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At least 667 records · Page 37
All sourcesNASA NTRSDOE OSTI
NASA NTRS2002

Subcutaneous administration of insulin-like growth factor (IGF)-II/IGF binding protein-2 complex stimulates bone formation and prevents loss of bone mineral density in a rat model of disuse osteoporosis

Elevated serum levels of insulin-like growth factor binding protein-2 (IGFBP-2) and a precursor form of IGF-II are associated with marked increases in bone formation and skeletal mass in patients with hepatitis C-associated osteosclerosis. In vitro studies indicate that IGF-II in complex with IGFBP-2 has high affinity for bone matrix and is able to stimulate osteoblast proliferation. The purpose of this study was to determine the ability of the IGF-II/IGFBP-2 complex to increase bone mass in vivo. Osteopenia of the femur was induced by unilateral sciatic neurectomy in rats. At the time of surgery, 14-day osmotic minipumps containing vehicle or 2 microg IGF-II+9 microg IGFBP-2/100g body weight/day were implanted subcutaneously in the neck. Bone mineral density (BMD) measurements were taken the day of surgery and 14 days later using a PIXImus small animal densitometer. Neurectomy of the right hindlimb resulted in a 9% decrease in right femur BMD (P<0.05 vs. baseline). This loss in BMD was completely prevented by treatment with IGF-II/IGFBP-2. On the control limb, there was no loss of BMD over the 14 days and IGF-II/IGFBP-2 treatment resulted in a 9% increase in left femur BMD (P<0.05). Bone histomorphometry indicated increases in endocortical and cancellous bone formation rates and in trabecular thickness. These results demonstrate that short-term administration of the IGF-II/IGFBP-2 complex can prevent loss of BMD associated with disuse osteoporosis and stimulate bone formation in adult rats. Furthermore, they provide proof of concept for a novel anabolic approach to increasing bone mass in humans with osteoporosis.

NASA Discipline Regulatory Physiology↗
NASA NTRS1987

PMR polyimide compositions for improved performance at 371 C

Studies were conducted to identify matrix resins which have potential for use at 371 C (700 F). Utilizing PMR methodology, neat resin moldings were prepared with various monomer reactants and screened for thermo-oxidative stability at 371 C (700 F) under both ambient and a four-atmosphere air pressure. The results of the resin screening studies indicate that high molecular weight (HMW) formulated resins of first (PMR-15) and second (PMR-II) generation PMR materials exhibit lower levels of weight loss at 371 C (700) than PMR-15 and PMR-II resins. The resin systems which exhibited the best overall balance of processability, Tg and thermo-oxidative stability at 371 C were used to prepare unidirectional Celion 6000 and T-40R graphite fiber laminates. Laminates were evaluated for thermo-oxidative stability and 371 C mechanical properties. Results of the laminate evaluation studies indicate that two of the resin compositions have potential for use in 371 C applications. The most promising resin composition provided laminates which exhibited no drop in 371 C mechanical properties and only 11 percent weight loss after 200 hr exposure to atmospheres of air at 371 C.

Vannucci, Raymond D.↗
NASA NTRS1995

Theoretical position-velocity diagrams of flux, electron density, and electron temperature in Herbig-Haro objects

Many features of Herbig-Haro objects can be reproduced using a kinematical bow shock model. We use the model to generate position-velocity (PV) diagrams of flux in H-alpha (O I) lambda lambda 6300+63, (S II) lambda lambda 6716+31, (O III) lambda lambda 4959+5007, and (C I) lambda lambda 9823+50, line ratios of (O I)/H-alpha, (O I)/(S II), (S II)/H-alpha, H-alpha(S II), and (O III)/H-alpha, electron density N(sub e), and electron temperature T(sub e). We show how position-velocity diagrams of N(sub e) and flux vary with shock velocity. By matching the diagrams from single lines, the line ratios, and N(sub e) with observations, we determined a narrow range of shock parameters for HH 1F, 2(A' + H), and 43 (B + C). We model the N(sub e) features of HH 2(A' + H) as a superposition of two bowshocks. We also show that the effects of slight misalignments of the two diagrams to be divided can produce artifacts in the line ratios and N(sub e) which obliterate the physical features. We show that N(sub e) in HH 1 can only be explained using the kinematical model by taking these misalignments into account.

Indebetouw, Remy↗
NASA NTRS2000

The limits of low-temperature performance of Li-ion cells

The results of electrode and electrolyte studies reveal that the poor low-temperature (<-30 degrees C) performance of Li-ion cells is mainly caused by the carbon electrodes and not the organic electrolytes and solid electrolyte interphase, as previously suggested. It is suggested that the main causes for the poor performance in the carbon electrodes are (i) the low value and concentration depedence of the Li diffusivity and (ii) limited Li capacity.

Diffusion Electrolytes Lithium Secondary cells↗
NASA NTRS1989

A CO and far-infrared study of the S254-S258 region

The molecular cloud associated with compact radio and bright optical H II regions is studied from observations of (C-12)O, (C-13)O, HCN J = 1-0 emission. The far-infrared and millimeter molecular line emission from the S254-S258 molecular cloud is analyzed, using co-added survey data from IRAS, to investigate the coupling between the dust and gas components and the internal energetics associated with molecular clouds. The dust component is analyzed by fitting model intensities, derived from a dust mass column density temperature relation, to the observed far-infrared emission. Such modeling is shown to provide a more complete description of the cold dust component which comprises most of the dust mass than can be determined from the standard single temperature analysis. Local heating of the dust component by newborn massive stars associated with the H II regions of the cloud is inferred from the spatial distribution of temperatures of grains which make the largest contributions to the observed 60 and 100 micron emission.

Heyer, Mark H.↗
NASA NTRS1987

PMR polyimide compositions for improved performance at 371 deg C

Studies were conducted to identify matrix resins which have potential for use at 371 C (700 F). Utilizing PMR methodology, neat resin moldings were prepared with various monomer reactants and screened for thermo-oxidative stability at 371 C (700 F) under both ambient and a four-atmosphere air pressure. The results of the resin screening studies indicate that high molecular weight (HMW) formulated resins of first (PMR-15) and second (PMR-II) generation PMR materials exhibit lower levels of weight loss at 371 C (700 F) than PMR-15 and PMR-II resins. The resin systems which exhibited the best overall balance of processability, Tg and thermo-oxidative stability at 371 C were used to prepare unidirectional Celion 6000 and T-40R graphite fiber laminates. Laminates were evaluated for thermo-oxidative stability and 371 C mechanical properties. Results of the laminate evaluation studies indicate that two of the resin compositions have potential for use in 371 C applications. The most promising resin composition provided laminates which exhibited no drop in 371 C mechanical properties and only 11 percent weight loss after 200 hr exposure to 4 atmospheres of air at 371 C.

Vannucci, Raymond D.↗
NASA NTRS1992

Outbursts by low-mass white dwarfs in symbiotic variables

The high-resolution IUE spectra of the symbiotic variables BF Cygni and EG Andromedae are studied in order to describe the P Cygni-like features of these objects. The 10 high-dispersion IUE spectra are examined for orbital phase-dependent variations in the C IV resonance doublet in terms of velocity and/or structure. One image is found to have a strong He-II absorption feature that coincides in velocity with the C-IV absorption component in P Cygni. The absorbing material for both lines is related to outflow and P Cygni self-absorption near the hot component. The P Cygni profiles do not appear to be related to a red-giant wind nor an expanding circumbinary shell in the in both BF Cyg and EG And. Quasi-static evolutionary model calculations demonstrate an unexpected outburst behavior in response to the assumed accretion. These data are shown to be important for the study of symbiotic systems that contain low-mass white dwarfs.

Sion, Edward M.↗
NASA NTRS1993

Hydrogen and metal absorption lines in PKS 0405-123 from the halos of low redshift galaxies

HST ultraviolet spectra and ground-based optical spectra of the bright quasar PKS 0405-123 are used to identify two absorption-line systems probably produced by the halos of foreground galaxies. The quasar lies in a rich galaxy field. Loose groups of galaxies are present in the field at mean z1 = 0.1669 and mean z2 = 0.3519. Ly-alpha, C IV 1549 A, and probably Mg II 2798 A resonance lines are detected in an absorption system at z = 0.1670. An absorption system consisting of only Ly-alpha is observed at z = 0.3516. We cannot be completely certain which foreground galaxy is responsible for the metal line absorption system at z1. A likely candidate is a large, luminous, early-type spiral 40 arcsec to the east of the quasar. However, the origin of the z1 system could possibly be a small undetected galaxy more precisely aligned along our line of sight to PKS 0405-123, or a very faint galaxy whose redshift has not yet been measured.

Spinrad, Hyron↗
NASA NTRSDate not supplied

Titan Turtle: NIAC Phase II Design for a Submersible Vehicle for Titan Exploration

Conceptual designs for a submersible vehicle for exploration of the hydrocarbon seas of Saturn’s moon Titan were done by the NASA Glenn COMPASS systems engineering team, as part of the NASA’s Innovative Advanced Concepts (NIAC) program. The efforts investigated what approaches and technologies would allow exploration below the surface of the low temperature (–180 °C) hydrocarbon seas of Titan. The Phase-II design refined the design concepts, looking at a smaller design supported by an orbital relay, the “Titan Turtle”. The phase-II project resulted in a smaller vehicle using an orbiter supported relay/navigation link to eliminate the requirement for a large phased-array antenna. Eliminating the DTE communications requirement also reduced the associated high power required by the communications system.

Steven R Oleson↗
NASA NTRSDate not supplied

Titan Turtle: NIAC Phase II Design for a Submersible Vehicle for Titan Exploration

Conceptual designs for a submersible vehicle for exploration of the hydrocarbon seas of Saturn’s moon Titan were done by the NASA Glenn COMPASS systems engineering team, as part of the NASA’s Innovative Advanced Concepts (NIAC) program. The efforts investigated what approaches and technologies would allow exploration below the surface of the low temperature (–180 °C) hydrocarbon seas of Titan. The Phase-II design refined the design concepts, looking at a smaller design supported by an orbital relay, the “Titan Turtle”. The phase-II project resulted in a smaller vehicle using an orbiter supported relay/navigation link to eliminate the requirement for a large phased-array antenna. Eliminating the DTE communications requirement also reduced the associated high power required by the communications system.

Lunar and Planetary Scientific Exploration↗
NASA NTRS1988

Active region evolution in the chromosphere and transtition region

Images in the C IV 1548 A and the Si II 1526 S lines taken with the ultraviolet spectrometer polarimeter (UVSP) instrument on board the Solar Maximum Mission (SMM) satellite were combined into movies showing the evolution of active regions and the neighboring supergranulation over several days. The data sets generally consist of 240 by 240 arc second rasters with 3 arc second pixels taken one per orbit (about every 90 minutes). The images are projected on a latitude/longitude grid to remove the forshortening as the region rotates across the solar disk and further processed to remove jitter and gain variations. Movies were made with and without differential rotation. Although there are occasional missing orbits, these series do not suffer from the long nighttime gaps that occur in observations taken at a single groundbased observatory and are excellent for studying changes on time scales of several hours. The longest sequence processed to date runs from 20 Oct. 1980 to 25 Oct. 1980. This was taken during an SMM flare buildup study on AR 2744. Several shorter sequences taken in 1980 and 1984 will also be shown. The results will be presented on a video disk which can be interactively controlled to view the movies.

Shine, R. A.↗