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At least 703 records · Page 39

Applications of Anabolic Vitamin D Analogs as Countermeasures to Bone Loss

The experiments in Round 2 were designed to extend the results of our efforts in Round 1 which led us to hypothesize that the seco-steroid, 1,25-dihydroxyvitamin D3[1,25(OH)2D3], acts in synergy with parathyroid hormone (PTH) to regulate bone calcium homeostasis. Our work centered on one particular target of 1,25(OH)2D3 action, the voltage-sensitive calcium channels (VSCC's), which are activated acutely by this steroid within milliseconds of exposure . A second area of research focused on the effects of mechanical strain on VSCC expression in bone. These experiments were performed in collaboration with Dr. Steven Goldstein (Univ. Michigan), who generously provided RNA extracted from dog bones that had been exposed to mechanical strain in vivo. Our results suggest that mechanical loading elevated VSCC expression in the long bones from 3 of the 6 animals tested. A second line of experimentation, carried out in collaboration with Dr. Randall Duncan, a NASA-funded investigator in Indianapolis, centered on RT-PCR analysis of effects of mechanical strain on Ca2(+) channel expression in cultured bone cells. Compared to unstrained controls, the expression of vitamin-D-sensidve Ca2(+) channels is elevated 3- to 5-fold over a 24 hr period.

Karin, Norman J.↗

Development of flight experiment work performance and workstation interface requirements. Part 2: Appendix H

A skill requirement definition method was applied to the problem of determining, at an early stage in system/mission definition, the skills required of on-orbit crew personnel whose activities will be related to the conduct or support of earth-orbital research. The experiment data base was selected from proposed experiments in NASA's Earth Orbital Research and Application Investigation program as related to space shuttle missions, specifically those being considered for sortie lab. Activities during the study, include identification of basic functions dealing with man's research and/or servicing activities on orbit. A crew function taxonomy was prepared relative to these activities. Likely candidate experiments for shuttle sortie missions were selected through extensive review of experiment and mission descriptions. Crew functions and tasks were initially identified for more than fifty representative earth orbital experiments, and a comprehensive task analysis was conducted on these tasks for selected payloads.

Hatterick, R. G.↗

Shock-induced fine-grained recrystallization of olivine - Evidence against subsolidus reduction of Fe/2+/

Electron spin resonance (ESR) studies have been carried out on three single grains of terrestrial olivine (Fo90) shock loaded along the 010 line to peak pressures of 280, 330, and 440 kbar. The results indicate that neither metallic Fe similar to that observed in returned lunar soils nor paramagnetic Fe(3+) caused by oxidation of Fe(2+) has been produced in these shock experiments. Trace amounts of Mn (2+) have been detected in both shocked and unshocked olivine. The ESR signals of Mn(2+) show spectral features which are found to correlate with the degree of shock-induced recrystallization observed petrographically. The increasing mass fraction of recrystallized olivine correlates with increasing shock pressures. This phenomenon is modelled assuming it results from the progressive effect of the shock-induced transformation of the olivine to a yet unknown high-pressure phase and its subsequent reversion to the low-pressure olivine phase. The mass fraction of recrystallized material is predicted to be nearly linear with shock pressure.

Ahrens, T. J.↗

Differential electron scattering cross sections for the 3 (2)S to 3 (2)P0 h, k transitions in Mg II - Comparison of experiment and theory

Angular differential electron scattering cross sections are reported for the unresolved inelastic 3s (2)S to 3p (2)P0 h, k transitions in Mg II for the first time. Relative differential cross sections have been measured at 35 eV and 50 eV in the angular range of Theta between 6 and 17 deg using the newly developed electron energy loss technique in a crossed electron-ion beam geometry. Theoretical values have been calculated in a five-state close-coupling approximation in which 3s, 3p, 3d, 4s, and 4p states were included, and to which measurements were normalized at Theta = 12 deg.

Williams, I. D.↗

The dish-Rankine SCSTPE program (Engineering Experiment no. 1)

Activities planned for phase 2 Of the Small Community Solar Thermal Power Experiment (PFDR) program are summarized with emphasis on a dish-Rankine point focusing distributed receiver solar thermal electric system. Major design efforts include: (1) development of an advanced concept indirect-heated receiver;(2) development of hardware and software for a totally unmanned power plant control system; (3) implementation of a hybrid digital simulator which will validate plant operation prior to field testing; and (4) the acquisition of an efficient organic Rankine cycle power conversion unit. Preliminary performance analyses indicate that a mass-produced dish-Rankine PFDR system is potentially capable of producing electricity at a levelized busbar energy cost of 60 to 70 mills per KWh and with a capital cost of about $1300 per KW.

Pons, R. L.↗

Ion cutoff whistlers.

Ion cut-off whistlers observed during VLF experiment aboard OGO 2 and OGO 4, noting possible application to relative ionospheric proton concentration determination

Muzzio, J. L. R.↗

Survey of auxiliary-propulsion systems for communications satellites.

In order to provide insight for the selection of attitude- and stationkeeping propulsion systems for future communications satellites, current auxiliary-propulsion systems are surveyed. Thruster systems specifically considered are stored gas, vaporizing ammonia/electrothermal, catalytic monopropellant hydrazine, electrothermal monopropellant hydrazine, plenum monopropellant hydrazine, ion, colloid, and pulsed plasma. Each of the thruster types is discussed in three sections: (1) description of thruster system and how it functions, (2) space flight experience, and (3) survey of state-of-the-art thrusters. In addition, a qualitative tabulation of thruster characteristics is included.

Holcomb, L. B.↗

Phase 0 study for a geothermal superheated water proof of concept facility

A Phase 0 study for the selection of a representative liquid-dominated geothermal resource of moderate salinity and temperature is discussed. Selection and conceptual design of a nominal 10-MWe energy conversion system, and implementation planning for Phase 1: subsystem (component, experiments) and Phase 2: final design, construction, and operation of experimental research facilities are reported. The objective of the overall program is to demonstrate the technical and economic viability of utilizing moderate temperature and salinity liquid-dominated resources with acceptable environmental impact, and thus encourage commercial scale development of geothermal electrical power generation.

Douglass, R. H.↗

Skylab medical program overview

The following major medical subsystems in Skylab are outlined: (1) operational equipment; (2) life science experiments; (3) medical operations; and (4) operational experience. Throughout the Skylab flight program, alterations in equipment and procedures were made for each succeeding mission to capitalize on the flight experience of the previous mission.

Johnson, R. S.↗

A hard X-ray and gamma ray observation of the 22 November 1977 solar flare

The Franco-Soviet experiment package Signe 2 MP for solar and cosmic X and gamma ray observations, launched aboard a Soviet Prognoz satellite into a highly eccentric earth orbit is described. An uncollimated NaI detector 37 mm thick by 90 mm diameter, placed on the upper surface of the satellite faced the sun. A collimated lateral NaI detector 14 mm thick by 38 mm diameter also faced the sun, and a similar lateral detector faced the anti-solar direction. Data tapes reveal an intense solar flare up to energies of up to 5 MeV, with evidence for line emission at 2.23 MeV and possibly 4.4 MeV. The event observed was associated with the Mc Math Plage Region 15031, and an H-alpha flare of importance 2B. It is not yet clear what radio emission is associated with the X-ray observation.

Chambon, G.↗

An economical approach to space power systems

Projected energy demand for all NASA, DoD and civil missions for the time span 1981 to 1995 are illustrated. Typical energy cost range from about $300 to $2000 per kW-hr, with an average of about $800 per kW-hr for long-duration missions. At these levels, the cost of the required energy would be several billion dollars per year by about 1985 and might constrain the number and types of NASA programs to be carried out. NASA is extensively pursuing approaches for reducing nonrecurring costs. Two programs are presented for the development of an economical approach to space power systems. They are: (1) Economical Orbital Power (ECOP) with the objective to demonstrate the applicability of a commercial approach to the development of a low cost photovoltaic space power system; and (2) Space Power Experiment (SPEX) which has the objective to demonstrate the application of industrial hardware for space power systems.

Teren, F.↗

State of technology in optical systems

The use of silicon photodiode sensors and locator systems for lightning experiments is discussed. Tables are presented on: (1) satellite optical lightning experiments (silicon detectors); (2) reticon photodiode linear arrays; and (3) locator systems (grey code and reticon). An illustration of a grey code locator system for a low altitude satellite is also given.

Edgar, B. C.↗

Magnetic field studies at Jupiter by Voyager 2: Preliminary results

The Voyager 2 magnetic field experiment is described and compared to the Voyager 1 experiment and data. The magnetosphere, the bow shock, the magnetopause, and the extended magnetic tail of Jupiter are discussed. Two crossings of the near equatorial current sheet were observed in the magnetosphere and its tail every 10 hour rotation period of the planet. A definitive mapping of the geometry and character of these enhanced plasma and depressed magnetic field regions is discussed. The interaction of the satellite Ganymede with the Jovian magnetosphere, which leads to disturbances as the Jovian magnetosphere corotates with the planet past the satellite is analyzed.

Ness, N. F.↗

Emergency relief venting of the infrared telescope liquid helium dewar

An analysis is made of the emergency relief venting of the liquid helium dewar of the Spacelab 2 infrared telescope experiment in the event of a massive failure of the dewar guard vacuum. Such a failure, resulting from a major accident, could cause rapid heating and pressurization of the liquid helium in the dewar and lead to relief venting through the emergency relief system. The heat input from an accident is estimated for various fluid conditions in the dewar and the relief process as it takes place through one or both of the emergency relief paths is considered. It is shown that under all reasonable circumstances the dewar will safely relieve itself, and the pressure will not exceed 85 percent of the proof pressure or 63 percent of the burst pressure.

Urban, E. W.↗

Magnetic field studies at Jupiter by Voyager 2 - Preliminary results

The Voyager 2 magnetic field experiment, for which the instrumentation is identical to that on Voyager 1, operated flawlessly throughout the second Jupiter encounter. The paper presents a brief overview of the results obtained to date on the Jovian magnetosphere, the bow shock, the magnetopause, and the extended magnetic tail. The results and the magnetic field geometry confirm the earlier conclusion from Voyager 1 that Jupiter has an enormous magnetic tail, approximately 300-400 Jupiter radii in diameter, trailing behind the planet with respect to the supersonic flow of the solar wind. Additional observations of the distortion of the inner magnetosphere by a concentrated plasma show a spatial merging of the equatorial magnetodisk current with the current sheet in the magnetic tail. Disturbances near Ganymede are discussed.

Ness, N. F.↗

Space science on the Space Shuttle - Plans and prospects

The paper gives an overview of current planning for the use of the Space Shuttle and Spacelab for carrying out NASA's program in Space Science. Attention is given to the major categories of use: (1) as a launch and service vehicle; (2) as an experiment platform for carrying out passive observations; (3) as a component in active and controlled experiments in space; and (4) as a manned orbiting laboratory for carrying out investigations requiring hands-on access to equipment and samples. Examples of each type of use are given. Also discussed are some of the multi-user facility instruments which are planned for early development. Finally, payloads to be carried on the early missions are discussed with particular emphasis on the capabilities of the Shuttle/Spacelab.

Rosendhal, J. F.↗