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At least 703 records · Page 39

Viscoelastic properties of pressure overload hypertrophied myocardium: effect of serine protease treatment

To determine whether and to what extent one component of the extracellular matrix, fibrillar collagen, contributes causally to abnormalities in viscoelasticity, collagen was acutely degraded by activation of endogenous matrix metalloproteinases (MMPs) with the serine protease plasmin. Papillary muscles were isolated from normal cats and cats with right ventricular pressure overload hypertrophy (POH) induced by pulmonary artery banding. Plasmin treatment caused MMP activation, collagen degradation, decreased the elastic stiffness constant, and decreased the viscosity constant in both normal and POH muscles. Thus, whereas many mechanisms may contribute to the abnormalities in myocardial viscoelasticity in the POH myocardium, changes in fibrillar collagen appear to play a predominant role.

NASA Discipline Cardiopulmonary↗

A computational analysis of under-expanded jets in the hypersonic regime

Underexpanded axisymmetric jets are studied numerically using a full Navier-Stokes solver. Emphasis has been given to supersonic and hypersonic jets in supersonic and hypersonic ambient flows, a phenomenon previously overlooked. It is demonstrated that the shear layers and shock patterns in a jet plume can be captured without complicated viscous/inviscid and subsonic/supersonic coupling schemes. In addition, a supersonic pressure relief effect has been identified for underexpanded jets in supersonic ambient flows. While it is well known that an underexpanded jet in a quiescent ambience (or subsonic ambience) contains multiple shock cells, the present study shows that because of the supersonic pressure relief effect, an underexpanded jet in a supersonic or hypersonic ambience contains only one major shock cell.

Hsu, Andrew T.↗

A computational analysis of under-expanded jets in the hypersonic regime

Underexpanded axisymmetric jets are studied numerically using a full Navier-Stokes solver. Emphasis has been given to supersonic and hypersonic jets in supersonic and hypersonic ambient flows, a phehomenon previously being overlooked for the most part. The present work demonstrates that the shear layers and shock patterns in a jet plume can be captured without complicated viscous/inviscid and subsonic/supersonic coupling schemes. In addition, a supersonic pressure relief effect has been identified for underexpanded jets in supersonic ambient flows. While it is well known that an underexpanded jet in a quiescent ambience (or subsonic ambience) contains multiple shock cells, the present study shows that because of the supersonic pressure relief effect, an underexpanded jet in a supersonic or hypersonic ambience contains only one major shock cell.

Hsu, Andrew T.↗

Probabilistic Assessment of Hypobaric Decompression Sickness Treatment Success

The Hypobaric Decompression Sickness (DCS) Treatment Model links a decrease in computed bubble volume from increased pressure (DeltaP), increased oxygen (O2) partial pressure, and passage of time during treatment to the probability of symptom resolution [P(symptom resolution)]. The decrease in offending volume is realized in 2 stages: a) during compression via Boyle's Law and b) during subsequent dissolution of the gas phase via the O2 window. We established an empirical model for the P(symptom resolution) while accounting for multiple symptoms within subjects. The data consisted of 154 cases of hypobaric DCS symptoms along with ancillary information from tests on 56 men and 18 women. Our best estimated model is P(symptom resolution) = 1 / (1+exp(-(ln(Delta P) - 1.510 + 0.795×AMB - 0.00308×Ts) / 0.478)), where (DeltaP) is pressure difference (psid), AMB = 1 if ambulation took place during part of the altitude exposure, otherwise AMB = 0; and where Ts is the elapsed time in mins from start of the altitude exposure to recognition of a DCS symptom. To apply this model in future scenarios, values of DeltaP as inputs to the model would be calculated from the Tissue Bubble Dynamics Model based on the effective treatment pressure: (DeltaP) = P2 - P1 | = P1×V1/V2 - P1, where V1 is the computed volume of a spherical bubble in a unit volume of tissue at low pressure P1 and V2 is computed volume after a change to a higher pressure P2. If 100% ground level O2 (GLO) was breathed in place of air, then V2 continues to decrease through time at P2 at a faster rate. This calculated value of (DeltaP then represents the effective treatment pressure at any point in time. Simulation of a "pain-only" symptom at 203 min into an ambulatory extravehicular activity (EVA) at 4.3 psia on Mars resulted in a P(symptom resolution) of 0.49 (0.36 to 0.62 95% confidence intervals) on immediate return to 8.2 psia in the Multi-Mission Space Exploration Vehicle. The P(symptom resolution) increased to near certainty (0.99) after 2 hrs of GLO at 8.2 psia or with less certainty on immediate pressurization to 14.7 psia [0.90 (0.83 - 0.95)]. Given the low probability of DCS during EVA and the prompt treatment of a symptom with guidance from the model, it is likely that the symptom and gas phase will resolve with minimum resources and minimal impact on astronaut health, safety, and productivity.

Conkin, Johnny↗

A Priori Analysis of a Compressible Flamelet Model using RANS Data for a Dual-Mode Scramjet Combustor

In an effort to make large eddy simulation of hydrocarbon-fueled scramjet combustors more computationally accessible using realistic chemical reaction mechanisms, a compressible flamelet/progress variable (FPV) model was proposed that extends current FPV model formulations to high-speed, compressible flows. Development of this model relied on observations garnered from an a priori analysis of the Reynolds-Averaged Navier-Stokes (RANS) data obtained for the Hypersonic International Flight Research and Experimentation (HI-FiRE) dual-mode scramjet combustor. The RANS data were obtained using a reduced chemical mechanism for the combustion of a JP-7 surrogate and were validated using avail- able experimental data. These RANS data were then post-processed to obtain, in an a priori fashion, the scalar fields corresponding to an FPV-based modeling approach. In the current work, in addition to the proposed compressible flamelet model, a standard incompressible FPV model was also considered. Several candidate progress variables were investigated for their ability to recover static temperature and major and minor product species. The effects of pressure and temperature on the tabulated progress variable source term were characterized, and model coupling terms embedded in the Reynolds- averaged Navier-Stokes equations were studied. Finally, results for the novel compressible flamelet/progress variable model were presented to demonstrate the improvement attained by modeling the effects of pressure and flamelet boundary conditions on the combustion.

Quinlan, Jesse R.↗

Advanced turbo-prop airplane interior noise reduction-source definition

Acoustic pressure amplitudes and phases were measured in model scale on the surface of a rigid semicylinder mounted in an acoustically treated wind tunnel near a prop-fan (an advanced turboprop with many swept blades) model. Operating conditions during the test simulated those of a prop-fan at 0.8 Mach number cruise. Acoustic pressure amplitude and phase contours were defined on the semicylinder surface. Measurements obtained without the semi-cylinder in place were used to establish the magnitude of pressure doubling for an aircraft fuselage located near a prop-fan. Pressure doubling effects were found to be 6dB at 90 deg incidence decreasing to no effect at grazing incidence. Comparisons of measurements with predictions made using a recently developed prop-fan noise prediction theory which includes linear and non-linear source terms showed good agreement in phase and in peak noise amplitude. Predictions of noise amplitude and phase contours, including pressure doubling effects derived from test, are included for a full scale prop-fan installation.

Magliozzi, B.↗

The effects of equal-pressure fixed slots on the characteristics of a Clark Y Airfoil

A type of fixed open slot so arranged that no flow would pass through it at a lift coefficient corresponding to high-speed flight was investigated in the N.A.C.A. 7 by 10 foot wind tunnel to determine the possibilities of such a high-lift device for increasing the speed-range ratio of a wing. The condition of no through flow was achieved by locating the slot openings at points of equal static pressure at the design lift coefficient as determined from the pressure distribution about the plain wing. Two models of Clark Y wings with such equal-pressure slots were tested and the smoke-flow patterns about them observed. The results of this investigation show that the condition of no air flow through the slot at the desired lift coefficient is attainable. The surface discontinuities produced by the slot openings have, however, such a large effect on the drag that such slots show little promise. An appreciable increase is produced in the maximum lift and the speed-range can be as high as for the plain wing.

Harris, Thomas A↗

Apparatus and method for generating large mass flow of high temperature air at hypersonic speeds

High temperature, high mass air flow and a high Reynolds number test air flow in the Mach number 8-10 regime of adequate test flow duration is attained by pressurizing a ceramic-lined storage tank with air to a pressure of about 100 to 200 atmospheres. The air is heated to temperatures of 7,000 to 8,000 R prior to introduction into the tank by passing the air over an electric arc heater means. The air cools to 5,500 to 6,000 R while in the tank. A decomposable gas such as nitrous oxide or a combustible gas such as propane is injected into the tank after pressurization and the heated pressurized air in the tank is rapidly released through a Mach number 8-10 nozzle. The injected gas medium upon contact with the heated pressurized air effects an exothermic reaction which maintains the pressure and temperature of the pressurized air during the rapid release.

Sabol, A. P.↗

Small scale wind tunnel model investigation of hybrid high lift systems combining upper surface blowing with the internally blown flap

A small-scale wind tunnel test of a two engine hybrid model with upper surface blowing on a simulated expandable duct internally blown flap was accomplished in a two phase program. The low wing Phase I model utilized 0.126c radius Jacobs/Hurkamp flaps and 0.337c radius Coanda flaps. The high wing Phase II model was utilized for continued studies on the Jacobs/Hurkamp flap. Principal study areas included: basic data both engines operative and with an engine out, control flap utilization, horizontal tail effectiveness, spoiler effectiveness, USB nacelle deflector study and USB/IBF pressure ratio effects.

Waites, W. L.↗

An experimental investigation of heat transfer to reusable surface insulation tile array gaps in a turbulent boundary layer with pressure gradient

An experimental investigation was performed to determine the effect of pressure gradient on the heat transfer to space shuttle reusable surface insulation (RSI) tile array gaps under thick, turbulent boundary layer conditions. Heat transfer and pressure measurements were obtained on a curved array of full-scale simulated RSI tiles in a tunnel wall boundary layer at a nominal freestream Mach number of 10.3 and freestream unit Reynolds numbers of 1.6, 3.3, and and 6.1 million per meter. Transverse pressure gradients were induced over the model surface by rotating the curved array with respect to the flow. Definition of the tunnel wall boundary layer flow was obtained by measurement of boundary layer pitot pressure profiles, and flat plate wall pressure and heat transfer. Flat plate wall heat transfer data were correlated and a method was derived for prediction of smooth, curved array heat transfer in the highly three-dimensional tunnel wall boundary layer flow and simulation of full-scale space shuttle vehicle pressure gradient levels was assessed.

Throckmorton, D. A.↗

Resin impregnation process for producing a resin-fiber composite

Process for vacuum impregnation of a dry fiber reinforcement with a curable resin to produce a resin-fiber composite, by drawing a vacuum to permit flow of curable liquid resin into and through a fiber reinforcement to impregnate same and curing the resin-impregnated fiber reinforcement at a sufficient temperature and pressure to effect final curing. Both vacuum and positive pressure, e.g. autoclave pressure, are applied to the dry fiber reinforcement prior to application of heat and prior to any resin flow to compact the dry fiber reinforcement, and produce a resin-fiber composite of reduced weight, thickness and resin content, and improved mechanical properties. Preferably both a vacuum and positive pressure, e.g. autoclave pressure, are also applied during final curing.

Palmer, Raymond J.↗

Two-Phase Flow in Packed Beds, Filters and Orifices: Summary of Findings of the Packed Bed Reactor Experiment Onboard of the International Space Station

Understanding the hydrodynamics of adiabatic two-phase flows in packed bed reactors enables the optimization of chemical reaction rates and products that crucial in pharmaceuticals and energy production industries. Additionally, this understanding aids in designing more efficient and compact reactors and reducing space and resource requirements. Insights gained from studying and understanding such flows in microgravity contribute to advancements of space technologies and the enhancement of our capabilities for undertaking future long duration safe, and sustainable space exploration missions. The objective of the Packed Bed Reactor Experiment series (PBRE and PBRE-2) was to develop a fundamental understanding of the hydrodynamics of adiabatic two-phase flows through porous media in microgravity. This work provides a description of the PBRE fluid system and presents the highlights of the PBRE and PBRE-2 previously flown with different packings and operated onboard of the International Space Station Microgravity Science Glovebox (ISS-MSG). These highlights include flow patterns and two-phase pressure drop, and the impact of capillary effects on pressure drop at various gas and liquid flow rates. This work also presents preliminary results from the Packed Bed Reactor Experiment-Water Recovery Series (PBRE-WRS) recently flown with filters and orifices, which was also operated on the ISS-MSG. The objective of the experiment is to validate hydrodynamic models at a range of gas and liquid flow rates pertinent to the operation of these test articles. The microgravity environment allows for measurement and observation of aspects of fluid dynamics that are unique when compared to observations made in full or partial gravity environments.

ISS↗

First Look at the Upper Tropospheric Ozone Mixing Ratio from OMI Estimated using the Cloud Slicing Technique

The Cloud Slicing technique has emerged as a powerful tool for the study of ozone in the upper troposphere. In this technique one looks at the variation with cloud height of the above-cloud column ozone derived from the backscattered ultraviolet instruments, such as TOMS, to determine the ozone mixing ratio. For this technique to work properly one needs an instrument with relatively good horizontal resolution with very good signal to noise in measuring above-cloud column ozone. In addition, one needs the (radiatively) effective cloud pressure rather than the cloud-top pressure, for the ultraviolet photons received by a satellite instrument are scattered from inside the cloud rather than from the top. For this study we use data from the OMI sensor, which was recently launched on the EOS Aura satellite. OMI is a W-Visible backscattering instrument with a nadir pixel size of 13 x 24 km. The effective cloud pressure is derived from a new algorithm based on Rotational Raman Scattering and O2-O2, absorption in the 340-400 nm band of OMI.

Bhartia, Pawan K.↗

Determination of wind tunnel constraint effects by a unified pressure signature method. Part 2: Application to jet-in-crossflow

The development of an improved jet-in-crossflow model for estimating wind tunnel blockage and angle-of-attack interference is described. Experiments showed that the simpler existing models fall seriously short of representing far-field flows properly. A new, vortex-source-doublet (VSD) model was therefore developed which employs curved trajectories and experimentally-based singularity strengths. The new model is consistent with existing and new experimental data and it predicts tunnel wall (i.e. far-field) pressures properly. It is implemented as a preprocessor to the wall-pressure-signature-based tunnel interference predictor. The supporting experiments and theoretical studies revealed some new results. Comparative flow field measurements with 1-inch "free-air" and 3-inch impinging jets showed that vortex penetration into the flow, in diameters, was almost unaltered until 'hard' impingement occurred. In modeling impinging cases, a 'plume redirection' term was introduced which is apparently absent in previous models. The effects of this term were found to be very significant.

Hackett, J. E.↗