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At least 667 records · Page 37

Comparison of Four Strong Acids on the Precipitation Potential of Gypsum in Brines During Distillation of Pretreated, Augmented Urine

In this study, three different mineral acids were substituted for sulfuric acid (H2SO4) in the urine stabilizer solution to eliminate the excess of sulfate ions in pretreated urine and assess the impact on maximum water recovery to avoid precipitation of minerals during distillation. The study evaluated replacing 98% sulfuric acid with 85% phosphoric acid (H3PO4), 37% hydrochloric acid (HCl), or 70% nitric acid (HNO3). The effect of lowering the oxidizer concentration in the pretreatment formulation also was studied. This paper summarizes the test results, defines candidate formulations for further study, and specifies the injection masses required to stabilize urine and minimize the risk of mineral precipitation during distillation. In the first test with a brine ersatz acidified with different acids, the solubility of calcium in gypsum saturated solutions was measured. The solubility of gypsum was doubled in the brines acidified with the alternative acids compared to sulfuric acid. In a second series of tests, the alternative acid pretreatment concentrations were effective at preventing precipitation of gypsum and other minerals up to 85% water recovery from 95th-percentile pretreated, augmented urine. Based on test results, phosphoric acid is recommended as the safest alternative to sulfuric acid. It also is recommended that the injected mass concentration of chromium trioxide solution be reduced by 75% to minimize liquid resupply mass by about 50%, reduce toxicity of brines, and reduce the concentration of organic acids in distillate. The new stabilizer solution formulations and required doses to stabilize urine and prevent precipitation of minerals up to 85% water recovery are given. The formulations in this study were tested on a limited number of artificially augmented urine batches collected from employees at the Johnson Space Center (JSC). This study successfully demonstrated that the desired physical and chemical stability of pretreated urine and brines can be achieved using alternate pretreatment formulations under laboratory conditions. Additional testing and hazard assessments will be required to determine the feasibility of utilizing the proposed urine pretreatment formulations on ISS.

Muirhead, Dean↗

First Cloud-to-Ground Lightning Timing Study

NASA's LSP, GSDO and other programs use the probability of cloud-to-ground (CG) lightning occurrence issued by the 45th Weather Squadron (45 WS) in their daily and weekly lightning probability forecasts. These organizations use this information when planning potentially hazardous outdoor activities, such as working with fuels, or rolling a vehicle to a launch pad, or whenever personnel will work outside and would be at-risk from lightning. These organizations would benefit greatly if the 45 WS could provide more accurate timing of the first CG lightning strike of the day. The Applied Meteorology Unit (AMU) has made significant improvements in forecasting the probability of lightning for the day, but forecasting the time of the first CG lightning with confidence has remained a challenge. To address this issue, the 45 WS requested the AMU to determine if flow regimes, wind speed categories, or a combination of the two could be used to forecast the timing of the first strike of the day in the Kennedy Space Center (KSC)/Cape Canaveral Air Force Station (CCAFS) lightning warning circles. The data was stratified by various sea breeze flow regimes and speed categories in the surface to 5,000-ft layer. The surface to 5,000-ft layer was selected since that is the layer the 45 WS uses to predict the behavior of sea breeze fronts, which are the dominant influence on the occurrence of first lightning in Florida during the warm season. Due to small data sample sizes after stratification, the AMU could not determine a statistical relationship between flow regimes or speed categories and the time of the first CG strike.. As expected, although the amount and timing of lightning activity varies by time of day based on the flow regimes and speed categories, there are extended tails of low lightning activity making it difficult to specify times when the threat of the first lightning flash can be avoided. However, the AMU developed a graphical user interface with input from the 45 WS that allows forecasters to visualize the climatological frequencies of the timing of the first lightning strike. This tool should contribute directly to the 45 WS goal of improving lightning timing capability for its NASA, US Air Force and commercial customers.

statistical analysis↗

Fully Automated Volumetric Modulated Arc Therapy Plan Generation for Prostate Cancer Patients

Purpose: To develop and evaluate fully automated volumetric modulated arc therapy (VMAT) treatment planning for prostate cancer patients, avoiding manual trial-and-error tweaking of plan parameters by dosimetrists. Methods and Materials: A system was developed for fully automated generation of VMAT plans with our commercial clinical treatment planning system (TPS), linked to the in-house developed Erasmus-iCycle multicriterial optimizer for preoptimization. For 30 randomly selected patients, automatically generated VMAT plans (VMAT{sub auto}) were compared with VMAT plans generated manually by 1 expert dosimetrist in the absence of time pressure (VMAT{sub man}). For all treatment plans, planning target volume (PTV) coverage and sparing of organs-at-risk were quantified. Results: All generated plans were clinically acceptable and had similar PTV coverage (V{sub 95%} > 99%). For VMAT{sub auto} and VMAT{sub man} plans, the organ-at-risk sparing was similar as well, although only the former plans were generated without any planning workload. Conclusions: Fully automated generation of high-quality VMAT plans for prostate cancer patients is feasible and has recently been implemented in our clinic.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

Enhancing the Chemical Mixture Methodology in Emergency Preparedness and Consequence Assessment

Emergency preparedness personnel at US Department of Energy (DOE) facilities use the chemical mixture methodology (CMM) to estimate the potential health impacts to workers and the public from the unintended airborne release of chemical mixtures. The CMM uses a Hazard Index (HI) to compare a chemical’s concentration at a receptor location to an appropriate concentration limit for that chemical. This limit is typically based on Protection Action Criteria (PAC) values developed and published by the DOE. As a first cut, the CMM sums the HIs for all the chemicals in a mixture to conservatively estimate their combined health impact. A cumulative HI ≥ 1.0 represents a concentration at or exceeding the concentration limit and indicates the potential for adverse health effects. Next, health code numbers (HCNs) are used to identify the target organ sets that may be impacted by exposure to each chemical in a mixture. The sum of the HIs for the maximally impacted target organ set is used to provide a refined, though still conservative estimate, of the potential for adverse health effects from exposure to the chemical mixture. This paper explores approaches to further enhance the effectiveness of the CMM by using HCN weighting factors to reduce over-conservatism. A series of 24 case studies have been defined to evaluate both the existing CMM and three new approaches for improving the CMM. The first approach uses a set of HCN weighting factors that are applied based on the priority ranking of the HCNs for each chemical. The second approach uses weighting factors based on the priority rankings of the HCNs established for a given type of concentration limit. The third approach uses information on the exposure route used to derive PAC values and the second approach’s HCN ranking to derive and apply its HCN weighting factors. Initial testing indicates that applying weighting factors reduces the over-conservatism in the CMM for certain types of chemical mixtures, though care must be taken to avoid introducing non-conservative results. In the near future, additional testing and analysis will be conducted that will lead to the adoption of one of the tested approaches into the CMM. The long-term goal is to develop and implement a more comprehensive approach that will take into account the specific health effects that were observed during the studies used to derive the chemical-specific concentration limits used in the CMM.

acute health effects↗

Transportation of Radioactive Waste in Support of Ontario Power Generation's Darlington Nuclear Generating Station Refurbishment Project - 19384

Ontario Power Generation's (OPG) Darlington Nuclear Generating Station (DNGS) is currently executing a major refurbishment of the first of their four Candu reactors. As expected, the volumes of Low and Intermediate Level Waste (LILW) generated from this large-scale project have been significant. As a result, unique solutions were needed for the safe and efficient transportation of radioactive waste from the Darlington Nuclear Generating Station to OPG's Western Waste Management Facility for volume reduction and interim storage. OPG's Nuclear Waste Management Division and the Darlington Refurbishment Project worked together to identify unique radioactive waste transportation solutions. These solutions included staging and temporary storage facilities, new waste containers and specialized transportation packages, additional human resources and enhanced planning and logistics required to transport large volumes of routine and non-routine radioactive waste in a manner that minimized the impact on employee and public safety, project schedule and project costs. From a facilities perspective a shielded 'Marshalling Area' that allowed for loaded transportation packages to be staged was built on the Darlington site and a temporary licensed off-site radioactive waste storage facility close to the DNGS was contracted through a third party vendor. These two facilities allowed for more consistent and efficient schedules that limited radioactive waste shipments during off-hours and avoided peak traffic periods thereby limiting the risk to Refurbishment critical path activities. Special purpose-built transportation packages and waste containers were designed and fabricated to handle unique waste streams such as feeder pipes and other miscellaneous intermediate level waste items associated with reactor dismantling. Twenty-four Type A qualified transportation packages mounted to six flat deck trailers were designed and fabricated to support the shipment of contaminated feeder pipes. An Intermediate Level Waste Utility Container (ILWUC) to be used in conjunction with the Type B qualified Trillium Transportation Package was designed and fabricated to handle unique intermediate level waste streams arising from the reactor dismantling process. Logistics software was used to plan the shipments to ensure waste transportation packages could be loaded, transported, unloaded and returned safely to the project site in a timely manner without impacting project schedules. Several shipping scenarios were simulated and adjusted using the software to ensure that the most efficient use of equipment and resources for the radioactive waste transportation aspects of the project. (authors)

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

Adaptation of Commercially Available Robots for Conditioning and Packaging ILW at Sellafield - 18282

The Legacy Ponds and Silos at Sellafield site contain some of the most hazardous Intermediate Level Waste (ILW) in the UK. As part of a multi-billion pound decommissioning programme, this waste will be retrieved and transported across the site for conditioning and packaging in the Box Encapsulation Plant (BEP). Current plans are to commence plant active commissioning in 2022, which will represent a major milestone in the UK nuclear decommissioning programme. Within the plant, skips of waste will be transferred from the shielded transport package into standard 3 cubic metre ILW containers. Waste from the Pile Fuel Storage Pond and First Generation Magnox Storage Pond will be immobilised in cementitious grout before being transferred to an adjacent store. Waste from the Magnox Swarf Storage Silo will not be immobilised in grout, but will be packaged, providing multi-barrier containment. During the concept design, the project team selected commercially available robots as the most viable technology for carrying out the numerous dexterous and repetitive tasks involved in characterising, conditioning and packaging the waste within the shielded 'hot' cells. Significant technical challenges had to be overcome during the design to adapt a commercially available robot for use within a high radiation / high contamination environment, where human access is not safe even for short periods of time. These challenges included: - Designing robot assemblies that could be retrofitted into the existing cell structure that was constructed as part of an earlier project but never completed; - Designing robot assemblies that could be recovered to their 'transport' position without requiring manual intervention; - Designing robot assemblies that could be remotely removed and replaced with new ones if they failed part way through the plant operational life; - Designing through-wall service and power connections that allow maintenance and recovery; - Designing control systems and human-machine interfaces that enable both manual and automated operation of the robot, whilst avoiding collisions with the in-cell cranes and other in cell furniture; - Assessing the radiation tolerance of all items. Bespoke computer simulations and full-scale development trials have been carried out, using non-active test materials, in order to demonstrate the Technology Readiness Level (TRL) required by Sellafield Limited (SL) at each stage of the project [1]. The results of these trials have been recorded in both video and written form so that they can form part of the project's Knowledge Management database. Detailed designs and specifications for the robot assemblies have been updated to incorporate the recommendations from the development trials. Procurement and manufacture of robot assemblies has already commenced to deliver two waste handling robots, two waste container lidding / swabbing robots and associated critical spares. (authors)

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

SU-E-J-59: Effective Adaptive DMLC Gated Radiotherapy with OAR Sparing

Purpose: Patient respiratory motion degrades the effectiveness of cancer radiation treatment. Advanced respiratory gating delivers radiation dose accurately yet with elongated treatment time. The goal of this research is to propose a novel adaptive dMLC dynamic gating with high delivery efficiency and precision. Methods: The dose delivery of dMLC is aided by simultaneous tracking of tumor and organ at risk (OAR). The leaf opening/closing will follow the motion trajectory of the tumor while sparing the OAR. The treatment beam turns on only when there is no overlapping between OAR and tumor in BEV. A variety of evaluation metrics were considered and calculated, including duty cycle, beam toggling rate, and direct irradiation avoidance to OAR, under various combinations of different tumor margins and the distance between the centers of the tumor and OAR in BEV (expressed as dx). Results: Retrospective simulation was performed to investigate the feasibility and superiority of this technique using four groups of synchronized tumor and OAR motion data. The simulation results indicate that the tumor and OAR motion patterns and their relative positions are the dominant influential factors. The duty cycle can be greater than 96.71% yet can be as low as 6.69% depending different motion groups. This proposed technique provides good OAR protection, especially for such cases with low duty cycle for which as high as 77.71% maximal direct irradiation to OAR can be spared. Increasing dx improves the duty cycle (treatment efficiency) and provides better OAR volume sparing, whereas, that of the tumor margins has the opposite influence. Conclusion: This real-time adaptive dMLC gated radiation treatment with synchronous tumor and OAR tracking has inherent accurate dose delivery to tumor with reduced treatment time. In addition, the OAR protection capability make it an outstanding potential treatment strategy for mobile tumors.

60 APPLIED LIFE SCIENCES↗

Analysis of Droplet Size during the Ice Accumulation Phase Of Flight Testing

There are numerous hazards associated with air travel. One of the most serious dangers to the pilot and passengers safety is the result of flying into conditions which are conducive to the formation of ice on the surface of an aircraft. Being a pilot myself I am very aware of the dangers that Icing can pose and the effects it can have on an airplane. A couple of the missions of the Icing branch is to make flying safer with more research to increase our knowledge of how ice effects the aerodynamics of an airfoil, and to increase are knowledge of the weather for better forecasting. The Icing Branch uses three different tools to determine the aerodynamic affects that icing has on a wing. The Icing research tunnel is an efficient way to test various airfoils in a controlled setting. To make sure the data received from the wind tunnel is accurate the Icing branch conducts real flight tests with the DHC-6 Twin Otter. This makes sure that the methods used in the wind tunnel accurately model what happens on the actual aircraft. These two tools are also compared to the LEWICE code which is a program that models the ice shape that would be formed on an airfoil in the particular weather conditions that are input by the user. One benefit of LEWICE is that it is a lot cheaper to run than the wind tunnel or flight tests which make it a nice tool for engineers designing aircraft that don t have the money to spend on icing research. Using all three of these tools is a way to cross check the data received from one and check it against the other two. industries, but it is also looked at by weather analysts who are trying to improve forecasting methods. The best way to avoid the troubles of icing encounters is to not go into it in the first place. By looking over the flight data the analyst can determine which conditions will most likely lead to an icing encounter and then this information will aid forecasters when briefing the pilots on the weather conditions. am looking at the weather data from certain flights and analyzing the type of precipitation that the plane is flying through. During flight tests there is a probe on the bottom of the aircraft that gathers information on the size and shape of the particles that it is flying through. The data can then be viewed on a computer. After grouping the weather into certain groups we can then pick certain groups which we think should be analyzed farther. The goal is to remove all the ice particles because they do not contribute to the icing on an aircraft. We use a 2D analyzer which measures the droplet size and categorizes the drops into bins of certain sizes. We can then look at what the characteristics of the weather that we were flying through such as the temperature and dew point and compare this with the size of the drops that the 2D analyzer measured. We can then look at what type and shape of ice that formed on the wing during this time period. Having this data will help us to reproduce these conditions using LEWICE and the wind tunnel. Having consistency among the tests will make things more accurate. With respect to weather forecasting we will be able to learn which conditions can lead to icing. Better accuracy in weather reporting will lead to fewer run-ins with icing which will also lead to fewer accidents.

Miller, Eric James↗

Predictors of Rectal Tolerance Observed in a Dose-Escalated Phase 1-2 Trial of Stereotactic Body Radiation Therapy for Prostate Cancer

Purpose: To convey the occurrence of isolated cases of severe rectal toxicity at the highest dose level tested in 5-fraction stereotactic body radiation therapy (SBRT) for localized prostate cancer; and to rationally test potential causal mechanisms to guide future studies and experiments to aid in mitigating or altogether avoiding such severe bowel injury. Methods and Materials: Clinical and treatment planning data were analyzed from 91 patients enrolled from 2006 to 2011 on a dose-escalation (45, 47.5, and 50 Gy in 5 fractions) phase 1/2 clinical study of SBRT for localized prostate cancer. Results: At the highest dose level, 6.6% of patients treated (6 of 91) developed high-grade rectal toxicity, 5 of whom required colostomy. Grade 3+ delayed rectal toxicity was strongly correlated with volume of rectal wall receiving 50 Gy >3 cm{sup 3} (P<.0001), and treatment of >35% circumference of rectal wall to 39 Gy (P=.003). Grade 2+ acute rectal toxicity was significantly correlated with treatment of >50% circumference of rectal wall to 24 Gy (P=.010). Conclusion: Caution is advised when considering high-dose SBRT for treatment of tumors near bowel structures, including prostate cancer. Threshold dose constraints developed from physiologic principles are defined, and if respected can minimize risk of severe rectal toxicity.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

Icing Research Tunnel

The Icing Research Tunnel in Building 11 at the NASA Glenn Research Center is committed to researching the effects of in flight icing on aircraft and testing ways to stop the formation of hazardous icing conditions on planes. During this summer, I worked here with Richard DelRosa, the lead engineer for this area. address one of the major concerns of aviation: icing conditions. During the war, many planes crashed (especially supply planes going over the.Himalayas) because ice built up in their wings and clogged the engines. To this day, it remains the largest ice tunnel in the world, with a test section that measures 6 feet high, 9 feet long, and 20 feet wide. It can simulate airspeeds from 50 to 300 miles per hour at temperatures as low as -50 Fahrenheit. Using these capabilities, IRT can simulate actual conditions at high altitudes. The first thing I did was creating a cross reference in Microsoft Excel. It lists commands for the DPU units that control the pressure and temperature variations in the tunnel, as well as the type of command (keyboard, multiplier, divide, etc). The cross reference also contains the algorithm for every command, and which page it is listed in on the control sheet (visual Auto-CAD graphs, which I helped to make). I actually spent most of the time on the computer using Auto-CAD. I drew a diagram of the entire icing tunnel and then drew diagrams of its various parts. Between my mentor and me, we have drawings of every part of it, from the spray bars to the thermocouples, power cabinets, input-output connectors for power systems, and layouts of various other machines. I was also responsible for drawing schematics for the Escort system (which controls the spray bars), the power system, DPUs, and other electrical systems. In my spare time, I am attempting to build and program the "toddler". Toddler is a walking robot that I have to program in PBASIC language. When complete, it should be able to walk on level terrain while avoiding obstacles in real-time. It features an infrared detector that can keep it from falling over edges, as well as follow or avoid a light source. The toddler is giving me a much better understanding of the basics of electronic circuitry and computer programming.

Chennault, Jonathan↗

Systematic drug safety evaluation based on public genomic expression (Connectivity Map) data: Myocardial and infectious adverse reactions as application cases

Adverse drug reaction (ADR) is of great importance to both regulatory agencies and the pharmaceutical industry. Various techniques, such as quantitative structure–activity relationship (QSAR) and animal toxicology, are widely used to identify potential risks during the preclinical stage of drug development. Despite these efforts, drugs with safety liabilities can still pass through safety checkpoints and enter the market. This situation raises the concern that conventional chemical structure analysis and phenotypic screening are not sufficient to avoid all clinical adverse events. Genomic expression data following in vitro drug treatments characterize drug actions and thus have become widely used in drug repositioning. In the present study, we explored prediction of ADRs based on the drug-induced gene-expression profiles from cultured human cells in the Connectivity Map (CMap) database. The results showed that drugs inducing comparable ADRs generally lead to similar CMap expression profiles. Based on such ADR-gene expression association, we established prediction models for various ADRs, including severe myocardial and infectious events. Drugs with FDA boxed warnings of safety liability were effectively identified. We therefore suggest that drug-induced gene expression change, in combination with effective computational methods, may provide a new dimension of information to facilitate systematic drug safety evaluation. - Highlights: • Drugs causing common toxicity lead to similar in vitro gene expression changes. • We built a model to predict drug toxicity with drug-specific expression profiles. • Drugs with FDA black box warnings were effectively identified by our model. • In vitro assay can detect severe toxicity in the early stage of drug development.

60 APPLIED LIFE SCIENCES↗

The application of ALARP to legacy residues recovery processes on the Springfields site in the United Kingdom - 14333

In the United Kingdom, the legal framework for nuclear safety is established principally through the Health and Safety at Work Act 1974 (HSAW74) and the Nuclear Installations Act 1965 (NIA 65). Under HSAW74, employers are responsible for reducing risks, so far as is reasonably practicable, to their workers and others (including the public). This responsibility is elaborated further in relation to nuclear sites by NIA65, which establishes a nuclear site licensing regime whereby Nuclear Site Licenses are granted and subsequently regulated by the Office for Nuclear Regulation (ONR) within the Health and Safety Executive (HSE). In essence, ensuring that a risk has been reduced to 'As Low As Reasonably Practicable' (ALARP) is about weighing-up the risk against the sacrifice needed to reduce it. To avoid having to make this sacrifice, the Nuclear Site License holder (the Site Licensee) must be able to show that it would be grossly disproportionate to the benefits of risk reduction that would be achieved. Using 'reasonably practicable' allows the ONR to set goals for the Site Licensee, rather than being prescriptive. This flexibility can be a great advantage in that it allows the Site Licensee to consider a variety of options, and hence supports innovative approaches. However, it has drawbacks in that it requires both the Site Licensee and the regulators to exercise judgement; in reality, many decisions about risks and the measures that achieve ALARP are not straight-forward. Fortunately, various resources are available to the Site Licensee to aid these decisions. Three key facilities on the Westinghouse, Springfields Fuels Limited site at Preston in the UK (including the National Nuclear Laboratory's Preston Laboratory) undertake the clean-up of legacy residues from both fuel manufacturing operations on the site itself (dating back well over fifty years) and the wider nuclear industry. This paper discusses the key features of these three facilities to illustrate how ALARP considerations have shaped the operating regimes and associated criticality controls in those areas. (authors)

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗

Streamlining and Transparently Automating Complex Waste Determinations at Los Alamos National Laboratory - 17286

Environmental programs at Los Alamos National Laboratory (LANL) generate a large amount of sampling activities that can result in waste that needs to be characterized and properly disposed. Since 2011, sampling results are managed in the cloud-based Environmental Information Management (EIM) database, which contains over 16 million current and historical data records. In many cases, the database's analytical records are used to characterize and dispose waste from environmental operations. Three factors contribute to streamlining of the waste disposition operations: (1) if possible, use of the existing analytical data for waste characterization to avoid additional laboratory analysis; (2) reduction in time spent on data evaluation for various waste acceptance criteria; and (3) choice of the proper and least expensive disposal alternative. Use of the existing analytical data, when allowed by law, creates some paradoxical problems: when chemical analysis is requested with the purpose of characterizing waste, it creates only 100 to 400 analytical records. However, use of exiting analytical data at LANL may lead to evaluation of tens of thousands of analytical records, with many records for each single analyte. This occurs because data were collected for environmental characterization and not waste characterization. To streamline data analysis for waste disposition using existing data, LANL has created a Waste Data Summary (WDS) module in the site's EIM database. Recognizing that waste determination is performed by groups outside the environmental program at LANL, the WDS allows for logically guided data selection for a specific waste determination (solids, liquids, radiological, etc.) and reduces potentially thousands of rows of data into simple formatted data reports that are easy to comprehend and process. This allows the waste evaluators to review data using multiple approaches to make their own determination on the most appropriate disposal method. There are four basic principles of WDS operation: (1) The highest detected analytical result is evaluated for the selected samples (or the lowest undetected result if there are no detected results); (2) All approved disposal pathways are evaluated; (3) Any failures of the Waste Acceptance Criteria are visibly highlighted to focus the attention of the evaluator; and (4) The decision of the disposal path is left to the trained waste evaluator (WDS does not choose or suggest any disposal paths). The summary results are presented as the set of short data reports. These reports can be divided into two groups: general comparison reports and disposal pathway specific forms. The general comparison forms show all Resource Conservation and Recovery Act (RCRA) analytes with pass/fail evaluation and with preference for toxicity characteristic leaching procedure (TCLP) results (or 20x rule) for solid samples, the potential RCRA hazard codes assignment for detected analytes, and all rad results. The detected chemical and radioactivity results are compared to the background values and to Soil Screening and Soil Action limits (SSL/SAL limits). Disposal pathway specific forms follow Waste Acceptance Criteria requirements for all disposal pathways available at LANL. The programming of the WDS tries to maximize existing data by analyte substitutions (like using gross alpha for necessary alpha emitting isotopes) or by making calculations when analytical results do not agree with legal requirements (like total chlordane in the RCRA regulations, which is most often analyzed and reported as individual isomers). All forms may be annotated by the waste evaluator to provide additional information to support decision making. Upon final decision of a disposal path, the complete dataset used in the evaluation and the WDS forms with annotations is 'frozen' as an un-editable PDF export to document the data used in the waste disposal determination. The streamlined process results in less work for waste evaluators and reduces overall labor and analytical costs. By comparison, a full review of a 10,000 record parent dataset may take a waste evaluator over a week to review, whereas with the WDS module, the task can be accomplished in less than one hour with clear, reproducible results. These results can be reviewed and checked at any time by quality assurance personnel, thus ensuring transparency in the decision making process. LANL believes this approach has broad applicability to other sites where waste determination is based on review of existing data collected for more generalized environmental purposes. (authors)

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

Sensing and Sampling of Trace Contaminations by a Dexterous Hexrotor UAV at Nuclear Facilities - 18600

Safe and efficient cleanups are a priority for decontamination and decommissioning of nuclear facilities. The contaminations of byproducts and wastes in such nuclear facilities pose a serious problems while decommissioning, to both the operators and public. Sensing these contaminations and cleaning them is an essential part of the safety procedures. The contaminations might range from low-energy to high-energy byproducts. Sensing these byproducts would require contact based or non-contact based sensing, based on its energy levels. Byproducts such as americium, are low-energy which makes it difficult to sense and sample without contact. Therefore, the workers need to physically swab the surfaces to collect the samples of these contaminations. These tasks pose a great danger for the safety of the human workers which includes the risk to reach greater heights, exposure to the radiation and sampling the entire building. A robotic solution is much more desirable in these cases, where the worker can safely handle the contaminations from a safe area. Use of robotic technologies inside these hazardous environments ensures the safety and enhances the performance. The more suitable robotic solution for reaching great heights and covering large areas of nuclear facilities, are aerial vehicles. Multi-rotor unmanned aerial vehicle (UAV) are chosen for their ability to hover at a position and also fly around in confined spaces. Quadrotors are a common choice of multi-rotor UAVs both research and industry because of its ease to fly and commercial availability. For the applications during the cleanups we need the UAV to not only hover and fly in confined spaces, but also interact with the physical world. Despite of quadrotor's advantages, they are not a best suit as they can't interact with the physical world. The tasks involving physical interactions would require the UAV to apply arbitrary forces and torques in all six degrees of freedom (DOF). As quadrotors are under-actuated and non-holonomic in motion, they cannot exert all the required forces. At Collaborative Robotics Lab, Purdue University, we developed a novel multi-rotor UAV solution, Dexterous Hexrotor, which can exert arbitrary forces and torques in all six DOF, independently and instantaneously. This enables the UAV platform to quickly respond to the external disturbances and precisely hold its position during the mission. The Dexterous Hexrotor serves as a robotic tool for the workers to perform sensing and sampling during the cleanups. Workers can operate Dexterous Hexrotor manually and/or semi-autonomously with human intervention. Manual control requires the worker to fly the Dexterous Hexrotor using a remote control. So the workers should possess knowledge on flying the UAV and to perform physical interaction. A semiautonomous Dexterous Hexrotor requires human input to some extent and requires very less knowledge of flying. The autonomy is designed to operate in flight mode and sampling mode. In flight mode, Dexterous Hexrotor takes off from a 'safe' area, reaches the desired altitude, and fly autonomously towards a sampling point. This sampling point is the target position specified on the 2D reference map. This mode also includes navigation towards the sampling point, avoiding the obstacles in the constrained environment. After reaching a stopping point, Dexterous Hexrotor waits for the human input for a target location to swab and collect samples. The Dexterous Hexrotor is now in sampling mode and waits for the human input. The human operator selects the swabbing location through the live streaming video from onboard camera. Through visual servoing, aided by the map, the UAV will move closer towards the target position. It then transitions to the impact control scheme to perform physical interaction with the wall and collects samples. Once the sample is collected, it autonomously returns back to the takeoff position in 'safe' area for the analysis by mass spectrometry. In this paper, we majorly focus on the physical interaction strategy and the required components which enables the autonomy. Decommissioning of nuclear facilities requires decontamination inside the entire buildings. Decontamination of nuclear facilities involves sensing and sampling the huge buildings, long shafts, etc. Sampling the entire facility is not possible due to the limitation in Dexterous Hexrotor's flight time. But this can be achieved by using a swarm of Dexterous Hexrotors to cover larger areas. The onboard robotic arm can be designed based on the applications such as cleaning, applying sealants, etc. The modularity of the design allows us to switch components as per the requirements of the task. These kind of robotic solutions functioning as tools for the workers, aims to make the work environment safer and playful. (authors)

42 ENGINEERING↗

To Decommission or Not To Decommission? That is the Question... Revisited

Major Highlights Comparing 1998 to 2014: Favoring Plant Shutdown: Electric utility deregulation has created greater competition; Markets have been disrupted by cheap natural gas; Despite high availability, cost of electric power from natural gas still below break-even cost of nuclear generation; Emerging ISO acceptance of fluctuating renewable energy on the grid. Favoring DECON: D and D technologies have matured; Reactor Vessel and Internals segmentation methods still being refined; Nuclear workforce is 16 years older and leaving the nuclear industry (Impact on D and D TBD); Avoiding risk of more restrictive regulation and higher LLW disposal costs. Favoring SAFSTOR: Full funding of NDT still major driver for deferring immediate dismantlement. SAFSTOR vs. near term D and D influenced by: Status of and confidence in decommissioning fund (NDT) and cost estimate; Local and state politics; Public pressure. Most early shutdown plants tend to have under-funded decommissioning funds and opt for SAFSTOR. SAFSTOR allows for fund growth through interest compounding, but must assume that cost increase is less than fund growth: May not be true across the board, Much uncertainty/risk in waste disposal costs, regulatory requirements, etc. when projected out several decades. Once initiated SAFSTOR decision is not easily changed to DECON: Plant infrastructure equipment and components not readily available, RCS chemical decontamination can be very challenging, Key/knowledgeable plant personnel are gone. Consideration for phased approach to DECON: Remove >95% of the radiological source term under today's known regulations and cost by full System Decontamination of the primary circuit systems, and removal of NSSS and decontamination of the Containment Building; Improves risk profile in those areas most vulnerable to excessive cost growth; Able to defer D and D of the remainder of the plant to allow for the NDT to grow with interest.

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

Risk of Hippocampal Metastases in Small Cell Lung Cancer Patients at Presentation and After Cranial Irradiation: A Safety Profile Study for Hippocampal Sparing During Prophylactic or Therapeutic Cranial Irradiation

Purpose: Neurocognitive impairment (NI) in patients with small cell lung cancer (SCLC) after whole brain radiation treatment (WBRT) is a significant cause of morbidity. Hippocampal avoidance (HA) during WBRT may mitigate or prevent NI in such patients. However, this has not been tested in SCLC patients. The estimated risk of metastases in the HA region (HM) in patients with SCLC at diagnosis or after WBRT is unknown. Our study aimed to determine the risk of HM in patients with SCLC and to assess correlated clinical factors. Methods and Materials: Patients with SCLC who experienced brain metastases (BM) at presentation (de novo) or after WBRT treated at the Saskatoon Cancer Centre between 2005 and 2012 were studied. Relevant neuroimaging was independently reviewed by a neuroradiologist. HM was defined as metastases within 5 mm of the hippocampus. Logistic regression analysis was performed to assess correlation between various clinical variables and HM. Results: Seventy eligible patients were identified. Of 59 patients presenting with de novo BM, 3 patients (5%, 95% confidence interval [CI]: 0%-10.7%) had HM. Collectively there were 359 (range, 1-33) de novo BM with 3 (0.8%, 95% CI: 0%-1.7%) HM deposits. Twenty patients experienced progression of metastatic disease in the brain after WBRT. Of the 20 patients, only 1 patient (5%, 95% CI: 0%-14.5%) experienced HM. On logistic regression, no factors significantly correlated with HM. Conclusion: The overall incidence of HM before or after WBRT in SCLC patients is low, providing preliminary support for the safety of HA during planned clinical trials of HA-WBRT for SCLC.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

Brownfields to Brightfields: A Sustainability Initiative at DOE'S East Tennessee Technology Park Cleanup - 16120

As DOE works toward completing their cleanup mission at the East Tennessee Technology Park (ETTP), the ultimate goal is to return property no longer needed for government use to the community for beneficial re-use. The vision for ETTP is to transform the former gaseous diffusion facility into a commercial industrial park, leveraging the site's infrastructure to attract businesses to the site. While hundreds of acres at ETTP have been transferred for re-use, areas within the former production footprint of the site have future use restricted due to the presence of residual contamination, underground structures and utilities and/or physical features that limit their reuse potential. Brownfield redevelopment with solar energy generation has proven to be an excellent option for beneficial reuse and sustainability thanks to the flexible nature of solar photovoltaic technology and design that can address the restrictions and limitations of the site. Developing a solar project on a cleanup site can be challenging due to a large number of stakeholders and regulatory compliance issues of the environmental legacy at DOE cleanup sites; however, the challenges can be offset by the available infrastructure and low cost property. The requirement for large amounts of land or surface area is a major constraint to the growth of photovoltaic solar systems. An average solar generating facility requires 2 or more hectares (5 acres) for each megawatt (MW) of power generated. Re-using land that is otherwise un-developable provides a cost effective site for renewable energy generation to innovative solar developers. At ETTP, DOE's Oak Ridge Office of Environmental Management and the community reuse organization (Community Reuse Organization of East Tennessee - CROET) supported a local small business (Restoration Services, Inc. - RSI) familiar with the site and environmental regulations to secure a power purchase agreement with the regional electric provider (Tennessee Valley Authority - TVA) for a 1 MW utility-scale photovoltaic solar facility. The solar facility, Powerhouse Six, was developed through a commercial partnership (RSI and Vis Solis, Inc.) that worked closely with the lead ETTP site cleanup contractor (URS-CH2M Oak Ridge LLC - UCOR) and the local government. The selected site at ETTP had limitations on subsurface disturbance to 10 feet below ground surface because of utility ducts and residual contamination. Near surface relics (facility foundation remnants) were also found to prohibit ground penetration. A photovoltaic solar design using a ballasted ground mount system was developed to conform to the restrictions. The ballasted system could follow existing land contours, eliminating the need for any extensive site preparation and avoiding the risk of ground penetration. The lead cleanup contractor's role in facilitating the completion of this project included making the necessary environmental assessment documentation available to obtain the construction notice to proceed from the regional electric provider. They accelerated the transfer of ETTP power lines and electric demand to the city electric department to accommodate connection to the electric grid and supplied the communication connection required for metering the electric power generation. DOE's support along with their cleanup contractor's re-industrialization program and power integration group provided regular communication with the project stakeholders for more than six months to facilitate the early transfer of the utility infrastructure. Powerhouse Six sustainability benefits: - Generates enough clean energy to power more than 100 homes or prevents pollution equivalent to removing 240 cars from the road annually (1,141 metric tons of carbon dioxide); - Provides Brownfield reuse/redevelopment at ETTP; - Eliminates the generation of wastes through excavation and saves money to cleanup other areas for re-use; - Supports regional electric provider's renewable energy initiative; - Offers community economic development/ jobs and property tax income to the City of Oak Ridge; - Demonstrates benefit of ETTP re-industrialization; - Provides long-term lease payments to the community reuse organization; - Supports DOE renewable energy goals; - Demonstrates collaboration between DOE and a public utility for renewable energy development. (authors)

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

TH-CD-202-08: Feasibility Study of Planning Phase Optimization Using Patient Geometry-Driven Information for Better Dose Sparing of Organ at Risks

Purpose: To propose a simple and effective cost value function to search optimal planning phase (gating window) and demonstrated its feasibility for respiratory correlated radiation therapy. Methods: We acquired 4DCT of 10 phases for 10 lung patients who have tumor located near OARs such as esophagus, heart, and spinal cord (i.e., central lung cancer patients). A simplified mathematical optimization function was established by using overlap volume histogram (OVH) between the target and organ at risk (OAR) at each phase and the tolerance dose of selected OARs to achieve surrounding OARs dose-sparing. For all patients and all phases, delineation of the target volume and selected OARs (esophagus, heart, and spinal cord) was performed (by one observer to avoid inter-observer variation), then cost values were calculated for all phases. After the breathing phases were ranked according to cost value function, the relationship between score and dose distribution at highest and lowest cost value phases were evaluated by comparing the mean/max dose. Results: A simplified mathematical cost value function showed noticeable difference from phase to phase, implying it is possible to find optimal phases for gating window. The lowest cost value which may result in lower mean/max dose to OARs was distributed at various phases for all patients. The mean doses of the OARs significantly decreased about 10% with statistical significance for all 3 OARs at the phase with the lowest cost value. Also, the max doses of the OARs were decreased about 2∼5% at the phase with the lowest cost value compared to the phase with the highest cost value. Conclusion: It is demonstrated that optimal phases (in dose distribution perspective) for gating window could exist differently through each patient and the proposed cost value function can be a useful tool for determining such phases without performing dose optimization calculations. This research was supported by the Mid-career Researcher Program through NRF funded by the Ministry of Science, ICT & Future Planning of Korea (NRF-2014R1A2A1A10050270) and by the Radiation Technology R&D program through the National Research Foundation of Korea funded by the Ministry of Science, ICT & Future Planning (No. 2013M2A2A7038291)

60 APPLIED LIFE SCIENCES↗