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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 703 records · Page 39
All sourcesNASA NTRSDOE OSTI
NASA NTRS2011

Analysis of Terminal Deletions using a Generalized Time-Dependent Model of Radiation-Induced Formation of Chromosomal Aberrations

We have developed a model that can simulate different types of radiation induced chromosomal aberrations (CA's) and can provide predictions on the frequency and size of chromosomes with terminal deletions. Chromosomes with terminal deletions lack telomeres and this can elicit sister chromatid unions and the prolonged breakage/fusion/bridge (B/F/B) cycles that have been observed in mammalian tumors. The loss of a single telomere has been shown to cause extensive genomic instability through the B/F/B cycle process. Our model uses a stochastic process of DNA broken end joining, in which a realistic spectrum of CA's is created from improperly joined DNA free ends formed by DNA double strand breaks (DSBs). The distribution of the DNA free ends is given by a mechanistic model that takes into account the chromatin structure and track structure for high-LET radiation. The model allows for DSB clustering from high-LET radiation and simulates the formation of CA's in stages that correspond to the actual time after radiation exposure. The time scale for CA formation is derived from experimental data on DSB repair kinetics. At any given time a nucleus may have intact chromosomes, CA's, and/or unrepaired fragments, some of which are defined as terminal deletions, if they are capped by one telomere. The model produces a spectrum of terminal deletions with their corresponding probabilities and size distributions for different heavy ions exposures for the first division after exposure. This data provides valuable information because there is limited experimental data available in the literature on the on the actual size of terminal deletions. We compare our model output to the available experimental data and make a reasonable extrapolation on the number of chromosomes lacking telomeres in human lymphocytes exposed to heavy ions. This model generates data which may lead to predictions on the rate of genomic instability in cells after exposure to high charge and energy nuclei affecting astronauts during space missions.

Ponomarev, Artem L.↗
NASA NTRS2021

Improved Rainfall Data in the Philippines through Concurrent Use of GPM IMERG and Ground-Based Measurements

The availability of accurate and reliable rainfall data that are applicable to various phenomenological, climatological, and modeling studies is important, especially in the Philippines, which is considered to be highly vulnerable to natural hazards and a changing climate. The presented strategy involved constructing a dataset consisting of synoptic data, automatic rain gauge (ARG) measurements, and satellite data that are co-registered, consistent, and formatted in the same manner. Although sparse in number, the synoptic stations provide the most accurate rainfall information and were used as the baseline for creating the dataset. The ARGs that are within a distance of 1 km to the synoptic stations were used to determine the correction factors needed to make the synoptic and ARG data consistent. Subsequently, the corrected ARGs were used to make the satellite IMERG data consistent with both ARG and synoptic data. In case of the latter, only IMERG pixels with at least 10 ARGs within the relatively large footprint of the satellite sensor were used in estimating the required correction parameters derived from a combination of a power transform and linear regression correction techniques. The final results show good agreement of synoptic and corrected ARG data with correlation coefficients of 0.94 and 0.97 for the 10 day and monthly data, respectively, and improvement in the linear regression slope from 0.67 to 0.90 for 10 day data, and 0.70 to 0.94 for monthly data. In addition, the corrected ARG data agree well with the corrected IMERG data, with correlation coefficients of 0.88 and 0.93 for the 10 day and monthly data, respectively, and an improvement in slope from 0.66 to 0.87 for 10 day data, and 0.74 to 0.99 for monthly data. The merit of using a combined dataset is illustrated through comparative analyses of the IMERG data and spatially interpolated synoptic and ARG data. The results show general agreements in spatial patterns of rainfall across the datasets, especially in areas where in situ measurements are recorded. The observed discrepancy when ground data is limited emphasizes the need for satellite IMERG data to obtain the true spatial patterns of rainfall distribution.

rainfall↗
NASA NTRS2020

ICESat 2/ATLAS Onboard Flight Science Receiver Algorithms: Purpose, Process, and Performance

The Advanced Topographic Laser Altimetry System (ATLAS) is the sole instrument on the Ice, Cloud, and land Elevation Satellite 2 (ICESat-2). Without some method of reducing the transmitted data, the volume of ATLAS telemetry would far exceed the normal X-band downlink capability or require many more ground station contacts. The ATLAS Onboard Flight Science Receiver Algorithms (hereinafter Receiver Algorithms or Algorithms) control the amount of science data that is telemetered from the instrument, limiting the data volume by distinguishing surface echoes from background noise, and allowing the instrument to telemeter data from only a small vertical region about the signal. This is accomplished through the transfer of the spacecraft's location and attitude to the instrument every second, use of an onboard Digital Elevation Model, implementation of signal processing techniques, and use of onboard relief and surface type reference maps. Extensive ground testing verified the performance of the Algorithms. On-orbit analysis shows that the Algorithms are working as expected from the ground testing; they are performing well and meeting the mission requirements.

Algoritms, Signal Processing, Optimization, Flight↗
DOE OSTI2021

Patient-Reported Outcomes in Pediatric Cancer Registration Trials: A US Food and Drug Administration Perspective

Pediatric patient-reported outcome (PRO) data can help inform the US Food and Drug Administration’s (FDA’s) benefit-risk assessment of cancer therapeutics by quantifying symptom and functional outcomes from the patient’s perspective. This study assessed use of PROs in commercial pediatric oncology trials submitted to the FDA for regulatory review. FDA databases were searched to identify pediatric oncology product applications approved between 1997 and 2020. Sponsor-submitted documents were reviewed to determine whether PRO data were collected, which instruments were used, and the quality of collected data (ie, sample size, completion rates, and use of fit-for-purpose instruments). The role of PROs in each trial (endpoint hierarchy) was also recorded in addition to whether any PRO endpoints were included in product labeling. We reviewed 17 pediatric oncology applications, 4 of which included PRO data: denosumab, tisagenlecleucel, larotrectinib, and selumetinib. In these 4 instances, PROs served as exploratory endpoints and were not incorporated in product labeling. Trials that collected PRO data were phase II or phase I/II single-arm studies with sample sizes of 28 to 88 patients. Symptomatic adverse events (AEs) were characterized using clinician-reported Common Terminology Criteria for Adverse Events (CTCAE) without additional patient self-report. PROs were infrequently used in pediatric cancer registration trials. When PROs were used, PRO data were limited by lack of a clear research objective and corresponding prospective statistical analysis plan. Contemporary PRO symptom libraries, such as the National Cancer Institute’s Pediatric PRO-CTCAE, may provide an opportunity to better evaluate the occurrence and impact of symptomatic AEs, from the patient’s perspective, in pediatric oncology trials.

Oncology↗
NASA NTRS1991

On the estimation of jet-induced fountain lift and additional suckdown in hover for two-jet configurations

Currently available methods for estimating the net suckdown induced on jet V/STOL aircraft hovering in ground effect are based on a correlation of available force data and are, therefore, limited to configurations similar to those in the data base. Experience with some of these configurations has shown that both the fountain lift and additional suckdown are overestimated but these effects cancel each other for configurations within the data base. For other configurations, these effects may not cancel and the net suckdown could be grossly overestimated or underestimated. Also, present methods do not include the prediction of the pitching moments associated with the suckdown induced in ground effect. An attempt to develop a more logically based method for estimating the fountain lift and suckdown based on the jet-induced pressures is initiated. The analysis is based primarily on the data from a related family of three two-jet configurations (all using the same jet spacing) and limited data from two other two-jet configurations. The current status of the method, which includes expressions for estimating the maximum pressure induced in the fountain regions, and the sizes of the fountain and suckdown regions is presented. Correlating factors are developed to be used with these areas and pressures to estimate the fountain lift, the suckdown, and the related pitching moment increments.

Kuhn, Richard E.↗
NASA NTRS2014

Analyzing a 35-Year Hourly Data Record: Why So Difficult?

At the Goddard Distributed Active Archive Center, we have recently added a 35-Year record of output data from the North American Land Assimilation System (NLDAS) to the Giovanni web-based analysis and visualization tool. Giovanni (Geospatial Interactive Online Visualization ANd aNalysis Infrastructure) offers a variety of data summarization and visualization to users that operate at the data center, obviating the need for users to download and read the data themselves for exploratory data analysis. However, the NLDAS data has proven surprisingly resistant to application of the summarization algorithms. Algorithms that were perfectly happy analyzing 15 years of daily satellite data encountered limitations both at the algorithm and system level for 35 years of hourly data. Failures arose, sometimes unexpectedly, from command line overflows, memory overflows, internal buffer overflows, and time-outs, among others. These serve as an early warning sign for the problems likely to be encountered by the general user community as they try to scale up to Big Data analytics. Indeed, it is likely that more users will seek to perform remote web-based analysis precisely to avoid the issues, or the need to reprogram around them. We will discuss approaches to mitigating the limitations and the implications for data systems serving the user communities that try to scale up their current techniques to analyze Big Data.

computational performance↗
DOE OSTI2024

Enhancing Electron Microscopy Image Classification Using Data Augmentation

Manual labeling for machine learning tasks such as image classification is tedious and labor-intensive; as a result, scientific datasets suitable for deep learning applications are scarce and limited. While data augmentation techniques have shown promise for extending image datasets, very little work has been done to understand the impact of combining multiple augmentation methods sequentially or the limits of their effectiveness when combined. Our work addresses this gap by examining how standard and combinatorial data augmentation affects the performance of machine learning models when trained on small datasets for label classification tasks. For our analysis, we generate single, double and quadruple-augmented datasets for a microscopy image classification task using six standard augmentation methods, and compare the resultant improvements observed in binary classification accuracy with three standard image classification models (DenseNet169, MobileNetV2, ResNet101V2). Our experiments show a non-monotonic relationship between the number of simultaneous augmentation methods and classification accuracy, indicating that there is a trade-off between the degree of augmentation and the model performance. These findings suggest that the optimal number of augmentation methods will vary by domain and use case. We also find that the order in which augmentation methods are applied to a limited dataset matters when combining augmentation schemes, with our use case showing performance differences up to 2.6% when the augmentation order is reversed for double-augmented datasets. Our work offers insights to the limits of data augmentation when working on image classification tasks with limited datasets.

Welsman, Jordan A↗
DOE OSTI2024

Reliability of Copper Inverse Opal Surfaces for Extreme-Heat-Flux Micro-Coolers in Low-Global-Warming-Potential Refrigerant R-1233zd Pool Boiling Experiments

This presentation provides a brief snapshot of the InterPACK paper InterPACK2023-113781. The paper explores copper inverse opal (CIO) surface reliability in pool boiling experiments in water and a new, low-global-warming-potential (GWP = 1) hydrofluoroolefin (HFO) refrigerant R-1233zd. The CIO-based structure is intended to develop enhanced two-phase heat transfer surfaces for extreme-heat-flux (approximately 1 kW/cm2) micro-coolers. In this study, a limited number of pool boiling experiments were performed using water and HFO-1233zd fluid, and the reliability of the CIO-based surfaces was evaluated. Critical heat flux (CHF) values in HFO-1233zd at 40 Degrees Celsius to 45 Degrees Celsius saturation temperatures and the corresponding saturation pressures were also measured. The CHF values with the refrigerant are significantly lower compared to those with water, but the refrigerant allows for a wider usable temperature range in the end application of the micro-coolers and is not limited to data centers with controlled ambient conditions. Reliability experiments with CIO surface samples - involving pool boiling with water on the CIO surfaces for approximately 48 hours and with HFO-1233zd for 144 hours - showed no structural degradation of the enhanced surface or any significant performance drop in heat transfer coefficients. The CIO surface samples in water were oxidized, most likely due to the presence of air in water and in the experimental vessel.

critical heat flux↗
NASA NTRS1978

A technique for scale model rocket base heating tests in a very large vacuum chamber

A series of tests was performed with a 0.040 scale Shuttle Orbiter Base Heating Model in a large vacuum chamber to determine the thermal effects of engine plume recirculation and direct engine plume impingement. The oxygen- and hydrogen-fueled model was fired through a range of simulated altitudes and configurations with varied engine gimbal angles and 'engine-out' combinations. Some of the special problems associated with conducting tests of this type related primarily to obtaining valid temperature and pressure data in the extremely short run times available. Run time is limited by the reflection of shock waves from the chamber wall, propellant charge-tube wave times, the time required to reach steady-state conditions for the engines, and model heating limitations. The 'data window' for potentially valid data usually begins with stabilized engine conditions and terminates with pressure perturbations from either of the aforementioned shock waves. The general approach for coping with these limitations and the method used to obtain valid data during the short data window (of the order of thirty milliseconds) are discussed.

Williams, F. U.↗
NASA NTRS1992

Underlying modal data issues for detecting damage in truss structures

The modal strain energy distribution and frequency and mode shape sensitivities to structural stiffness changes are studied in order to overcome the current limits of modal data limit measurements in damage location. It is established that damage detection is feasible for members significantly contributing to the strain energy of the measured modes; the modes that are most effective in detecting the damage of critical members are identifiable, and a relationship is formulated between the accuracy of the measured modes and frequencies and the probability of damage detection.

Kashangaki, Thomas A.-L.↗
DOE OSTI2021

Forecasting influenza activity using machine-learned mobility map

Human mobility is a primary driver of infectious disease spread. However, existing data is limited in availability, coverage, granularity, and timeliness. Data-driven forecasts of disease dynamics are crucial for decision-making by health officials and private citizens alike. In this work, we focus on a machine-learned anonymized mobility map (hereon referred to as AMM) aggregated over hundreds of millions of smartphones and evaluate its utility in forecasting epidemics. We factor AMM into a metapopulation model to retrospectively forecast influenza in the USA and Australia. We show that the AMM model performs on-par with those based on commuter surveys, which are sparsely available and expensive. We also compare it with gravity and radiation based models of mobility, and find that the radiation model’s performance is quite similar to AMM and commuter flows. Additionally, we demonstrate our model’s ability to predict disease spread even across state boundaries. Our work contributes towards developing timely infectious disease forecasting at a global scale using human mobility datasets expanding their applications in the area of infectious disease epidemiology.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2023

Point-particle drag, lift, and torque closure models using machine learning: Hierarchical approach and interpretability

Developing deterministic neighborhood-informed point-particle closure models using machine learning has garnered interest recently from the dispersed multiphase flow community. The robustness of neural models for this complex multibody problem is hindered by the availability of particle-resolved data. Here, the present work addresses this unavoidable limitation of data paucity by implementing two strategies: (1) by using a rotation and reflection equivariant neural network and (2) by pursuing a physics-based hierarchical machine learning approach. The resulting machine-learned models are observed to achieve a maximum accuracy of 85% and 96% in the prediction of neighbor-induced force and torque fluctuations, respectively, for a wide range of Reynolds number and volume fraction conditions considered. Furthermore, we pursue force and torque network architectures that provide universal prediction spanning a wide range of Reynolds number (0.25 ≤ Re ≤250) and particle volume fraction (0 ≤ φ ≤0.4). The hierarchical nature of the approach enables improved prediction of quantities such as streamwise torque, by going beyond binary interactions to include trinary interactions.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗
DOE OSTI2024

Bridging the gap between experiments and simulations using machine learning

The physics of inertial confinement fusion is rich and complex. Simulation codes that are used to design experiments are computationally expensive and lack the predictive capability required for extensive parameter exploration in search of a high-performing design for laser direct drive. In this work we use deep learning to build a fast emulator of experiments. To facilitate the development of the deep-learning model, an autoencoder is used to reduce the dimensionality of the input space. Two deep learning models are developed. One model is trained on a vast array of simulation data and is subsequently calibrated to expensive and limited experimental data using a technique known as “transfer learning.” The other model is trained on a statistical model and is subsequently calibrated using experimental data. A comparative study of the two predictive models is carried out. The models potentially reproduce key experimental observables with high accuracy and unprecedented inference times relative to those achieved with simulation codes. These models facilitate rapid exploration of a high dimensional input parameter space.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗
NASA NTRS1972

The geocentric orientation vector from limited Astro-geodetic data

Test computations using the comprehensive sets of both astro-geodetic and gravimetric data indicate that the accuracy of the geocentric orientation vector determined from incomplete representations of the earth's gravitational fields, is dependent on the overall extent of the datum. The lack of an astro-geodetic determination of the geoid due to an inadequate density of astro-geodetic stations over certain parts of the datum does not materially affect these determinations. The effect is only marginal if the station density of the area referred to does not markedly differ from the average for the region.

Mather, R. S.↗
NASA NTRS1976

Failure rate analysis of Goddard Space Flight Center spacecraft performance during orbital life

The reported study presents the results of analyses conducted with the aid of both Duane and Weibull growth models. The failure rate values provided may be useful for estimating future space performance, and comparing past, present, and future space performance. Failure rate data from thermal-vacuum system tests are examined and related to the space values. Attention is given to the data base, the time distribution of space malfunctions, limitations on data, and average component reliability for three years in space.

Norris, H. P.↗
NASA NTRS1978

Long-term radiation effects on GaAs solar cell characteristics

This report investigates preliminary design considerations which should be considered for a space experiment involving Gallium Arsenide (GaAs) solar cells. The electron radiation effects on GaAs solar cells were conducted in a laboratory environment, and a statistical analysis of the data is presented. In order to augment the limited laboratory data, a theoretical investigation of the effect of radiation on GaAs solar cells is also developed. The results of this study are empirical prediction equations which can be used to estimate the actual damage of electrical characteristics in a space environment. The experimental and theoretical studies also indicate how GaAs solar cell parameters should be designed in order to withstand the effects of electron radiation damage.

Heinbockel, J. H.↗
NASA NTRS1982

Inversion of data from diffraction-limited multiwavelength remote sensors. II - Nonlinear dependence of observables on the geophysical parameters

Linear shift-invariant spatial filtering is applied to inversion of radiometric measurements of the earth in both polarizations at the following frequencies: 6.6, 10.7, 18, 21, and 37 GHz. For purposes of radiative transfer calculations at these frequencies, the state of the ocean-atmosphere system is described by a seven-parameter model. The parameters are near-surface wind speed, sea surface temperature, integrated water vapor mass, scale height of water vapor in an exponential distribution, integrated liquid water mass, height of the liquid water, and characteristic drop radius in a Best (1950) drop size distribution. Also described is a spatial filtering algorithm by means of which geophysical parameters are retrieved from measurements made over the ocean by the scanning multichannel microwave radiometer on the Nimbus 7 satellite. The parameters here are near-surface wind speed, sea surface temperature, rain rate, integrated atmospheric water vapor content, and integrated liquid water content (including rain).

Rosenkranz, P. W.↗