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At least 685 records · Page 38

Base excision repair and double strand break repair cooperate to modulate the formation of unrepaired double strand breaks in mouse brain

Abstract We lack the fundamental information needed to understand how DNA damage in the brain is generated and how it is controlled over a lifetime in the absence of replication check points. To address these questions, here, we integrate cell-type and region-specific features of DNA repair activity in the normal brain. The brain has the same repair proteins as other tissues, but normal, canonical repair activity is unequal and is characterized by high base excision repair (BER) and low double strand break repair (DSBR). The natural imbalance creates conditions where single strand breaks (SSBs) can convert to double strand breaks (DSBs) and reversibly switch between states in response to oxidation both in vivo and in vitro. Our data suggest that, in a normal background of repair, SSBs and DSBs are in an equilibrium which is pushed or pulled by metabolic state. Interconversion of SSB to DSBs provides a physiological check point, which would allow the formation of unrepaired DSBs for productive functions, but would also restrict them from exceeding tolerable limits.

Science & Technology - Other Topics↗

Nuclear imaging of the fuel assembly in ignition experiments

First results from the analysis of neutron image data collected on implosions of cryogenically layered deuterium-tritium capsules during the 2011-2012 National Ignition Campaign are reported. The data span a variety of experimental designs aimed at increasing the stagnation pressure of the central hotspot and areal density of the surrounding fuel assembly. Images of neutrons produced by deuterium–tritium fusion reactions in the hotspot are presented, as well as images of neutrons that scatter in the surrounding dense fuel assembly. The image data are compared with 1D and 2D model predictions, and consistency checked using other diagnostic data. The results indicate that the size of the fusing hotspot is consistent with the model predictions, as well as other imaging data, while the overall size of the fuel assembly, inferred from the scattered neutron images, is systematically smaller than models' prediction. Preliminary studies indicate these differences are consistent with a significant fraction (20%–25%) of the initial deuterium-tritium fuel mass outside the compact fuel assembly, due either to low mode mass asymmetry or high mode 3D mix effects at the ablator-ice interface.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Triple point temperature of neon isotopes: Dependence on nitrogen impurity and sealed-cell model

This paper illustrates a study conducted at INRIM, to further check how some quantities influence the value of the triple point temperature of the neon high-purity isotopes {sup 20}Ne and {sup 22}Ne. The influence of nitrogen as a chemical impurity in neon is critical with regard to the present best total uncertainty achieved in the measurement of these triple points, but only one determination is available in the literature. Checks are reported, performed on two different samples of {sup 22}Ne known to contain a N{sub 2} amount of 157⋅10{sup −6}, using two different models of sealed cells. The model of the cell can, in principle, have some effects on the shape of the melting plateau or on the triple point temperature observed for the sample sealed in it. This can be due to cell thermal parameters, or because the INRIM cell element mod. c contains many copper wires closely packed, which can, in principle, constrain the interface and induce a premelting-like effect. The reported results on a cell mod. Bter show no evident effect from the cell model and provide a value for the effect of N{sub 2} in Ne liquidus point of 8.6(1.9) μK ppm N{sub 2}{sup −1}, only slightly different from the literature datum.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗

Design study of the geometry of the blanking tool to predict the burr formation of Zircaloy-4 sheet

In this work, we investigated factors that influence burr formation for zircaloy-4 sheet used for spacer grids of nuclear fuel roads. Factors we considered are geometric factors of punch. We changed clearance and velocity in order to consider the failure parameters, and we changed shearing angle and corner radius of L-shaped punch in order to consider geometric factors of punch. First, we carried out blanking test with failure parameter of GTN model using L-shaped punch. The tendency of failure parameters and geometric factors that affect burr formation by analyzing sheared edges is investigated. Consequently, geometric factor's influencing on the burr formation is also high as failure parameters. Then, the sheared edges and burr formation with failure parameters and geometric factors is investigated using FE analysis model. As a result of analyzing sheared edges with the variables, we checked geometric factors more affect burr formation than failure parameters. To check the reliability of the FE model, the blanking force and the sheared edges obtained from experiments are compared with the computations considering heat transfer.

97 MATHEMATICS AND COMPUTING↗

Quantum breathers in Heisenberg ferromagnetic chains with Dzyaloshinsky-Moriya interaction

We present an analytical study on quantum breathers in one-dimensional ferromagnetic XXZ chains with Dzyaloshinsky-Moriya interaction by means of the time-dependent Hartree approximation and the semidiscrete multiple-scale method. The stationary localized single-boson wave functions are obtained and these analytical solutions are checked by numerical simulations. With such stationary localized single-boson wave functions, we construct quantum breather states. Furthermore, the role of the Dzyaloshinsky-Moriya interaction is discussed.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

The role of Nb in intensity increase of Er ion upconversion luminescence in zirconia

It is found that Nb co-doping increases the luminescence and upconversion luminescence intensity in rare earth doped zirconia. Er and Yb-doped nanocrystalline samples with or without Nb co-doping were prepared by sol-gel method and thermally annealed to check for the impact of phase transition on luminescence properties. Phase composition and grain sizes were examined by X-ray diffraction; the morphology was checked by scanning- and high-resolution transmission electron microscopes. Both steady-state and time-resolved luminescence were studied. Comparison of samples with different oxygen vacancy concentrations and different Nb concentrations confirmed the known assumption that oxygen vacancies are the main agents for tetragonal or cubic phase stabilization. The oxygen vacancies quench the upconversion luminescence; however, they also prevent agglomeration of rare-earth ions and/or displacement of rare-earth ions to grain surfaces. It is found that co-doping with Nb ions significantly (>20 times) increases upconversion luminescence intensity. Hence, ZrO{sub 2}:Er:Yb:Nb nanocrystals may show promise for upconversion applications.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗

Mapping the genome of meta-generalized gradient approximation density functionals: The search for B97M-V

A meta-generalized gradient approximation density functional paired with the VV10 nonlocal correlation functional is presented. The functional form is selected from more than 10{sup 10} choices carved out of a functional space of almost 10{sup 40} possibilities. Raw data come from training a vast number of candidate functional forms on a comprehensive training set of 1095 data points and testing the resulting fits on a comprehensive primary test set of 1153 data points. Functional forms are ranked based on their ability to reproduce the data in both the training and primary test sets with minimum empiricism, and filtered based on a set of physical constraints and an often-overlooked condition of satisfactory numerical precision with medium-sized integration grids. The resulting optimal functional form has 4 linear exchange parameters, 4 linear same-spin correlation parameters, and 4 linear opposite-spin correlation parameters, for a total of 12 fitted parameters. The final density functional, B97M-V, is further assessed on a secondary test set of 212 data points, applied to several large systems including the coronene dimer and water clusters, tested for the accurate prediction of intramolecular and intermolecular geometries, verified to have a readily attainable basis set limit, and checked for grid sensitivity. Compared to existing density functionals, B97M-V is remarkably accurate for non-bonded interactions and very satisfactory for thermochemical quantities such as atomization energies, but inherits the demonstrable limitations of existing local density functionals for barrier heights.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

A method for in situ absolute DD yield calibration of neutron time-of-flight detectors on OMEGA using CR-39-based proton detectors

Neutron time of flight (nTOF) detectors are used routinely to measure the absolute DD neutron yield at OMEGA. To check the DD yield calibration of these detectors, originally calibrated using indium activation systems, which in turn were cross-calibrated to NOVA nTOF detectors in the early 1990s, a direct in situ calibration method using CR-39 range filter proton detectors has been successfully developed. By measuring DD neutron and proton yields from a series of exploding pusher implosions at OMEGA, a yield calibration coefficient of 1.09 ± 0.02 (relative to the previous coefficient) was determined for the 3m nTOF detector. In addition, comparison of these and other shots indicates that significant reduction in charged particle flux anisotropies is achieved when bang time occurs significantly (on the order of 500 ps) after the trailing edge of the laser pulse. This is an important observation as the main source of the yield calibration error is due to particle anisotropies caused by field effects. The results indicate that the CR-39-nTOF in situ calibration method can serve as a valuable technique for calibrating and reducing the uncertainty in the DD absolute yield calibration of nTOF detector systems on OMEGA, the National Ignition Facility, and laser megajoule.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Homogeneity and structure of CuZrAlY metallic glass ribbons

Metallic glasses are metastable amorphous structures produced by quenching-rapid cooling technique. Due to very high cooling rates during the production process, it is very difficult to produce homogeneous samples with identical chemical composition. In this paper we will present preliminary results of homogeneity and structure examinations of a CuZrAlY metallic glass ribbon. The ribbon, approximately 1.5 m long and 1 mm wide, was produced using melt spinning technique. Samples from the middle and the end of the ribbon were chosen for further examination. Surface was checked by metallographic and electron scanning microscopy. Chemical composition in different areas of each sample was checked by energy-dispersive X-ray spectroscopy. Electrical resistivity measurements in the temperature range from 80 K to 280 K were also conducted.

36 MATERIALS SCIENCE↗

Bayesian tomography and integrated data analysis in fusion diagnostics

In this article, a Bayesian tomography method using non-stationary Gaussian process for a prior has been introduced. The Bayesian formalism allows quantities which bear uncertainty to be expressed in the probabilistic form so that the uncertainty of a final solution can be fully resolved from the confidence interval of a posterior probability. Moreover, a consistency check of that solution can be performed by checking whether the misfits between predicted and measured data are reasonably within an assumed data error. In particular, the accuracy of reconstructions is significantly improved by using the non-stationary Gaussian process that can adapt to the varying smoothness of emission distribution. The implementation of this method to a soft X-ray diagnostics on HL-2A has been used to explore relevant physics in equilibrium and MHD instability modes. This project is carried out within a large size inference framework, aiming at an integrated analysis of heterogeneous diagnostics.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

What happens to full-f gyrokinetic transport and turbulence in a toroidal wedge simulation?

Here, in order to save the computing time or to fit the simulation size into a limited computing hardware in a gyrokinetic turbulence simulation of a tokamak plasma, a toroidal wedge simulation may be utilized in which only a partial toroidal section is modeled with a periodic boundary condition in the toroidal direction. The most severe restriction in the wedge simulation is expected to be in the longest wavelength turbulence, i.e., ion temperature gradient (ITG) driven turbulence. The global full-f gyrokinetic code XGC1 is used to compare the transport and turbulence properties from a toroidal wedge simulation against the full torus simulation in an ITG unstable plasma in a model toroidal geometry. It is found that (1) the convergence study in the wedge number needs to be conducted all the way down to the full torus in order to avoid a false convergence, (2) a reasonably accurate simulation can be performed if the correct wedge number N can be identified, (3) the validity of a wedge simulation may be checked by performing a wave-number spectral analysis of the turbulence amplitude |δΦ| and assuring that the variation of δΦ between the discrete kθ values is less than 25% compared to the peak |δΦ|, and (4) a frequency spectrum may not be used for the validity check of a wedge simulation.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

DETERMINATION OF THE POINT-SPREAD FUNCTION FOR THE FERMI LARGE AREA TELESCOPE FROM ON-ORBIT DATA AND LIMITS ON PAIR HALOS OF ACTIVE GALACTIC NUCLEI

The Large Area Telescope (LAT) on the Fermi Gamma-ray Space Telescope is a pair-conversion telescope designed to detect photons with energies from Almost-Equal-To 20 MeV to >300 GeV. The pre-launch response functions of the LAT were determined through extensive Monte Carlo simulations and beam tests. The point-spread function (PSF) characterizing the angular distribution of reconstructed photons as a function of energy and geometry in the detector is determined here from two years of on-orbit data by examining the distributions of {gamma} rays from pulsars and active galactic nuclei (AGNs). Above 3 GeV, the PSF is found to be broader than the pre-launch PSF. We checked for dependence of the PSF on the class of {gamma}-ray source and observation epoch and found none. We also investigated several possible spatial models for pair-halo emission around BL Lac AGNs. We found no evidence for a component with spatial extension larger than the PSF and set upper limits on the amplitude of halo emission in stacked images of low- and high-redshift BL Lac AGNs and the TeV blazars 1ES0229+200 and 1ES0347-121.

79 ASTRONOMY AND ASTROPHYSICS↗

TWO ACCURATE TIME-DELAY DISTANCES FROM STRONG LENSING: IMPLICATIONS FOR COSMOLOGY

Strong gravitational lenses with measured time delays between the multiple images and models of the lens mass distribution allow a one-step determination of the time-delay distance, and thus a measure of cosmological parameters. We present a blind analysis of the gravitational lens RXJ1131-1231 incorporating (1) the newly measured time delays from COSMOGRAIL, the COSmological MOnitoring of GRAvItational Lenses, (2) archival Hubble Space Telescope imaging of the lens system, (3) a new velocity-dispersion measurement of the lens galaxy of 323 {+-} 20 km s{sup -1} based on Keck spectroscopy, and (4) a characterization of the line-of-sight structures via observations of the lens' environment and ray tracing through the Millennium Simulation. Our blind analysis is designed to prevent experimenter bias. The joint analysis of the data sets allows a time-delay distance measurement to 6% precision that takes into account all known systematic uncertainties. In combination with the Wilkinson Microwave Anisotropy Probe seven-year (WMAP7) data set in flat wCDM cosmology, our unblinded cosmological constraints for RXJ1131-1231 are H{sub 0}=80.0{sup +5.8}{sub -5.7} km s{sup -1} Mpc{sup -1}, {Omega}{sub de} = 0.79 {+-} 0.03, and w=-1.25{sup +0.17}{sub -0.21}. We find the results to be statistically consistent with those from the analysis of the gravitational lens B1608+656, permitting us to combine the inferences from these two lenses. The joint constraints from the two lenses and WMAP7 are H{sub 0}=75.2{sup +4.4}{sub -4.2} km s{sup -1} Mpc{sup -1}, {Omega}{sub de}=0.76{sup +0.02}{sub -0.03}, and w = -1.14{sup +0.17}{sub -0.20} in flat wCDM, and H{sub 0}=73.1{sup +2.4}{sub -3.6} km s{sup -1} Mpc{sup -1}, {Omega}{sub {Lambda}}=0.75{sup +0.01}{sub -0.02}, and {Omega}{sub k}=0.003{sup +0.005}{sub -0.006} in open {Lambda}CDM. Time-delay lenses constrain especially tightly the Hubble constant H{sub 0} (5.7% and 4.0% respectively in wCDM and open {Lambda}CDM) and curvature of the universe. The overall information content is similar to that of Baryon Acoustic Oscillation experiments. Thus, they complement well other cosmological probes, and provide an independent check of unknown systematics. Our measurement of the Hubble constant is completely independent of those based on the local distance ladder method, providing an important consistency check of the standard cosmological model and of general relativity.

79 ASTRONOMY AND ASTROPHYSICS↗

EXOPLANET CHARACTERIZATION BY PROXY: A TRANSITING 2.15 R{sub Circled-Plus} PLANET NEAR THE HABITABLE ZONE OF THE LATE K DWARF KEPLER-61

We present the validation and characterization of Kepler-61b: a 2.15 R{sub Circled-Plus} planet orbiting near the inner edge of the habitable zone of a low-mass star. Our characterization of the host star Kepler-61 is based upon a comparison with a set of spectroscopically similar stars with directly measured radii and temperatures. We apply a stellar prior drawn from the weighted mean of these properties, in tandem with the Kepler photometry, to infer a planetary radius for Kepler-61b of 2.15 {+-} 0.13 R{sub Circled-Plus} and an equilibrium temperature of 273 {+-} 13 K (given its period of 59.87756 {+-} 0.00020 days and assuming a planetary albedo of 0.3). The technique of leveraging the physical properties of nearby ''proxy'' stars allows for an independent check on stellar characterization via the traditional measurements with stellar spectra and evolutionary models. In this case, such a check had implications for the putative habitability of Kepler-61b: the planet is 10% warmer and larger than inferred from K-band spectral characterization. From the Kepler photometry, we estimate a stellar rotation period of 36 days, which implies a stellar age of >1 Gyr. We summarize the evidence for the planetary nature of the Kepler-61 transit signal, which we conclude is 30,000 times more likely to be due to a planet than a blend scenario. Finally, we discuss possible compositions for Kepler-61b with a comparison to theoretical models as well as to known exoplanets with similar radii and dynamically measured masses.

79 ASTRONOMY AND ASTROPHYSICS↗

Constraints on cosmology from the cosmic microwave background power spectrum of the 2500 deg{sup 2} SPT-SZ survey

We explore extensions to the ΛCDM cosmology using measurements of the cosmic microwave background (CMB) from the recent SPT-SZ survey, along with data from WMAP7 and measurements of H {sub 0} and baryon acoustic oscillation (BAO). We check for consistency within ΛCDM between these data sets, and find some tension. The CMB alone gives weak support to physics beyond ΛCDM, due to a slight trend relative to ΛCDM of decreasing power toward smaller angular scales. While it may be due to statistical fluctuation, this trend could also be explained by several extensions. We consider running of the primordial spectral index (dn{sub s} /dln k), as well as two extensions that modify the damping tail power (the primordial helium abundance Y{sub p} and the effective number of neutrino species N {sub eff}) and one that modifies the large-scale power due to the integrated Sachs-Wolfe effect (the sum of neutrino masses ∑m {sub ν}). These extensions have similar observational consequences and are partially degenerate when considered simultaneously. Of the six one-parameter extensions considered, we find CMB to have the largest preference for dn{sub s} /dln k with –0.046 < dn{sub s} /dln k < –0.003 at 95% confidence, which strengthens to a 2.7σ indication of dn{sub s} /dln k < 0 from CMB+BAO+H {sub 0}. Detectable dn{sub s} /dln k ≠ 0 is difficult to explain in the context of single-field, slow-roll inflation models. We find N {sub eff} = 3.62 ± 0.48 for the CMB, which tightens to N {sub eff} = 3.71 ± 0.35 from CMB+BAO+H {sub 0}. Larger values of N {sub eff} relieve the mild tension between CMB, BAO, and H {sub 0}. When the Sunyaev-Zel'dovich selected galaxy cluster abundances (SPT{sub CL}) data are also included, we obtain N {sub eff} = 3.29 ± 0.31. Allowing for ∑m {sub ν} gives a 3.0σ detection of ∑m {sub ν} > 0 from CMB+BAO+H {sub 0} +SPT{sub CL}. The median value is (0.32 ± 0.11) eV, a factor of six above the lower bound set by neutrino oscillation observations. All data sets except H {sub 0} show some preference for massive neutrinos; data combinations including H {sub 0} favor nonzero masses only if BAO data are also included. We also constrain the two-parameter extensions N {sub eff} + ∑m {sub ν} and N {sub eff} + Y{sub p} to explore constraints on additional light species and big bang nucleosynthesis, respectively.

79 ASTRONOMY AND ASTROPHYSICS↗

Mergers and mass accretion for infalling halos both end well outside cluster virial radii

We find that infalling dark matter halos (i.e., the progenitors of satellite halos) begin losing mass well outside the virial radius of their eventual host halos. The peak mass occurs at a range of clustercentric distances, with median and 68th percentile range of 1.8{sub −1.0}{sup +2.3} R{sub vir,host} for progenitors of z = 0 satellites. The peak circular velocity for infalling halos occurs at significantly larger distances (3.7{sub −2.2}{sup +3.3} R{sub vir,host} at z = 0). This difference arises because different physical processes set peak circular velocity (typically, ∼1:5 and larger mergers which cause transient circular velocity spikes) and peak mass (typically, smooth accretion) for infalling halos. We find that infalling halos also stop having significant mergers well before they enter the virial radius of their eventual hosts. Mergers larger than a 1:40 ratio in halo mass end for infalling halos at similar clustercentric distances (∼1.9 R {sub vir,} {sub host}) as the end of overall mass accretion. However, mergers larger than 1:3 typically end for infalling halos at more than four virial radial away from their eventual hosts. This limits the ability of mergers to affect quenching and morphology changes in clusters. We also note that the transient spikes which set peak circular velocity may lead to issues with abundance matching on that parameter, including unphysical galaxy stellar mass growth profiles near clusters; we propose a simple observational test to check if a better halo proxy for galaxy stellar mass exists.

79 ASTRONOMY AND ASTROPHYSICS↗

Lower limits on the anisotropy of the extragalactic gamma-ray background implied by the 2FGL and 1FHL catalogs

In principle, the angular anisotropy in the extragalactic gamma-ray background (EGRB) places severe constraints upon putative populations of unresolved gamma-ray point sources. Existing estimates of the EGRB anisotropy have been constructed by excising known point sources, e.g., taken from the First or Two Year Fermi-LAT Source Catalog (1FGL or 2FGL, respectively) and statistically analyzing the residual gamma-ray sky maps. We perform an independent check of the EGRB anisotropy limits by comparing the values obtained from the 1FGL-masked sky maps to the signal implied by sources that lie below the 1FGL detection threshold in the more sensitive 2FGL and 1FHL (First Fermi-LAT catalog of >10 GeV sources). As such, our analysis provides an internal consistency check of implications for source counts and spectral index distributions of gamma-ray bright active galactic nuclei obtained from Fermi-LAT data. Based on this, we find evidence for substantially larger anisotropies than those previously reported at energies above 5 GeV, where BL Lac objects are likely to provide the bulk of their contribution to the EGRB. This uncertainty in the EGRB anisotropy cautions against using it as an independent constraint for the high-redshift gamma-ray universe. Moreover, this would suggest that contrary to previous claims, smooth extensions of the resolved point-source population may be able to simultaneously explain both the isotropic and anisotropic components of the EGRB.

79 ASTRONOMY AND ASTROPHYSICS↗

Chandrasekhar's relation and stellar rotation in the Kepler field

According to the statistical law of large numbers, the expected mean of identically distributed random variables of a sample tends toward the actual mean as the sample increases. Under this law, it is possible to test the Chandrasekhar's relation (CR), (V) = (π/4){sup –1}(Vsin i), using a large amount of Vsin i and V data from different samples of similar stars. In this context, we conducted a statistical test to check the consistency of the CR in the Kepler field. In order to achieve this, we use three large samples of V obtained from Kepler rotation periods and a homogeneous control sample of Vsin i to overcome the scarcity of Vsin i data for stars in the Kepler field. We used the bootstrap-resampling method to estimate the mean rotations ((V) and (Vsin i)) and their corresponding confidence intervals for the stars segregated by effective temperature. Then, we compared the estimated means to check the consistency of CR, and analyzed the influence of the uncertainties in radii measurements, and possible selection effects. We found that the CR with (sin i) = π/4 is consistent with the behavior of the (V) as a function of (Vsin i) for stars from the Kepler field as there is a very good agreement between such a relation and the data.

79 ASTRONOMY AND ASTROPHYSICS↗