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NASA NTRS2016

Estimating the Rate of Occurrence of Renal Stones in Astronauts

Changes in urine chemistry, during and post flight, potentially increases the risk of renal stones in astronauts. Although much is known about the effects of space flight on urine chemistry, no inflight incidence of renal stones in US astronauts exists and the question "How much does this risk change with space flight?" remains difficult to accurately quantify. In this discussion, we tackle this question utilizing a combination of deterministic and probabilistic modeling that implements the physics behind free stone growth and agglomeration, speciation of urine chemistry and published observations of population renal stone incidences to estimate changes in the rate of renal stone presentation. The modeling process utilizes a Population Balance Equation based model developed in the companion IWS abstract by Kassemi et al. (2016) to evaluate the maximum growth and agglomeration potential from a specified set of urine chemistry values. Changes in renal stone occurrence rates are obtained from this model in a probabilistic simulation that interrogates the range of possible urine chemistries using Monte Carlo techniques. Subsequently, each randomly sampled urine chemistry undergoes speciation analysis using the well-established Joint Expert Speciation System (JESS) code to calculate critical values, such as ionic strength and relative supersaturation. The Kassemi model utilizes this information to predict the mean and maximum stone size. We close the assessment loop by using a transfer function that estimates the rate of stone formation from combining the relative supersaturation and both the mean and maximum free stone growth sizes. The transfer function is established by a simulation analysis which combines population stone formation rates and Poisson regression. Training this transfer function requires using the output of the aforementioned assessment steps with inputs from known non-stone-former and known stone-former urine chemistries. Established in a Monte Carlo system, the entire renal stone analysis model produces a probability distribution of the stone formation rate and an expected uncertainty in the estimate. The utility of this analysis will be demonstrated by showing the change in renal stone occurrence predicted by this method using urine chemistry distributions published in Whitson et al. 2009. A comparison to the model predictions to previous assessments of renal stone risk will be used to illustrate initial validation of the model.

gravitational physiology↗

NASA NTRS1983

Analysis of Wind Gust Data

Wind gust data were analyzed by statistical and mathematical procedures, developed for the bivariate gamma distribution. The results of the analysis are summarized.

Tubbs, J. D.↗

NASA NTRS1987

Distributed computer system enhances productivity for SRB joint optimization

The Programming System for Structural Synthesis software package, which couples structural analysis and optimization, has been distributed over a network of work stations for use in Space Shuttle Solid Rocket Booster joint redesign optimization. Finite difference computing techniques were applied to the optimization gradients in parallel execution, allowing several work stations to simultaneously contribute to the problem's solution. An optimal joint shape was obtained which achieves minimum weight while keeping the gap between joints well closed and limiting structural stresses. The optimization cycle was reduced from two hours to one-half hour.

Rogers, James L., Jr.↗

NASA NTRS1995

Propagation and damping of broadband upstream whistlers

Previous studies indicated that damping rates of upstream whistlers strongly depend on the details of the electron distribution function. Moreover, detailed analysis of Doppler-shift and whistler dispersion relation indicated that upstream whistlers propagate obliquely in a broad band. In this paper we present results of a kinetic calculation of damping lengths of wide-band whistlers using the sum of 7-drifting bi-Maxwellian electron distributions as a best fit to the International Sun Earth Explorer (ISEE) 1 electron data. For 2 cases, when upstream whistlers are observed, convective damping lengths derived from ISEE magnetic field and ephemeris data are compared with theoretical results. We find that the calculated convective damping lengths are consistent with the data and that upstream whistlers remain marginally stable. We also show that the slope of plasma frame spectra of upstream whistlers, obtained by direct fitting of the observed spectra is between 5 and 7 with a sharp lower frequency cutoff corresponding to a wavelength of about one ion inertial length. When the solar wind velocity is directed largely along the wave normal of the upstream whistlers the polariztion of the right hand waves becomes reversed and low frequencies are switched to high resulting in a peaked spectrum with a strong high frequency cutoff. The overall spectral, wave and particle characteristics, proximity to the shock as well as propagation and damping properties indicate that these waves cannot be generated locally. Instead the observed upstream whistlers arise in the shock ramp most likely by a variety of cross-field drift and/or anisotropy driven instabilities.

Orlowski, D. S.↗

NASA NTRS1993

Wave generation by contaminant ions

Investigations dealing with the generation of waves by contaminant ions are reported. The studies included the properties of the velocity distribution function of such ions. It was found that it takes about one ion-cyclotron period for the distribution function to transform from a beam to a ring distribution. A linear instability analysis was performed to examine the possibility of wave excitation by an ion beam streaming perpendicular to the ambient magnetic field in an ionospheric type of plasma. A simulation code was developed to study the nonlinear behavior of the waves excited by beam and ring types of ion distributions. The code treats both electrons and ions as particles kinetically to also factor in the possible involvement of lower-hybrid waves.

Singh, N.↗

NASA NTRS2001

The AutoBayes Program Synthesis System: System Description

AUTOBAYES is a fully automatic program synthesis system for the statistical data analysis domain. Its input is a concise description of a data analysis problem in the form of a statistical model; its output is optimized and fully documented C/C++ code which can be linked dynamically into the Matlab and Octave environments. AUTOBAYES synthesizes code by a schema-guided deductive process. Schemas (i.e., code templates with associated semantic constraints) are applied to the original problem and recursively to emerging subproblems. AUTOBAYES complements this approach by symbolic computation to derive closed-form solutions whenever possible. In this paper, we concentrate on the interaction between the symbolic computations and the deductive synthesis process. A statistical model specifies for each problem variable (i.e., data or parameter) its properties and dependencies in the form of a probability distribution, A typical data analysis task is to estimate the best possible parameter values from the given observations or measurements. The following example models normal-distributed data but takes prior information (e.g., from previous experiments) on the data's mean value and variance into account.

Fischer, Bernd↗

NASA NTRS1979

Aerodynamic design and analysis of the AST-200 supersonic transport configuration concept

The design and analysis of a supersonic transport configuration was conducted using linear theory methods in conjunction with appropriate constraints. Wing optimization centered on the determination of the required twist and camber and proper integration of the wing and fuselage. Also included in the design are aerodynamic refinements to the baseline wing thickness distribution and nacelle shape. Analysis to the baseline and revised configurations indicated an improvement in lift-to-drag ratio of 0.36 at the Mach 2.7 cruise condition. Validation of the design is planned through supersonic wing tunnel tests.

Walkley, K. B.↗

NASA NTRS1982

KC-135 wing and winglet flight pressure distributions, loads, and wing deflection results with some wind tunnel comparisons

A full-scale winglet flight test on a KC-135 airplane with an upper winglet was conducted. Data were taken at Mach numbers from 0.70 to 0.82 at altitudes from 34,000 feet to 39,000 feet at stabilized flight conditions for wing/winglet configurations of basic wing tip, 15/-4 deg, 15/-2 deg, and 0/-4 deg winglet cant/incidence. An analysis of selected pressure distribution and data showed that with the basic wing tip, the flight and wind tunnel wing pressure distribution data showed good agreement. With winglets installed, the effects on the wing pressure distribution were mainly near the tip. Also, the flight and wind tunnel winglet pressure distributions had some significant differences primarily due to the oilcanning in flight. However, in general, the agreement was good. For the winglet cant and incidence configuration presented, the incidence had the largest effect on the winglet pressure distributions. The incremental flight wing deflection data showed that the semispan wind tunnel model did a reasonable job of simulating the aeroelastic effects at the wing tip. The flight loads data showed good agreement with predictions at the design point and also substantiated the predicted structural penalty (load increase) of the 15 deg cant/-2 deg incidence winglet configuration.

Montoya, L. C.↗

NASA NTRS2018

Molecular Distribution, 13C-Isotope, and Enantiomeric Compositions of Carbonaceous Chondrite Monocarboxylic Acids

The water-soluble organic compounds in carbonaceous chondrite meteorites constitute a record of the synthetic reactions occurring at the birth of the solar system and those taking place during parent body alteration and may have been important for the later origins and development of life on Earth. In this present work, we have developed a novel methodology for the simultaneous analysis of the molecular distribution, compound-specific (delta)(exp 13)C, and enantiomeric compositions of aliphatic monocarboxylic acids (MCA) extracted from the hot-water extracts of 16 carbonaceous chondrites from CM, CR, CO, CV, and CK groups. We observed high concentrations of meteoritic MCAs, with total carbon weight percentages which in some cases approached those of carbonates and insoluble organic matter. Moreover, we found that the concentration of MCAs in CR chondrites is higher than in the other meteorite groups, with acetic acid exhibiting the highest concentration in all samples. The abundance of MCAs decreased with increasing molecular weight and with increasing aqueous and/or thermal alteration experienced by the meteorite sample. The (delta)(exp 13)C isotopic values of MCAs ranged from 52 to +27(0/00), and aside from an inverse relationship between (delta)(exp 13)C value and carbon straight-chain length for C3–C6 MCAs in Murchison, the 13C-isotopic values did not correlate with the number of carbon atoms per molecule. We also observed racemic compositions of 2-methylbutanoic acid in CM and CR chondrites. We used this novel analytical protocol and collective data to shed new light on the prebiotic origins of chondritic MCAs.

Aponte, Jose C.↗

NASA NTRS1971

Response characteristics of a thermal-heliotrope solar-array orientation device

The thermal heliotrope is a passive solar-array orientation device containing a bimetallic helix that rotates when activated by solar energy. The rate and extent of the rotation depends upon the properties of the two metals and the temperature of the helix. An energy-balance analysis is performed to determine the temperature distribution in the helix. By initially restricting the analysis, a simplified equation governing the response of the heliotrope is obtained. In order to gain insight into the response of the heliotrope, a series of experiments were performed. The results of these tests and the implications are presented.

Morse, F. H.↗

NASA NTRS1974

Energy transfer in volume-reflecting heat shields

An approximate analysis of radiative transfer in highly scattering materials was developed based on the Kubelka-Munk differential equations--a set of two differential equations representing the spatial rate of change of radiative half-fluxes within the scattering media. These approximate solutions of the Kubelka-Munk equations together with analytic solutions for the steady state temperature distribution for two types of boundary conditions are given. These solutions show the influence of back surface reflectance, scattering power, incident radiative flux parameter and boundary conductive flux parameter on overall reflectance and temperature distributions. This radiation field analysis, adapted to spherical geometry, was applied to the evaluation of the thermal performance of teflon and fritted quartz as heat protection materials for entry into the atmosphere of Jupiter.

Weston, K. C.↗

NASA NTRS1989

Aerosol in the Pacific troposphere

The use of near real-time optical techniques is emphasized for the measurement of mid-tropospheric aerosol over the Central Pacific. The primary focus is on measurement of the aerosol size distribution over the range of particle diameters from 0.15 to 5.0 microns that are essential for modeling CO2 backscatter values in support of the laser atmospheric wind sounder (LAWS) program. The measurement system employs a LAS-X (Laser Aerosol Spectrometer-PMS, Boulder, CO) with a custom 256 channel pulse height analyzer and software for detailed measurement and analysis of aerosol size distributions. A thermal preheater system (Thermo Optic Aerosol Descriminator (TOAD) conditions the aerosol in a manner that allows the discrimination of the size distribution of individual aerosol components such as sulfuric acid, sulfates and refractory species. This allows assessment of the relative contribution of each component to the BCO2 signal. This is necessary since the different components have different sources, exhibit independent variability and provide different BCO2 signals for a given mass and particle size. Field activities involve experiments designed to examine both temporal and spatial variability of these aerosol components from ground based and aircraft platforms.

Clarke, Antony D.↗

NASA NTRS1991

Building a generalized distributed system model

A number of topics related to building a generalized distributed system model are discussed. The effects of distributed database modeling on evaluation of transaction rollbacks, the measurement of effects of distributed database models on transaction availability measures, and a performance analysis of static locking in replicated distributed database systems are covered.

Mukkamala, Ravi↗

NASA NTRS2005

Distribution and Diversity of Organic and Biological Signatures in Soils From the Atacama Desert

The Atacama Desert is amongst the driest places on Earth. It is considered to be a suitable analog for the Martian surface in which to conduct studies of life and life detection. Soil samples were collected in June 2005 from the Atacama Desert and analyzed in the lab for amino acid content. HPLC was the primary tool used to analyze samples. The amino acids of interest are aspartic acid, serine, glutamic acid, glycine, and alanine. D and L isomers of each amino acid (except for glycine) were separated through HPLC. The purpose of this study is to find correlations between location of the sample collection sites and amino acid content as well as D/L isomer ratios in order to formulate theories of how different types of environments may affect the abundance and distribution of life forms. Initial analysis of data shows a general lack of or slight correlation between location and amino acid content. Some data appears to contradict the hypothesis that harsher environments would have lower amino acid content than less harsh environments. Further analysis of data is needed to come up with a more conclusive report of the distribution of amino acids in the Atacama Desert.

Sharma, Aditi↗

NASA NTRS1993

The out-of-plane distribution of zodiacal dust near the earth

Analysis of IRAS data of the thermal zodiacal emission reveals an out-of-plane dust distribution near the Earth which is well-represented by a Lorentzian function. We suggest a possible explanation for the similarity as near-Earth gravitational perturbations of dust grains. Such perturbations are expected to be chaotic and will randomize any residual band structure near the Earth.

Clark, F. O.↗

NASA NTRS2004

High Pressure X-Ray Diffraction Studies of Nanocrystalline Materials

Experimental evidence obtained for a variety of nanocrystalline materials suggest that the crystallographic structure of a very small size particle deviates from that in the bulk crystals. In this paper we show the effect of the surface of nanocrystals on their structure by the analysis of generation and distribution of macro- and micro-strains at high pressures and their dependence on the grain size in nanocrystalline powders of Sic. We studied the structure of Sic nanocrystals by in-situ high-pressure powder diffraction technique using synchrotron and neutron sources and hydrostatic or isostatic pressure conditions. The diffraction measurements were done in HASYLAB at DESY using a Diamond Anvil Cell (DAC) in the energy dispersive geometry in the diffraction vector range up to 3.5 - 4/A and under pressures up to 50 GPa at room temperature. In-situ high pressure neutron diffraction measurements were done at LANSCE in Los Alamos National Laboratory using the HIPD and HIPPO diffractometers with the Paris-Edinburgh and TAP-98 cells, respectively, in the diffraction vector range up to 26 Examination of the response of the material to external stresses requires nonstandard methodology of the materials characterization and description. Although every diffraction pattern contains a complete information on macro- and micro-strains, a high pressure experiment can reveal only those factors which contribute to the characteristic diffraction patterns of the crystalline phases present in the sample. The elastic properties of powders with the grain size from several nm to micrometers were examined using three methodologies: (l), the analysis of positions and widths of individual Bragg reflections (used for calculating macro- and micro-strains generated during densification) [I], (2). the analysis of the dependence of the experimental apparent lattice parameter, alp, on the diffraction vector Q [2], and (3), the atomic Pair Distribution Function (PDF) technique [3]. The results of our studies show, that Sic nanocrystals have the features of two phases, each with its distinct elastic properties. and under pressures up to 8 GPa.

Palosz, B.↗

NASA NTRS2015

X-Raying the Coronae of HD 155555

We present an analysis of the high-resolution Chandra observation of the multiple system, HD 155555 (an RS CVn type binary system, HD 155555 AB, and its spatially resolved low-mass companion HD 155555 C). This is an intriguing system which shows properties of both an active pre-main sequence star and a synchronised (main sequence) binary. We obtain the emission measure distribution, temperature structures, plasma densities, and abundances of this system and compare them with the coronal properties of other young/active stars. HD 155555 AB and HD 155555 C produce copious X-ray emission with log L(sub x) of 30.54 and 29.30, respectively, in the 0.3-6.0 kiloelectronvolt energy band. The light curves of individual stars show variability on timescales of few minutes to hours. We analyse the dispersed spectra and reconstruct the emission measure distribution using spectral line analysis. The resulting elemental abundances exhibit inverse first ionisation potential effect in both cases. An analysis of He-like triplets yields a range of coronal electron densities 1010 − 1013 per cubic centimeter. Since HD 155555 AB is classified both as an RS CVn and a PMS star, we compare our results with those of other slightly older active main-sequence stars and T Tauri stars, which indicates that the coronal properties of HD 155555 AB closely resemble that of an older RS CVn binary rather than a younger PMS star. Our results also suggests that the properties of HD 155555 C is very similar to those of other active M dwarfs.

stars: coronae↗

NASA NTRS2004

Gravitational Lenses and the Structure and Evolution of Galaxies

During the first year of the project we completed five papers, each of which represents a new direction in the theory and interpretation of gravitational lenses. In the first paper, The Importance of Einstein Rings, we developed the first theory for the formation and structure of the Einstein rings formed by lensing extended sources like the host galaxies of quasar and radio sources. In the second paper, Cusped Mass Models Of Gravitational Lenses, we introduced a new class of lens models. In the third paper, Global Probes of the Impact of Baryons on Dark Matter Halos, we made the first globally consistent models for the separation distribution of gravitational lenses including both galaxy and cluster lenses. The last two papers explore the properties of two lenses in detail. During the second year we have focused more closely on the relationship of baryons and dark matter. In the third year we have been further examining the relationship between baryons and dark matter. In the present year we extended our statistical analysis of lens mass distributions using a self-similar model for the halo mass distribution as compared to the luminous galaxy.

Oliversen, Ronald J.↗