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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 685 records · Page 38
All sourcesNASA NTRSDOE OSTI
NASA NTRS2001

Muscle sympathetic nerve responses to physiological changes in prostaglandin production in humans

Previous studies suggest that prostaglandins may contribute to exercise-induced increases in muscle sympathetic nerve activity (MSNA). To test this hypothesis, MSNA was measured at rest and during exercise before and after oral administration of ketoprofen, a cyclooxygenase inhibitor, or placebo. Twenty-one subjects completed two bouts of graded dynamic and isometric handgrip to fatigue. Each exercise bout was followed by 2 min of postexercise muscle ischemia. The second exercise bouts were performed after 60 min of rest in which 11 subjects were given ketoprofen (300 mg) and 10 subjects received a placebo. Ketoprofen significantly lowered plasma thromboxane B(2) in the drug group (from 36 +/- 6 to 22 +/- 3 pg/ml, P < 0.04), whereas thromboxane B(2) in the placebo group increased from 40 +/- 5 to 61 +/- 9 pg/ml from trial 1 to trial 2 (P < 0.008). Ketoprofen and placebo did not change sympathetic and cardiovascular responses to dynamic handgrip, isometric handgrip, and postexercise muscle ischemia. There was no relationship between thromboxane B(2) concentrations and MSNA or arterial pressure responses during both exercise modes. The data indicate that physiological increases or decreases in prostaglandins do not alter exercise-induced increases in MSNA and arterial pressure in humans. These findings suggest that contraction-induced metabolites other than prostaglandins mediate MSNA responses to exercise in humans.

Clinical Trial↗
NASA NTRS2019

Cardiopulmonary Inflammatory Response to Meteorite Dust Exposures - Implications for Human Health on Earth and Beyond

This year marks the 50th anniversary of Apollo 11, the first time humans set foot on the Moon. The Apollo missions not only help answer questions related to our solar system, they also highlight many hazards associated with human space travel. One major concern is the effect of extraterrestrial dust on astronaut health. In an effort to expand upon previous work indicating lunar dust is respirable and reactive, the authors initiated an extensive study evaluating the role of a particulate’s innate geochemical features (e.g., bulk chemistry, internal composition, morphology, size, and reactivity) in generating adverse toxicological responses in vitro and in vivo. To allow for a broader planetary and geochemical assessment, seven samples were evaluated: six meteorites from either the Moon, Mars, or Asteroid 4 Vesta and a terrestrial basalt analogue. Even with the relatively small geochemical differences (all samples basaltic in nature), significant difference in cardiopulmonary inflammatory markers developed in both single exposure and multiple exposure studies. More specifically: 1) the single exposure studies reveal relationships between toxicity and a meteorite sample’s origin, its pre-ejected state (weathered versus un-weathered), and geochemical features (e.g. bulk iron content) and 2) multiple exposure studies reveal a correlation with particle derived reactive oxygen species (ROS) formation and neutrophil infiltration. Extended human exploration will further increase the probability of inadvertent and repeated exposures to extraterrestrial dusts. This comprehensive dataset allows for not only the toxicological evaluation of extraterrestrial materials but also clarifies important correlations between geochemistry and health. The utilization of an array of extraterrestrial samples from Moon, Mars, and asteroid 4Vesta will enable the development of a geochemical based toxicological hazard model that can be used for: 1) mission planning, 2) rapid risk assessment in cases of unexpected exposures, and 3) evaluation of the efficacy of various in situ techniques in gauging surface dust toxicity. Furthermore, by better understanding the importance of geochemical features on exposure related health outcomes in space, it is possible to better understand of the deleterious nature of dust exposure on Earth.

Harrington, A. D.↗
NASA NTRS1979

Optimal estimator model for human spatial orientation

A model is being developed to predict pilot dynamic spatial orientation in response to multisensory stimuli. Motion stimuli are first processed by dynamic models of the visual, vestibular, tactile, and proprioceptive sensors. Central nervous system function is then modeled as a steady-state Kalman filter which blends information from the various sensors to form an estimate of spatial orientation. Where necessary, this linear central estimator has been augmented with nonlinear elements to reflect more accurately some highly nonlinear human response characteristics. Computer implementation of the model has shown agreement with several important qualitative characteristics of human spatial orientation, and it is felt that with further modification and additional experimental data the model can be improved and extended. Possible means are described for extending the model to better represent the active pilot with varying skill and work load levels.

Borah, J.↗
NASA NTRS1986

Adaptive filtering of biodynamic stick feedthrough in manipulation tasks on board moving platforms

A novel approach to suppress the effects of biodynamic interference is presented. An adaptive noise canceling technique is employed for substracting the platform motion correlated components from the control stick output. The effects of biodynamic interference and its suppression by adaptive noise cancellation has been evaluated in a series of tracking tasks performed in a moving base simulator. Simulator motions were in pitch, roll and combined pitch and roll. Human operator performance was assessed from the mean square values of the tracking error and the control activity. The tracking error and the total stick output signal were found to increase significantly with motion and to diminish substantially with adaptive noise cancellation, thus providing a considerable improvement in tracking performance under conditions in which platform motion were present. The adaptive filter was found to cause a significant increase in the cross-over frequency and decrease in the phase margin. Moreover, the adaptive filter was found to significantly improve the human operator visual motor response. This improvement is manifested as an increased human operator gain, a smaller time delay and lower pilot workload.

Velger, M.↗
NASA NTRS1978

Human operator identification model and related computer programs

Four computer programs which provide computational assistance in the analysis of man/machine systems are reported. The programs are: (1) Modified Transfer Function Program (TF); (2) Time Varying Response Program (TVSR); (3) Optimal Simulation Program (TVOPT); and (4) Linear Identification Program (SCIDNT). The TV program converts the time domain state variable system representative to frequency domain transfer function system representation. The TVSR program computes time histories of the input/output responses of the human operator model. The TVOPT program is an optimal simulation program and is similar to TVSR in that it produces time histories of system states associated with an operator in the loop system. The differences between the two programs are presented. The SCIDNT program is an open loop identification code which operates on the simulated data from TVOPT (or TVSR) or real operator data from motion simulators.

Kessler, K. M.↗
DOE OSTI2022

Investigating uncertainties in human adaptation and their impacts on water scarcity in the Colorado river Basin, United States

The Colorado River Basin (CRB) supports the water supply for seven states and forty million people in the Western United States (US) and has been suffering an extensive drought for more than two decades. As climate change continues to reshape water resources distribution in the CRB, its impact can differ in intensity and location, resulting in variations in human adaptation behaviors. The feedback from human systems in response to the environmental changes and the associated uncertainty is critical to water resources management, especially for water-stressed basins. This paper investigates how human adaptation affects water scarcity uncertainty in the CRB and highlights the uncertainties in human behavior modeling. Our focus is on agricultural water consumption, as approximately 80% of the water consumption in the CRB is used in agriculture. We adopted a coupled agent-based and water resources modeling approach for exploring human-water system dynamics, in which an agent is a human behavior model that simulates a farmer’s water consumption decisions. We examined uncertainties at the system, agent, and parameter levels through uncertainty, clustering, and sensitivity analyses. The uncertainty analysis results suggest that the CRB water system may experience 13 to 30 years of water shortage during the 2019–2060 simulation period, depending on the paths of farmers’ adaptation. The clustering analysis identified three decision-making classes: bold, prudent, and forward-looking, and quantified the probabilities of an agent belonging to each class. The sensitivity analysis results indicated agents whose decision-making models require further investigation and the parameters with the higher uncertainty reduction potentials. Here, by conducting numerical experiments with the coupled model, this paper presents quantitative and qualitative information about farmers’ adaptation, water scarcity uncertainties, and future research directions for improving human behavior modeling.

Agent-based modeling↗
DOE OSTI2020

Literature Review of Documented Persistent Secondary Uranium Sources at DOE LM Sites

The U.S. Department of Energy Office of Legacy Management (LM) has the responsibility to protect human health and the environment at 101 legacy uranium sites across the nation by implementing long-term surveillance and maintenance requirements. Included in these responsibilities is to provide for the safe and environmentally sound disposal, long-term stabilization, and control of uranium mill tailings in a manner that minimizes or eliminates radiation health hazards to the public at 21 Uranium Mill Tailings Radiation Control Act (UMTRCA) Title I sites; 6 UMTRCA Title II sites; and 9 Comprehensive Environmental Response, Compensation, and Liability Act/Resource Conservation and Recovery Act sites. These sites are former uranium mills (processing sites), or sites with wastes from processing sites encapsulated in engineered disposal cells (disposal sites), or sites where components of atomic weapons were manufactured. During site characterization, groundwater contamination was often discovered and evaluated or modeled for future movement with the inclusion of uranium sorption in the groundwater plume. Much of this original work did identify uranium processing wastes as the original contaminant source. However, more recent work has identified the existence and influence of persistent secondary uranium sources that may prevent uranium in groundwater from attenuating as quickly as initial evaluations or modeling indicated. By understanding these processes, better decisions can be made to choose the appropriate remediation and closure strategies, identify long-term surveillance and maintenance activities, and more accurately estimate life-cycle costs. The purpose of this report is to summarize the literature available on documented persistence secondary uranium sources at LM sites as part of the Applied Studies and Technology Persistent Secondary Contaminant Sources Project.

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗
NASA NTRS2019

Human Performance Contributions to Safety in Commercial Aviation

In the commercial aviation domain, large volumes of data are collected and analyzed on the failures and errors that result in infrequent incidents and accidents, but in the absence of data on behaviors that contribute to routine successful outcomes, safety management and system design decisions are based on a small sample of non- representative safety data. Analysis of aviation accident data suggests that human error is implicated in up to 80% of accidents, which has been used to justify future visions for aviation in which the roles of human operators are greatly diminished or eliminated in the interest of creating a safer aviation system. However, failure to fully consider the human contributions to successful system performance in civil aviation represents a significant and largely unrecognized risk when making policy decisions about human roles and responsibilities. Opportunities exist to leverage the vast amount of data that has already been collected, or could be easily obtained, to increase our understanding of human contributions to “things going right” in commercial aviation. The principal focus of this assessment was to identify current gaps and explore methods for identifying human “success” data generated by the aviation system, from personnel and within the supporting infrastructure.

Holbrook, Jon B.↗
NASA NTRS2018

Playbook for UAS: UX of Goal-Oriented Planning & Execution

We are evaluating the tool Playbook, a mission planning and scheduling tool used for analog missions and research experiments at NASA. We are adapting Playbook to support an unmanned aerial vehicle (UAV) demonstration that will simulate a "search and recover" mission. To support this demonstration, we need to test this software and its usability with human subjects. Playbook will be used to plan, edit, and monitor simulated UAV swarms, and we are interested in evaluating these capabilities. Allocation of roles and responsibilities between human-automation systems is key to promoting productive cooperation between these two agents. When guiding swarms the user should not be concerned with moving waypoints, adjusting heading and altitude or any other small actions that traditional pilots control. Providing situational awareness through sensor data including radar, heat, live camera feed, and topographic information are key when managing multiple UAVs together. First responders need a good picture of disaster areas in order to make informed decisions. These sensors can initiate movements in the mission that indicate when the human should take control of single aircraft.

UAV swarms↗
NASA NTRS1975

Effects of three activities on annoyance responses to recorded flyovers

Human subjects participated in an experiment in which they were engaged in TV viewing, telephone listening, or reverie (no activity) for a 1/2-hour session. During the session, they were exposed to a series of recorded aircraft sounds at the rate of one flight every 2 minutes. At each session, four levels of flyover noise, separated by 5 db increments were presented several times in a Latin Square balanced sequence. The peak levels of the noisiest flyover in any session was fixed at 95, 90, 85, 75, or 70 db. At the end of the test session, subjects recorded their responses to the aircraft sounds, using a bipolar scale which covered the range from very pleasant to extremely annoying. Responses to aircraft noises are found to be significantly affected by the particular activity in which the subjects are engaged.

Gunn, W. J.↗
NASA NTRS2016

Human-Robot Interaction in High Vulnerability Domains

Future NASA missions will require successful integration of the human with highly complex systems. Highly complex systems are likely to involve humans, automation, and some level of robotic assistance. The complex environments will require successful integration of the human with automation, with robots, and with human-automation-robot teams to accomplish mission critical goals. Many challenges exist for the human performing in these types of operational environments with these kinds of systems. Systems must be designed to optimally integrate various levels of inputs and outputs based on the roles and responsibilities of the human, the automation, and the robots; from direct manual control, shared human-robotic control, or no active human control (i.e. human supervisory control). It is assumed that the human will remain involved at some level. Technologies that vary based on contextual demands and on operator characteristics (workload, situation awareness) will be needed when the human integrates into these systems. Predictive models that estimate the impact of the technologies on the system performance and the on the human operator are also needed to meet the challenges associated with such future complex human-automation-robot systems in extreme environments.

workload↗
NASA NTRSDate not supplied

Achieving Resilient In-Flight Performance for Advanced Air Mobility through Simplified Vehicle Operations

A research and development (R&D) approach is proposed for developing and validating concepts and technologies to achieve vehicle autonomy goals of Advanced Air Mobility (AAM) through Simplified Vehicle Operations (SVO). The approach applies resilience-engineering and human-automation teaming (HAT) principles to a framework for defining vehicle-based functions for the management of missions and flight trajectories, focusing initially on the en route flight domain. To achieve the SVO goal of reducing pilot training requirements and thereby increasing the pilot pool for AAM, while at the same time promoting ever-safer operations, a framework for identifying essential functions is proposed. In this framework, functions are first categorized by high-level functional purpose (mission management, flightpath management, tactical operations, and vehicle control) and then subcategorized by attributes of resilient-performing systems (abilities to monitor, respond, learn, and anticipate). The categorization by functional purpose provides structure within which HAT designs can be holistically explored and total levels of human vs. automation responsibility can be varied. The subcategorization by resilient-system attributes provides a mechanism for capturing safety-critical functions that may not be codified in current operational procedures and training curricula, particularly those where humans proactively enhance safety in currently undocumented ways. An R&D approach consisting of seven strategies is proposed in which automation engineering and human-factors communities can collaborate in the research, development, and design of an SVO roadmap to enable the ambitious objectives of AAM.

AAM↗
DOE OSTI2020

The cytochrome bc 1 complex as an antipathogenic target

The cytochrome bc 1 complex is a key component of the mitochondrial respiratory chains of many eukaryotic microorganisms that are pathogenic for plants or humans, such as fungi responsible for crop diseases and Plasmodium falciparum, which causes human malaria. Cytochrome bc 1 is an enzyme that contains two (ubi)quinone/quinol-binding sites, which can be exploited for the development of fungicidal and chemotherapeutic agents. In this article, we review recent progress in determination of the structure and mechanism of action of cytochrome bc 1 , and the associated development of antimicrobial agents (and associated resistance mechanisms) targeting its activity.

59 BASIC BIOLOGICAL SCIENCES↗
NASA NTRS2002

Cardiovascular and sympathetic neural responses to handgrip and cold pressor stimuli in humans before, during and after spaceflight

Astronauts returning to Earth have reduced orthostatic tolerance and exercise capacity. Alterations in autonomic nervous system and neuromuscular function after spaceflight might contribute to this problem. In this study, we tested the hypothesis that exposure to microgravity impairs autonomic neural control of sympathetic outflow in response to peripheral afferent stimulation produced by handgrip and a cold pressor test in humans. We studied five astronauts approximately 72 and 23 days before, and on landing day after the 16 day Neurolab (STS-90) space shuttle mission, and four of the astronauts during flight (day 12 or 13). Heart rate, arterial pressure and peroneal muscle sympathetic nerve activity (MSNA) were recorded before and during static handgrip sustained to fatigue at 40 % of maximum voluntary contraction, followed by 2 min of circulatory arrest pre-, in- and post-flight. The cold pressor test was applied only before (five astronauts) and during flight (day 12 or 13, four astronauts). Mean (+/- S.E.M.) baseline heart rates and arterial pressures were similar among pre-, in- and post-flight measurements. At the same relative fatiguing force, the peak systolic pressure and mean arterial pressure during static handgrip were not different before, during and after spaceflight. The peak diastolic pressure tended to be higher post- than pre-flight (112 +/- 6 vs. 99 +/- 5 mmHg, P = 0.088). Contraction-induced rises in heart rate were similar pre-, in- and post-flight. MSNA was higher post-flight in all subjects before static handgrip (26 +/- 4 post- vs. 15 +/- 4 bursts min(-1) pre-flight, P = 0.017). Contraction-evoked peak MSNA responses were not different before, during, and after spaceflight (41 +/- 4, 38 +/- 5 and 46 +/- 6 bursts min(-1), all P > 0.05). MSNA during post-handgrip circulatory arrest was higher post- than pre- or in-flight (41 +/- 1 vs. 33 +/- 3 and 30 +/- 5 bursts min(-1), P = 0.038 and 0.036). Similarly, responses of MSNA and blood pressure to the cold pressor test were well maintained in-flight. We conclude that modulation of muscle sympathetic neural outflow by muscle metaboreceptors and skin nociceptors is preserved during short duration spaceflight.

NASA Discipline Neuroscience↗
NASA NTRS1991

Man in space - The use of animal models

The use of animal surrogates as experimental subjects in order to provide essential missing information on the effects of long-term spaceflights, to validate countermeasures, and to test medical treatment techniques is discussed. Research needs also include the definition of biomedical adaptations to flight, and the developments of standards for safe space missions to assure human health and productivity during and following flight. NASA research plans in this area are outlined. Over the next 40 years, NASA plans to concentrate on the use of rodents and nonhuman primates as the models of choice for various physiological responses observed in humans during extended stays in space. This research will include flights on the Space Shuttle, unmanned biosatellites, and the Space Station Freedom.

Ballard, Rodney W.↗
DOE OSTI2023

Activation of human STING by a molecular glue-like compound

Stimulator of interferon genes (STING) is a dimeric transmembrane adapter protein that plays a key role in the human innate immune response to infection and has been therapeutically exploited for its antitumor activity. The activation of STING requires its high-order oligomerization, which could be induced by binding of the endogenous ligand, cGAMP, to the cytosolic ligand-binding domain. Here we report the discovery through functional screens of a class of compounds, named NVS-STGs, that activate human STING. Our cryo-EM structures show that NVS-STG2 induces the high-order oligomerization of human STING by binding to a pocket between the transmembrane domains of the neighboring STING dimers, effectively acting as a molecular glue. Our functional assays showed that NVS-STG2 could elicit potent STING-mediated immune responses in cells and antitumor activities in animal models.

60 APPLIED LIFE SCIENCES↗