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All sourcesNASA NTRSDOE OSTI
NASA NTRS2009

Stability of Dosage Forms in the Pharmaceutical Payload Aboard Space Missions

Efficacious pharmaceuticals with adequate shelf lives are essential for successful space medical operations. Stability of pharmaceuticals, therefore, is of paramount importance for assuring the health and wellness of astronauts on future space exploration missions. Unique physical and environmental factors of space missions may contribute to the instability of pharmaceuticals, e.g., radiation, humidity and temperature variations. Degradation of pharmaceutical formulations can result in inadequate efficacy and/or untoward toxic effects, which could compromise astronaut safety and health. Methods: Four identical pharmaceutical payload kits containing 31 medications in different dosage forms (liquid, tablet, capsule, ointment and suppository) were transported to the International Space Station aboard the Space Shuttle (STS-121). One of the 4 kits was stored on the Shuttle and the other 3 were stored on the International Space Station (ISS) for return to Earth at 6-month interval aboard a pre-designated Shuttle flight for each kit. The kit stored on the Shuttle was returned to Earth aboard STS-121 and 2 kits from ISS were returned on STS 117 and STS-122. Results: Analysis of standard physical and chemical parameters of degradation was completed for pharmaceuticals returned by STS-121 after14 days, STS - 117 after11 months and STS 122 after 19 months storage aboard ISS. Analysis of all flight samples along with ground-based matching controls was completed and results were compiled. Conclusion: Evaluation of results from the shuttle (1) and ISS increments (2) indicate that the number of formulations degraded in space increased with duration of storage in space and was higher in space compared to their ground-based counterparts. Rate of degradation for some of the formulations tested was faster in space than on Earth. Additionally, some of the formulations included in the medical kits were unstable, more so in space than on the ground. These results indicate that the space flight environment may adversely affect the shelf life of pharmaceuticals aboard space missions.

Du, Brian J.↗
NASA NTRS2011

Changes in the High-Latitude Topside Ionospheric Vertical Electron-Density Profiles in Response to Solar-Wind Perturbations During Large Magnetic Storms

The latest results from an investigation to establish links between solar-wind and topside-ionospheric parameters will be presented including a case where high-latitude topside electron-density Ne(h) profiles indicated dramatic rapid changes in the scale height during the main phase of a large magnetic storm (Dst < -200 nT). These scale-height changes suggest a large heat input to the topside ionosphere at this time. The topside profiles were derived from ISIS-1 digital ionograms obtained from the NASA Space Physics Data Facility (SPDF) Coordinated Data Analysis Web (CDA Web). Solar-wind data obtained from the NASA OMNIWeb database indicated that the magnetic storm was due to a magnetic cloud. This event is one of several large magnetic storms being investigated during the interval from 1965 to 1984 when both solar-wind and digital topside ionograms, from either Alouette-2, ISIS-1, or ISIS-2, are potentially available.

Benson, Robert F.↗
NASA NTRS2019

High-Fidelity Multidisciplinary Sensitivity Analysis Framework for Multipoint Rotorcraft Optimization

A multidisciplinary, gradient-based sensitivity-analysis methodology is evaluated for optimization of rotorcraft configurations. The tightly coupled discipline models include physics-based fluid dynamics and rotorcraft comprehensive analysis. A discretely-consistent adjoint method accounts for sensitivities of the unsteady flow and unstructured, dynamic, over set grids, while sensitivities of structural responses to aerodynamic loads are computed using a complex-variable method. The methodology is applied to optimize the shape of UH-60A Blackhawk helicopter blades for hover and forward flight conditions. The objective of the multipoint design is to simultaneously increase the rotorcraft figure of merit in a hover flight and reduce the rotor power in a forward flight. Trimmed loose-coupling solutions for the baseline configuration are used to initiate the tight-coupling multidisciplinary analysis. Target thrust and rolling and pitching moments are enforced as optimization constraints. The optimized configuration improves the optimization metrics at both design points. The improved performance and all constraints are maintained over many revolutions beyond the optimization interval, satisfying the required flight conditions. Computational cost of the optimization cycle is assessed in a high-performance computing environment and found affordable for design of rotorcraft in general level-flight conditions.

Wang, Li↗
NASA NTRS1985

Analysis of low-altitude wind speed and direction shears

Horizontal wind profile measurements recorded at the NASA 150-Meter Ground Winds Tower Facility at the Kennedy Space Center, Fla., are analyzed to evaluate wind shears known to be hazardous to the ascent and descent of conventional aircraft and the Space Shuttle. Twenty 5-s intervals of high (between 10 and 18 m/s) and gale force (18 to 33 m/s) surface winds provided instantaneous recordings every 0.1 s per speed, direction, and tower level from 3-150 m. Mathematical (maximum, mean, standard deviation) and graphical (percentage frequency distribution) descriptions of absolute, positive, and negative speed and direction shears with altitude (six vertical layers) and along flight path (one horizontal distance) are presented as functions of the intensity categories and significant values.

Alexander, M. B.↗
NASA NTRS1985

Remarks on the ATMAP Campaigns in November 1981 and May 1982 at Collm (52 Deg N, 15 Deg E)

The results given are based on daily nighttime L. F. wind measurements over Central Europe on three measuring paths at 179, 227, and 272 kHz. Absolute reflection height measurements were carried out for the first time in August 1982 so that values of the months of 1982 and 1983 have been taken for the campaigns in November 1981 and May 1982. The prevailing wind and the semidiurnal tidal wind components are calculated daily. Means of the month or means of parts of a month are formed for climatological investigations. A 24 hour analysis is not possible due to the very different reflection heights during the daytime and nighttime, even with measurements being carried out the whole ay long in the winter season. The critical examination of the choice of the measuring intervals selected is dependent on the visual angle. A wind ield change is observed over Central Europe very often around the 20th of November 1981 this wind field variation being in the core period and leading over to a more stable tidal wind.

Schminder, R.↗
NASA NTRS1990

Analysis of pressure-broadened ozone spectra in the 3 micron region

The Molecular Spectroscopy Lab at NASA-Langley has been involved in a long term effort to carefully characterize the infrared spectra of small molecules of atmospheric interest, including methane, water vapor, ozone, and their isotopic counterparts. High resolution gas phase infrared spectra are obtained using both a tunable diode laser system, and the McMath Fourier transform spectrometer at the Kitt Peak Solar Observatory. Spectra are obtained at various pressures and temperatures for pure gas samples, and for samples containing mixtures of the species of interest in nitrogen, oxygen, or air. From these spectra, using a nonlinear least squares fitting technique, spectral parameters of position, intensity, and half-width were determined for varying laboratory conditions that approximate atmospheric conditions experienced in remote sensing situations. These parameters are of interest in theoretical studies of these species, as well as in allowing more accurate interpretation of remote sensing data. The current work involves the analysis of a series of McMath FTIR spectra of ozone broadened by mixing with air, nitrogen, or oxygen. Each spectrum covers the region from 2396 to 4057/cm. Each vibrational band is analyzed by first diving its region into small intervals containing a few well isolated absorption lines of reasonable intensity. Each of these small intervals is fit by multiple iterations of the nonlinear least square program until residuals are minimized to a reasonable value which corresponds to the noise level of the measured spectrum. Intervals for the 3 nu(sub 3) ozone band in the region from 3000 to 3060 wavenumbers are being examined.

Prochaska, Eleanor S.↗
NASA NTRS1992

Viking 2 electron observations at Mars

An analysis of the electron mode sweeps made in Viking 2 above the ionosphere is presented. An observation of the electron energy spectrum over the range 0 to 78 eV was recorded in 1 s and observations were made at intervals of 4 or 8 s. The concentrations and temperatures were highly variable in the altitude range 14,000 to 9000 km. Evidence for two Maxwellian components were present in most of the records. The general trend of concentration and temperature for the predominant component was from 2/cu cm and 100,000 K at 15,600 km to 5/cu cm at 220,000 K and 900 km, in good agreement with the Mars 3 observations of Gringauz et al. (1974). The higher-temperature component was generally characterized by a temperature near 400,000 K and concentrations near 0.1/cu cm. The electron plasma pressures near 800 km were about a factor of 20 lower than those obtained from Viking 1, the difference being much greater than expected from the normal distribution around the stagnation point in the shocked solar wind.

Johnson, Francis S.↗
NASA NTRS2003

Toroidal wave frequency at L=6-10: AMPTE/CCE Observations and Comparison with Theoretical Model

Magnetospheric standing Alfven waves are guided along the ambient magnetic field and their frequency depends on the mass density of the plasma distributed along the field lines. These properties allow us to use Alfen waves to map time-dependent phenomena between space and ground and to estimate the mass density. In this paper we present a statistical study of the spatial variation of the fundamental frequency f(sub T1) of toroidal-mode standing Alfen waves in the L range from 6 to 10, where L indicates the maximum geocentric distance on the field line. The data used for this analysis are energetic particle flux anisotropy (proxy of transverse electric field) and magnetic field measurements from the Active Magnetospheric Particle Tracer Explorers Charge Composition Explorer (CCE) spacecraft. Using CCE data covering 4 years we obtained approximately 5000 20-min intervals containing a clear signature of toroidal waves. The median f(sub T1), is 6-10 mHz at L=7 and decreases to 4-8 mHz at L = . The frequency tends to be lower at noon than at midnight. The observed frequencies are compared with numerically derived frequencies using an empirical mass density model and a magnetic field model. We found a good agreement for 12-24 MLT but a large discrepancy near MLT= 3. This may indicate that the flux tubes at this local time are more heavily loaded than specified in the Gallagher et al. model.

Takahashi, Kazue↗
NASA NTRS2016

Bone Turnover Does Not Reflect Skeletal Aging in Older Hispanic Men with Type 2 Diabetes

The paradox of fragility fracture in the presence of non-osteoporotic bone mineral density in older patients with type 2 diabetes mellitus (DM2) makes it difficult to clinically predict fracture in this vulnerable group. Serum osteocalcin (OC), a marker of bone turnover, increases with normal skeletal aging indicating risk of fracture. However, OC has been reported to be lower in patients with DM2. An inverse association between higher glycated hemoglobin levels (HbA1c) and lower serum OC in older DM2 patients triggered discussions encouraging further investigation. A key question to be answered is whether changes in glucose metabolism is responsible for bone metabolic changes, ultimately leading to increased risk of fragility fractures in DM2 patients. While these studies were conducted among Caucasian and Asian populations, this has not been studied in Hispanic populations who suffer from a higher prevalence of DM2. The Cameron County Hispanic Cohort (CCHC) in Texas is a homogeneous Hispanic cohort known to have high prevalence of DM2 (30%). Our preliminary data from this cohort reported OC levels lower than the suggested threshold for fragility fracture in post-menopausal women. We further investigated whether bone turnover in older CCHC adults with DM2 show a normal pattern of skeletal aging. Samples and data were obtained from a nested cohort of 68 (21 men and 47 women) Hispanic older adults (≥50 years) who had a diagnosis of DM2. Given high prevalence of uncontrolled DM2 in this cohort, we divided population into two groups: i) poor DM2 control with HbA1c level ≥8 (48% men and 38% women) and ii) good DM2 control with HbA1c level <8). A crosssectional analysis documented associations between serum OC and age adjusted HbA1c levels. There was no direct association between age and OC concentrations in our study. Higher HbA1c was associated with lower serum OC in men (odds ratio -6.5, 95% confidence interval -12.7 to - 0.3, p < 0.04). No significant associations were identified in women. Bone turnover in older Hispanic men with DM2 in our study does not reflect normal pattern of skeletal aging. It is unclear why similar results were not identified in women. We will continue to follow this cohort to investigate longitudinal trend of changes of bone turnover and its relationship with HbA1c in both men and women of this cohort.

Rianon, N.↗
NASA NTRS2000

RXTE and BATSE Observations of the Recent Outbursts of 2S 1417-624

25 1417-624 is a 57 mHz transient Be/X-ray pulsar system first discovered by SAS 3 in 1978. After the discovery outburst it was not seen again until 1994 when BATSE observed an outburst that peaked at 40 Srab (pulsed flux, 20-50 keV) and lasted 110 days, followed by a series of 5 shorter, 10-15 mCrab outbursts occurring every 42 days. Pulse timing analysis showed that these smaller outbursts began a few days after periastron passage of the system's eccentric, 42 day period orbit. Renewed activity from the source was detected by BATSE beginning in 1999 November. BATSE monitoring shows a 10 mCrab peak flux outburst lasting 10 days, followed in the next orbit by a 30 mCrab peak flux outburst, which to date has lasted 56 days. Regular monitoring with RXTE began during the 1999 November outburst and has continued in to the current outburst. The data provides good coverage of the low flux state between BATSE detections, which includes the periastron passage. Pulses are detected through this interval, showing that the source did not enter the propeller regime. The PCA monitoring from the lowest flux level, which occurs shortly before periastron, until the peak of the current outburst, show a continuous evolution of the pulse profile. These profiles contain a narrow notch feature which allow us to present a phase aligned history of this pulse evolution. We present a timing analysis of the PCA and BATSE observations that provide corrections to the binary orbit, and measurements of the torque during the observations. From the observed torque and flux we show that disc accretion is occurring in the current outburst, most probably was also occurring in the smaller outburst.

Finger, M. H.↗
NASA NTRS1998

Monitoring MRK 509: The Origin of the Reprocessor and Broad Band X-ray Spectrum of Narrow Line Seyfert 1 AKN 564

The ten monitoring observations of Mrk 509 were made successfully between October 20 and November 26 last year. These observations were simultaneously with RXTE observations. A preliminary analysis of the RXTE observations has been done, and the light curve is shown in figure 1. Our aim in this experiment is to determine the location of the emission region of the reflection component by reverberation mapping. This component could be emitted from the accretion disk, within 100 Scwartzschild radii (R(sub s)) from the source. Note that the monitoring interval of 2.5 days corresponds to 100 R(sub s) for a 2 x 10(exp 8) solar mass black hole, which may be appropriate for this luminous object. In that case, we would expect the reflected component to vary along the direct flux, and there should be no spectral variability between observations. Alternatively, the reflected emission could come from the molecular torus, several parsecs from the nucleus. In that case, the reflection component flux should not vary. The light curve in figure 1 shows that during the monitoring period, the target varied in an ideal way, since significant variability was observed between observations and yet the most rapid variability is apparently sampled. The analysis of this data is not yet completed. The measurement of the reflection component in the combined ASCa and RXTE spectra depends critically on the RXTE background subtraction and calibration, but these have not yet progressed to the point where the analysis can be done.

Halpern, Jules P.↗
NASA NTRS1994

Observed solar UV irradiance variations of importance to middle atmosphere energetics and photochemistry

Absorption of solar UV irradiance in the spectral interval 120-420 nm is chiefly responsible for radiative heating and photodissociation of important atmospheric constituents (e.g., O2, O3, H2O, NO2, etc.) in the stratosphere, mesosphere, and lower thermosphere. Thus, the absolute value and time perturbations of the UV irradiance could significantly affect the energetics, photochemistry, and subsequent dynamics of these regions. Analysis of preliminary data from the SOLSTICE (UARS) observations for a period of 244 days (3 Oct 1991-2 Jun 1992) is discussed in this paper. The data provide mean daily values of the spectral distribution of the observed irradiances at 1-nm resolution and their solar rotation and semirotation variations. The average amplitudes of the 27-day irradiance oscillations for the 244-day data period were 5.7% at Lyman-alpha (121 nm), 1% at 200 nm, 0.5% at 210 nm, and generally less than 0.2% at wavelengths longer than 280 nm. The average amplitudes of 13.5-day oscillations were, by and large, about half of these values. Solar irradiance variations at 10.7 cm are highly correlated with those at Ly-alpha and other chromospheric emission lines (r = 0.7 to 0.8) and only moderately correlated with irradiances at wavelengths of 180-208 nm (r = 0.5). The correlation decreases as the source region of the irradiance gets closer to the base of the photosphere. At the 2-nm interval 279-281 nm, however, which contains the cores of the Mg II h and k lines, the correlation is again approximately 0.8.

London, Julius↗
NASA NTRS1992

The atmosphere of Neptune - An analysis of radio occultation data acquired with Voyager 2

The vertical structure of Neptune's atmosphere is studied on the basis of recordings of the tracking signals received from Voyager 2 during its occultation by Neptune. The measurements began at a planetographic latitude of 62 deg north and ended near 45 deg south, and cover an altitude interval of about 5000 km. The 1-bar isobaric surface has equatorial and polar radii of 24,766 +/-15 km and 24,342 +/-30 km, respectively, and a corresponding oblateness of 0.0171 +/-0.0014. At this pressure, the temperature was 72 +/-2 K. The tropopause was detected approximately 40 km above the 1-bar level at a pressure of about 100 mbar. A comparison with IR observations indicates that the gas at the tropopause consists of 78-84-percent hydrogen by number density with the rest being mostly helium. The temperature in this region was 52 +/-2 K.

Lindal, Gunnar F.↗
NASA NTRS1996

Common View Time Transfer Using Worldwide GPS and DMA Monitor Stations

Analysis of the on-orbit Navstar clocks and the Global Positioning System (GPS) monitor station reference clocks is performed by the Naval Research Laboratory using both broadcast and postprocessed precise ephemerides. The precise ephemerides are produced by the Defense Mapping Agency (DMA) for each of the GPS space vehicles from pseudo-range measurements collected at five GPS and at five DMA monitor stations spaced around the world. Recently, DMA established an additional site co-located with the US Naval Observatory precise time site. The time reference for the new DMA site is the DoD Master Clock. Now, for the first time, it is possible to transfer time every 15 minutes via common view from the DoD Master Clock to the 11 GPS and DMA monitor stations. The estimated precision of a single common-view time transfer measurement taken over a 15-minute interval was between 1.4 and 2.7 nanoseconds. Using the measurements from all Navstar space vehicles in common view during the 15-minute interval, typically 3-7 space vehicles, improved the estimate of the precision to between 0.65 and 1.13 nanoseconds. The mean phase error obtained from closure of the time transfer around the world using the 11 monitor stations and the 25 space vehicle clocks over a period of 4 months had a magnitude of 31 picoseconds. Analysis of the low noise time transfer from the DoD Master Clock to each of the monitor stations yields not only the bias in the time of the reference clock, but also focuses attention on structure in the behaviour of the reference clock not previously seen. Furthermore, the time transfer provides a a uniformly sampled database of 15-minute measurements that make possible, for the first time, the direct and exhaustive computation of the frequency stability of the monitor station reference clocks. To lend perspective to the analysis, a summary is given of the discontinuities in phase and frequency that occurred in the reference clock at the Master Control Station during the period covered by the analysis.

Reid, Wilson G.↗
NASA NTRS1975

The energy spectrum of 10-50 BeV/nuc cosmic rays

We have obtained measurements of the energy spectra of cosmic ray nuclei with charge Z equals 5-14 in the 10-50 BeV/nuc energy interval from a gas Cerenkov detector flown aboard a high altitude balloon at Sioux Falls, South Dakota in September, 1974. The gas Cerenkov detector consists of a pressurized light diffusion chamber viewed by two separate banks of photomultiplier tubes. An analysis of the two signals permits a very effective rejection of background events as well as an understanding of the sources of broadening to be removed in the extraction of kinetic energy spectra from the gas Cerenkov detector pulse height distributions. The ratio of secondary to primary nuclei display a decrease with increasing energy as reported by other investigators.

Lezniak, J. A.↗
NASA NTRS1981

The isotopic composition of solar flare accelerated magnesium

Measurements of the abundances of three isotopes of magnesium in solar energetic particles are reported. Data were obtained from the Heavy Isotope Spectrometer Telescope on board the ISEE 3 spacecraft during a large solar particle event following the 2B solar flare of September 23, 1978. A two-dimensional maximum likelihood analysis of the mass determinations for each event, which were taken with a resolution of 0.23 amu, indicates a Mg-25/Mg-24 ratio of 0.14 (+0.05, -0.02) and a Mg-26/Mg-24 ratio of 0.15 (+0.04, -0.03) in the energy interval 12-36 MeV/n. The results are consistent with terrestrial magnesium isotope abundances.

Mewaldt, R. A.↗
NASA NTRS1981

The effects of transmitter/receiver clock time base instability on coherent communication system performance

The purpose of this paper is to present a model and associated analysis of the deleterious effects which both transmitter and receiver data clock time-base instability have on bit error probability. The types of time-base instability modeled and analyzed include bit jitter (epoch jitter), bit jitter rate (time interval jitter) and data asymmetry. The bit error probability is determined as a function of the statistical characteristics of the time-base instability, the data transition density, the signal-to-noise ratio in the bit rate bandwidth and the mechanizations of both the data bit detector and bit synchronizer. Numerical results are provided.

Chie, C. M.↗
NASA NTRS2002

Progress on the Cluster Mission

Prof M. G. Kivelson and Dr. K. K. Khurana (UCLA (University of California, Los Angeles)) are co-investigators on the Cluster Magnetometer Consortium (CMC) that provided the fluxgate magnetometers and associated mission support for the Cluster Mission. The CMC designated UCLA as the site with primary responsibility for the inter-calibration of data from the four spacecraft and the production of fully corrected data critical to achieving the mission objectives. UCLA will also participate in the analysis and interpretation of the data. The UCLA group here reports its excellent progress in developing fully intra-calibrated data for large portions of the mission and an excellent start in developing inter-calibrated data for selected time intervals, especially extended intervals in August, 2001 on which a workshop held at ESTEC in March, 2002 focused. In addition, some scientific investigations were initiated and results were reported at meetings.

Kivelson, Margaret↗