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At least 667 records · Page 37
All sourcesNASA NTRSDOE OSTI
NASA NTRS2017

An Intercomparison of Changes Associated with Earth's Lower Tropospheric Temperature Using Traditional and AMIP-Style Reanalyses

Reanalyses have become an integral tool for evaluating regional and global climate variations, and an important component of this is modifications to the energy budget. Reductions in Arctic Sea ice extent has induced an albedo feedback, causing the Arctic to warm more rapidly than anywhere else in the world, referred to as "Arctic Amplification." This has been demonstrated by observations and numerous reanalyses, including the Modern Era Retrospective Analysis for Research and Applications, Version 2 (MERRA-2). However, the Arctic Amplification signal is non-existent in a ten member ensemble of the MERRA-2 Atmospheric Model Intercomparison Project (M2AMIP) simulations, using the same prescribed climate forcing, including Sea Surface Temperature (SST) and ice. An evaluation of the temperature tendency within the lower troposphere due to radiation, moisture, and dynamics as well as the surface energy budget in MERRA-2 and M2AMIP will demonstrate that despite identical prescribed SSTs and sea ice in both versions, enhanced warming in the Arctic in MERRA-2 is in response to the analysis increment tendency due to temperature observations. Furthermore, the role of boundary conditions, model biases and changes in observing systems on the Arctic Amplification signal will be assessed. Literature on the topic of Arctic Amplification demonstrates that the enhanced warming begins in the mid-1990s. Anomalously warm Arctic SST in the early time period of MERRA-2 can mute the trend in Arctic lower troposphere temperature without the constraint of observations in M2AMIP. Additionally, MERRA-2 uses three distinct datasets of SST and sea ice concentration, which also plays a role.

Arcti↗
NASA NTRS2019

Nonmodal Growth of TravelingWaves on Blunt Cones at Hypersonic Speeds

The existing database of transition measurements in hypersonic ground facilities has established that, as the nosetip bluntness is increased, the onset of boundary layer transition over a circular cone at zero angle of attack shifts downstream. However, this trend is reversed at sufficiently large values of the nose Reynolds number, so that the transition onset location eventually moves upstream with a further increase in nose-tip bluntness. Because modal amplification is too weak to initiate transition at moderate-to-large bluntness values, nonmodal growth has been investigated as the potential basis for a physics-based model for the frustum transition. The present analysis investigates the nonmodal growth of traveling disturbances initiated within the nose-tip vicinity that peak within the entropy layer. Results show that, with increasing nose bluntness, both planar and oblique traveling disturbances experience appreciable energy amplification up to successively higher frequencies. For moderately blunt cones, the initial nonmmodal growth is followed by a partial decay that is more than overcome by an eventual, modal growth as Mack-mode waves. For larger bluntness values, the Mack-mode waves are not amplified anywhere upstream of the experimentally measured transition location, but the traveling modes still undergo a significant amount of nonmodal growth. This finding does not provide a definitive link between optimal growth and the onset of transition, but it is qualitatively consistent with the experimental observations that frustum transition in the absence of sufficient Mack-mode amplification implies a double peak in disturbance amplification and the appearance of transitional events above the boundary-layer edge.

Hypersonic speed↗
DOE OSTI2015

THEORETICAL INVESTIGATION OF COHERENT SYNCHROTRON RADIATION INDUCED MICROBUNCHING INSTABILITY IN TRANSPORT AND RECIRCULATION ARCS

The coherent synchrotron radiation (CSR) of a high brightness electron beam traversing a series of dipoles, such as recirculation or transport arcs, may lead to the microbunching instability. We extend and develop a semi-analytical approach of the CSR-induced microbunching instability for a general lattice, based on the previous formulation with 1-D CSR model [Phys. Rev. ST Accel. Beams 5, 064401 (2002)] and apply it to investigate the physical processes of microbunching amplification for two example transport arc lattices. We find that the microbunching instability in transport arcs has a distinguishing feature of multistage amplification (e.g, up to 6th stage for our example arcs in contrast to two stage amplification for a 3-dipole chicane). By further extending the concept of stage gain as proposed by Huang and Kim [Phys. Rev. ST Accel. Beams 5, 074401 (2002)], we developed a method to quantitatively characterize the microbunching amplification in terms of iterative or staged orders that allows the comparison of optics impacts on microbunching gain for different lattices. The parametric dependencies and Landau damping for our example lattices are also studied. Excellent agreement of the gain functions and spectra from Vlasov analysis with results from ELEGANT is achieved which helps to validate our analyses.

Tsai, C. -Y.↗
DOE OSTI2015

Multistage CSR Microbunching Gain Development in Transport or Recirculation Arcs

Coherent synchrotron radiation (CSR) induced microbunching instability has been one of the most challenging issues in the design of modern accelerators. A linear Vlasov solver has been developed [1] and applied to investigate the physical processes of microbunching gain amplification for several example lattices [2]. In this paper, by further extending the concept of stage gain as proposed by Huang and Kim [3], we develop a method to characterize the microbunching development in terms of stage orders that allow the quantitative comparison of optics impacts on microbunching gain for different lattices. We find that the microbunching instability in our demonstrated arcs has a distinguishing feature of multistage amplification (e.g, up to 6th stage amplification for our example transport arcs, in contrast to two-stage amplification for a typical 4-dipole bunch compressor chicane). We also try to connect lattice optics pattern with the obtained stage gain functions by a physical interpretation. This Vlasov analysis is validated by ELEGANT [4] tracking results with excellent agreement.

Tsai, C. -Y.↗
DOE OSTI2022

DenKv: Addressing Design Trade-offs of Key-value Stores for Scientific Applications

High-performance computing (HPC) facilities have employed flash-based storage tier near to compute nodes to absorb high I/O demand by HPC applications during periodic system-level checkpoints. To accelerate these checkpoints, proxy-based distributed key-value stores (PD-KVS) gained particular attention for their flexibility to support multiple backends and different network configurations. PD-KVS rely internally on monolithic KVS, such as LevelDB or RocksDB, to exploit the KV interface and query support. However, PD-KVS are unaware of the high redundancy factor in checkpoint data, which can be up to GBs to TBs, and therefore, tend to generate high write and space amplification on these storage layers. In this paper, we propose DenKv which is deduplication-extended node-local LSM-tree-based KVS. DenKv employs asynchronous partially inline dedup (APID) and aims to maintain the performance characteristics of LSM-tree-based KVS while reducing the write and space amplification problems. We implemented DenKv atop BlobDB and showed that our proposed solution maintains performance while reducing write amplification up to 2× and space amplification by 4× on average.

Khan, Awais↗
DOE OSTI2018

Characterization of Novel and Efficient Poly-3-hydroxybutyrate (PHB) Producing Bacteria Isolated from Rhizospheric Soils

Polyhydroxybutyrate (PHB) is an eco-friendly, biodegradable plastic which exhibits properties very similar to the conventional plastic, thus, having high potential for replacing non-degradable conventional polypropylene plastic that is responsible for several environmental problems at global level. The present study focuses on the isolation and characterization of potential novel PHB producers. A total of 194 PHB producing bacteria were isolated from rhizospheric soils of three different crops; and subjected to microscopic, biochemical and molecular characterization studies. Quantification of PHB production exhibited significant amount of PHB accumulation (120–132 mg/ml) by a few isolates (KW-4, MS-6, RoW-1, AW-1 and RoS-4). Fourier transform infrared spectroscopy (FTIR) analysis of PHB extracted from the isolates was found to be comparable to the spectra of standard PHB, thus, establishing the chemical nature of the extracted polymer. Detection of PHB granules by transmission electron microscopy (TEM) confirmed the isolates to be efficient PHB producers. For molecular characterization of the isolates, phbC gene amplification studies were undertaken, which resulted into an amplification product of 1089 bp, representing the complete PHB synthase gene. Using 16S rRNA gene amplification and sequencing, the selected isolates were identified as belonging to four major genera, viz., Bacillus, Lysinibacillus, Clostridium and Klebsiella; however, Bacillus being the predominant genera. Analysis of 16S rDNA sequences showed that a few isolates exhibited significant differences from their nearest neighbours (similarity level ranging between 93 and 99%), thus, strongly suggesting that they might represent novel strains. Some of these probable novel high PHB producers reported in the present study hold high potential to be exploited for further industrial-scale mass production of biodegradable polymer.

36 MATERIALS SCIENCE↗
DOE OSTI2019

Two-frequency laser with distributed feedback formed by a space charge wave

The regimes of amplification and generation of optical TE waves arising on a grating formed by a space charge wave (SCW) in a plane optical waveguide based on an n-GaAs semiconductor are considered. For the perturbed n-GaAs waveguide, the reflectance and transmittance of TE modes with the same indices (m = n = 0) are calculated depending on the pump level and length of interaction between the optical and SCWs. It is shown that even with a relatively small depth of modulation of the dielectric constant (Δε≈10{sup −5}) under conditions of high optical pumping (with an amplification factor γ≈150 cm{sup −1}) and corresponding SCW-optical interaction length, there is a possibility of not only amplification, but also generation of forward and backward optical modes at a wavelength of 10.6 μm. The results can be used to create tunable semiconductor laser generators based on the SCW-optical interaction and operating in the near and mid-IR range.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗
DOE OSTI2017

Development of a highly specific HER2 monoclonal antibody for immunohistochemistry using protein microarray chips

HER2 is an orphan receptor tyrosine kinase of the EGFR families and is considered to be a key tumor driver gene [1]. Breast cancer and gastric cancer with HER2 amplification can be effectively treated by its neutralizing antibody, Herceptin. In clinic, Immunohistochemistry (IHC) was used as the primary screening method to diagnose HER2 amplification [2]. However, recent evidence suggested that the frequently used rabbit HER2 antibody 4B5 cross reacted with another family member HER4 [3]. IHC staining with 4B5 also indicated that there was strong non-specific cytoplasmic and nuclear signals in normal gastric mucosal cells and some gastric cancer samples. Using a protein lysate array which covers 85% of the human proteome, we have confirmed that the 4B5 bound to HER4 and a nuclear protein ZSCAN18 besides HER2. The non-specific binding accounts for the unexpected cytoplasmic and nuclear staining of 4B5 of normal gastric epithelium. Finally, we have developed a novel mouse HER2 monoclonal antibody UMAB36 with similar sensitivity to 4B5 but only reacted to HER2 across the 17,000 proteins on the protein chip. In 129 breast cancer and 158 gastric cancer samples, UMAB36 showed 100% sensitivity and specificity comparing to the HER2 FISH reference results with no unspecific staining in the gastric mucosa layer. Therefore, UMAB36 could provide as an alternative highly specific IHC reagent for testing HER2 amplification in gastric cancer populations. - Highlights: • HER2 antibody 4B5 cross-interacts with HER4 and ZSCAN18, which would interfere with the accuracy of IHC diagnosis of HER2. • A HER2 antibody UMAB36 has been developed with high sensitivity and specificity and can be utilized in HER2 diagnosis. • Protein lysate array is a novel strategy to screen for highly specific antibody.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2016

Ion Accumulation and Migration Effects on Redox Cycling in Nanopore Electrode Arrays at Low Ionic Strength

Ion permselectivity can lead to accumulation in zero-dimensional nanopores, producing a significant increase in ion concentration, an effect which may be combined with unscreened ion migration to improve sensitivity in electrochemical measurements, as demonstrated by the enormous current amplification (~2000-fold) previously observed in nanopore electrode arrays (NEA) in the absence of supporting electrolyte. Ionic strength is a key experimental factor that governs the magnitude of the additional current amplification (AF ad ) beyond simple redox cycling through both ion accumulation and ion migration effects. Here, separate contributions from ion accumulation and ion migration to the overall AF ad were identified by studying NEAs with varying geometries, with larger AF ad values being achieved in NEAs with smaller pores. In addition, larger AF ad values were observed for Ru(NH 3 ) 6 3/2+ than for ferrocenium/ferrocene (Fc + /Fc) in aqueous solution, indicating that coupling efficiency in redox cycling can significantly affect AF ad . While charged species are required to observe migration effects or ion accumulation, poising the top electrode at an oxidizing potential converts neutral species to cations, which can then exhibit current amplification similar to starting with the cation. The electrical double layer effect was also demonstrated for Fc/Fc + in acetonitrile and 1,2-dichloroethane, producing AF ad up to 100× at low ionic strength. The pronounced AF ad effects demonstrate the advantage of coupling redox cycling with ion accumulation and migration effects for ultrasensitive electrochemical measurements.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
DOE OSTI2013

Spectral characteristics of ultra-short laser pulses in plasma amplifiers

Amplification of laser pulses based on the backscattering process in plasmas can be performed using either the response of an electron plasma wave or an ion-acoustic wave. However, if the pulse durations become very short and the natural spread in frequency a substantial amount of the frequency itself, the Raman and Brillouin processes start to mix. Kinetic simulations show the transition from a pure amplification regime, in this case strong-coupling Brillouin, to a regime where a considerable downshift of the frequency of the amplified pulse takes place. It is conjectured that in the case of very short pulses, multi-modes are excited which contribute to the amplification process.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗
DOE OSTI2015

Earthquake response of storey building in Jakarta using accelerographs data analysis

As seismotectonic, the Jakarta city will be greatly affected by the earthquake which originated from the subduction zone of the Sunda Strait and south of Java. Some occurrences of earthquakes in these location are often perceived by the occupants in the upper floors of multi-storey buildings in Jakarta but was not perceived by the occupants on the ground floor. The case shows the difference in ground-motion parameters on each floor height. The analysis of the earthquake data recorded by accelerographs on different floors need to be done to know the differences in ground-motion parameters. Data used in this research is accelerograph data installed on several floors in the main building of Meteorology Climatology and Geophysics Agency with a case study of Kebumen earthquake on January 25{sup th} 2014. Parameters analyzed include the Peak Ground Acceleration (PGA), Peak Ground Displacement (PGD), Peak Spectral Acceleration (PSA), Amplification (Ag), and the Effective Duration of earthquake (t{sub e}). Research stages include accelerographs data acquisition in three (3) different floors, conversion and data partition for each component, conversion to units of acceleration, determination of PGA, PGD, PSA, Ag and t{sub e} as well as data analysis. The study shows the value of PGA on the ground floor, 7{sup th} floor and 15{sup th} floors, respectively are 0.016 g, 0.053 g and 0.116 g. PGD on the ground floor, 7{sup th} floor and 15{sup th} floor respectively are 2.15 cm, 2.98 cm and 4.92 cm. PSA on the ground floor, 7{sup th} floor and 15{sup th} floor respectively are 0.067 g, 0.308 g and 0.836 g. Amplification of the peak acceleration value on the ground floor, 7{sup th} floor and 15{sup th} floor to the surface rock are 4.37, 6.07 and 7.30. Effective duration of the earthquake on the ground floor, 7{sup th} floor and 15{sup th} floor respectively are 222.28 s, 202.28 s and 91.58 s. In general, with increasing floor of the building, the value of the peak ground acceleration, peak ground displacement, peak spectral acceleration and amplification growing, contrary to the value of the effective duration of earthquake decreases. The difference in this parameter is strongly influenced by local soil conditions and building construction.

58 GEOSCIENCES↗
DOE OSTI2015

Single trap in liquid gated nanowire FETs: Capture time behavior as a function of current

The basic reason for enhanced electron capture time, τ{sub c}, of the oxide single trap dependence on drain current in the linear operation regime of p{sup +}-p-p{sup +} silicon field effect transistors (FETs) was established, using a quantum-mechanical approach. A strong increase of τ{sub c} slope dependence on channel current is explained using quantization and tunneling concepts in terms of strong field dependence of the oxide layer single trap effective cross-section, which can be described by an amplification factor. Physical interpretation of this parameter deals with the amplification of the electron cross-section determined by both decreasing the critical field influence as a result of the minority carrier depletion and the potential barrier growth for electron capture. For the NW channel of n{sup +}-p-n{sup +} FETs, the experimentally observed slope of τ{sub c} equals (−1). On the contrary, for the case of p{sup +}-p-p{sup +} Si FETs in the accumulation regime, the experimentally observed slope of τ{sub c} equals (−2.8). It can be achieved when the amplification factor is about 12. Extraordinary high capture time slope values versus current are explained by the effective capture cross-section growth with decreasing electron concentration close to the nanowire-oxide interface.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗
DOE OSTI2015

Multilayer-graphene-based amplifier of surface acoustic waves

The amplification of surface acoustic waves (SAWs) by a multilayer graphene (MLG)-based amplifier is studied. The conductivity of massless carriers (electrons or holes) in graphene in an external drift electric field is calculated using Boltzmann’s equation. At some carrier drift velocities, the real part of the variable conductivity becomes negative and MLG can be employed in SAW amplifiers. Amplification of Blustein’s and Rayleigh’s SAWs in CdS, a piezoelectric hexagonal crystal of the symmetry group C{sub 6v}, is considered. The corresponding equations for SAW propagation in the device are derived and can be applied to other substrate crystals of the same symmetry. The results of the paper indicate that MLG can be considered as a perspective material for SAW amplification and related applications.

36 MATERIALS SCIENCE↗
DOE OSTI2016

Single laser pulse compression via strongly coupled stimulated Brillouin scattering in plasma

Laser amplification in plasma, including stimulated Raman scattering amplification and strongly coupled stimulated Brillouin scattering (sc-SBS) amplification, is very promising to generate ultrahigh-power and ultrashort laser pulses. But both are quite complex in experiments: at least three different laser pulses must be prepared; temporal delay and spatial overlap of these three pulses are difficult. We propose a single pulse compression scheme based on sc-SBS in plasma. Only one moderately long laser is applied, the front part of which ionizes the gas to produced plasma, and gets reflected by a plasma mirror at the end of the gas channel. The reflected front quickly depletes the remaining part of the laser by sc-SBS in the self-similar regime. The output laser is much stronger and shorter. This scheme is at first considered theoretically, then validated by using 1D PIC simulations.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗
DOE OSTI2014

Stretchers and compressors for ultra-high power laser systems

This review is concerned with pulse stretchers and compressors as key components of ultra-high power laser facilities that take advantage of chirped-pulse amplification. The potentialities, characteristics, configurations and methods for the matching and alignment of these devices are examined, with particular attention to the history of the optics of ultra-short, ultra-intense pulses before and after 1985, when the chirped-pulse amplification method was proposed, which drastically changed the view of the feasibility of creating ultra-high power laser sources. The review is intended primarily for young scientists and experts who begin to address the amplification and compression of chirped pulses, experts in laser optics and all who are interested in scientific achievements in the field of ultra-high power laser systems. (review)

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗
DOE OSTI2017

Parametric interaction of optical waves in metamaterials under low-frequency pumping

The influence of phase effects under three-wave parametric interaction and low-frequency pumping in metamaterials is studied in the case of a negative refractive index at a signal-wave frequency. It is found that the efficiency of the backward signal-wave amplification is the higher, the greater the ratio of the intensities of the idler and signal waves at the input to the metamaterial. An increase in the idler wave intensity at the input by five times, as compared to the signal-wave intensity, leads to a nonlinear increase in the signal-wave amplification by almost 20 times. According to the analytic expressions obtained in the constant-intensity approximation, the choice of the optimal parameters for the pump intensity, total length of the metamaterial and phase detuning will facilitate the implementation of regimes of effective amplification and generation of the signal wave. A comparison is made with the results obtained in the constant-field approximation, and a numerical estimate of the expected efficiency of the frequency conversion is presented. Control of frequency and pump power is shown to make possible the smooth tuning of the parametric converter frequency. The developed method can be used to design frequency converters based on nonlinear metamaterials.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗
DOE OSTI2018

Accelerating pathway evolution by increasing the gene dosage of chromosomal segments

Experimental evolution is a critical tool in many disciplines, including metabolic engineering and synthetic biology. However, current methods rely on the chance occurrence of a key step that can dramatically accelerate evolution in natural systems, namely increased gene dosage. Our studies sought to induce the targeted amplification of chromosomal segments to facilitate rapid evolution. Since increased gene dosage confers novel phenotypes and genetic redundancy, we developed a method, Evolution by Amplification and Synthetic Biology (EASy), to create tandem arrays of chromosomal regions. In Acinetobacter baylyi , EASy was demonstrated on an important bioenergy problem, the catabolism of lignin-derived aromatic compounds. The initial focus on guaiacol (2-methoxyphenol), a common lignin degradation product, led to the discovery of Amycolatopsis genes ( gcoAB ) encoding a cytochrome P450 enzyme that converts guaiacol to catechol. However, chromosomal integration of gcoAB in Pseudomonas putida or A. baylyi did not enable guaiacol to be used as the sole carbon source despite catechol being a growth substrate. We report in ~1,000 generations, EASy yielded alleles that in single chromosomal copy confer growth on guaiacol. Different variants emerged, including fusions between GcoA and CatA (catechol 1,2-dioxygenase). This study illustrates the power of harnessing chromosomal gene amplification to accelerate the evolution of desirable traits.

09 BIOMASS FUELS↗
DOE OSTI2025

Increased frequency of planetary wave resonance events over the past half-century

We demonstrate a tripling in the frequency of planetary wave resonance events over the past halfcentury, coinciding with the rise in persistent boreal summer weather extremes. This increase aligns with changes in the underlying climate conditions favoring these events, including amplified Arctic warming and land-sea thermal contrast. We also observe increased prevalence of resonant amplification events following the mature phase of strong El Niño events, suggesting that such events may precondition the mean state conditions in ways that favor large-scale quasi-stationary wave patterns and quasi-resonant wave amplification. Since the impact of anthropogenic warming on quasi-resonant amplification is not well captured by current-generation climate models, it is likely that models are underpredicting the potential increase, indicating even greater risk of persistent extreme summer weather events with ongoing warming.

Arctic amplification↗