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At least 667 records · Page 37

Shear stress reduces protease activated receptor-1 expression in human endothelial cells

Shear stress has been shown to regulate several genes involved in the thrombotic and proliferative functions of endothelial cells. Thrombin receptor (protease-activated receptor-1: PAR-1) increases at sites of vascular injury, which suggests an important role for PAR-1 in vascular diseases. However, the effect of shear stress on PAR-1 expression has not been previously studied. This work investigates effects of shear stress on PAR-1 gene expression in both human umbilical vein endothelial cells (HUVECs) and microvascular endothelial cells (HMECs). Cells were exposed to different shear stresses using a parallel plate flow system. Northern blot and flow cytometry analysis showed that shear stress down-regulated PAR-1 messenger RNA (mRNA) and protein levels in both HUVECs and HMECs but with different thresholds. Furthermore, shear-reduced PAR-1 mRNA was due to a decrease of transcription rate, not increased mRNA degradation. Postshear stress release of endothelin-1 in response to thrombin was reduced in HUVECs and HMECs. Moreover, inhibitors of potential signaling pathways applied during shear stress indicated mediation of the shear-decreased PAR-1 expression by protein kinases. In conclusion, shear stress exposure reduces PAR-1 gene expression in HMECs and HUVECs through a mechanism dependent in part on protein kinases, leading to altered endothelial cell functional responses to thrombin.

Non-NASA Center↗

Fluid mechanics and meteorological studies directed toward improved forecasting of CAT.

Discussion of fluid mechanics experiments designed to verify theoretical understanding of the stability of stratified shear flows. Meteorological analyses of CAT encounters are reviewed, and attempts are made to tie this information together to investigate possible improvements in CAT forecasting methods. The essential facts are presented in a form intended to be useful to forecasters and flight crews.

Stoeffler, R. C.↗

Research in the aerospace physical sciences

Research efforts are reported in various areas including dynamics of thin films, polymer chemistry, mechanical and chemical properties of materials, radar system engineering, stabilization of lasers, and radiation damage of organic crystals. Brief summaries of research accomplished and literature citations are included.

Whitehurst, R. N.↗

Ion heating by strong electrostatic ion cyclotron turbulence

A theory of the ion heating due to electrostatic ion cyclotron (EIC) waves in the auroral zone is presented. Due to the slowly convecting nature of the EIC mode, quasi-linear plateau formation cannot stabilize the waves, and growth occurs until the nonlinear mechanisms of ion resonance broadening and electron trapping provide saturation. The large amplitude and coherent nature of the resulting wave imply that quasi-linear theory provides only a lower limit to the ion heating. An upper bound on the heating rate is derived using a time-average model of ion dynamics in the coherent waves. The effects of ion heating in the presence of the magnetic gradient force and parallel electric fields are considered, with the result that perpendicular energies over 100 eV are easily attainable from a 1 eV source plasma. Perpendicular heating in the absence of a parallel electric field yields conical ion distributions, which in the presence of an electric field become field-aligned beams.

Lysak, R. L.↗

One dimensional modelling of failure in laminated plates by delamination buckling

When low speed objects impact composite laminated plates delamination may result. Under inplane compression such delaminations may buckle and tend to enlarge the delaminated area which can lead to loss of global plate stability. This process is modelled here in a first attempt by a delaminating beam-column wherein the local delamination growth, stability and arrest are governed by a fracture mechanics-based energy release rate criterion.

Chai, H.↗

The applicability of Lyapunov characteristic numbers in the study of the stability of satellite orbits

It is pointed out that the Lyapunov Characteristic Numbers constitute a new tool for determining stability of trajectories of dynamical systems, or, even more generally, of solutions of systems of ordinary differential equations. In contrast with the characteristic exponents, which apply only to periodic solutions, the Lyapunov Characteristic Numbers apply to arbitrary nonperiodic solutions as well. A description is presented of the numerical experiments which have been made in order to investigate the practical value of the Lyapunov Characteristic Number and the Kolmogorov Entropy for the purpose of estimating the stability of trajectories and/or numerical integration methods in celestial mechanics. It is found that the Lyapunov Characteristic Numbers are extremely useful for the classification of the solutions of nonintegrable dynamical systems, especially in order to distinguish between quasi-periodic and chaotic solutions. However, the Lyapunov Characteristics Numbers do not appear to be useful for the purpose of evaluating numerical integration methods.

Broucke, R.↗

Metal ion-containing epoxies

A variety of metallic and organometallic complexes to be used as potential additives for an epoxy used by the aerospace industry as a composite matrix resin were investigated. A total of 9 complexes were screened for compatibility and for their ability to accelerate or inhibit the cure of a highly crosslinkable epoxy resin. Methods for combining the metallic complexes with the resin were investigated, gel times recorded, and cure exotherms studied by differential scanning calorimetry. Glass transition temperatures of cured metal ion containing epoxy castings were determined by thermomechanical analysis. Thermal stabilities of the castings were determined by thermogravimetric analysis. Mechanical strength and stiffness of these doped epoxies were also measured.

Stoakley, D. M.↗

Measurements of distributed polarized radio sources from spinning spacecraft - Effect of a tilted axial antenna ISEE-3 application and results

An analysis is presented of the system response of a satellite receiver-antenna system to locate a radio source when the satellite is tilted on its axis. The satellite is spin stabilized but experiences a tilt due to either a mechanical misalignment or a shift in the electrical axis caused by parasitic currents in other spacecraft structures. The shorter the antenna, the more significant the effects. Numerical techniques are developed for obtaining the Stokes parameters and the angular parameters of a uniform conical source sensed by a linear antenna in order to derive the average power response of a synthesized dipole to a point on a distributed polarized source. Relative gains are calculated along the antenna at different angles to the source. The techniques are applied to sample ISEE-3 satellite data for Type III solar radio bursts which were sensed by an axial and an equatorial antenna. The two antennas permit localization of the source and quantification of the polarization and angular extent of the source. The resulting high precision in calculations of all three source parameters commends use of the model in analyses of data from the planned ULYSSES mission.

Fainberg, J.↗

Advanced technology for the Space Station

The goals and objectives of the Space Station Advanced Development Program are discussed. Data from tests and experiments in the areas of attitude control and stabilization, communications and tracking, data management systems, man systems, mechanisms, power systems, structures, thermal systems, and EVA are examined. The approaches used to implement these programs and for data transfer are described. The plans for the development of the Space Station are presented.

Nolan, Mark B.↗

Driving forces: Slab subduction and mantle convection

Mantle convection is the mechanism ultimately responsible for most geological activity at Earth's surface. To zeroth order, the lithosphere is the cold outer thermal boundary layer of the convecting mantle. Subduction of cold dense lithosphere provides tha major source of negative buoyancy driving mantle convection and, hence, surface tectonics. There are, however, importnat differences between plate tectonics and the more familiar convecting systems observed in the laboratory. Most important, the temperature dependence of the effective viscosity of mantle rocks makes the thermal boundary layer mechanically strong, leading to nearly rigid plates. This strength stabilizes the cold boundary layer against small amplitude perturbations and allows it to store substantial gravitational potential energy. Paradoxically, through going faults at subduction zones make the lithosphere there locally weak, allowing rapid convergence, unlike what is observed in laboratory experiments using fluids with temperature dependent viscosities. This bimodal strength distribution of the lithosphere distinguishes plate tectonics from simple convection experiments. In addition, Earth has a buoyant, relatively weak layer (the crust) occupying the upper part of the thermal boundary layer. Phase changes lead to extra sources of heat and bouyancy. These phenomena lead to observed richness of behavior of the plate tectonic style of mantle convection.

Hager, Bradford H.↗

The kink instability in infinite cylindrical flux tubes - Eigenvalues for power-law twist profiles

Simple, accurate methods of calculating ideal MHD instability eigenvalues for infinitely long cylindrical tubes with twist function T(r) are developed. The results show that the most rapidly growing and energetic instabilities occur in the Gold-Hoyle v = 0 field, with the instability progressively weakening with increasing v. However, the maximum force eigenvalue is always small, so that even in the Gold-Hoyle case only a small proportion of the available magnetic energy can be released in the linear phase. The results also confirm that the linear pinch is remarkably weak yet relatively resistant to line-tying. It is shown that the weakness of the force eigenvalue implies that the influence of uniform gas pressure on stability is negligible. Implications for the energy-release mechanism in solar flares are discussed.

Craig, I. J. D.↗

Suppression of pressure oscillations in an open cavity by passive pneumatic control

A computational investigation has been conducted to determine the effectiveness of a passive control technique in suppressing the oscillations in an open cavity exposed to a supersonic flow. Time-accurate solutions of the unsteady, Reynolds-averaged, Navier-Stokes equations were obtained with an explicit predictor-corrector algorithm; the passive control was implemented through the use of a simple linear pressure-velocity law along the porous cavity floor. The computational code was validated by comparisons with experimental data for the cavity flow without control. The computational results with control demonstrate that the oscillations are suppressed; the fluid dynamic mechanism of the control is seen to be a stabilization of the free-shear layer. Spectral analysis of the unsteady data shows that the resonant frequencies are essentially unchanged by the control. Beneficial reductions in the cavity resonant drag are also observed.

Chokani, N.↗

Characterisation of frequency doubling in Eu(2+) doped aluminosilicate fibres

The results of a series of experiments on efficient second-harmonic generation in a fiber with a Eu(2+)-doped aluminosilicate core are reported. The fiber was prepared by the seeding method with CW mode-locked radiation at 1.06 micron and produced ultrastable peak conversion efficiencies of 0.001 during mode-locked readout. Experiments were performed to determine the IR preparation intensity dependence, the stability of the output, and the type of erasure mechanisms which occur. The results are compared with those of germanosilicate fibers and some similarities and differences are discussed.

Driscoll, T. J.↗

Effects of a noncoplanar biphenyldiamine on the processing and properties of addition polyimides

Addition curing polyimides, prepared from noncoplanar 2,2'-bis(trifluoromethyl) 4,4' diaminobiphenyl (BTDB) with various dianhydrides were evaluated as high temperature polymer matrix materials. T sub g of these polymers were measured by mechanical methods as well as by thermal mechanical analysis. Physical and mechanical properties as well as the thermo-oxidative stability of neat resins and the corresponding G40-600 graphite fiber reinforced composites were compared to that of PMR-II-50 and V-CAP-75.

Chuang, Kathy C.↗

Passive control of supersonic cavity flowfields

A computational investigation has been conducted to study the effect and mechanisms of the passive control of a supersonic flow over a rectangular two-dimensional cavity. The passive control was included through the use of a porous surface over a vent chamber in the floor of the cavity. The passive control effectively suppressed the low-frequency pressure oscillations for the open type cavity, (length-to-depth ratio = 6.0). The mechanism for the suppression was observed to be the stabilization of the motion of the free shear layer. For the closed type cavity flow, (length-to-depth ratio = 17.5), the passive control modified the flowfield to nearly that of an open type cavity flow; further the cavity drag was reduced by a factor of four. The computational results of both cases showed good agreement with the available experimental data and the predictions of a semiempirical formula. This study demonstrates that the passive control concept can be used to improve the aerodynamic characteristics of open and closed cavity flowfields.

Chokani, N.↗

Beam-Steering Subsystem For Laser Communication

Proposed free-space laser communication system contains fewer optical and mechanical components. Involves novel fast beam-steering subsystem stabilizing only angle between transmitting and receiving beams instead of stabilizing both transmitting and receiving lines of sight individually. Received and transmitted beams of light both imaged onto CCD array at focal plane. Relative angular positions of beams computed from centroids of their images.

Lesh, James R.↗

Dynamics of Variable Mass Systems

This report presents the results of an investigation of the effects of mass loss on the attitude behavior of spinning bodies in flight. The principal goal is to determine whether there are circumstances under which the motion of variable mass systems can become unstable in the sense that their transverse angular velocities become unbounded. Obviously, results from a study of this kind would find immediate application in the aerospace field. The first part of this study features a complete and mathematically rigorous derivation of a set of equations that govern both the translational and rotational motions of general variable mass systems. The remainder of the study is then devoted to the application of the equations obtained to a systematic investigation of the effect of various mass loss scenarios on the dynamics of increasingly complex models of variable mass systems. It is found that mass loss can have a major impact on the dynamics of mechanical systems, including a possible change in the systems stability picture. Factors such as nozzle geometry, combustion chamber geometry, propellant's initial shape, size and relative mass, and propellant location can all have important influences on the system's dynamic behavior. The relative importance of these parameters on-system motion are quantified in a way that is useful for design purposes.

Eke, Fidelis O.↗

An Energy Decaying Scheme for Nonlinear Dynamics of Shells

A novel integration scheme for nonlinear dynamics of geometrically exact shells is developed based on the inextensible director assumption. The new algorithm is designed so as to imply the strict decay of the system total mechanical energy at each time step, and consequently unconditional stability is achieved in the nonlinear regime. Furthermore, the scheme features tunable high frequency numerical damping and it is therefore stiffly accurate. The method is tested for a finite element spatial formulation of shells based on mixed interpolations of strain tensorial components and on a two-parameter representation of director rotations. The robustness of the, scheme is illustrated with the help of numerical examples.

Bottasso, Carlo L.↗