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At least 649 records · Page 36

Comparison of Two Digital Stethoscopes with the Traditional Stethoscope Used on International Space Station

A traditional stethoscope is currently flown on the International Space Station (ISS). The background noise on the ISS is much higher than a normal exam room, and the literature shows that traditional stethoscopes are unable to function effectively in high noise environments. Digital stethoscopes provide amplification which improves the audibility in a quiet environment. This study is designed to determine if digital stethoscopes offer any advantage over traditional stethoscopes in being able to identify normal and abnormal sounds in the ISS noise environment. Methods: An ISS noise simulation facility was created to reproduce ISS noise profiles by modifying pink noise with a software-based graphic equalizer. The files were played in a continuous loop on a computer, amplified through a high-end stereo system and adjusted using a sound level meter. Nine caregiver analogues were given the same auscultation lesson received by astronauts. They began testing by becoming familiar with normal and abnormal sounds on a Student Auscultation Manikin . They then used two digital stethoscopes and a traditional stethoscope identical to the one flown on the ISS to auscultate the manikin sounds in the noise facility. They identified the sounds on a questionnaire and picked which of the three stethoscopes they preferred. Results: Evaluators displayed equivalent accuracy in sound identification when using either the 3M model 4000 digital stethoscope or traditional stethoscope. However, the 3M was preferred 2 to 1 by the evaluators, primarily because of additional amplification of the sounds. Discussion: Although our results show that the current ISS stethoscope and the "best-of-breed" digital stethoscope provide essentially the same auscultation utility, the latter has the advantage of recording and transmitting sounds to a remote physician. Since the astronaut caregivers are non-physiCians, this capability may be worth the additional expense and effort needed to certify the digital stethoscope for flight.

Rasbury, Jack↗

Test of Shi et al. Method to Infer the Magnetic Reconnection Geometry from Spacecraft Data: MHD Simulation with Guide Field and Antiparallel Kinetic Simulation

When analyzing data from an array of spacecraft (such as Cluster or MMS) crossing a site of magnetic reconnection, it is desirable to be able to accurately determine the orientation of the reconnection site. If the reconnection is quasi-two dimensional, there are three key directions, the direction of maximum inhomogeneity (the direction across the reconnection site), the direction of the reconnecting component of the magnetic field, and the direction of rough invariance (the "out of plane" direction). Using simulated spacecraft observations of magnetic reconnection in the geomagnetic tail, we extend our previous tests of the direction-finding method developed by Shi et al. (2005) and the method to determine the structure velocity relative to the spacecraft Vstr. These methods require data from four proximate spacecraft. We add artificial noise and calibration errors to the simulation fields, and then use the perturbed gradient of the magnetic field B and perturbed time derivative dB/dt, as described by Denton et al. (2010). Three new simulations are examined: a weakly three-dimensional, i.e., quasi-two-dimensional, MHD simulation without a guide field, a quasi-two-dimensional MHD simulation with a guide field, and a two-dimensional full dynamics kinetic simulation with inherent noise so that the apparent minimum gradient was not exactly zero, even without added artificial errors. We also examined variations of the spacecraft trajectory for the kinetic simulation. The accuracy of the directions found varied depending on the simulation and spacecraft trajectory, but all the directions could be found within about 10 for all cases. Various aspects of the method were examined, including how to choose averaging intervals and the best intervals for determining the directions and velocity. For the kinetic simulation, we also investigated in detail how the errors in the inferred gradient directions from the unmodified Shi et al. method (using the unperturbed gradient) depended on the amplitude of the calibration errors. For an accuracy of 3 for the maximum gradient direction, the calibration errors could be as large as 3% of reconnection magnetic field, while for the same accuracy for the minimum gradient direction, the calibration errors could only be as large as 0.03% of the reconnection magnetic field. These results suggest that the maximum gradient direction can normally be determined by the unmodified Shi et al. method, while the modified method or some other method must be used to accurately determine the minimum gradient direction. The structure velocity was found with magnitude accurate to 2% and direction accurate to within 5%.

Denton, R.↗

Measurements of $\textrm{t}\overline{\textrm{t}}\textrm{W}$ differential cross sections and the leptonic charge asymmetry at $\sqrt{s}=13$ TeV

Measurements of properties of top quark-antiquark pair production in association with a W boson in proton-proton collisions at a center-of-mass energy of 13 TeV are presented, using a data sample corresponding to an integrated luminosity of 138 fb −1 , recorded by the CMS experiment at the CERN LHC. Events are selected based on the presence of either two leptons with the same electric charge or three leptons, and multiple jets and b-tagged jets. We present measurements of differential production cross sections as a function of kinematic variables sensitive to different aspects of the process modeling, using a multivariate discriminator in the two-lepton selection region and a simple selection-based method in the three-lepton region. The normalized cross section measurements are generally consistent with the standard model expectations, while we observe larger values compared to the expectations in the absolute cross section measurements, consistent with previous inclusive cross section measurements. In addition, we measure the leptonic charge asymmetry of this process, obtaining an observed value of ${A}_c^{\ell }=-{0.19}_{-0.18}^{+0.16}$, consistent with the expectation of −0.085 ± 0.006 predicted by next-to-leading order simulations.

Hadron-Hadron Scattering↗

An iterative bidirectional gradient boosting approach for CVR baseline estimation

Here this paper presents a novel Iterative Bidirectional Gradient Boosting Model (IBi-GBM) for estimating the baseline of Conservation Voltage Reduction (CVR) programs. In contrast to many existing methods, we treat CVR baseline estimation as a missing data retrieval problem. The approach involves dividing the load and its corresponding temperature profiles into three periods: pre-CVR, CVR, and post-CVR. To restore the missing load profile during the CVR period, the method employs a three-step process. First, a forward-pass GBM is executed using data from the pre-CVR period as inputs. Subsequently, a backward-pass GBM is applied using data from the post-CVR period. The two restored load profiles are reconciled, considering pre-calculated weights derived from forecasting accuracy, and only the leftmost and rightmost points are retained. The newly restored points are then included as inputs for the subsequent iteration. This iterative procedure continues until the original load data in the CVR period is fully restored. We develop IBi-GBM using actual smart meter and Supervisory Control and Data Acquisition (SCADA) data. Our results demonstrate that IBi-GBM exhibits robust performance across various data resolutions and in different seasons and outperforms existing methods by achieving a 1-2% reduction in normalized Root Mean Square Error (nRMSE).

42 ENGINEERING↗

The good, the bad, and the ugly: Data-driven load profile discord identification in a large building portfolio

Reducing the overall energy consumption and associated greenhouse gas emissions in the building sector is essential for meeting our future sustainability goals. Recently, smart energy metering facilities have been deployed to enable monitoring of energy consumption data with hourly or subhourly temporal resolution. This unprecedented data collection has created various opportunities for advanced data analytics involving load profiles (e.g., building energy benchmarking programs, building-to-grid integration, and calibration of urban-scale energy models). These applications often need preprocessing steps to detect daily load profile discords, such as: 1) outliers due to system malfunctions (the bad) and 2) irregular energy consumption patterns, such as those resulting from holidays (the ugly) compared to normal consumption patterns (the good). However, current preprocessing methods predominantly focus on filtering using statistical threshold values, which fail to capture the contextual discords of daily profiles. In addition, discord detection algorithms in building research are often aimed at finding individual building-level discords, which are not suitable at a large scale. Thus, here, we develop a method for automated load profile discord identification (ALDI) in a large portfolio of buildings (more than 100 buildings). Specifically, ALDI 1) uses the matrix profile (MP) method to quantify the similarities of daily subsequences in time series meter data, 2) compares daily MP values with typical-day MP distributions using the Kolmogorov-Smirnov test, and 3) identifies daily load profile discords in a large building portfolio. We evaluate ALDI using the metering data of both an academic campus and a residential neighborhood. Our results demonstrate that ALDI efficiently discovers measurement errors by system malfunctions and low energy consumption days in the academic campus portfolio, and it detects unique load shape patterns likely driven by occupant behavior and extreme weather conditions in the residential neighborhood.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗

An ICP-OES method for the precise and accurate quantification of rare earth elements in natural water: A comparative study from mine waste sites in New Mexico, USA

Inductively coupled plasma techniques such as ICP-OES and ICP-MS are routinely used to determine the concentrations of rare earth elements (REE) in water samples. However, their performance for the determination of REE concentration in mine drainage waters from epithermal vein and porphyry copper mining districts has not been evaluated extensively. In this work, we develop an REE analysis method on an Agilent 5900 ICP-OES instrument and assess the accuracy and precision for the quantification of REE in the natural waters collected from mine adits and an acid seep of mine sites in the Steeple Rock and Hillsboro mining districts, New Mexico, USA. The total REE concentrations in the water samples were measured using the methods we developed for both ICP-OES and ICP-MS. The power of the new ICP-OES method lies in routine analysis of μg/L level concentrations normally analyzed using ICP-MS, including a U.S. Geological Survey standard reference sample, laboratory blank samples spiked with a National Institute of Standards and Technology traceable standard, and surface water samples from mine waste sites. This ICP-OES method achieves low quantification limits ranging from 0.2 to 5 μg/L and excellent analytical accuracy and precision for REE analysis. The precision of light (La-Gd) and heavy (Tb-Lu) REE analysis using this method are better than 5% at average concentrations above 5 ± 4 μg/L and 3 ± 2 μg/L, respectively, and 3% at average concentrations above 10 ± 9 μg/L and 5 ± 4 μg/L, respectively. This method also shows excellent sensitivity and reproducibility for our laboratory and field samples.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

GWAS identifies candidate genes controlling adventitious rooting in Populus trichocarpa

Adventitious rooting (AR) is critical to the propagation, breeding, and genetic engineering of trees. The capacity for plants to undergo this process is highly heritable and of a polygenic nature; however, the basis of its genetic variation is largely uncharacterized. To identify genetic regulators of AR, we performed a genome-wide association study (GWAS) using 1148 genotypes of Populus trichocarpa. GWASs are often limited by the abilities of researchers to collect precise phenotype data on a high-throughput scale; to help overcome this limitation, we developed a computer vision system to measure an array of traits related to adventitious root development in poplar, including temporal measures of lateral and basal root length and area. GWAS was performed using multiple methods and significance thresholds to handle non-normal phenotype statistics and to gain statistical power. These analyses yielded a total of 277 unique associations, suggesting that genes that control rooting include regulators of hormone signaling, cell division and structure, reactive oxygen species signaling, and other processes with known roles in root development. Numerous genes with uncharacterized functions and/or cryptic roles were also identified. These candidates provide targets for functional analysis, including physiological and epistatic analyses, to better characterize the complex polygenic regulation of AR.

59 BASIC BIOLOGICAL SCIENCES↗

Deep Generative Models that Solve PDEs: Distributed Computing for Training Large Data-Free Models

Recent progress in scientific machine learning (SciML) has opened up the possibility of training novel neural network architectures that solve complex partial differential equations (PDEs). Several (nearly data free) approaches have been recently reported that successfully solve PDEs, with examples including deep feed forward networks, generative networks, and deep encoder-decoder networks. However, practical adoption of these approaches is limited by the difficulty in training these models, especially to make predictions at large output resolutions (≥1024×1024). Here we report on a software framework for data parallel distributed deep learning that resolves the twin challenges of training these large SciML models - training in reasonable time as well as distributing the storage requirements. Our framework provides several out of the box functionality including (a) loss integrity independent of number of processes, (b) synchronized batch normalization, and (c) distributed higher-order optimization methods. We show excellent scalability of this framework on both cloud as well as HPC clusters, and report on the interplay between bandwidth, network topology and bare metal vs cloud. We deploy this approach to train generative models of sizes hitherto not possible, showing that neural PDE solvers can be viably trained for practical applications. We also demonstrate that distributed higher-order optimization methods are 2-3× faster than stochastic gradient-based methods and provide minimal convergence drift with higher batch-size.

PDEs↗

TransPlatformer

We propose TransPlatformer for translating toxicogenomics from one platform to another. Transcriptomic profiling has evolved through multiple generations of technology, from microarrays (e.g., Affymetrix, CodeLink) to more recent high-throughput sequencing and targeted panels such as S1500+. Microarrays, which dominated gene expression studies in the early 2000s, provided affordable and high-throughput transcript quantification but suffered from cross-hybridization issues and limited dynamic range . RNA-Seq, introduced in the late 2000s, revolutionized transcriptomics by enabling unbiased and comprehensive gene expression analysis, albeit at higher costs and computational demands . Despite advances, many studies rely on historical microarray data, necessitating the translation of legacy data into modern platforms to ensure continuity and comparability. This translation is complicated by factors such as platform-specific probe design, differences in transcript coverage, and batch effects . Existing methods for cross-platform mapping include statistical normalization, machine learning models, and biological anchoring approaches. The ability to translate transcriptomic data between platforms has broad implications, including enhanced meta-analyses, improved toxicological modeling, and better integration of historical datasets with contemporary research. TransPlatformer seeks to contribute to this effort by evaluating translation methodologies and proposing novel strategies to improve cross-platform gene expression harmonization. In this repository there are code examples for TransPlatformer implementation

Cong, Guojing↗

MadNIS - Neural multi-channel importance sampling

Theory predictions for the LHC require precise numerical phase-space integration and generation of unweighted events. We combine machine-learned multi-channel weights with a normalizing flow for importance sampling, to improve classical methods for numerical integration. We develop an efficient bi-directional setup based on an invertible network, combining online and buffered training for potentially expensive integrands. We illustrate our method for the Drell-Yan process with an additional narrow resonance.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Initial Temperature Testing of Advanced Manufactured Melt Wire Package

As a part of the In-Pile Instrumentation Program, The Idaho National Laboratory (INL) has recently established in-house capabilities to fabricate and test new advanced manufactured sensors for measuring the peak irradiation temperature inside a nuclear test reactor. Although nuclear test reactors can use standard methods of real-time temperature monitoring, such as thermocouples, the complexity of feedthroughs and attachment complications to collect real-time measurements greatly increases the cost of the experiment. Passive monitoring techniques may be utilized that exploit the melting point of well characterized material (standard melt wires), however, the limited space available for instrumentation during experiments is also a challenge. To accommodate the challenge, INL has expanded its temperature detection instrumentation capabilities paired with the advancement of in-house advanced manufacturing options to include printed melt wires for peak irradiation temperature measurement. The advanced manufactured melt wire package can determine peak temperatures in experiments that can fit the challenging space available during irradiation. Recent results and knowledge from this ongoing work have made it possible to develop unique temperature sensors that can accomplish user specific temperature ranges inside the harsh environments experienced during radiation testing. This report summarizes the initial temperature testing using fabricated melt wires with two different melting temperatures, silver (melting temperature of ~960 °C) and solder (melting temperature of ~160 °C), that were initially tested for their relative melting points using non-standard method of furnace and hot plate testing under normal air conditions. Future work will include more controlled way of testing printed melt wires under inert gas with multiple temperature measurements followed by comparison of standard melt wire package performance for baseline characterization.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Use of hexafluoroethane to simulate the inviscid real-gas effects on blunt entry vehicles

Results are presented of an experimental and theoretical investigation of the use of equilibrium hexafluoroethane C2F6 as an undissociated test gas in a wind tunnel to simulate the inviscid aerodynamic characteristics of blunt bodies in high-speed flight where dissociation occurs. The results indicate that the use of C2F6 as a test gas in wind tunnels is a practical and relatively simple and inexpensive method of obtaining test conditions with large normal-shock density ratios. Equations for the thermodynamic and transport properties of C2F6 are also included.

Hunt, J. L.↗

Surfaces and interfaces of glass and ceramics; Proceedings of the International Symposium on Special Topics in Ceramics, Alfred University, Alfred, N.Y., August 27-29, 1973

The characterization of surfaces and interfaces is considered along with the infrared spectra of several N-containing compounds absorbed on montmorillonites, applications of surface characterization techniques to glasses, the observation of electronic spectra in glass and ceramic surfaces, a method for determining the preferred orientation of crystallites normal to a surface, and the friction and wear behavior of glasses and ceramics. Attention is given to the wear behavior of cast surface composites, an experimental investigation of the dynamic and thermal characteristics of the ceramic stock removal process, a dynamic elastic model of ceramic stock removal, and the structure and properties of solid surfaces. Individual items are announced in this issue.

Frechette, V. D.↗

Axial flow rotor unsteady response to circumferential inflow distortions

The unsteady response of an axial flow fan rotor to steady, circumferential inflow velocity and stagnation pressure distortions is assessed by two different methods. These are: (1) investigation of the unsteady normal force and pitching moment on a chordwise element of a rotor blade; and (2) investigation of the variation of the stagnation pressure distortion between the inlet and exit of the rotor. Experimental measurements of these unsteady characteristics are presented as a function of the geometry of the rotor -- stagger angle, solidity and steady angle of incidence -- for sinusoidally varying circumferential distortions with different numbers of distortion cycles. These measurements are compared with several theoretical analyses. While these comparisons indicate some of the deficiencies which exist in the theories, the existence of an unsteady cascade effect and the ability of the theories to adequately predict the trend of the unsteady response due to variations in reduced frequency, rotor stagger angle, solidity and mean incidence angle is clearly demonstrated.

Bruce, E. P.↗

Time-dependent, non-Newtonian behavior of viscoelastic materials

A kinetic model for characterizing the shear stress or shear strain rate of thixotropic materials is developed and combined with Oldroyd's viscoelastic model (1953) modified in this paper in order to predict the first normal stress difference. In order to test the method, transient and steady state data have been obtained with a Weissenberg rheogoniometer used to measure the constant stress and constant shear rate of a solution of polymethyl methacrylate in diethylphthalate. A computer was used to facilitate data acquisition.

Jachimiak, P. D.↗