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At least 667 records · Page 37
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NASA NTRS2002

Inhibition of the active lymph pump by flow in rat mesenteric lymphatics and thoracic duct

There are only a few reports of the influence of imposed flow on an active lymph pump under conditions of controlled intraluminal pressure. Thus, the mechanisms are not clearly defined. Rat mesenteric lymphatics and thoracic ducts were isolated, cannulated and pressurized. Input and output pressures were adjusted to impose various flows. Lymphatic systolic and diastolic diameters were measured and used to determine contraction frequency and pump flow indices. Imposed flow inhibited the active lymph pump in both mesenteric lymphatics and in the thoracic duct. The active pump of the thoracic duct appeared more sensitive to flow than did the active pump of the mesenteric lymphatics. Imposed flow reduced the frequency and amplitude of the contractions and accordingly the active pump flow. Flow-induced inhibition of the active lymph pump followed two temporal patterns. The first pattern was a rapidly developing inhibition of contraction frequency. Upon imposition of flow, the contraction frequency immediately fell and then partially recovered over time during continued flow. This effect was dependent on the magnitude of imposed flow, but did not depend on the direction of flow. The effect also depended upon the rate of change in the direction of flow. The second pattern was a slowly developing reduction of the amplitude of the lymphatic contractions, which increased over time during continued flow. The inhibition of contraction amplitude was dependent on the direction of the imposed flow, but independent of the magnitude of flow. Nitric oxide was partly but not completely responsible for the influence of flow on the mesenteric lymph pump. Exposure to NO mimicked the effects of flow, and inhibition of the NO synthase by N (G)-monomethyl-L-arginine attenuated but did not completely abolish the effects of flow.

NASA Discipline Musculoskeletal↗
NASA NTRS2007

Data Fusion for Earth Science Remote Sensing

Beginning in 2004, NASA has supported the development of an international network of ground-based remote sensing installations for the measurement of greenhouse gas columns. This collaboration has been successful and is currently used in both carbon cycle investigations and in the efforts to validate the GOSAT space-based column observations of CO2 and CH4. With the support of a grant, this research group has established a network of ground-based column observations that provide an essential link between the satellite observations of CO2, CO, and CH4 and the extensive global in situ surface network. The Total Carbon Column Observing Network (TCCON) was established in 2004. At the time of this report seven sites, employing modern instrumentation, were operational or were expected to be shortly. TCCON is expected to expand. In addition to providing the most direct means of tying the in situ and remote sensing data sets together, TCCON provides a means of testing the retrieval algorithms of SCIAMACHY and GOSAT over the broadest variation in atmospheric state. TCCON provides a critically maintained and long timescale record for identification of temporal drift and spatial bias in the calibration of the space-based sensors. Finally, the global observations from TCCON are improving our understanding of how to use column observations to provide robust estimates of surface exchange of C02 and CH4 in advance of the launch of OCO and GOSAT. TCCON data are being used to better understand the impact of both regional fluxes and long-range transport on gradients in the C02 column. Such knowledge is essential for identifying the tools required to best use the space-based observations. The technical approach and methodology of retrieving greenhouse gas columns from near-IR solar spectra, data quality and process control are described. Additionally, the impact of and relevance to NASA of TCCON and satellite validation and carbon science are addressed.

data fusion↗
NASA NTRS2004

Pseudo-Random Modulation of a Laser Diode for Generating Ultrasonic Longitudinal Waves

Laser generated ultrasound systems have historically been more complicated and expensive than conventional piezoelectric based systems, and this fact has relegated the acceptance of laser based systems to niche applications for which piezoelectric based systems are less suitable. Lowering system costs, while improving throughput, increasing ultrasound signal levels, and improving signal-to-noise are goals which will help increase the general acceptance of laser based ultrasound. One current limitation with conventional laser generated ultrasound is a material s damage threshold limit. Increasing the optical power to generate more signal eventually damages the material being tested due to rapid, high heating. Generation limitations for laser based ultrasound suggests the use of pulse modulation techniques as an alternate generation method. Pulse modulation techniques can spread the laser energy over time or space, thus reducing laser power densities and minimizing damage. Previous experiments by various organizations using spatial or temporal pulse modulation have been shown to generate detectable surface, plate, and bulk ultrasonic waves with narrow frequency bandwidths . Using narrow frequency bandwidths improved signal detectability, but required the use of expensive and powerful lasers and opto-electronic systems. The use of a laser diode to generate ultrasound is attractive because of its low cost, small size, light weight, simple optics and modulation capability. The use of pulse compression techniques should allow certain types of laser diodes to produce usable ultrasonic signals. The method also does not need to be limited to narrow frequency bandwidths. The method demonstrated here uses a low power laser diode (approximately 150 mW) that is modulated by controlling the diode s drive current and the resulting signal is recovered by cross correlation. A potential application for this system which is briefly demonstrated is in detecting signals in thick composite materials where attenuation is high and signal amplitude and bandwidth are at a premium.

Madaras, Eric I.↗
NASA NTRS2015

ORION Environmental Control and Life Support Systems Suit Loop and Pressure Control Analysis

Under NASA's ORION Multi-Purpose Crew Vehicle (MPCV) Environmental Control and Life Support System (ECLSS) Project at Johnson Space Center's (JSC), the Crew and Thermal Systems Division has developed performance models of the air system using Thermal Desktop/FloCAD. The Thermal Desktop model includes an Air Revitalization System (ARS Loop), a Suit Loop, a Cabin Loop, and Pressure Control System (PCS) for supplying make-up gas (N2 and O2) to the Cabin and Suit Loop. The ARS and PCS are designed to maintain air quality at acceptable O2, CO2 and humidity levels as well as internal pressures in the vehicle Cabin and during suited operations. This effort required development of a suite of Thermal Desktop Orion ECLSS models to address the need for various simulation capabilities regarding ECLSS performance. An initial highly detailed model of the ARS Loop was developed in order to simulate rapid pressure transients (water hammer effects) within the ARS Loop caused by events such as cycling of the Pressurized Swing Adsorption (PSA) Beds and required high temporal resolution (small time steps) in the model during simulation. A second ECLSS model was developed to simulate events which occur over longer periods of time (over 30 minutes) where O2, CO2 and humidity levels, as well as internal pressures needed to be monitored in the cabin and for suited operations. Stand-alone models of the PCS and the Negative Pressure relief Valve (NPRV) were developed to study thermal effects within the PCS during emergency scenarios (Cabin Leak) and cabin pressurization during vehicle re-entry into Earth's atmosphere. Results from the Orion ECLSS models were used during Orion Delta-PDR (July, 2014) to address Key Design Requirements (KDR's) for Suit Loop operations for multiple mission scenarios.

Eckhardt, Brad↗
NASA NTRS2007

Symbolic LTL Compilation for Model Checking: Extended Abstract

In Linear Temporal Logic (LTL) model checking, we check LTL formulas representing desired behaviors against a formal model of the system designed to exhibit these behaviors. To accomplish this task, the LTL formulas must be translated into automata [21]. We focus on LTL compilation by investigating LTL satisfiability checking via a reduction to model checking. Having shown that symbolic LTL compilation algorithms are superior to explicit automata construction algorithms for this task [16], we concentrate here on seeking a better symbolic algorithm.We present experimental data comparing algorithmic variations such as normal forms, encoding methods, and variable ordering and examine their effects on performance metrics including processing time and scalability. Safety critical systems, such as air traffic control, life support systems, hazardous environment controls, and automotive control systems, pervade our daily lives, yet testing and simulation alone cannot adequately verify their reliability [3]. Model checking is a promising approach to formal verification for safety critical systems which involves creating a formal mathematical model of the system and translating desired safety properties into a formal specification for this model. The complement of the specification is then checked against the system model. When the model does not satisfy the specification, model-checking tools accompany this negative answer with a counterexample, which points to an inconsistency between the system and the desired behaviors and aids debugging efforts.

Rozier, Kristin Y.↗
NASA NTRS2002

Identifying head-trunk and lower limb contributions to gaze stabilization during locomotion

The goal of the present study was to determine how the multiple, interdependent full-body sensorimotor subsystems respond to a change in gaze stabilization task constraints during locomotion. Nine subjects performed two gaze stabilization tasks while walking at 6.4 km/hr on a motorized treadmill: 1) focusing on a central point target; 2) reading numeral characters; both presented at 2 m in front at the level of their eyes. While subjects performed the tasks we measured: temporal parameters of gait, full body sagittal plane segmental kinematics of the head, trunk, thigh, tibia and foot, accelerations along the vertical axis at the head and the tibia, and the vertical forces acting on the support surface. We tested the hypothesis that with the increased demands placed on visual acuity during the number recognition task, subjects would modify full-body segmental kinematics in order to reduce perturbations to the head in order to successfully perform the task. We found that while reading numeral characters as compared to the central point target: 1) compensatory head pitch movement was on average 22% greater despite the fact that the trunk pitch and trunk vertical translation movement control were not significantly changed; 2) coordination patterns between head and trunk as reflected by the peak cross correlation between the head pitch and trunk pitch motion as well as the peak cross correlation between the head pitch and vertical trunk translation motion were not significantly changed; 3) knee joint total movement was on average 11% greater during the period from the heel strike event to the peak knee flexion event in stance phase of the gait cycle; 4) peak acceleration measured at the head was significantly reduced by an average of 13% in four of the six subjects. This was so even when the peak acceleration at the tibia and the transmission of the shock wave at heel strike (measured by the peak acceleration ratio of the head/tibia and the time lag between the tibial and head peak accelerations) remained unchanged. Taken together these results provide further evidence that the full body contributes to gaze stabilization during locomotion, and that its different functional elements can be modified online to contribute to gaze stabilization for different visual task constraints.

NASA Center JSC↗
NASA NTRS2010

Improved Hypoxia Modeling for Nutrient Control Decisions in the Gulf of Mexico

As required by the Harmful Algal Bloom and Hypoxia Research Control Act of 1998, the Mississippi River/Gulf of Mexico Watershed Nutrient Task Force issued the 2001 Gulf Hypoxia Action Plan (updated in 2008). In response to the Gulf Hypoxia Action Plan of 2001 (updated in 2008), the EPA Gulf of Mexico Hypoxia Modeling and Monitoring Project has established a detailed model for the Mississippi-Attchafalaya River Basin which provides a capability to forecast the multi-source nutrient loading to the Gulf and the subsequent bio-geochemical processes leading to hypoxic conditions and subsequent effects on Gulf habitats and fisheries. The primary purpose of the EPA model is to characterize the impacts of nutrient management actions, or proposed actions on the spatial and temporal characteristics of the Gulf hypoxic zone. The model is expected to play a significant role in determining best practices and improved strategies for incentivizing nutrient reduction strategies, including installation of on-farm structures to reduce sediment and nutrient runoff, use of cover crops and other agricultural practices, restoration of wetlands and riparian buffers, improved waste water treatment and decreased industrial nitrogen emissions. These decisions are currently made in a fragmented way by federal, state, and local agencies, using a variety of small scale models and limited data. During the past three years, EPA has collected an enormous amount of in-situ data to be used in the model. We believe that the use of NASA satellite data products in the model and for long term validation of the model has the potential to significantly increase the accuracy and therefore the utility of the model for the decision making described above. This proposal addresses the Gulf of Mexico Alliance (GOMA) priority issue of reductions in nutrient inputs to coastal ecosystem. It further directly relates to water quality for healthy beaches and shellfish beds and wetland and coastal conservation restoration.

Habib, Shaid↗
NASA NTRS2003

Identifying Head-Trunk and Lower Limb Contributions to Gaze Stabilization During Locomotion

The goal of the present study was to determine how the multiple, interdependent full-body sensorimotor subsystems respond to a change in gaze stabilization task constraints during locomotion. Nine subjects performed two gaze stabilization tasks while walking at 6.4 km/hr on a motorized treadmill: 1) focusing on a central point target; 2) reading numeral characters; both presented at 2m in front at the level of their eyes. While subjects performed the tasks we measured: temporal parameters of gait, full body sagittal plane segmental kinematics of the head, trunk, thigh, shank and foot, accelerations along the vertical axis at the head and the shank, and the vertical forces acting on the support surface. We tested the hypothesis that with the increased demands placed on visual acuity during the number recognition task, subjects would modify full-body segmental kinematics in order to reduce perturbations to the head in order to successfully perform the task. We found that while reading numeral characters as - compared to the central point target: 1) compensatory head pitch movement was on average 22% greater despite the fact that the trunk pitch and trunk vertical translation movement control were not significantly changed; 2) coordination patterns between head and trunk as reflected by the peak cross correlation between the head pitch and trunk pitch motion as well as the peak cross correlation between the head pitch and vertical trunk translation motion were not significantly changed; 3) knee joint total movement was on average 11% greater during the period from the heel strike event to the peak knee flexion event in stance phase of the gait cycle; 4) peak acceleration measured at the head was significantly reduced by an average of 13% in four of the six subjects. This was so even when the peak acceleration at the shank and the transmissibility of the shock wave at heel strike (measured by the peak acceleration ratio of the head/shank) remained unchanged. Taken together these results provide further evidence that the full body contributes to gaze stabilization during locomotion, and that its different functional elements can be modified online to contribute to gaze stabilization for different visual task constraints.

Mulavara, Ajitkumar P.↗
NASA NTRS2006

Constraining Numerical Geodynamo Modeling with Surface Observations

Numerical dynamo solutions have traditionally been generated entirely by a set of self-consistent differential equations that govern the spatial-temporal variation of the magnetic field, velocity field and other fields related to dynamo processes. In particular, those solutions are obtained with parameters very different from those appropriate for the Earth s core. Geophysical application of the numerical results therefore depends on correct understanding of the differences (errors) between the model outputs and the true states (truth) in the outer core. Part of the truth can be observed at the surface in the form of poloidal magnetic field. To understand these differences, or errors, we generate new initial model state (analysis) by assimilating sequentially the model outputs with the surface geomagnetic observations using an optimal interpolation scheme. The time evolution of the core state is then controlled by our MoSST core dynamics model. The final outputs (forecasts) are then compared with the surface observations as a means to test the success of the assimilation. We use the surface geomagnetic data back to year 1900 for our studies, with 5-year forecast and 20-year analysis periods. We intend to use the result; to understand time variation of the errors with the assimilation sequences, and the impact of the assimilation on other unobservable quantities, such as the toroidal field and the fluid velocity in the core.

Kuang, Weijia↗
NASA NTRSDate not supplied

Isolator Shock Train Response to Dual-Mode Scramjet Throttling-Like Forcing

Typical dual-mode scramjet designs employ an isolator component situated between the inlet and combustor. The isolator fluidically buffers the inlet from the combustor via the formation of a shock train, an interconnected series of shock-boundary layer interactions. The isolator is required during ramjet-engine operation and at the lower edges of the scramjet operational envelope. In an operational engine, transient behavior imposes fluidic dynamics due to attitude adjustments, combustor throttling, aberrant resonances within the combustor, etc. To accommodate these transients, the shock train adjusts on both temporal and spatial scales. Sufficiently large downstream pressure increases in the combustor play a critical role during unstart, whereby strong compression waves propagate upstream in the isolator to ultimately force the shock train out the inlet, if it cannot stabilize to the pressure increase. This critically reduces the engine mass flow rate, potentially causing a catastrophic reduction in thrust and loss of the vehicle. A nearly instantaneous unstart can, in principle, be predicted by a ratio of the normal shock pressure jump in an inviscid isolator. However, lower-magnitude perturbations, below this bound, also induce unstarts. Understanding the transient behavior inherent in unsteady isolator operation is critical to reducing safety margin in isolator length and refining engine control algorithms to improve engine performance. The Isolator Dynamics Research Lab (IDRL) is a cold-flow, direct-connect isolator facility ideal for assessing the fundamental fluid dynamics of shock trains. The internal flow of a scramjet isolator is modeled using a 2D, symmetric Mach 2.5 nozzle followed by a 695 mm long, 25.4x50.8 mm rectangular isolator test section. A blockage cone on a high-speed ball screw actuator downstream of the isolator is pulsed to simulate the throttling behavior in an operational combustor. Wall flush high-speed static pressure transducers detect the streamwise shock train within the isolator. Time delays between the onset of the throttling and the response motion of the shock train are analyzed to assess the controlling scales and parameters. From this analysis, the response time of the isolator shock train system is found to depend primarily on the isolator back pressure time-rate-of-change but quickly saturates to a maximum propagation speed along the isolator. These results inform dual-mode scramjet engine designers of the critical parameters and limits of an unstart resistant engine.

scramjet↗
NASA NTRS1988

Variability of pigment biomass in the California Current system as determined by satellite imagery. II - Temporal variability

Characteristics of temporal variability in the California Current system are analyzed using a 30-month time series of CZCS imagery. About 20-25 percent of the variance is produced by a periodic annual cycle with peak values in winter. Analysis of ship-based chlorophyll measurements indicates that the winter peak is only characteristic of the upper portion of the euphotic zone and that total water column chlorophyll peaks during the spring upwelling season. Satellite studies of intraannual variability are modulated by strong 5- to 6-day oscillation in the availability of usable imagery, resulting from a combination of satellite orbital dynamics, which produces images of the study area roughly 4 out of every 6 days, and an oscillation in cloud cover, which controls the availability of clear imagery. The cloud cover oscillation, which is also present in coastal winds, undoubtedly affects the ocean surface and biases the data obtained by satellites. Analysis of data using a 5-day time step indicates that the predominant mode of nonseasonal variability is characterized by in-phase fluctuations throughout the southern and central California coastal region.

Michaelsen, Joel↗
NASA NTRS1992

Cognition and procedure representational requirements for predictive human performance models

Models and modeling environments for human performance are becoming significant contributors to early system design and analysis procedures. Issues of levels of automation, physical environment, informational environment, and manning requirements are being addressed by such man/machine analysis systems. The research reported here investigates the close interaction between models of human cognition and models that described procedural performance. We describe a methodology for the decomposition of aircrew procedures that supports interaction with models of cognition on the basis of procedures observed; that serves to identify cockpit/avionics information sources and crew information requirements; and that provides the structure to support methods for function allocation among crew and aiding systems. Our approach is to develop an object-oriented, modular, executable software representation of the aircrew, the aircraft, and the procedures necessary to satisfy flight-phase goals. We then encode in a time-based language, taxonomies of the conceptual, relational, and procedural constraints among the cockpit avionics and control system and the aircrew. We have designed and implemented a goals/procedures hierarchic representation sufficient to describe procedural flow in the cockpit. We then execute the procedural representation in simulation software and calculate the values of the flight instruments, aircraft state variables and crew resources using the constraints available from the relationship taxonomies. The system provides a flexible, extensible, manipulative and executable representation of aircrew and procedures that is generally applicable to crew/procedure task-analysis. The representation supports developed methods of intent inference, and is extensible to include issues of information requirements and functional allocation. We are attempting to link the procedural representation to models of cognitive functions to establish several intent inference methods including procedural backtracking with concurrent search, temporal reasoning, and constraint checking for partial ordering of procedures. Finally, the representation is being linked to models of human decision making processes that include heuristic, propositional and prescriptive judgement models that are sensitive to the procedural content in which the valuative functions are being performed.

Corker, K.↗
NASA NTRS2021

Single-Turnover Variable Chlorophyll Fluorescence as a Tool for Assessing Phytoplankton Photosynthesis and Primary Productivity: Opportunities, Caveats and Recommendations

Phytoplankton photosynthetic physiology can be investigated through single-turnover variable chlorophyll fluorescence (ST-ChlF) approaches, which carry unique potential to autonomously collect data at high spatial and temporal resolution. Over the past decades, significant progress has been made in the development and application of ST-ChlF methods in aquatic ecosystems, and in the interpretation of the resulting observations. At the same time, however, an increasing number of sensor types, sampling protocols, and data processing algorithms have created confusion and uncertainty among potential users, with a growing divergence of practice among different research groups. In this review, we assist the existing and upcoming user community by providing an overview of current approaches and consensus recommendations for the use of ST-ChlF measurements to examine in-situ phytoplankton productivity and photo-physiology. We argue that a consistency of practice and adherence to basic operational and quality control standards is critical to ensuring data inter-comparability. Large datasets of inter-comparable and globally coherent ST-ChlF observations hold the potential to reveal large-scale patterns and trends in phytoplankton photo-physiology, photosynthetic rates and bottom-up controls on primary productivity. As such, they hold great potential to provide invaluable physiological observations on the scales relevant for the development and validation of ecosystem models and remote sensing algorithms.

variable chlorophyll fluorescence↗
NASA NTRS1983

Atmospheric temperatures near the tropical tropopause Temporal variations, zonal asymmetry and implications for stratospheric water vapor

Analysis of temperature measurements obtained over an eight-year period in the vicinity of the low-latitude tropopause confirms the existence of longitude regions which are consistently colder by approximately 2-3 K than elsewhere in the tropics. These temperature differences, however, are confined to a layer of thickness 3-5 km centered on the tropopause. The lowest monthly mean temperatures observed at the colder stations yield saturation mixing ratios that are consistent with the range of measured stratospheric water vapor. Examination of the daily variations in temperature at a given station reveals a more complex pattern than indicated by the monthly averages. On many days temperatures at the colder longitudes correspond to water vapor abundances that are less than observed in the stratosphere despite the favorable comparison of the monthly means. The results point to the need for a series of water vapor soundings at selected longitudes and times in order to define the extent to which the tropical tropopause controls the stratospheric water vapor abundance.

Frederick, J. E.↗
NASA NTRS2012

Satellite Perspective of Aerosol Intercontinental Transport: From Qualitative Tracking to Quantitative Characterization

Evidence of aerosol intercontinental transport (ICT) is both widespread and compelling. Model simulations suggest that ICT could significantly affect regional air quality and climate, but the broad inter-model spread of results underscores a need of constraining model simulations with measurements. Satellites have inherent advantages over in situ measurements to characterize aerosol ICT, because of their spatial and temporal coverage. Significant progress in satellite remote sensing of aerosol properties during the Earth Observing System (EOS) era offers opportunity to increase quantitative characterization and estimates of aerosol ICT, beyond the capability of pre-EOS era satellites that could only qualitatively track aerosol plumes. EOS satellites also observe emission strengths and injection heights of some aerosols, aerosol precursors, and aerosol-related gases, which can help characterize aerosol ICT. After an overview of these advances, we review how the current generation of satellite measurements have been used to (1) characterize the evolution of aerosol plumes (e.g., both horizontal and vertical transport, and properties) on an episodic basis, (2) understand the seasonal and inter-annual variations of aerosol ICT and their control factors, (3) estimate the export and import fluxes of aerosols, and (4) evaluate and constrain model simulations. Substantial effort is needed to further explore an integrated approach using measurements from on-orbit satellites (e.g., A-Train synergy) for observational characterization and model constraint of aerosol intercontinental transport and to develop advanced sensors for future missions.

Yu, Hongbin↗
NASA NTRS2000

Remote Sensing of In-Flight Icing Conditions: Operational, Meteorological, and Technological Considerations

Remote-sensing systems that map aircraft icing conditions in the flight path from airports or aircraft would allow icing to be avoided and exited. Icing remote-sensing system development requires consideration of the operational environment, the meteorological environment, and the technology available. Operationally, pilots need unambiguous cockpit icing displays for risk management decision-making. Human factors, aircraft integration, integration of remotely sensed icing information into the weather system infrastructures, and avoid-and-exit issues need resolution. Cost, maintenance, power, weight, and space concern manufacturers, operators, and regulators. An icing remote-sensing system detects cloud and precipitation liquid water, drop size, and temperature. An algorithm is needed to convert these conditions into icing potential estimates for cockpit display. Specification development requires that magnitudes of cloud microphysical conditions and their spatial and temporal variability be understood at multiple scales. The core of an icing remote-sensing system is the technology that senses icing microphysical conditions. Radar and microwave radiometers penetrate clouds and can estimate liquid water and drop size. Retrieval development is needed; differential attenuation and neural network assessment of multiple-band radar returns are most promising to date. Airport-based radar or radiometers are the most viable near-term technologies. A radiometer that profiles cloud liquid water, and experimental techniques to use radiometers horizontally, are promising. The most critical operational research needs are to assess cockpit and aircraft system integration, develop avoid-and-exit protocols, assess human factors, and integrate remote-sensing information into weather and air traffic control infrastructures. Improved spatial characterization of cloud and precipitation liquid-water content, drop-size spectra, and temperature are needed, as well as an algorithm to convert sensed conditions into a measure of icing potential. Technology development also requires refinement of inversion techniques. These goals can be accomplished with collaboration among federal agencies including NASA, the FAA, the National Center for Atmospheric Research, NOAA, and the Department of Defense. This report reviews operational, meteorological, and technological considerations in developing the capability to remotely map in-flight icing conditions from the ground and from the air.

Ryerson, Charles C.↗
NASA NTRS1996

Microgravity in the STS-29 space shuttle discovery affected the vestibular system of chick embryos

Out of 32 embryos flown (16 @ E2 + 16 @ E9) for 5 days, 16 survived. All sixteen E2 were dead at landing. Eight were opened and eight were incubated at 1.0G. Autopsy showed that 4 E2 survived over 24 hours in space. Eight E14 hatched without anatomical malformations, and 8 E14 were fixed. The height of the macular epithelia was 31 mu m (mean) in control and 26 mu m in flight chicks. The cross-sectional area of macular nuclei of control was 17 mu m(2) for hair cells and 14 mu m(2) in supporting cells. In flight, cross-sectional area was 17 mu m(2) in hair cells and 15 mu m(2) in supporting cells (n=250). The shape factor of cartilage cells (1.0 = perfect circle) between control (mean = 0.70) and flight (mean = 0.72), and the area of cartilaginous cells between controls (mean = 9 mu m(2)) and flight (mean = 9 mu m(2)) did not differ (n=300). The nuclei of support cells were closer to the basement membrane in flight than in control chicks. The immunoreactivity of otoconia with anti keratan, fibronectin or chrondroitin sulfate was not different between flight and control ears. There were more afferent fibers inside the macular epithelia of flight (p<0.05) than control. Three of 8 flight animals had elevated vestibular thresholds (VT), with normal mean response amplitudes and latencies. Modified afferent innervation patterns requiring weeks to compensate are sufficient to elevate VT, and should be investigated further. Other reversible (sublethal) microgravity effects on sensory epithelia (vacuoles, swelling, etc) require quantification.

Flight Experiment↗
NASA NTRS2016

Global and Regional Radiative Forcing from 20 Reductions in BC, OC and SO4 an HTAP2 Multi-Model Study

In the Hemispheric Transport of Air Pollution Phase 2 (HTAP2) exercise, a range of global atmospheric general circulation and chemical transport models performed coordinated perturbation experiments with 20% reductions in emissions of anthropogenic aerosols, or aerosol precursors, in a number of source regions. Here, we compare the resulting changes in the atmospheric load and vertically resolved profiles of black carbon (BC), organic aerosols (OA) and sulfate (SO4/ from 10 models that include treatment of aerosols. We use a set of temporally, horizontally and vertically resolved profiles of aerosol forcing efficiency (AFE) to estimate the impact of emission changes in six major source regions on global radiative forcing (RF) pertaining to the direct aerosol effect, finding values between. 51.9 and 210.8mW/sq m/Tg for BC, between -2.4 and -17.9mW/sq m/Tg for OA and between -3.6 and -10.3W/sq m/Tg for SO4. In most cases, the local influence dominates, but results show that mitigations in south and east Asia have substantial impacts on the radiative budget in all investigated receptor regions, especially for BC. In Russia and the Middle East, more than 80 % of the forcing for BC and OA is due to extra-regional emission reductions. Similarly, for North America, BC emissions control in east Asia is found to be more important than domestic mitigations, which is consistent with previous findings. Comparing fully resolved RF calculations to RF estimates based on vertically averaged AFE profiles allows us to quantify the importance of vertical resolution to RF estimates. We find that locally in the source regions, a 20% emission reduction strengthens the radiative forcing associated with SO4 by 25% when including the vertical dimension, as the AFE for SO4 is strongest near the surface. Conversely, the local RF from BC weakens by 37% since BC AFE is low close to the ground. The fraction of BC direct effect forcing attributable to intercontinental transport, on the other hand, is enhanced by one-third when accounting for the vertical aspect, because long-range transport primarily leads to aerosol changes at high altitudes, where the BC AFE is strong. While the surface temperature response may vary with the altitude of aerosol change, the analysis in the present study is not extended to estimates of temperature or precipitation changes.

profiles of aerosol forcing efficiency (AFE)↗