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At least 703 records · Page 39

Quality Assurance With Plan Veto: Reincarnation of a Record and Verify System and Its Potential Value

Purpose: To quantify the potential impact of the Integrating the Healthcare Enterprise–Radiation Oncology Quality Assurance with Plan Veto (QAPV) on patient safety of external beam radiation therapy (RT) operations. Methods and Materials: An institutional database of events (errors and near-misses) was used to evaluate the ability of QAPV to prevent clinically observed events. We analyzed reported events that were related to Digital Imaging and Communications in Medicine RT plan parameter inconsistencies between the intended treatment (on the treatment planning system) and the delivered treatment (on the treatment machine). Critical Digital Imaging and Communications in Medicine RT plan parameters were identified. Each event was scored for importance using the Failure Mode and Effects Analysis methodology. Potential error occurrence (frequency) was derived according to the collected event data, along with the potential event severity, and the probability of detection with and without the theoretical implementation of the QAPV plan comparison check. Failure Mode and Effects Analysis Risk Priority Numbers (RPNs) with and without QAPV were compared to quantify the potential benefit of clinical implementation of QAPV. Results: The implementation of QAPV could reduce the RPN values for 15 of 22 (71%) of evaluated parameters, with an overall average reduction in RPN of 68 (range, 0-216). For the 6 high-risk parameters (>200), the average reduction in RPN value was 163 (range, 108-216). The RPN value reduction for the intermediate-risk (200 > RPN > 100) parameters was (0-140). With QAPV, the largest RPN value for “Beam Meterset” was reduced from 324 to 108. The maximum reduction in RPN value was for Beam Meterset (216, 66.7%), whereas the maximum percentage reduction was for Cumulative Meterset Weight (80, 88.9%). Conclusion: This analysis quantifies the value of the Integrating the Healthcare Enterprise–Radiation Oncology QAPV implementation in clinical workflow. We demonstrate that although QAPV does not provide a comprehensive solution for error prevention in RT, it can have a significant impact on a subset of the most severe clinically observed events.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

Hierarchical Membrane Dynamics in Phase-Separated Model Membranes

Lipid membranes, the primary matrix of cell membranes, exhibit a hierarchy of dynamics from molecular motions to collective undulations, which control spatiotemporal membrane phenomena and regulate various cellular functions. Thus, understanding how various dynamic modes influence membrane behavior is crucial to uncovering the design rules of cell membranes and implementing them in future technologies. Previous membrane dynamics studies using neutron spin-echo spectroscopy (NSE) have shed light on the dependence of collective membrane fluctuations on viscoelastic membrane properties, demonstrating that thickness fluctuation modes (100ns) are dictated by membrane viscosity, which directly governs fast (ps) molecular diffusive motions. Here, we focus on phase-separating lipid membranes, composed of DMPC:DSPC mixtures, to understand the effect of domain formation/growth on hierarchical matrix dynamics using selective lipid deuteration and different neutron spectroscopy techniques. NSE measurements on DMPC:DSPC-d83 (70:30 mol%) show that bending rigidity of the DMPC-rich matrix graduallyincreases with decreasing temperature - as the fully-fluid membrane approaches the upper phase transition (i.e. with the formation of transient DSPC clusters) - and increases further in the phase coexistence region with the growth of DSPC domains. Comparatively, NSE measurements on DMPC-d54:DSPC-d83 vesicles show pronounced matrix thickness fluctuations in the fully-fluid phase and drastic suppression of this fluctuation mode in the gel-fluid coexistence phase, even when the DMPC-rich matrix is still in its fluid phase. This suppression in fluctuations suggests an increase in the matrix viscosity with the growth of gel DSPC domains, which is further investigated by selectively measuring lipid diffusion in the DMPC-rich matrix using neutron backscattering spectroscopy. Comparisons of the experimental results with coarse-grained MD simulationsillustrate the underlying coupling mechanisms. Overall, these observations indicate a clear mechanical and viscoelastic coupling betweenlipid domains and their host matrix, suggesting that domain formation influences membrane properties beyond local effects.

Carrillo, Jan Michael↗

When do molecular polaritons behave like optical filters?

This review outlines several linear optical effects featured by molecular polaritons arising in the collective strong light–matter coupling regime. Under weak laser irradiation and when the single-molecule light–matter coupling can be neglected (often in the limit when the number of molecules per photon mode is large), we show that the excited-state molecular dynamics under collective strong coupling can be exactly replicated without the cavity using a shaped (or “filtered”) laser, whose field amplitude is enhanced by the cavity quality factor, shining on the bare molecules. As a consequence, the absorption within a cavity can be understood as the overlap between the polariton transmission and the bare molecular absorption, suggesting that polaritons act in part as optical filters. This framework demystifies and provides a straightforward explanation for a large class of experiments and theoretical models in molecular polaritonics, highlighting that the same effects can be achieved without the cavity with shaped laser pulses. With a few modifications, this simple conceptual picture can also be adapted to understand the incoherent nonlinear response of polaritonic systems. This review establishes a clear distinction between polaritonic phenomena that can be fully explained through classical linear optics and those that require a quantum electrodynamics approach. It also highlights the need to differentiate between effects that necessitate polaritons (i.e., hybrid light–matter states) and those that can occur in the weak coupling regime. Here, we further discuss that certain quantum optical effects like fluorescence can be partially described as optical filtering, whereas some others like cavity-induced Raman scattering go beyond this. Further exploration in these areas is needed to uncover novel polaritonic phenomena beyond optical filtering.

Schwennicke, Kai [University of California, San Di↗

Plasmonic materials for energy: From physics to applications

Physical mechanisms unique to plasmonic materials, which can be exploited for the existing and emerging applications of plasmonics for renewable energy technologies, are reviewed. The hybrid nature of surface plasmon (SP) modes – propagating surface plasmon polaritons (SPPs) and localized surface plasmons (LSPs) – as collective photon–electron oscillations makes them attractive candidates for energy applications. A high density of optical states in the vicinity of plasmonic structures enhances light absorption and emission, enables localized heating, and drives near-field heat exchange between hot and cold surfaces. SP modes channel the energy of absorbed photons directly to the free electrons, and the generated hot electrons can be utilized in thermoelectric, photovoltaic and photo-catalytic platforms. The advantages and disadvantages of using plasmonics over conventional technologies for solar energy and waste heat harvesting are discussed, and areas where plasmonics is expected to lead to performance improvements not achievable by other methods are identified.

36 MATERIALS SCIENCE↗

Laser dissection sampling modes for direct mass spectral analysis [using a hybrid optical microscopy/laser ablation liquid vortex capture/electrospray ionization system

Here, laser microdissection coupled directly with mass spectrometry provides the capability of on-line analysis of substrates with high spatial resolution, high collection efficiency, and freedom on shape and size of the sampling area. Establishing the merits and capabilities of the different sampling modes that the system provides is necessary in order to select the best sampling mode for characterizing analytically challenging samples. The capabilities of laser ablation spot sampling, laser ablation raster sampling, and laser 'cut and drop' sampling modes of a hybrid optical microscopy/laser ablation liquid vortex capture electrospray ionization mass spectrometry system were compared for the analysis of single cells and tissue. Single Chlamydomonas reinhardtii cells were monitored for their monogalactosyldiacylglycerol (MGDG) and diacylglyceryltrimethylhomo-Ser (DGTS) lipid content using the laser spot sampling mode, which was capable of ablating individual cells (4-15 m) even when agglomerated together. Turbid Allium Cepa cells (150 m) having unique shapes difficult to precisely measure using the other sampling modes could be ablated in their entirety using laser raster sampling. Intact microdissections of specific regions of a cocaine-dosed mouse brain tissue were compared using laser 'cut and drop' sampling. Since in laser 'cut and drop' sampling whole and otherwise unmodified sections are captured into the probe, 100% collection efficiencies were achieved. Laser ablation spot sampling has the highest spatial resolution of any sampling mode, while laser ablation raster sampling has the highest sampling area adaptability of the sampling modes. In conclusion, laser ablation spot sampling has the highest spatial resolution of any sampling mode, useful in this case for the analysis of single cells. Laser ablation raster sampling was best for sampling regions with unique shapes that are difficult to measure using other sampling modes. Laser 'cut and drop' sampling can be used for cases where the highest sensitivity is needed, for example, monitoring drugs present in trace amounts in tissue.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Actual Versus Estimated Utility Factor of a Large Set of Privately Owned Chevrolet Volts

In order to determine the overall fuel economy of a plug-in hybrid electric vehicle (PHEV), the amount of operation in charge depleting (CD) versus charge sustaining modes must be determined. Mode of operation is predominantly dependent on customer usage of the vehicle and is therefore highly variable. The utility factor (UF) concept was developed to quantify the distance a group of vehicles has traveled or may travel in CD mode. SAE J2841 presents a UF calculation method based on data collected from travel surveys of conventional vehicles. UF estimates have been used in a variety of areas, including the calculation of window sticker fuel economy, policy decisions, and vehicle design determination. The EV Project, a plug-in electric vehicle charging infrastructure demonstration being conducted across the United States, provides the opportunity to determine the real-world UF of a large group of privately owned Chevrolet Volt extended range electric vehicles. Using data collected from Volts enrolled in The EV Project, this paper compares the real-world UF of two groups of Chevrolet Volts to estimated UF's based on J2841. The actual observed fleet utility factors (FUF) for the MY2011/2012 and MY2013 Volt groups studied were observed to be 72% and 74%, respectively. Using the EPA CD ranges, the method prescribed by J2841 estimates a FUF of 65% and 68% for the MY2011/2012 and MY2013 Volt groups, respectively. Volt drivers achieved higher percentages of distance traveled in EV mode for two reasons. First, they had fewer long-distance travel days than drivers in the national travel survey referenced by J2841. Second, they charged more frequently than the J2841 assumption of once per day - drivers of Volts in this study averaged over 1.4 charging events per day. Although actual CD range varied widely as driving conditions varied, the average CD ranges for the two Volt groups studied matched the EPA CD range estimates, so CD range variation did not affect FUF results.

33 ADVANCED PROPULSION SYSTEMS↗

Phonons reveal coupled cholesterol-lipid dynamics in ternary membranes

Experimental studies of collective dynamics in lipid bilayers have been challenging due to the energy resolution required to observe these low-energy phonon-like modes. However, inelastic X-ray scattering (IXS) measurements — a technique for probing vibrations in soft and biological materials — are now possible with sub-meV resolution, permitting direct observation of low energy, phonon-like modes in lipid membranes. Here, in this study, IXS measurements with sub-meV energy resolution reveal a low-energy optic-like phonon mode at roughly 3 meV in the liquid-ordered (L o ) and liquid-disordered (L d ) phases of a ternary lipid mixture. This mode is only observed experimentally at momentum transfers greater than 5 nm -1 in the L o system. A similar gapped mode is also observed in all-atom molecular dynamics (MD) simulations of the same mixture, indicating that the simulations accurately represnt the fast, collective dynamics in the L o phase. It’s optical nature and the Q range of the gap together suggest that the observed mode is due to the coupled motion of cholesterol-lipid pairs, separated by several hydrocarbon chains within the membrane plane. Analysis of the simulations provide molecular insight into the origin of the mode in transient, nanoscale substructures of hexagonally packed hydrocarbon chains. This nanoscale hexagonal packing was previously reported based on molecular dynamics simulations and later by NMR measurements. Here, however, the integration of IXS and MD simulations identifies a new signature of the L o substructure in the collective lipid dynamics, thanks to the recent confluence of IXS sensitivity and MD simulation capabilities.

36 MATERIALS SCIENCE↗

Fail-Slow at Scale: Evidence of Hardware Performance Faults in Large Production Systems

Fail-slow hardware is an under-studied failure mode. We present a study of 114 reports of fail-slow hardware incidents, collected from large-scale cluster deployments in 14 institutions. We show that all hardware types such as disk, SSD, CPU, memory, and network components can exhibit performance faults. We made several important observations such as faults convert from one form to another, the cascading root causes and impacts can be long, and fail-slow faults can have varying symptoms. From this study, we make suggestions to vendors, operators, and systems designers.

fail-slow↗

2022 Next-Generation National Household Travel Survey - Origin-Destination Data Addendum for the Oahu Region

# 2022 Next-Generation National Household Travel Survey – Origin-Destination Data Addendum for the Oahu Region The 2022 Next-Generation National Household Travel Survey – Origin-Destination Data Addendum for the Oahu Region covers the Hawaiian island of Oahu and five counties in surrounding islands. An addendum to the nationwide version of the study conducted in 2019, this regional survey provided additional information and spatial granularity about people’s movements to, from, and within the areas under study. ## Data Collection Agency The survey was conducted for the Oahu Metropolitan Planning Organization. ## Survey Methodology Data were collected in two zones: the core area (census blocks in the island of Oahu) and the halo area (five counties in adjacent Hawaiian islands). All trips were assigned an origin zone and a destination zone, as well as a travel mode, purpose, and distance. Sociodemographic information related to age, income, and gender was also collected. ## Survey Records, Data, and Documentation Survey records include 1,154,167,619 trips.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗

2022 Next-Generation National Household Travel Survey - Origin-Destination Data Addendum for the Oahu Region

# 2022 Next-Generation National Household Travel Survey – Origin-Destination Data Addendum for the Oahu Region The 2022 Next-Generation National Household Travel Survey – Origin-Destination Data Addendum for the Oahu Region covers the Hawaiian island of Oahu and five counties in surrounding islands. An addendum to the nationwide version of the study conducted in 2019, this regional survey provided additional information and spatial granularity about people’s movements to, from, and within the areas under study. ## Data Collection Agency The survey was conducted for the Oahu Metropolitan Planning Organization. ## Survey Methodology Data were collected in two zones: the core area (census blocks in the island of Oahu) and the halo area (five counties in adjacent Hawaiian islands). All trips were assigned an origin zone and a destination zone, as well as a travel mode, purpose, and distance. Sociodemographic information related to age, income, and gender was also collected. ## Survey Records, Data, and Documentation Survey records include 1,154,167,619 trips.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗

2022 Next-Generation National Household Travel Survey - Origin-Destination Data Addendum for the Oahu Region

# 2022 Next-Generation National Household Travel Survey – Origin-Destination Data Addendum for the Oahu Region The 2022 Next-Generation National Household Travel Survey – Origin-Destination Data Addendum for the Oahu Region covers the Hawaiian island of Oahu and five counties in surrounding islands. An addendum to the nationwide version of the study conducted in 2019, this regional survey provided additional information and spatial granularity about people’s movements to, from, and within the areas under study. ## Data Collection Agency The survey was conducted for the Oahu Metropolitan Planning Organization. ## Survey Methodology Data were collected in two zones: the core area (census blocks in the island of Oahu) and the halo area (five counties in adjacent Hawaiian islands). All trips were assigned an origin zone and a destination zone, as well as a travel mode, purpose, and distance. Sociodemographic information related to age, income, and gender was also collected. ## Survey Records, Data, and Documentation Survey records include 1,154,167,619 trips.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗

2022 Next-Generation National Household Travel Survey - Origin-Destination Data Addendum for the Oahu Region

# 2022 Next-Generation National Household Travel Survey – Origin-Destination Data Addendum for the Oahu Region The 2022 Next-Generation National Household Travel Survey – Origin-Destination Data Addendum for the Oahu Region covers the Hawaiian island of Oahu and five counties in surrounding islands. An addendum to the nationwide version of the study conducted in 2019, this regional survey provided additional information and spatial granularity about people’s movements to, from, and within the areas under study. ## Data Collection Agency The survey was conducted for the Oahu Metropolitan Planning Organization. ## Survey Methodology Data were collected in two zones: the core area (census blocks in the island of Oahu) and the halo area (five counties in adjacent Hawaiian islands). All trips were assigned an origin zone and a destination zone, as well as a travel mode, purpose, and distance. Sociodemographic information related to age, income, and gender was also collected. ## Survey Records, Data, and Documentation Survey records include 1,154,167,619 trips.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗

2022 Next-Generation National Household Travel Survey - Origin-Destination Data Addendum for the Oahu Region

# 2022 Next-Generation National Household Travel Survey – Origin-Destination Data Addendum for the Oahu Region The 2022 Next-Generation National Household Travel Survey – Origin-Destination Data Addendum for the Oahu Region covers the Hawaiian island of Oahu and five counties in surrounding islands. An addendum to the nationwide version of the study conducted in 2019, this regional survey provided additional information and spatial granularity about people’s movements to, from, and within the areas under study. ## Data Collection Agency The survey was conducted for the Oahu Metropolitan Planning Organization. ## Survey Methodology Data were collected in two zones: the core area (census blocks in the island of Oahu) and the halo area (five counties in adjacent Hawaiian islands). All trips were assigned an origin zone and a destination zone, as well as a travel mode, purpose, and distance. Sociodemographic information related to age, income, and gender was also collected. ## Survey Records, Data, and Documentation Survey records include 1,154,167,619 trips.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗

2022 Next-Generation National Household Travel Survey - Origin-Destination Data Addendum for the Oahu Region

# 2022 Next-Generation National Household Travel Survey – Origin-Destination Data Addendum for the Oahu Region The 2022 Next-Generation National Household Travel Survey – Origin-Destination Data Addendum for the Oahu Region covers the Hawaiian island of Oahu and five counties in surrounding islands. An addendum to the nationwide version of the study conducted in 2019, this regional survey provided additional information and spatial granularity about people’s movements to, from, and within the areas under study. ## Data Collection Agency The survey was conducted for the Oahu Metropolitan Planning Organization. ## Survey Methodology Data were collected in two zones: the core area (census blocks in the island of Oahu) and the halo area (five counties in adjacent Hawaiian islands). All trips were assigned an origin zone and a destination zone, as well as a travel mode, purpose, and distance. Sociodemographic information related to age, income, and gender was also collected. ## Survey Records, Data, and Documentation Survey records include 1,154,167,619 trips.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗

2022 Next-Generation National Household Travel Survey - Origin-Destination Data Addendum for the Oahu Region

# 2022 Next-Generation National Household Travel Survey – Origin-Destination Data Addendum for the Oahu Region The 2022 Next-Generation National Household Travel Survey – Origin-Destination Data Addendum for the Oahu Region covers the Hawaiian island of Oahu and five counties in surrounding islands. An addendum to the nationwide version of the study conducted in 2019, this regional survey provided additional information and spatial granularity about people’s movements to, from, and within the areas under study. ## Data Collection Agency The survey was conducted for the Oahu Metropolitan Planning Organization. ## Survey Methodology Data were collected in two zones: the core area (census blocks in the island of Oahu) and the halo area (five counties in adjacent Hawaiian islands). All trips were assigned an origin zone and a destination zone, as well as a travel mode, purpose, and distance. Sociodemographic information related to age, income, and gender was also collected. ## Survey Records, Data, and Documentation Survey records include 1,154,167,619 trips.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗

2022 Next-Generation National Household Travel Survey - Origin-Destination Data Addendum for the Oahu Region

# 2022 Next-Generation National Household Travel Survey – Origin-Destination Data Addendum for the Oahu Region The 2022 Next-Generation National Household Travel Survey – Origin-Destination Data Addendum for the Oahu Region covers the Hawaiian island of Oahu and five counties in surrounding islands. An addendum to the nationwide version of the study conducted in 2019, this regional survey provided additional information and spatial granularity about people’s movements to, from, and within the areas under study. ## Data Collection Agency The survey was conducted for the Oahu Metropolitan Planning Organization. ## Survey Methodology Data were collected in two zones: the core area (census blocks in the island of Oahu) and the halo area (five counties in adjacent Hawaiian islands). All trips were assigned an origin zone and a destination zone, as well as a travel mode, purpose, and distance. Sociodemographic information related to age, income, and gender was also collected. ## Survey Records, Data, and Documentation Survey records include 1,154,167,619 trips.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗

2022 Next-Generation National Household Travel Survey - Origin-Destination Data Addendum for the Oahu Region

# 2022 Next-Generation National Household Travel Survey – Origin-Destination Data Addendum for the Oahu Region The 2022 Next-Generation National Household Travel Survey – Origin-Destination Data Addendum for the Oahu Region covers the Hawaiian island of Oahu and five counties in surrounding islands. An addendum to the nationwide version of the study conducted in 2019, this regional survey provided additional information and spatial granularity about people’s movements to, from, and within the areas under study. ## Data Collection Agency The survey was conducted for the Oahu Metropolitan Planning Organization. ## Survey Methodology Data were collected in two zones: the core area (census blocks in the island of Oahu) and the halo area (five counties in adjacent Hawaiian islands). All trips were assigned an origin zone and a destination zone, as well as a travel mode, purpose, and distance. Sociodemographic information related to age, income, and gender was also collected. ## Survey Records, Data, and Documentation Survey records include 1,154,167,619 trips.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗

2022 Next-Generation National Household Travel Survey - Origin-Destination Data Addendum for the Oahu Region

# 2022 Next-Generation National Household Travel Survey – Origin-Destination Data Addendum for the Oahu Region The 2022 Next-Generation National Household Travel Survey – Origin-Destination Data Addendum for the Oahu Region covers the Hawaiian island of Oahu and five counties in surrounding islands. An addendum to the nationwide version of the study conducted in 2019, this regional survey provided additional information and spatial granularity about people’s movements to, from, and within the areas under study. ## Data Collection Agency The survey was conducted for the Oahu Metropolitan Planning Organization. ## Survey Methodology Data were collected in two zones: the core area (census blocks in the island of Oahu) and the halo area (five counties in adjacent Hawaiian islands). All trips were assigned an origin zone and a destination zone, as well as a travel mode, purpose, and distance. Sociodemographic information related to age, income, and gender was also collected. ## Survey Records, Data, and Documentation Survey records include 1,154,167,619 trips.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗