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DOE OSTI2024

A Functional Survey of the Regulatory Landscape of Estrogen Receptor–Positive Breast Cancer Evolution

Abstract Only a handful of somatic alterations have been linked to endocrine therapy resistance in hormone-dependent breast cancer, potentially explaining ∼40% of relapses. If other mechanisms underlie the evolution of hormone-dependent breast cancer under adjuvant therapy is currently unknown. In this work, we employ functional genomics to dissect the contribution of cis-regulatory elements (CRE) to cancer evolution by focusing on 12 megabases of noncoding DNA, including clonal enhancers, gene promoters, and boundaries of topologically associating domains. Parallel epigenetic perturbation (CRISPRi) in vitro reveals context-dependent roles for many of these CREs, with a specific impact on dormancy entrance and endocrine therapy resistance. Profiling of CRE somatic alterations in a unique, longitudinal cohort of patients treated with endocrine therapies identifies a limited set of noncoding changes potentially involved in therapy resistance. Overall, our data uncover how endocrine therapies trigger the emergence of transient features which could ultimately be exploited to hinder the adaptive process. Significance: This study shows that cells adapting to endocrine therapies undergo changes in the usage or regulatory regions. Dormant cells are less vulnerable to regulatory perturbation but gain transient dependencies which can be exploited to decrease the formation of dormant persisters.

Oncology↗

NASA NTRS2000

Viral carcinogenesis: revelation of molecular mechanisms and etiology of human disease

The RNA and DNA tumor viruses have made fundamental contributions to two major areas of cancer research. Viruses were vital, first, to the discovery and analysis of cellular growth control pathways and the synthesis of current concepts of cancer biology and, second, to the recognition of the etiology of some human cancers. Transforming retroviruses carry oncogenes derived from cellular genes that are involved in mitogenic signalling and growth control. DNA tumor viruses encode oncogenes of viral origin that are essential for viral replication and cell transformation; viral oncoproteins complex with cellular proteins to stimulate cell cycle progression and led to the discovery of tumor suppressors. Viral systems support the concept that cancer development occurs by the accumulation of multiple cooperating events. Viruses are now accepted as bona fide etiologic factors of human cancer; these include hepatitis B virus, Epstein-Barr virus, human papillomaviruses, human T-cell leukemia virus type I and hepatitis C virus, plus several candidate human cancer viruses. It is estimated that 15% of all human tumors worldwide are caused by viruses. The infectious nature of viruses distinguishes them from all other cancer-causing factors; tumor viruses establish long-term persistent infections in humans, with cancer an accidental side effect of viral replication strategies. Viruses are usually not complete carcinogens, and the known human cancer viruses display different roles in transformation. Many years may pass between initial infection and tumor appearance and most infected individuals do not develop cancer, although immunocompromised individuals are at elevated risk of viral-associated cancers. Variable factors that influence viral carcinogenesis are reviewed, including possible synergy between viruses and environmental cofactors. The difficulties in establishing an etiologic role for a virus in human cancer are discussed, as well as the different approaches that proved viral links to cancer. Future directions for tumor virus studies are considered.

NASA Program Biomedical Research and Countermeasur↗

NASA NTRS2015

Lidar Measurements of Atmospheric CO2 From Regional to Global Scales

Atmospheric CO2 is a critical forcing for the Earth's climate and the knowledge on its distributions and variations influences predictions of the Earth's future climate. Large uncertainties in the predictions persist due to limited observations. This study uses the airborne Intensity-Modulated Continuous-Wave (IMCW) lidar developed at NASA Langley Research Center to measure regional atmospheric CO2 spatio-temporal variations. Further lidar development and demonstration will provide the capability of global atmospheric CO2 estimations from space, which will significantly advances our knowledge on atmospheric CO2 and reduce the uncertainties in the predictions of future climate. In this presentation, atmospheric CO2 column measurements from airborne flight campaigns and lidar system simulations for space missions will be discussed. A measurement precision of approx.0.3 ppmv for a 10-s average over desert and vegetated surfaces has been achieved. Data analysis also shows that airborne lidar CO2 column measurements over these surfaces agree well with in-situ measurements. Even when thin cirrus clouds present, consistent CO2 column measurements between clear and thin cirrus cloudy skies are obtained. Airborne flight campaigns have demonstrated that precise atmospheric column CO2 values can be measured from current IM-CW lidar systems, which will lead to use this airborne technique in monitoring CO2 sinks and sources in regional and continental scales as proposed by the NASA Atmospheric Carbon and Transport â€" America project. Furthermore, analyses of space CO2 measurements shows that applying the current IM-CW lidar technology and approach to space, the CO2 science goals of space missions will be achieved, and uncertainties in CO2 distributions and variations will be reduced.

Lin, Bing↗

NASA NTRS1995

Cloud Masking and Surface Temperature Distribution in the Polar Regions Using AVHRR and other Satellite Data

Surface temperature is one of the key variables associated with weather and climate. Accurate measurements of surface air temperatures are routinely made in meteorological stations around the world. Also, satellite data have been used to produce synoptic global temperature distributions. However, not much attention has been paid on temperature distributions in the polar regions. In the polar regions, the number of stations is very sparse. Because of adverse weather conditions and general inaccessibility, surface field measurements are also limited. Furthermore, accurate retrievals from satellite data in the region have been difficult to make because of persistent cloudiness and ambiguities in the discrimination of clouds from snow or ice. Surface temperature observations are required in the polar regions for air-sea-ice interaction studies, especially in the calculation of heat, salinity, and humidity fluxes. They are also useful in identifying areas of melt or meltponding within the sea ice pack and the ice sheets and in the calculation of emissivities of these surfaces. Moreover, the polar regions are unique in that they are the sites of temperature extremes, the location of which is difficult to identify without a global monitoring system. Furthermore, the regions may provide an early signal to a potential climate change because such signal is expected to be amplified in the region due to feedback effects. In cloud free areas, the thermal channels from infrared systems provide surface temperatures at relatively good accuracies. Previous capabilities include the use of the Temperature Humidity Infrared Radiometer (THIR) onboard the Nimbus-7 satellite which was launched in 1978. Current capabilities include the use of the Advance Very High Resolution Radiometer (AVHRR) aboard NOAA satellites. Together, these two systems cover a span of 16 years of thermal infrared data. Techniques for retrieving surface temperatures with these sensors in the polar regions have been developed. Errors have been estimated to range from 1K to 5K mainly due to cloud masking problems. With many additional channels available, it is expected that the EOS-Moderate Resolution Imaging Spectroradiometer (MODIS) will provide an improved characterization of clouds and a good discrimination of clouds from snow or ice surfaces.

Comiso, Joey C.↗

NASA NTRS1994

Time scales of pattern evolution from cross-spectrum analysis of advanced very high resolution radiometer and coastal zone color scanner imagery

We have selected square subareas (110 km on a side) from coastal zone color scanner (CZCS) and advanced very high resolution radiometer (AVHRR) images for 1981 in the California Current region off northern California for which we could identify sequences of cloud-free data over periods of days to weeks. We applied a two-dimensional fast Fourier transformation to images after median filtering, (x, y) plane removal, and cosine tapering. We formed autospectra and coherence spectra as functions of a scalar wavenumber. Coherence estimates between pairs of images were plotted against time separation between images for several wide wavenumber bands to provide a temporal lagged coherence function. The temporal rate of loss of correlation (decorrelation time scale) in surface patterns provides a measure of the rate of pattern change or evolution as a function of spatial dimension. We found that patterns evolved (or lost correlation) approximately twice as rapidly in upwelling jets as in the 'quieter' regions between jets. The rapid evolution of pigment patterns (lifetime of about 1 week or less for scales of 50-100 km) ought to hinder biomass transfer to zooplankton predators compared with phytoplankton patches that persist for longer times. We found no significant differences between the statistics of CZCS and AVHRR images (spectral shape or rate of decorrelation). In addition, in two of the three areas studied, the peak correlation between AVHRR and CZCS images from the same area occurred at zero lag, indicating that the patterns evolved simutaneously. In the third area, maximum coherence between thermal and pigment patterns occurred when pigment images lagged thermal images by 1-2 days, mirroring the expected lag of high pigment behind low temperatures (and high nutrients) in recently upwelled water. We conclude that in dynamic areas such as coastal upwelling systems, the phytoplankton cells (identified by pigment color patterns) behave largely as passive scalars at the mesoscale and that growth, death, and sinking of phytoplankton collectively play at most a mariginal role in determining the spectral statistics of the pigment patterns.

Denman, Kenneth L.↗

NASA NTRS2018

Global-scale Evaluation of SMAP, SMOS and ASCAT Soil Moisture Products Using Triple Collocation

Global-scale surface soil moisture products are currently available from multiple remote sensing platforms. Footprint-scale assessments of these products are generally restricted to limited number of densely-instrumented validation sites. However, by taking active and passive soil moisture products together with a third independent soil moisture estimates via land surface modeling, triple collocation (TC) can be applied to estimate the correlation metric of satellite soil moisture products (versus an unknown ground truth) over a quasi-global domain. Here, an assessment of Soil Moisture Active Passive (SMAP), Soil Moisture Ocean Salinity (SMOS) and Advanced SCATterometer (ASCAT) surface soil moisture retrievals via TC is presented. Considering the potential violation of TC error assumptions, the impact of active-passive and satellite-model error cross correlations on the TC-derived inter-comparison results is examined at in situ sites using quadruple collocation analysis. In addition, confidence intervals for the TC-estimated correlation metric are constructed from moving-block bootstrap sampling designed to preserve the temporal persistence of the original (unevenly-sampled) soil moisture time-series. This study is the first to apply TC to obtain a robust global-scale cross-assessment of SMAP, SMOS and ASCAT soil moisture retrieval accuracy in terms of anomaly temporal correlation. Our results confirm the overall advantage of SMAP (with a global average anomaly correlation of 0.76) over SMOS (0.66) and ASCAT (0.63) that has been established in several recent regional, ground-based studies. SMAP is also the best-performing product over the majority of applicable land pixels (52%), although SMOS and ASCAT each shows advantage in distinct geographic regions.

global-scale↗

NASA NTRS2007

Persistent Nature of Secondary Diurnal Modes of Precipitation over Oceanic and Continental Regimes

This investigation seeks a better understanding of the assorted mechanisms controlling the global distribution of precipitation diurnal variability based on the use of Tropical Rainfall Measuring Mission (TRMM) microwave radiometer and radar data. The horizontal distributions of precipitation's diurnal cycle are derived from eight years of TRMM Microwave Imager (TMI) and Precipitation Radar (PR) measurements involving three TRMM standard rain rate retrieval algorithms -- the resultant distributions analyzed at various spatiotemporal scales. The results reveal the prominent and expected late-evening to early-morning (LE-EM) precipitation maxima over oceans and the counterpart prominent and expected mid- to late-afternoon (MLA) maxima over continents. Moreover, and not generally recognized, the results reveal a widespread distribution of secondary maxima occurring over both oceans and continents -- maxima which generally mirror their counterpart regime's behavior. That is, many ocean regions exhibit clearcut secondary MLA precipitation maxima while many continental regions exhibit just as evident secondary LE-EM maxima. This investigation is the first comprehensive study of these globally prevalent secondary maxima and their widespread nature, a type of study only made possible when the analysis procedure is applied to a high-quality global-scale precipitation dataset. The characteristics of the secondary maxima are mapped and described on global grids using an innovative clock-face format, while a current study to be published at a later date provides physically-based explanations of the seasonal-regional distributions of the secondary maxima. In addition to an "explicit" maxima identification scheme, a "Fourier decomposition" maxima identification scheme is used to examine the amplitude and phase properties of the primary and secondary maxima -- as well as tertiary and quaternary maxima. Accordingly, the advantages, ambiguities, and pitfalls resulting from use of Fourier harmonic analysis are explained.

Yang, S.↗

NASA NTRSDate not supplied

"Giovanni at 20: Consistency and Persistency in Making Earth Remote Sensing Data Available (and Useful) to the Earth Science Community"

Since its creation in the year 2000, the NASA Geospatial Interactive Online Visualization ANd aNalysis Infrastructure (Giovanni) has been an exemplar of how to provide remotely-sensed satellite data and related Earth science datasets to a broad and globally diverse researcher community. One of the hallmarks of Giovanni system usage is that it is common to see practitioners of many branches of science – particularly those in fields not traditionally associated with remote-sensing data, such as animal behavior and paleooceanography – both accessing and employing datasets which the system provides. This usage pattern is attested to by the diversity of published science citing Giovanni. Giovanni has evolved through several versions, each of which increased analytical and visualization options while also enhancing ease-of-use. Information resources supporting Giovanni from the Goddard Earth Sciences Data and Information Services Center (GES DISC), which hosts the system, start with basic mapping and plotting functions and extend to “How-to” recipes demonstrating interusability with other data analysis systems and software. Giovanni is now being developed for use in a cloud environment, potentially expanding datasets the system can be applied to, and also improving performance for data having high spatial and temporal resolution. This presentation covers the system’s historical success with interesting examples of Giovanni-citing research, and will apply its current capabilities to a multi-dataset examination of derecho events associated with mesoscale convective phenomena in the summer of 2020, indicating how Giovanni is prepared for ongoing support of Earth science in a changing world.

Giovanni Derecho visualization↗

NASA NTRS2015

Great New Insights from Failed Experiments, Unanticipated Results and Embracing Controversial Observations

Experimental data and observations, whether telescopic or analytical, are never wrong, though data derived from such sources can be misinterpreted or applied inappropriately to derive conclusions that are incorrect. Given that nature always behaves according to the laws of physics and chemistry, rather than according to currently popular models and theories, experimental results should always be considered correct even when the results are far from those that one might initially expect. We discuss a number of cases where the results of experiments, even one carried out as a simple calibration measure, produced wildly different results that generally required many years of effort or contemplation to understand. On the positive side, exploration of the circumstances that produced the errant results often led to new and interesting insights concerning processes that might occur in natural environments and that were well worth the effort involved. Specifically, we show how an experiment that "failed" due to a broken conductor led to experiments that made the first refractory oxide solids containing mass independently fractionated oxygen isotopes and to 1998 predictions of the oxygen isotopic composition of the sun that were confirmed by the analysis of Genesis samples in 2011. We describe a calibration experiment that unexpectedly produced single magnetic domain iron particles. We discuss how tracking down a persistent source of "contamination" in experiments intended to produce amorphous iron and magnesium silicate smokes led to a series of studies on the synthesis of carbonaceous grain coatings that turn out to be very efficient Fischer-Tropsch catalysts and have great potential for trapping the planetary noble gases found in meteorites. We describe how models predicting the instability of silicate grains in circumstellar environments spurred new measurements of the vapor pressure of SiO partially based on previous experiments showing unexpected but systematic non-equilibrium behavior instead of the anticipated equilibrium products resembling meteoritic minerals. We trace the process that led from observations of the presence of crystalline minerals detected in the comae of some comets to the 1999 prediction of large-scale circulation of materials from the hot, innermost regions of the solar nebula out to the cold dark nebular environments where comets form. This large-scale circulation was ultimately confirmed by analyses of highly refractory Stardust samples collected from the Kuiper Belt Comet Wild 2. Finally we discuss a modern and still unresolved conflict between the assumptions built into three well known processes: the CO Self Shielding Model for mass independent isotopic fractionation of oxygen in solar system solids, rapid and thorough mixing within the solar nebula, and the efficient conversion of CO into organic coatings and volatiles on the surfaces of nebular grains via Fischer-Tropsch-type processes.

controversial↗

NASA NTRS1993

Radio stimulation and diagnostics of space plasmas

We have investigated the small-scale topside ionospheric plasma structures first observed at Millstone Hill, Massachusetts with the 440 MHz incoherent scatter radar. These small-scale obliquely propagating plasma modes occurring in the vicinity of the midlatitude ionospheric trough, have large radar cross-sections and narrow spectral widths. They have, until recently, been dismissed solely as hard target contamination of the incoherent scatter radar. The geophysical conditions associated with the ionospheric trough, such as the field-aligned current activity and steep plasma density gradients, suggest that these recently discovered small-scale topside ionospheric plasmas may also appear in the auroral and polar ionosphere. In fact, this speculation has been corroborated by the preliminary experiments and data analyses at Tromso, Norway and Sondrestromfjord, Greenland. The primary research results are highlighted. Described in Section 3 are the experiments conducted at Arecibo, Puerto Rico in the past summer for simulating the geophysical conditions of generating these topside ionospheric plasma structures. Recommendation for the future research is finally given. Attached as the appendix of this report are several chapters which present the detailed results of research in the concerned topside ionospheric clutter. Highlights of the research results include: (1) causes of the enhanced radar backscatter (ERB) phenomenon; (2) occurrence of the ERB phenomenon; (3) altitudes of the ERB phenomenon; (4) strength of the ERB returns; (5) range of altitudes of the ERB returns; (6) occurrence frequency of the ERB phenomenon; (7) Doppler effect of the ERB phenomenon; (8) persistency of the ERB; and (9) distinction between ERB phenomenon and space object signatures.

Lee, Min-Chang↗

NASA NTRS2015

Evaluation of a Model-Based Groundwater Drought Indicator in the Conterminous U.S.

Monitoring groundwater drought using land surface models is a valuable alternative given the current lack of systematic in situ measurements at continental and global scales and the low resolution of current remote sensing based groundwater data. However, uncertainties inherent to land surface models may impede drought detection, and thus should be assessed using independent data sources. In this study, we evaluated a groundwater drought index (GWI) derived from monthly groundwater storage output from the Catchment Land Surface Model (CLSM) using a GWI similarly derived from in situ groundwater observations. Groundwater observations were obtained from unconfined or semi-confined aquifers in eight regions of the central and northeastern U.S. Regional average GWI derived from CLSM exhibited strong correlation with that from observation wells, with correlation coefficients between 0.43 and 0.92. GWI from both in situ data and CLSM was generally better correlated with the Standard Precipitation Index (SPI) at 12 and 24 month timescales than at shorter timescales, but it varied depending on climate conditions. The correlation between CLSM derived GWI and SPI generally decreases with increasing depth to the water table, which in turn depends on both bedrock depth (a CLSM parameter) and mean annual precipitation. The persistence of CLSM derived GWI is spatially varied and again shows a strong influence of depth to groundwater. CLSM derived GWI generally persists longer than GWI derived from in situ data, due at least in part to the inability of coarse model inputs to capture high frequency meteorological variability at local scales. The study also showed that groundwater can have a significant impact on soil moisture persistence where the water table is shallow. Soil moisture persistence was estimated to be longer in the eastern U.S. than in the west, in contrast to previous findings that were based on models that did not represent groundwater. Assimilation of terrestrial water storage data from the Gravity Recovery and Climate Experiment (GRACE) satellite mission improved the correlation between CLSM based regional average GWI and that based on in situ data in six of the eight regions. Practical issues regarding the application of GRACE assimilated groundwater storage for drought detection are discussed. An important conclusion of this study is that model parameters that control the depth to the water table, including bedrock depth, strongly influence the evolution and persistence of simulated groundwater and require careful configuration for drought monitoring.

Evaluation↗

NASA NTRS2014

Evaluation of a Model-Based Groundwater Drought Indicator in the Conterminous U.S.

hydrology↗

NASA NTRS2021

Quantifying Uncertainties in Nighttime Light Retrievals From Suomi-NPP and NOAA-20 VIIRS Day/Night Band Data

Satellite observations of nighttime lights (NTL) from Suomi-NPP and NOAA-20 VIIRS Day/Night Band data have been widely used to estimate human activities. Long-term changes such as urban development and abrupt short-term changes such as power outages have been monitored from temporal NTL acquired by satellites. While high temporal NTL variation has been found across NTL data of varying temporal scale (e.g., daily, monthly, and annual composites), the sources of measurement error and uncertainty are poorly understood. This paper quantifies the sources of VIIRS-derived NTL uncertainty due to view-illumination geometry, surface Bidirectional Reflectance Distribution Function (BRDF)/albedo, and the effects of snow cover, lunar irradiance, aerosol loading, cloud mask, vegetation, geometry, and ephemeral artifacts (e.g., the Aurora Borealis). Based on this current assessment of NASA Black Marble retrievals (VNP46, Collection V001), we found that angular and atmospheric effects dominate retrieval uncertainty. Errors introduced by upstream data inputs (e.g., a coarser nighttime snow cover flag and misclassification errors in the existing VIIRS nighttime cloud mask) were also found to impact retrieval quality. Despite these challenges, a consistent daily NTL time series record can be routinely generated from top-of-atmosphere VNP46 radiances. Key recommendations include: (1) the use of lunar-BRDF adjusted and atmospherically corrected NTL (i.e., as identified as high-quality retrievals in the VNP46 QA fields), (2) development and improvement to the VIIRS snow cover and cloud masks algorithms to accurately reflect NTL retrieval conditions, (3) characterizing seasonal variations in NTL due to vegetation and snow, (4) reducing geometric effects due to the spatial mismatch of gridded pixel and observation footprint, (5) employing angularly-consistent NTL observations from multiple VIIRS instruments (i.e., Suomi-NPP and NOAA-20) to reduce pixel-based uncertainties and address persistent data gaps, and (6) being mindful of surface-reflected radiance from aurora events at mid-to-high latitudes.

Zhuosen Wang↗

DOE OSTI2024

Assessing thermal comfort and participation in residential demand flexibility programs

Residential space-conditioning-based demand flexibility (DF) has become an increasingly sought-after method for demand-side load management to enhance grid reliability and facilitate integration of renewable energy generation. However, predicting the effectiveness and flexibility of residential DF resources is challenging due to the variability in household energy use behaviors. Current estimates show that only 50 % of projected savings from DF resources are actualized due to regulatory, technological, and social barriers. From a household perspective, concerns over thermal comfort during space conditioning-based DF events significantly impact participation decisions. Currently, there is a very limited understanding of how thermal comfort during space-conditioning-based DF events in real-world settings impacts household energy use behaviors and, consequently, the success of DF programs in achieving targeted savings. This paper proposes a method to comprehensively assess the thermal comfort implications of DF strategies and presents results of their impacts on DF event participation decisions and demand savings. Here, the proposed method was applied to a heat pump DF field study in Cordova, Alaska. The study’s key findings are: 1) DF event setpoint offsets that maintain indoor operative temperatures between 18 to 22 °C (65 to 71°F) may be preferred in Cordova, Alaska; 2) Household-level thermal comfort is more sensitive to the duration of the DF event than to the degree of temperature offset from baseline conditions; 3) The delayed impact of changes in indoor operative temperature in response to setpoint offsets, both during and after a DF event, influences occupants’ thermal comfort perceptions and willingness to persistently participate in events. The findings from application of the proposed method can help inform future larger-scale occupant-centric DF programs as it can capture information not readily available through utility and device-level energy use data. Thus, it can supplement these sources and help program administrators develop occupant-centric DF strategies, enabling more accurate predictions of participation rates and savings estimates for space-conditioning-based DF programs.

Demand side management↗

DOE OSTI2022

Multiscale Shear Properties and Flow Performance of Milled Woody Biomass

One dominant challenge facing the development of biorefineries is achieving consistent system throughput with highly variant biomass feedstock quality and handling performance. Current handling unit operations are adapted from other sectors (primarily agriculture), where some simplifying assumptions about granular mechanics and flow performance do not translate well to a highly compressible and anisotropic material with nonlinear time- and stress-dependent properties. This work explores the shear and frictional properties of loblolly pine at multiple experimental test apparatus and particle scales to elucidate a property window that defines the shear behavior over a range of material attributes (particle size, size distribution, moisture content, etc.). In general, it was observed that the bulk internal friction and apparent cohesion depend strongly on both the stress state of the sample in granular shear testers and the overall particle size and distribution span. For equipment designed to characterize the quasi-static shear stress failure of bulk materials ranging from 50 to 1,000 ml in test volume, similar test results were observed for finely milled particles (50% passing size of 1.4 mm) with a narrow size distribution (span between 10 and 90% passing size of 0.9 mm), while stress chaining and over-torque issues persisted for the bench-scale test apparatus for larger particle sizes or widely dispersed sample sizes. Measurement of the anisotropic particle–particle friction ranged from coefficients of approximately 0.20 to 0.45 and resulted in significantly higher and more variable friction measurements for larger particle sizes and in perpendicular alignment orientations. To supplement these laboratory-scale properties, this work explores the flow of loblolly pine and Douglas fir through a pilot-scale wedge-shaped hopper and a screw feeder. For the gravity-driven hopper flow, the critical arching distance and mass discharge rate ranged from approximately 10 to 30 mm and 2 to 16 tons/hour, respectively, for both materials, where the arching distance depends strongly on the overall particle size and depends less on the hopper inclination angle. Comparatively, the auger feeder was found to be much more impacted by the size of the particles, where smaller particles had a more consistent and stable flow while consuming less power.

09 BIOMASS FUELS↗

DOE OSTI2026

Interpretation of high-harmonic fast-wave propagation in the scrape-off layer of NSTX-U as a geometrically bounded-waveguide mode

This paper revisits the onset of high-harmonic fast-wave (HHFW) propagation in the scrape-off layer (SOL) plasma of the NSTX/NSTX-U spherical tokamak, motivated by past HHFW heating and current drive experiments and modelling. Previously, the fast-wave propagation in the SOL was correlated with the opening (suppression) of the fast-wave right-hand cutoff layer in front of the antenna. In this work, the SOL propagation is interpreted as a geometric waveguide mode guided by the SOL geometry, whose radial width can be comparable to the wave’s perpendicular wavelength in the HHFW regime. A two-dimensional circular model is first employed using full-wave solvers to characterise the poloidal eigenmode structures and to clarify their relationship to annulus resonance. By progressively adding a tokamak-like magnetic-field configuration, starting from a uniform axial field, the effects of magnetic-field gradients and pitch on the SOL waveguide mode are characterised. The poloidal mode numbers supported by the SOL plasma agree well with analytic estimates, indicating that an anisotropic plasma in a bounded geometry selectively supports and amplifies the resonant poloidal mode number. Additionally, two-dimensional axisymmetric NSTX-U simulations demonstrate that the SOL eigenmode features identified in the circular model persist in the experimentally relevant configurations. A control approach based on lengthening the wave perpendicular wavelength relative to the SOL width, including a higher magnetic (B)-field operation, is discussed. The analysis here shows the key role of a bounded geometry in interpreting HHFW eigenmode coupling and propagation in the NSTX-U SOL plasma.

plasma heating↗

DOE OSTI2024

Surface-to-Interior Transport Timescales and Ventilation Patterns in a Time-Dependent Circulation Driven by Sustained Climate Warming

Abstract The effect of climate warming in response to rising atmospheric CO 2 on the ventilation of the ocean remains uncertain. Here we make theoretical advances in elucidating the relationship between ideal age and transit time distribution (TTD) in a time-dependent flow. Subsequently, we develop an offline tracer-transport model to characterize the ventilation patterns and time scales in the time-evolving circulation for the 1850–2300 period as simulated with the Community Earth System Model version 1 (CESMv1) under a business-as-usual warming scenario. We found that by 2300 2.1% less water originates from the high-latitude deep water formation regions (both hemispheres) compared to 1850. In compensation, there is an increase in the water originating from the subantarctic. We also found that slowing meridional overturning circulation causes a gradual increase in mean age during the 1850–2300 period, with a globally averaged mean-age increase of ∼110 years in 2300. Where and when the water will be re-exposed to the atmosphere depends on the post-2300 circulation. For example, if we assume that the circulation persists in its year-2300 state (scenario 1), the mean interior-to-surface transit time in year 1850 is ∼1140 years. In contrast, if we assume that the circulation abruptly recovers to its year-1850 state (scenario 2), the mean interior-to-surface transit time in 1850 is only ∼740 years. By 2300, these differences become even larger; in scenario 1, the mean interior-to-surface transit time increases by ∼200 years, whereas scenario 2 decreases by ∼80 years. The dependence of interior-to-surface transit time on the future ocean circulation produces an additional unavoidable uncertainty in the long-term durability of marine carbon dioxide removal strategies. Significance Statement The ocean’s circulation, when altered by climate warming, can affect its capacity to absorb heat and CO 2 , which are crucial for the global climate. In our study, we investigated how global warming, caused by rising CO 2 levels, might impact the ocean circulation—the way water moves from deep ocean to the surface and vice versa. We discovered that by 2300, if we continue on our current warming trajectory, the origins of water within the ocean will shift, with less coming from deep, cold zones near the poles and more from subantarctic regions. As a result, deep water will take longer time before it resurfaces than shallow water. How quickly this water travels from deep regions to the surface could change, depending on the state of future ocean circulation. If the circulation remains as predicted in 2300, this journey will take longer. Conversely, if it reverts to the pattern in 1850, the process will be quicker. This variability introduces added uncertainty to strategies aimed at mitigating climate change by storing CO 2 in the ocean. Our work highlights the intricate ways in which climate change can influence our oceans, potentially affecting our plans to mitigate global warming.

54 ENVIRONMENTAL SCIENCES↗

DOE OSTI2025

Challenges of standard halo models in constraining galaxy properties from cosmic infrared background anisotropies

The halo model, combined with halo occupation distribution (HOD) prescriptions, is widely used to interpret cosmic infrared background (CIB) anisotropies and extract physical information about star-forming galaxies and their connection to large-scale structures. Recent CIB-specific implementations of the halo model have adopted more physical parameterizations. However, the extent to which these models can reliably recover meaningful physical parameters remains uncertain. We assessed whether the current parameterization of CIB halo models is sufficient to recover astrophysical quantities, such as star formation efficiency, η(M h , z), and halo mass at which the peak of star formation efficiency occurs, M max , when fit to mock data. We also assessed whether discrepancies arise from assumptions about galaxy emission (the HOD ingredients) or from more fundamental components in the halo model, such as bias and matter clustering. We fit the M21 CIB HOD model, implemented within the halo model framework, to mock CIB power spectra and star formation rate density (SFRD) data generated from the SIDES-Uchuu simulation, and compared the best-fit parameters to the known simulation inputs. We then repeated the analysis using a simplified version of the simulation (SSU), explicitly designed to match the HOD assumptions. A detailed comparison of model and simulation outputs was carried out to trace the origin of observed discrepancies. While the M21 HOD model provides a good fit to the mock data, it failed to recover the intrinsic parameters accurately, particularly the halo mass at which star formation efficiency peaks. This mismatch persists even when fitting data generated with the same model assumptions. We find strong agreement (within 5%) in the emission-related components (SFRD, emissivity), but observe a scale- and redshift-dependent offset exceeding 20% in the two-halo term of the CIB power spectrum. This likely arises from limitations in the treatment of halo bias and matter clustering within the linear approximation. Additionally, incorporating scatter in the SFR–halo mass relation and the spectral energy distribution (SED) templates significantly affects the shot noise (∼50%), but has only a modest impact (less than 10%) on the clustered component. These results suggest that recovering physical parameters from CIB clustering requires improvements to the cosmological ingredients of the halo model framework, such as adopting scale-dependent halo bias and nonlinear matter power spectra in addition to careful modeling of emission physics.

cosmic background radiation↗