 ± 0.4) × 10 4 M ⊙ of hot molecular gas. An unusually high rotational temperature T rot = 3020 ± 160 K is inferred. The molecular gas mass obeys a power-law temperature distribution, dM H2 /dT ∝ T –5 , from T ~300 K and up to ~3000 K. Both results support the idea that shocks (probably induced by the radio jet) contribute to the heating and excitation of the hot molecular gas. A molecular outflow is not detected. The coupling of the outflowing ionised and neutral outflows with the hot molecular gas is poor. Contrary to other studies, we claim that there is no evidence for star formation suppression in this object. If radio-induced feedback can regulate the star formation activity in galaxies, 4C12.50 is a promising candidate to reveal this phenomenon in action. However, we find no solid evidence for a current or past impact of this mechanism on the evolution of this system, neither by clearing out the dusty central cocoon efficiently, nor by suppressing the star formation activity.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2014

Positive feedback can lead to dynamic nanometer-scale clustering on cell membranes

Clustering of molecules on biological membranes is a widely observed phenomenon. A key example is the clustering of the oncoprotein Ras, which is known to be important for signal transduction in mammalian cells. Yet, the mechanism by which Ras clusters form and are maintained remains unclear. Recently, it has been discovered that activated Ras promotes further Ras activation. Here we show using particle-based simulation that this positive feedback is sufficient to produce persistent clusters of active Ras molecules at the nanometer scale via a dynamic nucleation mechanism. Furthermore, we find that our cluster statistics are consistent with experimental observations of the Ras system. Interestingly, we show that our model does not support a Turing regime of macroscopic reaction-diffusion patterning, and therefore that the clustering we observe is a purely stochastic effect, arising from the coupling of positive feedback with the discrete nature of individual molecules. These results underscore the importance of stochastic and dynamic properties of reaction diffusion systems for biological behavior.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
DOE OSTI2015

Local regulation of interchange turbulence in a dipole-confined plasma torus using current-collection feedback

Turbulence in plasma confined by a magnetic dipole is dominated by interchange fluctuations with complex dynamics and short spatial coherence. We report the first use of local current-collection feedback to modify, amplify, and suppress these fluctuations. The spatial extent of turbulence regulation is limited to a correlation length near the collector. Changing the gain and phase of collection results in power either extracted from or injected into the turbulence. The measured plasma response shows some agreement with calculations of the linear response of global interchange-like MHD and entropy modes to current-collection feedback.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗
DOE OSTI2015

Coherent control of plasma dynamics by feedback-optimized wavefront manipulation

Plasmas generated by an intense laser pulse can support coherent structures such as large amplitude wakefield that can affect the outcome of an experiment. We investigate the coherent control of plasma dynamics by feedback-optimized wavefront manipulation using a deformable mirror. The experimental outcome is directly used as feedback in an evolutionary algorithm for optimization of the phase front of the driving laser pulse. In this paper, we applied this method to two different experiments: (i) acceleration of electrons in laser driven plasma waves and (ii) self-compression of optical pulses induced by ionization nonlinearity. The manipulation of the laser wavefront leads to orders of magnitude improvement to electron beam properties such as the peak charge, beam divergence, and transverse emittance. The demonstration of coherent control for plasmas opens new possibilities for future laser-based accelerators and their applications.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗