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NASA NTRS2009

Modular and Stochastic Approaches to Molecular Pathway Models of ATM, TGF beta, and WNT Signaling

Deterministic pathway models that describe the biochemical interactions of a group of related proteins, their complexes, activation through kinase, etc. are often the basis for many systems biology models. Low dose radiation effects present a unique set of challenges to these models including the importance of stochastic effects due to the nature of radiation tracks and small number of molecules activated, and the search for infrequent events that contribute to cancer risks. We have been studying models of the ATM, TGF -Smad and WNT signaling pathways with the goal of applying pathway models to the investigation of low dose radiation cancer risks. Modeling challenges include introduction of stochastic models of radiation tracks, their relationships to more than one substrate species that perturb pathways, and the identification of a representative set of enzymes that act on the dominant substrates. Because several pathways are activated concurrently by radiation the development of modular pathway approach is of interest.

Cucinotta, Francis A.↗

NASA NTRS2009

Characterizing Space Environments with Long-Term Space Plasma Archive Resources

A significant scientific benefit of establishing and maintaining long-term space plasma data archives is the ready access the archives afford to resources required for characterizing spacecraft design environments. Space systems must be capable of operating in the mean environments driven by climatology as well as the extremes that occur during individual space weather events. Long- term time series are necessary to obtain quantitative information on environment variability and extremes that characterize the mean and worst case environments that may be encountered during a mission. In addition, analysis of large data sets are important to scientific studies of flux limiting processes that provide a basis for establishing upper limits to environment specifications used in radiation or charging analyses. We present applications using data from existing archives and highlight their contributions to space environment models developed at Marshall Space Flight Center including the Chandra Radiation Model, ionospheric plasma variability models, and plasma models of the L2 space environment.

Minow, Joseph I.↗

NASA NTRS2015

Automatic Event Detection in Search for Inter-Moss Loops in IRIS Si IV Slit-Jaw Images

The high-resolution capabilities of the Interface Region Imaging Spectrometer (IRIS) mission have allowed the exploration of the finer details of the solar magnetic structure from the chromosphere to the lower corona that have previously been unresolved. Of particular interest to us are the relatively short-lived, low-lying magnetic loops that have foot points in neighboring moss regions. These inter-moss loops have also appeared in several AIA pass bands, which are generally associated with temperatures that are at least an order of magnitude higher than that of the Si IV emission seen in the 1400 angstrom pass band of IRIS. While the emission lines seen in these pass bands can be associated with a range of temperatures, the simultaneous appearance of these loops in IRIS 1400 and AIA 171, 193, and 211 suggest that they are not in ionization equilibrium. To study these structures in detail, we have developed a series of algorithms to automatically detect signal brightening or events on a pixel-by-pixel basis and group them together as structures for each of the above data sets. These algorithms have successfully picked out all activity fitting certain adjustable criteria. The resulting groups of events are then statistically analyzed to determine which characteristics can be used to distinguish the inter-moss loops from all other structures. While a few characteristic histograms reveal that manually selected inter-moss loops lie outside the norm, a combination of several characteristics will need to be used to determine the statistical likelihood that a group of events be categorized automatically as a loop of interest. The goal of this project is to be able to automatically pick out inter-moss loops from an entire data set and calculate the characteristics that have previously been determined manually, such as length, intensity, and lifetime. We will discuss the algorithms, preliminary results, and current progress of automatic characterization.

loops↗

NASA NTRS1994

Development of New Open-Shell Perturbation and Coupled-Cluster Theories Based on Symmetric Spin Orbitals

A new spin orbital basis is employed in the development of efficient open-shell coupled-cluster and perturbation theories that are based on a restricted Hartree-Fock (RHF) reference function. The spin orbital basis differs from the standard one in the spin functions that are associated with the singly occupied spatial orbital. The occupied orbital (in the spin orbital basis) is assigned the delta(+) = 1/square root of 2(alpha+Beta) spin function while the unoccupied orbital is assigned the delta(-) = 1/square root of 2(alpha-Beta) spin function. The doubly occupied and unoccupied orbitals (in the reference function) are assigned the standard alpha and Beta spin functions. The coupled-cluster and perturbation theory wave functions based on this set of "symmetric spin orbitals" exhibit much more symmetry than those based on the standard spin orbital basis. This, together with interacting space arguments, leads to a dramatic reduction in the computational cost for both coupled-cluster and perturbation theory. Additionally, perturbation theory based on "symmetric spin orbitals" obeys Brillouin's theorem provided that spin and spatial excitations are both considered. Other properties of the coupled-cluster and perturbation theory wave functions and models will be discussed.

Lee, Timothy J.↗

NASA NTRS1993

Interplanetary proton fluence model - JPL 1991

We describe an updated predictive engineering model for the interplanetary fluence of protons with energies respectively greater than 1, 4, 10, 30, and 60 MeV. This has been the first opportunity to derive a model from a data set that has been collected in space over a long enough period of time to produce a valid sample of solar proton events. The model provides a quantitative basis for estimating the exposures to solar protons of spacecraft during missions of varying length and of surfaces and atmospheres of solar system objects. The data sets contain several major proton events comparable to the 1972 event. For the cases of the over 10 and over 30 MeV particles, the fluences are somewhat lower than in our earlier model No over 1, over 4, and over 60 MeV proton fluence models have been published in the literature previously. We present our results in a convenient graphical form which may be used to calculate the 1 AU fluence expected at a given confidence level as a function of the length of the exposure. A method of extending this estimate to other heliocentric distances is described.

Feynman, J.↗

NASA NTRS1982

On current aspects of finite element computational fluid mechanics for turbulent flows

A set of nonlinear partial differential equations suitable for the description of a class of turbulent three-dimensional flow fields in select geometries is identified. On the basis of the concept of enforcing a penalty constraint to ensure accurate accounting of ordering effects, a finite element numerical solution algorithm is established for the equation set and the theoretical aspects of accuracy, convergence and stability are identified and quantized. Hypermatrix constructions are used to formulate the reduction of the computational aspects of the theory to practice. The robustness of the algorithm, and the computer program embodiment, have been verified for pertinent flow configurations.

Baker, A. J.↗

NASA NTRS1983

Galileo spacecraft inertial sensors in-flight calibration design

The successful navigation of Galileo depends on accurate trajectory correction maneuvers (TCM's) performed during the mission. A set of Inertial Sensor (INS) units, comprised of gyros and accelerometers, mounted on the spacecraft, are utilized to control and monitor the performance of the TCM's. To provide the optimum performance, in-flight calibrations of INS are planned. These calibrations will take place on a regular basis. In this paper, a mathematical description is given of the data reduction technique used in analyzing a typical set of calibration data. The design of the calibration and the inertial sensor error models, necessary for the above analysis, are delineated in detail.

Jahanshahi, M. H.↗

NASA NTRS2000

Ames Research Center FY 2000 Implementation Plan: Leading Technology into the New Millennium

This document presents the implementation plan for Ames Research Center (ARC) within the overall framework of the NASA Strategic Plan. It describes how ARC intends to implement its Center of Excellence responsibilities, Agency assigned missions, Agency and Enterprise lead programs, and other roles in support of NASA's vision and mission. All Federal agencies are required by the 1993 Government Performance and Results Act to implement a long-term strategic planning process that includes measurable outcomes and strict accountability. At NASA, this planning process is shaped by the Space Act of 1958, annual appropriations, and other external mandates, as well as by customer requirements. The resulting Strategic Plan sets the overall architecture for what we do, identifies who our customers are, and directs where we are going and why. The Strategic Plan is the basis upon which decisions regarding program implementation and resource deployment are made. Whereas the strategic planning process examines the long-term direction of the organization and identifies a specific set of goals, the implementation planning process examines the detailed performance of the organization and allocates resources toward meeting these goals. It is the purpose of this implementation document to provide the connection between the NASA Strategic Plan and the specific programs and support functions that ARC employees perform. This connection flows from the NASA Strategic Plan, through the various Strategic Enterprise plans to the ARC Center of Excellence, primary missions, Lead Center programs, program support responsibilities, and ultimately, to the role of the individual ARC employee.

Source record↗

NASA NTRS1961

ON THE ACCURACY OF MEASUREMENTS MADE UPON FILMS PHOTOGRAPHED BY BAKER-NUNN SATELLITE TRACKING CAMERAS

The photographs taken by the Baker-Nunn cameras of the Smithsonian Astrophysical Observatory were formerly measured with Van Biesbroeck goniometers, but are now measured exclusively with Mann two-screw comparators. Instead of measuring point images, we usually have to measure oblong images, either trails or breaks (the latter produced by interruption of the exposure). We can therefore expect that the accuracy of the determination of their positions is more influenced by the personal errors than it is in conventional astrometry. Approximately 800 measurements were made on 34 images of different length, and, from these, the frequency distribution of settings was determined. Then the relationship between this distribution and the length of the image (trail or break) was examined, and the relationship between the "magnitude error" and the length of image was determined. Measurements were made at different angles formed by the trails and the reticle lines, and it was found that the accuracy was not affected by the angle of the setting. Position determinations have been made using reference stars at different distances. On the basis of these results, we can conclude that the accuracy is neither influenced by the distortion of the emulsion nor by the optical distortion within an area of a diameter of S cm (5°.8). We believe that we are justified in using the linear plate constant method, at least within this area. From numerous double and multiple measurements, the following standard errors were determined for a single position.

ASTROMETRY↗

NASA NTRS1976

A Rayleigh-Ritz approach to the synthesis of large structures with rotating flexible components

The equations of motion for large structures with rotating flexible components are derived by regarding the structure as an assemblage of substructures. Based on a stationarity principle for rotating structures, it is shown that each continuous or discrete substructure can be simulated by a suitable set of admissible functions or admissible vectors. This substructure synthesis approach provides a rational basis for truncating the number of degrees of freedom both of each substructure and of the assembled structure.

Meirovitch, L.↗

NASA NTRS1977

Application of satellite remote sensing to North Carolina. Development of a monitoring methodology for trophic states of lakes in North Carolina

Conjunctive study of four shallow coastal plain lakes in northeastern North Carolina and their LANDSAT-2 images demonstrates that it is possible to differentiate between the lakes and their respective trophic states on the basis of the multispectral scanner imagery. The year-long investigation established that monitoring of the trophic states of the lakes on a seasonal basis through application of color additive imagery enchancement techniques is possible. Utilizing a standard setting of the color additive viewer, an investigator can normalize the imagery to an internal standard of constant reflectance characteristics. By comparison of the false color renditions with a standard interference color chart combined with brightness measurements made on the viewer screen, one can relate the lake reflectances to their trophic states. Two or more bands of the imagery are required, and the present study established that for the lakes studied, Band 5 and Band 6 form a good combination.

Welby, C. W.↗

NASA NTRS1977

A Rayleigh-Ritz approach to the synthesis of large gyroscopic structures

Meirovitch, L.↗

NASA NTRS1981

Logic analysis of complex systems by characterizing failure phenomena to achieve diagnosis and fault-isolation

A recent result shows that, for a certain class of systems, the interdependency among the elements of such a system together with the elements constitutes a mathematical structure a partially ordered set. It is called a loop free logic model of the system. On the basis of an intrinsic property of the mathematical structure, a characterization of system component failure in terms of maximal subsets of bad test signals of the system was obtained. Also, as a consequence, information concerning the total number of failure components in the system was deduced. Detailed examples are given to show how to restructure real systems containing loops into loop free models for which the result is applicable.

Wong, J. T.↗

NASA NTRS1990

Frequency analysis via the method of moment functionals

Several variants are presented of a linear-in-parameters least squares formulation for determining the transfer function of a stable linear system at specified frequencies given a finite set of Fourier series coefficients calculated from transient nonstationary input-output data. The basis of the technique is Shinbrot's classical method of moment functionals using complex Fourier based modulating functions to convert a differential equation model on a finite time interval into an algebraic equation which depends linearly on frequency-related parameters.

Pearson, A. E.↗

NASA NTRS1992

The NDSC Primary Site at the Observatoire De Haute-provence: Ozone and Aerosols Observations (1986-1992)

The primary site of the newly implemented Network for Detection of Stratospheric Changes (NDSC) includes three main sites in the alpine regions of southern Europe. At one of these observatories, a coherent set of experimental systems has been established to monitor on a long-term basis ozone, aerosols, minor constituents, and temperature vertical distributions in the troposphere and stratosphere. Such techniques include several lidar systems, balloon-borne sondes and ultraviolet visible spectrometry. Lidar measurements of stratospheric aerosols are performed on a routine basis, since 1980. These include the vertical distribution of the extinction and backscattering coefficients from the tropopause. Recently, measurements performed following the eruption of Mount Pinatubo, have allowed researchers to follow the time evolution of the aerosol cloud in middle latitude regions.

Megie, G.↗

NASA NTRS1992

Magellan stereo images and Venusian geology

Areas of Venus imaged by Magellan radar with multiple viewing conditions provide unique data that will contribute to the solution of venusian geologic problems and provide a basis for quantitative comparison of venusian landforms with those on other planetary bodies. Three sets of images with different viewing conditions have been acquired: (1) left-looking with variable incidence angles (cycle 1 profile), (2) right-looking with nearly constant incidence angles (cycle 2 profile), and (3) left-looking with variable incidence angles that are almost always smaller than those in (1) (cycle 3 profiles). The unique data provided by paired images of the same scene with different incidence angles arises from image displacements caused by the relief of individual landforms at scales comparable to the ground-range and azimuth resolutions of the images. There are two aspects of the data: (1) Stereopsis achieved by simultaneous viewing of paired left-looking images of the same scene permits three-dimensional perception and interpretation of the morphologies of landforms at resolutions much finer than the altimetry footprints. (2) Measurements of differences of image displacements (parallax) on paired images with known imaging geometries provide quantitative estimates of the relief and shapes of landforms. The potential scientific contributions of the data can be grouped into two interrelated classes: (A) geologic mapping, analysis, and interpretation and (B) topical studies that involve topographic measurements. Stereopsis, without quantitative measurements, enhances geologic mapping, analysis, and interpretation of the rock units of Venus to a degree that cannot be overestimated. In geologic mapping, assemblages of landforms, assessments of backscatter and variations in backscatter, and fine-scale topography are used to define and characterize geologic map units that represent laterally continuous deposits or rock units. Stereopsis adds the important dimension of local relief for characterization of geologic units at a scale that is not possible with Magellan altimetry or products derived from the altimetry. Relative ages of the geologic units are determined using the well-known principles of superposition and intersection. Here, the perception of relief is invaluable because superposition relations among the geological units are more readily and clearly established. The recognition of folds, faults, and fault systems, regardless of their orientations, is facilitated with stereopsis so that sequences of deformation of the geologic units can be determined and structural analyses vastly improved. Shapes of landforms are readily perceived so that they can be properly interpreted. The end result of the mapping, analyses, and interpretations is a geologic history of Venus that includes the sequences of formation and deformation of various geologic units. Measurements of relief at the finest scale possible are necessary for numerous topical studies. Standard altimetry will provide the necessary information on the relief of most large landforms, but it tends to underestimate the relief of small landforms and distorts their shapes. Although special processing of the altimeter echoes improves the estimates of the relief and shapes of some landforms, there are uncertainties in the interpretations of the echoes. Examples of topical studies requiring measurements of relief are given.

Moore, H. J.↗

NASA NTRS1993

Spacecraft computer technology at Southwest Research Institute

Southwest Research Institute (SwRI) has developed and delivered spacecraft computers for a number of different near-Earth-orbit spacecraft including shuttle experiments and SDIO free-flyer experiments. We describe the evolution of the basic SwRI spacecraft computer design from those weighing in at 20 to 25 lb and using 20 to 30 W to newer models weighing less than 5 lb and using only about 5 W, yet delivering twice the processing throughput. Because of their reduced size, weight, and power, these newer designs are especially applicable to planetary instrument requirements. The basis of our design evolution has been the availability of more powerful processor chip sets and the development of higher density packaging technology, coupled with more aggressive design strategies in incorporating high-density FPGA technology and use of high-density memory chips. In addition to reductions in size, weight, and power, the newer designs also address the necessity of survival in the harsh radiation environment of space. Spurred by participation in such programs as MSTI, LACE, RME, Delta 181, Delta Star, and RADARSAT, our designs have evolved in response to program demands to be small, low-powered units, radiation tolerant enough to be suitable for both Earth-orbit microsats and for planetary instruments. Present designs already include MIL-STD-1750 and Multi-Chip Module (MCM) technology with near-term plans to include RISC processors and higher-density MCM's. Long term plans include development of whole-core processors on one or two MCM's.

Shirley, D. J.↗

NASA NTRS1991

Frequency analysis via the method of moment functionals

Pearson, A. E.↗