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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 667 records · Page 37
All sourcesNASA NTRSDOE OSTI
NASA NTRS1992

Numerical analysis of turbine blade tip treatments

Three-dimensional solutions of the Navier-Stokes equations for a turbine blade with a turning angle of 180 degrees have been computed, including blade tip treatments involving cavities. The geometry approximates a preliminary design for the GGOT (Generic Gas Oxidizer Turbine). The data presented here will be compared with experimental data to be obtained from a linear cascade using original GGOT blades. Results have been computed for a blade with 1 percent clearance, based on chord, and three different cavity sizes. All tests were conducted at a Reynolds number of 4 x 10 exp 7. The grid contains 39,440 points with 10 spanwise planes in the tip clearance region of 5.008E-04 m. Streamline plots and velocity vectors together with velocity divergence plots reveal the general flow behavior in the clearance region. Blade tip temperature calculations suggest placement of a cavity close to the upstream side of the blade tip for reduction of overall blade tip temperature. The solutions do not account for the relative motion between the endwall and the turbine blade. The solutions obtained are generally consistent with previous work done in this area,

Gopalaswamy, Nath S.↗
NASA NTRS1991

A PC-based inverse design method for radial and mixed flow turbomachinery

An Inverse Design Method suitable for radial and mixed flow turbomachinery is presented. The codes are based on the streamline curvature concept; therefore, it is applicable for current personal computers from the 286/287 range. In addition to the imposed aerodynamic constraints, mechanical constraints are imposed during the design process to ensure that the resulting geometry satisfies production consideration and that structural considerations are taken into account. By the use of Bezier Curves in the geometric modeling, the same subroutine is used to prepare input for both aero and structural files since it is important to ensure that the geometric data is identical to both structural analysis and production. To illustrate the method, a mixed flow turbine design is shown.

Skoe, Ivar Helge↗
NASA NTRS1990

Correlation of boundary layer stability analysis with flight transition data

Recently, NASA completed a boundary-layer transition flight test on an F-14 aircraft which has variable-sweep capability. Transition data were acquired for a wide variety of sweep angles, pressure distributions, Mach numbers, and Reynolds numbers. In this paper, the F-14 flight test is briefly described and N-factor correlations with measured transition locations are presented for one of two gloves flown on the F-14 wing in the flight program; a thin foam and fiberglass glove which provided a smooth sailplane finish on the basic F-14, modified NACA 6-series airfoil. For these correlations, an improved linear boundary-layer stability theory was utilized that accounts for compressibility and surface and streamline curvature effects for the flow past swept wings.

Collier, F. S., Jr.↗
NASA NTRSDate not supplied

Simulation and Modeling of Hypersonic Turbulent Boundary Layers Subject to Adverse Pressure Gradients due to Concave Streamline Curvature

Direct numerical simulations (DNS) of adverse-pressure-gradient turbulent boundary layers over a planar concave wall are presented for a nominal freestream Mach number of 5, with the objective of assessing the limitations of the currently available Reynolds-averaged Navier-Stokes (RANS) models. The wall geometry and flow conditions of the DNS are representative of the experimental data for a Mach 4.9 turbulent boundary layer that was tested on a two-dimensional planar concave wall model in the high-speed blow-down wind tunnel located at the National Aerothermochemistry Laboratory at Texas A&M University (TAMU). The DNS was validated against the experimental results of TAMU for the same flow conditions and wall geometry. An analysis of the DNS datasets was also conducted to provide an assessment of the validity of Morkovin’s hypothesis and the strong Reynolds analog for turbulence subject to mechanical nonequilibrium. In addition to the DNS results, RANS predictions are obtained by using the Baldwin-Lomax (BL), Spalart-Allmaras (SA), and the k - w SST turbulence models. The comparisons between RANS and DNS showed little impact of an adverse pressure gradient on the accuracy of these models, at least up to an incompressible Clauser pressure gradient parameter of beta(sub inc) 1.22. While the Boussinesq assumption provided reasonable predictions for the Reynolds shear stress, it failed to adequately predict the normal components of the Reynolds stress.

turbulent boundary layers↗
NASA NTRS2017

Using the General Mission Analysis Tool (GMAT)

This is a software tutorial and presentation demonstrating the application of the General Mission Analysis Tool (GMAT). These slides will be used to accompany the demonstration. The demonstration discusses GMAT basics, then presents a detailed example of GMAT application to the Transiting Exoplanet Survey Satellite (TESS) mission. This talk is a combination of existing presentations and material; system user guide and technical documentation; a GMAT basics and overview, and technical presentations from the TESS projects on their application of GMAT to critical mission design. The GMAT basics slides are taken from the open source training material. The TESS slides are a streamlined version of the CDR package provided by the project with SBU and ITAR data removed by the TESS project. Slides for navigation and optimal control are borrowed from system documentation and training material.

trajectory↗
DOE OSTI2024

Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL

Overexpression of BCL-xL and BCL-2 play key roles in tumorigenesis and cancer drug resistance. Advances in PROTAC technology facilitated recent development of the first BCL-xL/BCL-2 dual degrader, 753b, a VHL-based degrader with improved potency and reduced toxicity compared to previous small molecule inhibitors. Here, we determine crystal structures of VHL/753b/BCL-xL and VHL/753b/BCL-2 ternary complexes. The two ternary complexes exhibit markedly different architectures that are accompanied by distinct networks of interactions at the VHL/753b-linker/target interfaces. The importance of these interfacial contacts is validated via functional analysis and informed subsequent rational and structure-guided design focused on the 753b linker and BCL-2/BCL-xL warhead. This results in the design of a degrader, WH244, with enhanced potency to degrade BCL-xL/BCL-2 in cells. Using biophysical assays followed by in cell activities, we are able to explain the enhanced target degradation of BCL-xL/BCL-2 in cells. Most PROTACs are empirically designed and lack structural studies, making it challenging to understand their modes of action and specificity. Our work presents a streamlined approach that combines rational design and structure-based insights backed with cell-based studies to develop effective PROTAC-based cancer therapeutics.

59 BASIC BIOLOGICAL SCIENCES↗
NASA NTRS2000

Forced Boundary-Layer Transition on X-43 (Hyper-X) in NASA LaRC 20-Inch Mach 6 Air Tunnel

Aeroheating and boundary layer transition characteristics for the X-43 (Hyper-X) configuration have been experimentally examined in the Langley 20-Inch Mach 6 Air Tunnel. Global surface heat transfer distributions, and surface streamline patterns were measured on a 0.333-scale model of the Hyper-X forebody. Parametric variations include angles-of-attack of 0-deg, 2-deg, and 4-deg; Reynolds numbers based on model length of 1.2 to 15.4 million; and inlet cowl door both open and closed. The effects of discrete roughness elements on the forebody boundary layer, which included variations in trip configuration and height, were investigated. This document is intended to serve as a release of preliminary data to the Hyper-X program; analysis is limited to observations of the experimental trends in order to expedite dissemination.

Berry, Scott A.↗
NASA NTRS1992

Navier-Stokes analysis and experimental data comparison of compressible flow within ducts

Many aircraft employ ducts with centerline curvature or changing cross-sectional shape to join the engine with inlet and exhaust components. S-ducts convey air to the engine compressor from the intake and often decelerate the flow to achieve an acceptable Mach number at the engine compressor by increasing the cross-sectional area downstream. Circular-to-rectangular transition ducts are used on aircraft with rectangular exhaust nozzles to connect the engine and nozzle. To achieve maximum engine performance, the ducts should minimize flow total pressure loss and total pressure distortion at the duct exit. Changes in the curvature of the duct centerline or the duct cross-sectional shape give rise to streamline curvature which causes cross stream pressure gradients. Secondary flows can be caused by deflection of the transverse vorticity component of the boundary layer. This vortex tilting results in counter-rotating vortices. Additionally, the adverse streamwise pressure gradient caused by increasing cross-sectional area can lead to flow separation. Vortex pairs have been observed in the exit planes of both duct types. These vortices are due to secondary flows induced by pressure gradients resulting from streamline curvature. Regions of low total pressure are produced when the vortices convect boundary layer fluid into the main flow. The purpose of the present study is to predict the measured flow field in a diffusing S-duct and a circular-to-rectangular transition duct with a full Navier-Stokes computer program, PARC3D, and to compare the numerical predictions with new detailed experimental measurements. The work was undertaken to extend previous studies and to provide additional CFD validation data needed to help model flows with strong secondary flow and boundary layer separation. The S-duct computation extends the study of Smith et al, and Harloff et al, which concluded that the computation might be improved by using a finer grid and more advanced turbulence models. The present study compares results for both the Baldwin-Lomas and k-epsilon turbulence models and is conducted with a refined grid. For the transition duct, two inlet conditions were considered, the first with straight flow and the second with swirling flow. The first case permits examination of the effects of the geometric transition on the flow field, while the second case includes the rotational flow effect characteristic of a gas turbine engine.

Harloff, G. J.↗
NASA NTRS1995

Dynamics of the Antarctic Circumpolar Current. Evidence for Topographic Effects from Altimeter Data and Numerical Model Output

Geosat altimeter data and numerical model output are used to examine the circulation and dynamics of the Antarctic Circumpolar Current (ACC). The mean sea surface height across the ACC has been reconstructed from height variability measured by the altimeter, without assuming prior knowledge of the geoid. The results indicate locations for the Subantarctic and Polar Fronts which are consistent with in situ observations and indicate that the fronts are substantially steered by bathymetry. Detailed examination of spatial and temporal variability indicates a spatial decorrelation scale of 85 km and a temporal e-folding scale of 34 days. Empirical Orthogonal Function analysis suggests that the scales of motion are relatively short, occuring on 1000 km length-scales rather than basin or global scales. The momentum balance of the ACC has been investigated using output from the high resolution primitive equation model in combination with altimeter data. In the Semtner-Chervin quarter-degree general circulation model topographic form stress is the dominant process balancing the surface wind forcing. In stream coordinates, the dominant effect transporting momentum across the ACC is bibarmonic friction. Potential vorticity is considered on Montgomery streamlines in the model output and along surface streamlines in model and altimeter data. (AN)

Gille, Sarah T.↗
DOE OSTI2026

Production and Evaluation of Fluorophore-Doped Polymer Substrates to Screen for Plastic-Degrading Enzymes

Fast and sensitive analytical methods are the key to efficient screening of plastic-degrading enzymes. Here, we present a streamlined and affordable approach to assess the enzymatic deconstruction of insoluble synthetic polymers by blending them with a fluorescent dye, rhodamine 6G, and we evaluate this screening method using poly(ethylene terephthalate) (PET) as a model material. Our results indicate that enzymatic depolymerization of the rhodamine-doped PET can be observed in a high-throughput fashion by following release of the fluorophore. The fluorescence data obtained during the hydrolysis of rhodamine-doped PET by 14 PET hydrolases, produced with a robotic platform, correlated with the quantitative chromatographic analysis of PET degradation products. Remarkably, the use of the rhodamine-loaded PET substrate resulted in negligibly low background signals even when detecting PETase activity in crude cell lysates, suggesting suitability for screening of a wide variety of samples. Encouraged by these results, we next produced a selection of polyethylene- and nylon-based materials loaded with rhodamine 6G. While rapid leaching of fluorophore observed with nylon substrates limits the utility of the method for detecting nylonase activity, the rhodamine-loaded polyethylene showed promising performance in passive diffusion tests, indicating that this latter substrate may be used to screen for polyolefin-degrading enzymes.

09 BIOMASS FUELS↗
DOE OSTI2025

NGPINT V3: a containerized orchestration Python software for discovery of next-generation protein–protein interactions

Abstract Summary Batch yeast two-hybrid (Y2H) assays, leveraged with next-generation sequencing, have afforded successful innovations for the analysis of protein–protein interactions. NGPINT is a Conda-based software designed to process the millions of raw sequencing reads resulting from Y2H–next-generation interaction screens. Over time, increasing compatibility and dependency issues have prevented clean NGPINT installation and operation. A system-wide update was essential to continue effective use with its companion software, Y2H-SCORES. We present NGPINT V3, a containerized implementation built with both Singularity and Docker, allowing accessibility across virtually any operating system and computing environment. Availability and implementation This update includes streamlined dependencies and container images hosted on Sylabs (https://cloud.sylabs.io/library/schuyler/ngpint/ngpint) and Dockerhub (https://hub.docker.com/r/schuylerds/ngpint), facilitating easier adoption and integration into high-throughput and cloud-computing workflows. Full instructions and software can be also found in the GitHub repository https://github.com/Wiselab2/NGPINT_V3 and Zenodo https://doi.org/10.5281/zenodo.15256036.

Biochemistry & Molecular Biology↗
DOE OSTI2013

Real Time Assays for Quantifying Cytotoxicity with Single Cell Resolution

A new live cell-based assay platform has been developed for the determination of complement dependent cytotoxicity (CDC), antibody dependent cellular cytotoxicity (ADCC), and overall cytotoxicity in human whole blood. In these assays, the targeted tumor cell populations are first labeled with fluorescent Cell Tracker dyes and immobilized using a DNA-based adhesion technique. This allows the facile generation of live cell arrays that are arranged arbitrarily or in ordered rectilinear patterns. Following the addition of antibodies in combination with serum, PBMCs, or whole blood, cell death within the targeted population can be assessed by the addition of propidium iodide (PI) as a viability probe. The array is then analyzed with an automated microscopic imager. The extent of cytotoxicity can be quantified accurately by comparing the number of surviving target cells to the number of dead cells labeled with both Cell Tracker and PI. Excellent batch-to-batch reproducibility has been achieved using this method. In addition to allowing cytotoxicity analysis to be conducted in real time on a single cell basis, this new assay overcomes the need for hazardous radiochemicals. Fluorescently-labeled antibodies can be used to identify individual cells that bear the targeted receptors, but yet resist the CDC and ADCC mechanisms. This new approach also allows the use of whole blood in cytotoxicity assays, providing an assessment of antibody efficacy in a highly relevant biological mixture. Given the rapid development of new antibody-based therapeutic agents, this convenient assay platform is well-poised to streamline the drug discovery process significantly.

59 BASIC BIOLOGICAL SCIENCES↗
NASA NTRS1989

Curvature effects on the stability of three-dimensional laminar boundary layers

The linear stability equations for compressible, three-dimensional laminar boundary layer flow are derived in an orthogonal curvilinear coordinate system. The system of equations is solved using a finite difference scheme in order to study the effects of streamline and surface curvature and compressibility on the stability of the flow past a swept wing. It is known that convex surface curvature can have a stabilizing effect on the laminar boundary layer. Conversely, concave surface curvature can be destabilizing. The magnitude of these effects for swept wings is determined. Results indicate that amplification rates and hence, N-factors, for the flow over the convex upper surface of a swept wing can be reduced by about 15 to 45 percent when curvature effects are included in the linear stability analysis. The results of the calculations show that concave curvature destabilizes crossflow type disturbances with a significant increase in amplification rate. In addition, comparisons are made with some experimental results on a swept concave-convex surface. Calculated velocity vector plots show good agreement with observed disturbances in the laminar boundary layer over the concave surface.

Collier, F. S., Jr.↗
NASA NTRS2000

Forced Boundary-Layer Transition on X-43 (Hyper-X) in NASA LaRC 31-Inch Mach 10 Air Tunnel

Aeroheating and boundary layer transition characteristics for the X-43 (Hyper-X) configuration have been experimentally examined in the Langley 31-Inch Mach 10 Air Tunnel. Global surface heat transfer distributions, and surface streamline patterns were measured on a 0.333-scale model of the Hyper-X forebody. Parametric variations include angles-of-attack of 0-deg, 2-deg, 3-deg, and 4-deg; Reynolds numbers based on model length of 1.2 to 5.1 million; and inlet cowl door both open and closed. The effects of discrete roughness elements on the forebody boundary layer, which included variations in trip configuration and height, were investigated. This document is intended to serve as a release of preliminary data to the Hyper-X program; analysis is limited to observations of the experimental trends in order to expedite dissemination.

Berry, Scott A.↗
DOE OSTI2017

A Face-on Accretion System in High-mass Star Formation: Possible Dusty Infall Streams within 100 AU

We report on interferometric observations of a face-on accretion system around the high-mass young stellar object, G353.273+0.641. The innermost accretion system of 100 au radius was resolved in a 45 GHz continuum image taken with the Jansky-Very Large Array. Our spectral energy distribution analysis indicated that the continuum could be explained by optically thick dust emission. The total mass of the dusty system is ∼0.2 M {sub ☉} at minimum and up to a few M {sub ☉} depending on the dust parameters. 6.7 GHz CH{sub 3}OH masers associated with the same system were also observed with the Australia Telescope Compact Array. The masers showed a spiral-like, non-axisymmetric distribution with a systematic velocity gradient. The line-of-sight velocity field is explained by an infall motion along a parabolic streamline that falls onto the equatorial plane of the face-on system. The streamline is quasi-radial and reaches the equatorial plane at a radius of 16 au. This is clearly smaller than that of typical accretion disks in high-mass star formation, indicating that the initial angular momentum was very small, or the CH{sub 3}OH masers selectively trace accreting material that has small angular momentum. In the former case, the initial specific angular momentum is estimated to be 8 × 10{sup 20} (M{sub ∗}/10 M {sub ☉}){sup 0.5} cm{sup 2} s{sup −1}, or a significant fraction of the initial angular momentum was removed outside of 100 au. The physical origin of such a streamline is still an open question and will be constrained by the higher-resolution (∼10 mas) thermal continuum and line observations with ALMA long baselines.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2024

Flash healing of laser-induced graphene

The advancement of laser-induced graphene (LIG) technology has streamlined the fabrications of flexible graphene devices. However, the ultrafast kinetics triggered by laser irradiation generates intrinsic amorphous characteristics, leading to high resistivity and compromised performance in electronic devices. Healing graphene defects in specific patterns is technologically challenging by conventional methods. Herein, we report the rapid rectification of LIG’s topological defects by flash Joule heating in milliseconds (referred to as F-LIG), whilst preserving its overall structure and porosity. The F-LIG exhibits a decreased I D /I G ratio from 0.84 – 0.33 and increased crystalline domain from Raman analysis, coupled with a 5-fold surge in conductivity. Pair distribution function and atomic-resolution imaging delineate a broader-range order of F-LIG with a shorter C-C bond of 1.425 Å. The improved crystallinity and conductivity of F-LIG with excellent flexibility enables its utilization in high-performance soft electronics and low-voltage disinfections. Notably, our F-LIG/polydimethylsiloxane strain sensor exhibits a gauge factor of 129.3 within 10% strain, which outperforms pristine LIG by 800%, showcasing significant potential for human-machine interfaces.

36 MATERIALS SCIENCE↗
DOE OSTI2018

The International Science and Technology Center: Product of the Past or Prototype for the Future?

The International Science and Technology Center (ISTC) – originally formed in the early 1990s to address the potential issue of “brain drain” from underemployed and underpaid nuclear weapons scientists, engineers, and technicians in the former Soviet Union – still exists to this day. Through more than two decades of changing circumstances and worldviews, the ISTC has had to reorganize, move countries, streamline its internal processes, and broaden its scope of work in an attempt to remain a relevant and useful tool for international science cooperation in the 21st century. Critics see it as a product of the past in a modern world that no longer requires the redirection of former Soviet scientists, while proponents argue that the established networks and trust from the international community that the ISTC has developed throughout its history make it a critical and useful tool for current and future science cooperation and threat reduction. Through historical and budget analysis, this paper hopes to answer the following questions: (1) how has the ISTC evolved throughout its history to become what it considers to be a useful tool for the future of science cooperation and threat reduction, and (2) if the ISTC still serves a purpose, what is that purpose, and how can they continue to adapt and evolve to better serve that purpose?

99 GENERAL AND MISCELLANEOUS↗
DOE OSTI2019

Win-Win Regulatory Strategies in Idaho - 19241

During the course of any waste management or environmental remediation project, the earliest goals must include the creation and maintenance of mutual trust, respect, and cooperation with regulatory agencies and stakeholders. The heavy equipment and treatment systems remain idled until bounding characterization and risk analysis is complete, technical and functional requirements are identified, required controls and limits are established, and the proper permits and approvals are issued. Once a project receives approval to start up or break ground, the regulatory process has only just begun. Process modifications and improvements, as well as unexpected events, will continue to necessitate further reviews, discussions, and approvals. Building healthy professional relationships with the regulatory community and consistently meeting or exceeding their expectations, while operating within controls, is a cornerstone to jointly finding cost-effective solutions to complex issues, and streamlining the path to success. Navigating the optimal routes to compliance through the myriad regulatory waypoints is essential to avoiding schedule delays, staying within budget, and keeping clients continuously satisfied and delighted. Two complex case studies from the Idaho Cleanup Project Core will examine regulatory communication and integration strategies that have proven effective to date in obtaining timely approvals and maintaining compliance: (1) conducting Decontamination and Decommissioning as non-time critical removal actions (NTCRA) under CERCLA, and (2) preparing the integrated documentation necessary to obtain DOE, EPA, DEQ, and NRC approvals to close calcine storage units at the Idaho Nuclear Technology and Engineering Center (INTEC). (author)

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗