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At least 667 records · Page 37
All sourcesNASA NTRSDOE OSTI
NASA NTRS2017

Radiation Impact on Pharmaceutical Stability: Retrospective Data Review

Historical studies performed by the JSC Pharmacotherapeutics Discipline suggest that exposure to spaceflight conditions may compromise the safety and efficacy of some medications. Follow-on studies have revealed that affected medications demonstrate reductions in active pharmaceutical ingredient (API) concentrations and altered release characteristics. It was hypothesized that the changes in API potency and release were from the medication's exposure to the harsh environmental conditions of spaceflight. Subsequent review of the spaceflight environmental control records from the time of these studies indicated that temperature and humidity levels aboard all spacecraft remained within United States Pharmacopeia (USP) recommended ranges to maintain optimal pharmaceutical stability. Therefore, space radiation was presumed to be the source of observed drug degradation. The Pharmacotherapeutics Discipline conducted a ground analog radiation experiment in 2006 at the NASA Space Radiation Laboratory (NSRL) at Brookhaven to validate this theory and to characterize the effects of high-energy radioactive particles on pharmaceutical stability. These data were never published. Recently, the Exploration Medical Capability (ExMC) Element finalized a research plan (RP) aimed at providing a safe and effective medication formulary for exploration spaceflight. As ExMC begins to design new flight and ground analog radiation studies, further analysis of the 2006 NSRL study data is essential for the characterization of the impact of radiation on medication potency and efficacy in the exploration spaceflight environment.

Daniels, V. R.↗
NASA NTRS2013

NASA Tech Briefs, January 2013

Topics include: Single-Photon-Sensitive HgCdTe Avalanche Photodiode Detector; Surface-Enhanced Raman Scattering Using Silica Whispering-Gallery Mode Resonators; 3D Hail Size Distribution Interpolation/Extrapolation Algorithm; Color-Changing Sensors for Detecting the Presence of Hypergolic Fuels; Artificial Intelligence Software for Assessing Postural Stability; Transformers: Shape-Changing Space Systems Built with Robotic Textiles; Fibrillar Adhesive for Climbing Robots; Using Pre-Melted Phase Change Material to Keep Payloads in Space Warm for Hours without Power; Development of a Centrifugal Technique for the Microbial Bioburden Analysis of Freon (CFC-11); Microwave Sinterator Freeform Additive Construction System (MS-FACS); DSP/FPGA Design for a High-Speed Programmable S-Band Space Transceiver; On-Chip Power-Combining for High-Power Schottky Diode-Based Frequency Multipliers; FPGA Vision Data Architecture; Memory Circuit Fault Simulator; Ultra-Compact Transputer-Based Controller for High-Level, Multi-Axis Coordination; Regolith Advanced Surface Systems Operations Robot Excavator; Magnetically Actuated Seal; Hybrid Electrostatic/Flextensional Mirror for Lightweight, Large-Aperture, and Cryogenic Space Telescopes; System for Contributing and Discovering Derived Mission and Science Data; Remote Viewer for Maritime Robotics Software; Stackfile Database; Reachability Maps for In Situ Operations; JPL Space Telecommunications Radio System Operating Environment; RFI-SIM: RFI Simulation Package; ION Configuration Editor; Dtest Testing Software; IMPaCT - Integration of Missions, Programs, and Core Technologies; Integrated Systems Health Management (ISHM) Toolkit; Wind-Driven Wireless Networked System of Mobile Sensors for Mars Exploration; In Situ Solid Particle Generator; Analysis of the Effects of Streamwise Lift Distribution on Sonic Boom Signature; Rad-Tolerant, Thermally Stable, High-Speed Fiber-Optic Network for Harsh Environments; Towed Subsurface Optical Communications Buoy; High-Collection-Efficiency Fluorescence Detection Cell; Ultra-Compact, Superconducting Spectrometer-on-a-Chip at Submillimeter Wavelengths; UV Resonant Raman Spectrometer with Multi-Line Laser Excitation; Medicine Delivery Device with Integrated Sterilization and Detection; Ionospheric Simulation System for Satellite Observations and Global Assimilative Model Experiments - ISOGAME; Airborne Tomographic Swath Ice Sounding Processing System; flexplan: Mission Planning System for the Lunar Reconnaissance Orbiter; Estimating Torque Imparted on Spacecraft Using Telemetry; PowderSim: Lagrangian Discrete and Mesh-Free Continuum Simulation Code for Cohesive Soils; Multiple-Frame Detection of Subpixel Targets in Thermal Image Sequences; Metric Learning to Enhance Hyperspectral Image Segmentation; Basic Operational Robotics Instructional System; Sheet Membrane Spacesuit Water Membrane Evaporator; Advanced Materials and Manufacturing for Low-Cost, High-Performance Liquid Rocket Combustion Chambers; Motor Qualification for Long-Duration Mars Missions.

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NASA NTRS2008

A Stereo Imaging Velocimetry Technique for Analyzing Structure of Flame Balls at Low Lewis-Number (SOFBALL) Data

Stereo Imaging Velocimetry (SIV) is a NASA Glenn Research Center (GRC) developed fluid physics technique for measuring threedimensional (3-D) velocities in any optically transparent fluid that can be seeded with tracer particles. SIV provides a means to measure 3-D fluid velocities quantitatively and qualitatively at many points. This technique provides full-field 3-D analysis of any optically clear fluid or gas experiment using standard off-the-shelf CCD cameras to provide accurate and reproducible 3-D velocity profiles for experiments that require 3-D analysis. A flame ball is a steady flame in a premixed combustible atmosphere which, due to the transport properties (low Lewis-number) of the mixture, does not propagate but is instead supplied by diffusive transport of the reactants, forming a premixed flame. This flame geometry presents a unique environment for testing combustion theory. We present our analysis of flame ball phenomena utilizing SIV technology in order to accurately calculate the 3-D position of a flame ball(s) during an experiment, which can be used as a direct comparison of numerical simulations.

McDowell, Mark↗
NASA NTRS1971

NASA multidisciplinary research grant

Research is discussed in the multidisciplinary areas of space and planetary science; materials and radiation; systems, instrumentation, and structures; and technology and man. Highlights are identified as an alpha-recoil track method of archeological dating; infrared astronomical telescope; reaction rates data, semiconductor radiation detectors, and analysis of time-dependent systems; Gunn effect devices for microwave generation and detection, mode-locked lasers, and radiation theory; and the application of a satellite communication system to educational development. Detectors to be flown on Apollo 16 to measure heavy particle flux in the solar wind and to be part of the HEAO-A experiment on extremely heavy nuclei in cosmic rays were developed. The impact of the multidisciplinary research on university activities is described, and individual departmental reports are included.

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NASA NTRS1971

Sounding rocket flight report: MUMP 9 and MUMP 10

The results of the launching of two Marshall-University of Michigan Probes (MUMP 9 and MUMP 10), Nike-Tomahawk sounding rocket payloads, are summarized. The MUMP 9 paylaod included an omegatron mass analyzer, a molecular fluorescence densitometer, a mini-tilty filter, and a lunar position sensor. This complement of instruments permitted the determination of the molecular nitrogen density and temperature in the altitude range from approximately 143 to 297 km over Wallops Island, Virginia, during January 1971. The MUMP 10 payload included an omegatron mass analyzer, an electron temperature probe (Spencer, Brace, and Carignan, 1962), a cryogenic densitometer, and a solar position sensor. This complement of instruments permitted the determination of the molecular nitrogen density and temperature and the charged particle density and temperature in the altitude range from approximately 145 to 290 km over Wallops Island, Virginia, during the afternoon preceding the MUMP 9 launch in January 1971. A general description of the payload kinematics, orientation analysis, and the technique for the reduction and analysis of the data is given.

Grassl, H. J.↗
NASA NTRS1972

Observation of lunar radon emanation with the Apollo 15 alpha particle spectrometer.

The alpha particle spectrometer, a component of the orbital Sim Bay group of 'geochemistry' experiments on Apollo 15, was designed to detect alpha particles emitted during the decay of isotopes of radon gas and her daughter products. The purpose was to measure the gross activity of radon on the lunar surface and to find possible regions of increased local activity. Results are presented from a partial analysis of Apollo 15 data. For the moon as a whole, Rn220 was not observed and the upper limit on its decay rate above the lunar surface is 0.00038 disintegrations/sq cm-sec. Rn222 was marginally observed. Possible variations of radon activity on the lunar surface are being investigated. Po210 (a daughter product of Rn222) has been detected in a broad region from west of Mare Crisium to the Van de Graaff-Orlov region. The observed count rate is (4.6 plus or minus 1.4) x 0.001 disintegrations/sq cm-sec. The observed level of Po210 activity is in excess of the amount that would be in equilibrium with Rn222 by about an order of magnitude. This implies that larger levels of radon emanation have occurred on the moon within a time scale of 10 to 100 years.

Gorenstein, P.↗
NASA NTRS1976

Research in space physics at the University of Iowa

Energetic particles in outer space and their relationship to electric, magnetic, and electromagnetic fields associated with the earth, sun, moon, and planets, and the interplanetary medium are investigated. Special attention was given to observations of earth and moon satellites and interplanetary spacecraft; phenomenological analysis and interpretation were emphasized. Data also cover ground based on radio astronomical and optical techniques and theoretical problems in plasma physics as revelant to solar planetary and interplanetary phenomena.

Vanallen, J. A.↗
NASA NTRS1983

Solar concentrator degradation in Low Earth Orbit (LEO)

The use of parabolically or spherically-shaped mirrors is being considered in order to increase the solar energy intensity on solar cells. Their use will significantly decrease the size and number of the cells needed for a particular application, hence the total array cost. Questions arise, however, regarding the long-term (five to ten years) efficiency of these devices. Performance degradation of the mirror surfaces might result from known hostile elements in the low earth orbit (LEO) environment (150-350 nautical miles). The degradation issue is addressed in light of present knowledge of this environment. The following characteristics of the LEO environment are identified for study: (1) the vacuum of space; (2) sputtering by the residual atoms and particles in space; (3) solar electromagnetic radiation; (4) contamination of the mirror surface; (5) atomic oxygen interactions with the surface; (6) bombardment of the surface by meteoroids; and (7) irradiation of the surface by ionizing particles (protons). Using the best available information for the magnitudes of the necessary quantities, a mathematical analysis was carried out, where possible, to determine the degradation in reflectance or other loss caused by each characteristic. Otherwise, reasonable estimates are made of corresponding losses, based on already published data.

Thomas, R. G.↗
NASA NTRS1989

Laser light scattering review

Since the development of laser light sources and fast digital electronics for signal processing, the classical discipline of light scattering on liquid systems experienced a strong revival plus an enormous expansion, mainly due to new dynamic light scattering techniques. While a large number of liquid systems can be investigated, ranging from pure liquids to multicomponent microemulsions, this review is largely restricted to applications on Brownian particles, typically in the submicron range. Static light scattering, the careful recording of the angular dependence of scattered light, is a valuable tool for the analysis of particle size and shape, or of their spatial ordering due to mutual interactions. Dynamic techniques, most notably photon correlation spectroscopy, give direct access to particle motion. This may be Brownian motion, which allows the determination of particle size, or some collective motion, e.g., electrophoresis, which yields particle mobility data. Suitable optical systems as well as the necessary data processing schemes are presented in some detail. Special attention is devoted to topics of current interest, like correlation over very large lag time ranges or multiple scattering.

Schaetzel, Klaus↗
NASA NTRS1992

Study of cosmic dust particles on board LDEF: The FRECOPA experiments AO138-1 and AO138-2

Two experiments, within the French Cooperative Payload (FRECOPA) and devoted to the detection of cosmic dust, were flown on the LDEF. A variety of sensors and collecting devices have made possible the study of impact processes on materials of technological interest. Preliminary examination of hypervelocity impact features gives valuable data on size distribution and nature of interplanetary dust particles in low earth orbit, within the 0.5 to 300 micrometer size range. Most of the events detected on the trailing face of LDEF are expected to be the result of impacts of meteoritic particles only. So far, chemical analysis of craters by EDS clearly shows evidence of elements (Na, Mg, Si, S, Ca, and Fe) consistent with cosmic origin. Systematic occurrence of C and O in crater residues is an important result, to be compared with the existence of CHON particles detected in P-Halley comet nucleus. Crater size distribution is in good agreement with results from other dust experiments flown on LDEF. However, no crater smaller than 1.5 micron was observed, thus suggesting a cutoff in the near earth particle distribution. Possible origin and orbital evolution of micrometeoroids is discussed.

Mandeville, J. C.↗
NASA NTRS1994

Shape, size, and distribution of magnetic particles in Bjurbole chondrules

Chondrules from the Bjurbole chondritic meteorite (L4) exhibit saturation remanence magnetization (SIRM) values which vary over three orders of magnitude. REM values (Natural Remanence Magnetization/SIRM) for Allende (C3V) and Chainpur (LL3) are less than 0.01 but in Bjurbole some chondrules were found to have REM values greater than 0.1 with several greater than 0.2. REM values greater than 0.1 are abnormal and cannot be acquired during weak field cooling. If exposure to a strong field (whatever the source) during the chondrules' history is responsible for the high REM values, was such history associated with a different processing which might have resulted in different shape, size, and distribution of metal particles compared to chondrules having REM values of less than 0.01? Furthermore, magnetic hysteresis results show a broad range of magnetic hardness and other intrinsic magnetic properties. These features must be related to (1) size and amount of metal; and (2) properties of, and amount of, tetrataenite in the chondrules (all chondrules thus far subjected to thermomagnetic analysis show the presence of tetrataenite). A scanning electron microscopy (SEM) study is underway to determine the relationship between the shape, size, and distribution of metal particles within individual chondrules and the magnetic properties of these chondrules. Results from the SEM study in conjunction with magnetic property data may also help to discern effects from possible lightning strikes in the nebula prior to incorporation of the chondrules into the parent body.

Nava, David F.↗
NASA NTRS1977

Laser velocimeter systems analysis applied to a flow survey above a stalled wing

A laser velocimeter operating in the backscatter mode was used to survey the flow above a stalled wing. Polarization was used to separate the two orthogonal velocity components of the fringe-type laser velocimeter, and digital counters were used for data processing. The velocities of the kerosene seed particles were measured with less than 2 percent uncertainty. The particle velocity measurements were collected into histograms. The flow field survey was carried out above an aspect-ratio-8 stalled wing with an NACA 0012 section. The angle of attack was 19.5 deg, the Mach number was 0.49, and the Reynolds number was 1,400,000. The flow field was characterized by the periodic shedding of discrete vortices from near the crest of the airfoil.

Young, W. H., Jr.↗
NASA NTRS2000

Cirrus Parameter Retrieval by Combined Analysis of Spectral Thermal Infrared and Lidar Sensing from Aircraft and Space

The distribution, radiative and microphysical parameters of cirrus clouds are an important factor for cloud effects on the global radiation balance and climate. Multispectral thermal infrared observation are the most significant method used to remote sense cirrus parameter from current and planned passive satellite observations. Passive sensing alone has the limitation that both the cloud radiative temperature, or height, and the spectral emissivity must be derived in the analysis. Factors such as multiple cloud laying, which is very common, are known to introduce ambiguities in results. The addition of lidar cloud height structure measurements significantly improves retrievals. Such active/passive observations have been applied from the NASA ER-2 high altitude remote sensing aircraft since 1983. Applications include the study of the effective effective particle size of cirrus and application toward remote sensing of the ice/water content of cirrus clouds in addition to radiative parameters. Limitations, accuracy and examples of retrievals are presented. In 1997 a space shuttle hitch hiker experiment was flown which included a new technology Infrared Spectral Imaging Radiometer and a laser altimeter for direct cloud height measurements. A 30 orbit data set to test global application of combined spectral infrared and laser height measurements were obtained. Initial results for cirrus analysis from the shuttle experiment will also be presented.

Spinhirne, James D.↗
NASA NTRS1995

Global electric field determination in the Earth's outer magnetosphere using energetic charged particles

Although many properties of the Earth's magnetosphere have been measured and quantified in the past 30 years since it was discovered, one fundamental measurement (for zeroth order MHD equilibrium) has been made infrequently and with poor spatial coverage - the global electric field. This oversight is due in part to the neglect of theorists. However, there is renewed interest in the convection electric field because it is now realized to be central to many magnetospheric processes, including the global MHD equilibrium, reconnection rates, Region 2 Birkeland currents, magnetosphere ionosphere coupling, ring current and radiation belt transport, substorm injections, and several acceleration mechanisms. Unfortunately the standard experimental methods have not been able to synthesize a global field (excepting the pioneering work of McIlwain's geostationary models) and we are left with an overly simplistic theoretical field, the Volland-Stern electric field model. Single point measurements of the plasmapause were used to infer the appropriate amplitudes of this model, parameterized by K(sub p). Although this result was never intended to be the definitive electric field model, it has gone nearly unchanged for 20 years. The analysis of current data sets requires a great deal more accuracy than can be provided by the Volland-Stern model. The variability of electric field shielding has not been properly addressed although effects of penetrating magnetospheric electric fields has been seen in mid-and low-latitude ionospheric data sets. The growing interest in substorm dynamics also requires a much better assessment of the electric fields responsible for particle injections. Thus we proposed and developed algorithms for extracting electric fields from particle data taken in the Earth's magnetosphere. As a test of the effectiveness of these new techniques, we analyzed data taken by the AMPTE/CCE spacecraft in equatorial orbit from 1984 to 1989.

Eastman, Timothy E.↗
NASA NTRS1974

Mariner 4 - A study of the cumulative flux of dust particles over a heliocentric range of 1-1.56 AU 1964-1967

Between December 1964 and December 1967, the Mariner 4 dust particle experiment obtained data concerning the distribution of minute zodiacal dust cloud particles over a heliocentric range of 1-1.56 AU. The first measurement was over the complete heliocentric range, while the two additional measurements were made between 1.1 and 1.25 AU in 1966, and between 1.2 and 1.5 AU in 1967. The initial results of these measurements presented the mean cumulative flux for the respective data periods. The results of a detailed study and comparison of the three measurements are presented, with particular emphasis on the variation of the flux as a function of heliocentric range. A small, but statistically significant, increase in the flux is observed between 1.15 and 1.4 AU. The initial reports showed a lower cumulative flux for the latter two measurements. However, a detailed analysis containing corrections for spacecraft attitude indicate that all three measurements yield similar results, and that the particles detected were in low inclination orbits.

Alexander, W. M.↗
NASA NTRS1975

Heavy Ion Fragmentation Experiments at the Bevatron

Fragmentation processes of heavy nuclei in matter using the heavy-ion capability of the Bevatron were studied. The purpose was to obtain the single particle inclusive spectra of secondary nuclei produced at 0 deg by the fragmentation of heavy ion beam projectiles. The process being examined is B+T yields F + anything, where B is the beam nucleus, T is the target nucleus, and F is the detected fragment. The fragments F are isotopically identified by experimental procedures involving magnetic analysis, energy loss and time-of-flight measurements. Attempts were also made to: (1) measure the total and partial production cross section for all isotopes, (2) test the applicability of high-energy multi-particle interaction theory to nuclear fragmentation, (3) apply the cross-section data and fragmentation probabilities to cosmic ray transport theory, and (4) search for systematic behavior of fragment production as a means to improve existing semi-empirical theories of cross sections.

Heckman, H. H.↗
NASA NTRS1975

Earth-moon system: Dynamics and parameter estimation

A theoretical development of the equations of motion governing the earth-moon system is presented. The earth and moon were treated as finite rigid bodies and a mutual potential was utilized. The sun and remaining planets were treated as particles. Relativistic, non-rigid, and dissipative effects were not included. The translational and rotational motion of the earth and moon were derived in a fully coupled set of equations. Euler parameters were used to model the rotational motions. The mathematical model is intended for use with data analysis software to estimate physical parameters of the earth-moon system using primarily LURE type data. Two program listings are included. Program ANEAMO computes the translational/rotational motion of the earth and moon from analytical solutions. Program RIGEM numerically integrates the fully coupled motions as described above.

Breedlove, W. J., Jr.↗
NASA NTRS1976

Electrophoretic characterization of aldehyde-fixed red blood cells, kidney cells, lynphocytes and chamber coatings

Ground-based electrokinetic data on the electrophoresis flight experiment to be flown on the Apollo-Soyuz Test Project experiment MA-011 are stipulated. Aldehyde-fixed red blood cells, embryonic kidney cells and lymphocytes were evaluated by analytical particle electrophoresis. The results which aided in the interpretation of the final analysis of the MA-011 experiment are documented. The electrophoresis chamber surface modifications, the buffer, and the material used in the column system are also discussed.

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