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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 667 records · Page 37
All sourcesNASA NTRSDOE OSTI
DOE OSTI2023

New insights into the natural history of bronchopulmonary dysplasia from proteomics and multiplexed immunohistochemistry

Bronchopulmonary dysplasia (BPD) is a disease of prematurity related to the arrest of normal lung development. The objective of this study was to better understand how proteome modulation and cell-type shifts are noted in BPD pathology. Pediatric human donors aged 1–3 yr were classified based on history of prematurity and histopathology consistent with “healed” BPD (hBPD, n = 3) and “established” BPD (eBPD, n = 3) compared with respective full-term born (n = 6) age-matched term controls. Proteins were quantified by tandem mass spectroscopy with selected Western blot validations. Multiplexed immunofluorescence (MxIF) microscopy was performed on lung sections to enumerate cell types. Protein abundances and MxIF cell frequencies were compared among groups using ANOVA. Cell type and ontology enrichment were performed using an in-house tool and/or EnrichR. Proteomics detected 5,746 unique proteins, 186 upregulated and 534 downregulated, in eBPD versus control with fewer proteins differentially abundant in hBPD as compared with age-matched term controls. Cell-type enrichment suggested a loss of alveolar type I, alveolar type II, endothelial/capillary, and lymphatics, and an increase in smooth muscle and fibroblasts consistent with MxIF. Histochemistry and Western analysis also supported predictions of upregulated ferroptosis in eBPD versus control. Finally, several extracellular matrix components mapping to angiogenesis signaling pathways were altered in eBPD. Despite clear parsing by protein abundance, comparative MxIF analysis confirms phenotypic variability in BPD. This work provides the first demonstration of tandem mass spectrometry and multiplexed molecular analysis of human lung tissue for critical elucidation of BPD trajectory-defining factors into early childhood.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2024

Evolutionary history of arbuscular mycorrhizal fungi and genomic signatures of obligate symbiosis

The colonization of land and the diversification of terrestrial plants is intimately linked to the evolutionary history of their symbiotic fungal partners. Extant representatives of these fungal lineages include mutualistic plant symbionts, the arbuscular mycorrhizal (AM) fungi in Glomeromycota and fine root endophytes in Endogonales (Mucoromycota), as well as fungi with saprotrophic, pathogenic and endophytic lifestyles. These fungal groups separate into three monophyletic lineages but their evolutionary relationships remain enigmatic confounding ancestral reconstructions. Their taxonomic ranks are currently fluid. In this study, we recognize these three monophyletic linages as phyla, and use a balanced taxon sampling and broad taxonomic representation for phylogenomic analysis that rejects a hard polytomy and resolves Glomeromycota as sister to a clade composed of Mucoromycota and Mortierellomycota. Low copy numbers of genes associated with plant cell wall degradation could not be assigned to the transition to a plant symbiotic lifestyle but appears to be an ancestral phylogenetic signal. Both plant symbiotic lineages, Glomeromycota and Endogonales, lack numerous thiamine metabolism genes but the lack of fatty acid synthesis genes is specific to AM fungi. Many genes previously thought to be missing specifically in Glomeromycota are either missing in all analyzed phyla, or in some cases, are actually present in some of the analyzed AM fungal lineages, e.g. the high affinity phosphorus transporter Pho89. Based on a broad taxon sampling of fungal genomes we present a well-supported phylogeny for AM fungi and their sister lineages. We show that among these lineages, two independent evolutionary transitions to mutualistic plant symbiosis happened in a genomic background profoundly different from that known from the emergence of ectomycorrhizal fungi in Dikarya. These results call for further reevaluation of genomic signatures associated with plant symbiosis.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2019

Natural History of Gastric Cancer: Observational Study of Gastric Cancer Patients Not Treated During Follow-Up

Background: Understanding the natural progression of untreated gastric cancer is critical for determining the disease prognosis as well as treatment options and timing. The aim of this study is to analyze the natural history of gastric cancer. Patients and Methods: We included patients with gastric cancer who had not received any treatment and were staged using endoscopy/endoscopic ultrasonography and computed tomography on at least two follow-up visits during intervals of nontreatment. Tumor volumes were also measured in addition to the staging. Survival of each stage at diagnosis was also analyzed. Results: A total of 101 patients were included. The mean follow-up period was 35.1 ± 34.4 months. The gastric cancer doubling time was 11.8 months for T1 and 6.2 months for T4. The progression time from early gastric cancer to advanced gastric cancer was 34 months. It decreased as the stages advanced: from 34 months between tumor-nodes-metastasis stage I and II to 1.8 months between stage III and IV. No variable was identified as a risk factor for cancer progression. The 5-year survival rates of untreated patients were 46.2% in stage I and 0% in stage II, stage III, and stage IV. Conclusions: The progression and doubling times of gastric cancer shorten as the stages advance. Objective data reported in this study can be a critical factor in determining treatment timing and screening interval.

62 RADIOLOGY AND NUCLEAR MEDICINE↗
DOE OSTI2016

Microanalysis of carbonate cement δ 18 O in a CO 2 -storage system seal: Insights into the diagenetic history of the Eau Claire Formation (Upper Cambrian), Illinois Basin

Oxygen isotope (δ 18 O) zonation in carbonate mineral cements is often employed as a proxy record (typically with millimeter-scale resolution) of changing temperature regimes during different stages of sediment diagenesis. Recent advances in secondary ion mass spectrometry allow for highly precise and accurate determinations of cement δ 18 O values to be made in situ on a micrometer scale, thus significantly increasing the spatial resolution available to studies of diagenesis in sandstone–shale and carbonate systems. Chemo-isotopically zoned dolomite–ankerite cements within shaly sandstone beds of the predominantly silty–shaly Eau Claire Formation (Cambrian, Illinois Basin) were investigated, revealing the following: with increasing depth of burial (from <0.5 to ~2 km [<1500 to 6500 ft]), cement δ 18 O values decrease from a high of approximately 24‰ down to approximately 14‰ (on the Vienna standard mean ocean water [VSMOW] scale, equivalent to -6.5‰ to -16.5‰ on the Vienna Peedee belemnite [VPDB] scale). The observed cross-basin trend is largely consistent with cements having formed in response to progressive sediment burial and heating. Within the context of independent burial and thermal history models for the Illinois Basin, cementation began soon after deposition and continued intermittently into the mid-Permian. Finally, however, temperatures in excess of burial model predictions are inferred at the time of latest ankerite cement precipitation, which we propose overlapped in time with conductive heating of the Eau Claire Formation (a closed system) from under- and overlying sandstone aquifers that channeled the flow of hot, Mississippi Valley–type mineralizing brines during the mid-Permian (ca. 270 Ma).

58 GEOSCIENCES↗
DOE OSTI2017

The History of a Decision: A Standard Vibration Test Method for Qualification

As Mil-Std-810G and subsequent versions have included multiple degree of freedom vibration test methodologies, it is important to understand the history and factors that drove the original decision in Mil-Std-810 to focus on single degree of freedom (SDOF) vibration testing. By assessing the factors and thought process of early Mil-Std-810 vibration test methods, it enables one to better consider the use of multiple degree of freedom testing now that it is feasible with today’s technology and documented in Mil-Std-810. This paper delves into the details of the decision made in the 1960s for the SDOF vibration testing standards in Mil-Std-810 beyond the limitations of technology at the time. We also consider the implications for effective test planning today considering the advances in test capabilities and improvements in understanding of the operational environment.

36 MATERIALS SCIENCE↗
DOE OSTI2020

The First Three Seconds: a Review of Possible Expansion Histories of the Early Universe

It is commonly assumed that the energy density of the Universe was dominated by radiation between reheating after inflation and the onset of matter domination 54,000 years later. While the abundance of light elements indicates that the Universe was radiation dominated during Big Bang Nucleosynthesis (BBN), there is scant evidence that the Universe was radiation dominated prior to BBN. It is therefore possible that the cosmological history was more complicated, with deviations from the standard radiation domination during the earliest epochs. Indeed, several interesting proposals regarding various topics such as the generation of dark matter, matter-antimatter asymmetry, gravitational waves, primordial black holes, or microhalos during a nonstandard expansion phase have been recently made. In this paper, we review various possible causes and consequences of deviations from radiation domination in the early Universe - taking place either before or after BBN - and the constraints on them, as they have been discussed in the literature during the recent years.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
DOE OSTI2025

Describing hadronization via histories and observables for Monte-Carlo event reweighting

We introduce a novel method for extracting a fragmentation model directly from experimental data without requiring an explicit parametric form, called Histories and Observables for Monte-Carlo Event Reweighting (HOMER), consisting of three steps: the training of a classifier between simulation and data, the inference of single fragmentation weights, and the calculation of the weight for the full hadronization chain. We illustrate the use of HOMER on a simplified hadronization problem, a q\bar{q} q q ‾ string fragmenting into pions, and extract a modified Lund string fragmentation function f(z) f ( z ) . We then demonstrate the use of HOMER on three types of experimental data: (i) binned distributions of high-level observables, (ii) unbinned event-by-event distributions of these observables, and (iii) full particle cloud information. After demonstrating that f(z) f ( z ) can be extracted from data (the inverse of hadronization), we also show that, at least in this limited setup, the fidelity of the extracted f(z) f ( z ) suffers only limited loss when moving from (i) to (ii) to (iii). Public code is available at https://gitlab.com/uchep/mlhad.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
DOE OSTI2019

The history of the muon (g-2) experiments

I discuss the history of the muon (g-2) ( g − 2 ) measurements, beginning with the Columbia-Nevis measurement that observed parity violation in muon decay, and also measured the muon g g -factor for the first time, finding g_\mu=2 g μ = 2 . The theoretical (Standard Model) value contains contributions from quantum electrodynamics, the strong interaction through hadronic vacuum polarization and hadronic light-by-light loops, as well as the electroweak contributions from the W W , Z Z and Higgs bosons. The subsequent experiments, first at Nevis and then with increasing precision at CERN, measured the muon anomaly a_\mu = (g_\mu-2)/2 a μ = ( g μ − 2 ) / 2 down to a precision of 7.3 parts per million (ppm). The Brookhaven National Laboratory experiment E821 increased the precision to 0.54 ppm, and observed for the first time the electroweak contributions. Interestingly, the value of a_\mu a μ measured at Brookhaven appears to be larger than the Standard Model value by greater than three standard deviations. A new experiment, Fermilab E989, aims to improve on the precision by a factor of four, to clarify whether this result is a harbinger of new physics entering through loops, or from some experimental, statistical or systematic issue.

Roberts, B. Lee↗
DOE OSTI2011

A brief history of Sandia National Laboratories and the Department of Energy%3CU%2B2019%3Es Office of Science : interplay between science, technology, and mission.

In 1957, Sandia National Laboratories (Sandia) initiated its first programs in fundamental science, in support of its primary nuclear weapons mission. In 1974, Sandia initiated programs in fundamental science supported by the Department of Energy's Office of Science (DOE-SC). These latter programs have grown to the point where, today in 2011, support of Sandia's programs in fundamental science is dominated by that Office. In comparison with Sandia's programs in technology and mission applications, however, Sandia's programs in fundamental science are small. Hence, Sandia's fundamental science has been strongly influenced by close interactions with technology and mission applications. In many instances, these interactions have been of great mutual benefit, with synergies akin to a positive 'Casimir's spiral' of progress. In this report, we review the history of Sandia's fundamental science programs supported by the Office of Science. We present: (a) a technical and budgetary snapshot of Sandia's current programs supported by the various suboffices within DOE-SC; (b) statistics of highly-cited articles supported by DOE-SC; (c) four case studies (ion-solid interactions, combustion science, compound semiconductors, advanced computing) with an emphasis on mutually beneficial interactions between science, technology, and mission; and (d) appendices with key memos and reminiscences related to fundamental science at Sandia.

99 GENERAL AND MISCELLANEOUS↗
DOE OSTI2013

Statistics of particle time-temperature histories :

Progress toward predictions of the statistics of particle time-temperature histories is presented. These predictions are to be made using Lagrangian particle models within the one-dimensional turbulence (ODT) model. In the present reporting period we have further characterized the performance, behavior and capabilities of the particle dispersion models that were added to the ODT model in the first period. We have also extended the capabilities in two manners. First we provide alternate implementations of the particle transport process within ODT; within this context the original implementation is referred to as the type-I and the new implementations are referred to as the type-C and type-IC interactions. Second we have developed and implemented models for two-way coupling between the particle and fluid phase. This allows us to predict the reduced rate of turbulent mixing associated with particle dissipation of energy and similar phenomena. Work in characterizing these capabilities has taken place in homogeneous decaying turbulence, in free shear layers, in jets and in channel flow with walls, and selected results are presented.

Hewson, John C.↗
DOE OSTI2016

MANHATTAN: The View From Los Alamos of History's Most Secret Project

This presentation covers the political and scientific events leading up to the creation of the Manhattan Project. The creation of the Manhattan Project’s three most significant sites--Los Alamos, Oak Ridge, and Hanford--is also discussed. The lecture concludes by exploring the use of the atomic bombs at the end of World War II. The presentation slides include three videos. The first is a short clip of the 100-ton Test. The 100-Ton Test was history’s largest measured blast at that point in time; it was a pre-test for Trinity, the world’s first nuclear detonation. The second clip features views of Trinity followed a short statement by the Laboratory’s first director, J. Robert Oppenheimer. The final clip shows Norris Bradbury talking about arms control.

99 GENERAL AND MISCELLANEOUS↗
DOE OSTI2017

Two-Person Control: A Brief History and Modern Industry Practices

Physical asset protection is the principal objective of many security and safeguard measures. One well-known means of asset protection is two-person control. This paper reviews literature regarding two-person control to gain insight into its origin, first demonstrated uses, and its presence in several modern industries. This literature review of two-person control is intended to benefit people and organizations with a desire to understand its origins and how the practice has evolved over time, as well as give some insight into the flexibility of this safeguarding technique. The literature review is focused in four main sections: (1) defining two-person control, (2) early history, (3) two-person control in modern industry, and (4) a theory on how two- person control entered modern industry. ACKNOWLEDGEMENTS The author would like to thank Jarret Lafleur and Scott Paap of Sandia National Laboratories, California's Systems Analysis & Engineering organization for the opportunity to work on this project. Jarret Lafleur provided very constructive and helpful feedback through all stages of the work. Amanda Thompson of the Sandia California Technical Library maintained a great spirit and always had a quick document turnaround that very much helped out this project's completion. Additionally, yet perhaps most importantly, the author would like to thank his wife and daughter, along with the rest of his family, for continued support over the years. Sandia National Laboratories is a multimission laboratory managed and operated by National Technology and Engineering Solutions of Sandia, LLC., a wholly owned subsidiary of Honeywell International, Inc., for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-NA0003525.

98 NUCLEAR DISARMAMENT, SAFEGUARDS, AND PHYSICAL P↗
DOE OSTI2018

History of Los Alamos Participation in Active Experiments in Space

Beginning with the Teak nuclear test in 1958, Los Alamos has a long history of participation in active experiments in space. The last pertinent nuclear tests were the five explosions as part of the Dominic series in 1962. The Partial Test Ban Treaty signed in August 1963 prohibited all test detonations of nuclear weapons except for those conducted underground. Beginning with the “Apple” thermite barium release in June 1968 Los Alamos has participated in nearly 100 non-nuclear experiments in space, the last being the NASA-sponsored “AA-2” strontium and europium doped barium thermite releases in the Arecibo beam in July of 1992. The rationale for these experiments ranged from studying basic plasma processes such as gradientdriven structuring and velocity-space instabilities to illuminating the convection of plasmas in the ionosphere and polar cap to ionospheric depletion experiments to the B.E.A.R. 1-MeV neutral particle beam test in 1989. This report reviews the objectives, techniques and diagnostics of Los Alamos participation in active experiments in space.

99 GENERAL AND MISCELLANEOUS↗
DOE OSTI2016

A History of Sandia’s Water Decision Modeling and Analysis Program

This document provides a brief narrative, and selected project descriptions, that represent Sandia’s history involving data, modeling, and analysis related to water, energy-water nexus, and energy-water-agriculture nexus within the context of climate change. Sandia National Laboratories has been engaged since the early-1990s with program development involving data, modeling, and analysis projects that address the interdependent issues, risks, and technology-based mitigations associated with increasing demands and stresses being placed on energy, water, and agricultural/food resources, and the related impacts on their security and sustainability in the face of both domestic and global population growth, expanding economic development, and climate change.

54 ENVIRONMENTAL SCIENCES↗