Results for “image alignment” — Page 36

DOE OSTI2016

WE-H-202-01: Memorial Introduction

Deformable image registration has now been commercially available for several years, with solid performance in a number of sites and for several applications including contour and dose mapping. However, more complex applications have arisen, such as assessing response to radiation therapy over time, registering images pre- and post-surgery, and auto-segmentation from atlases. These applications require innovative registration algorithms to achieve accurate alignment. The goal of this session is to highlight emerging registration technology and these new applications. The state of the art in image registration will be presented from an engineering perspective. Translational clinical applications will also be discussed to tie these new registration approaches together with imaging and radiation therapy applications in specific diseases such as cervical and lung cancers. Learning Objectives: To understand developing techniques and algorithms in deformable image registration that are likely to translate into clinical tools in the near future. To understand emerging imaging and radiation therapy clinical applications that require such new registration algorithms. Research supported in part by the National Institutes of Health under award numbers P01CA059827, R01CA166119, and R01CA166703. Disclosures: Phillips Medical systems (Hugo), Roger Koch (Christensen) support, Varian Medical Systems (Brock), licensing agreements from Raysearch (Brock) and Varian (Hugo).; K. Brock, Licensing Agreement - RaySearch Laboratories. Research Funding - Varian Medical Systems; G. Hugo, Research grant from National Institutes of Health, award number R01CA166119.; G. Christensen, Research support from NIH grants CA166119 and CA166703 and a gift from Roger Koch. There are no conflicts of interest.

60 APPLIED LIFE SCIENCES↗

DOE OSTI2016

WE-H-202-02: Biomechanical Modeling of Anatomical Response Over the Course of Therapy

Deformable image registration has now been commercially available for several years, with solid performance in a number of sites and for several applications including contour and dose mapping. However, more complex applications have arisen, such as assessing response to radiation therapy over time, registering images pre- and post-surgery, and auto-segmentation from atlases. These applications require innovative registration algorithms to achieve accurate alignment. The goal of this session is to highlight emerging registration technology and these new applications. The state of the art in image registration will be presented from an engineering perspective. Translational clinical applications will also be discussed to tie these new registration approaches together with imaging and radiation therapy applications in specific diseases such as cervical and lung cancers. Learning Objectives: To understand developing techniques and algorithms in deformable image registration that are likely to translate into clinical tools in the near future. To understand emerging imaging and radiation therapy clinical applications that require such new registration algorithms. Research supported in part by the National Institutes of Health under award numbers P01CA059827, R01CA166119, and R01CA166703. Disclosures: Phillips Medical systems (Hugo), Roger Koch (Christensen) support, Varian Medical Systems (Brock), licensing agreements from Raysearch (Brock) and Varian (Hugo).; K. Brock, Licensing Agreement - RaySearch Laboratories. Research Funding - Varian Medical Systems; G. Hugo, Research grant from National Institutes of Health, award number R01CA166119.; G. Christensen, Research support from NIH grants CA166119 and CA166703 and a gift from Roger Koch. There are no conflicts of interest.

60 APPLIED LIFE SCIENCES↗

DOE OSTI2016

WE-H-202-03: Accounting for Large Geometric Changes During Radiotherapy

Deformable image registration has now been commercially available for several years, with solid performance in a number of sites and for several applications including contour and dose mapping. However, more complex applications have arisen, such as assessing response to radiation therapy over time, registering images pre- and post-surgery, and auto-segmentation from atlases. These applications require innovative registration algorithms to achieve accurate alignment. The goal of this session is to highlight emerging registration technology and these new applications. The state of the art in image registration will be presented from an engineering perspective. Translational clinical applications will also be discussed to tie these new registration approaches together with imaging and radiation therapy applications in specific diseases such as cervical and lung cancers. Learning Objectives: To understand developing techniques and algorithms in deformable image registration that are likely to translate into clinical tools in the near future. To understand emerging imaging and radiation therapy clinical applications that require such new registration algorithms. Research supported in part by the National Institutes of Health under award numbers P01CA059827, R01CA166119, and R01CA166703. Disclosures: Phillips Medical systems (Hugo), Roger Koch (Christensen) support, Varian Medical Systems (Brock), licensing agreements from Raysearch (Brock) and Varian (Hugo).; K. Brock, Licensing Agreement - RaySearch Laboratories. Research Funding - Varian Medical Systems; G. Hugo, Research grant from National Institutes of Health, award number R01CA166119.; G. Christensen, Research support from NIH grants CA166119 and CA166703 and a gift from Roger Koch. There are no conflicts of interest.

60 APPLIED LIFE SCIENCES↗

DOE OSTI2016

WE-H-202-04: Advanced Medical Image Registration Techniques

Deformable image registration has now been commercially available for several years, with solid performance in a number of sites and for several applications including contour and dose mapping. However, more complex applications have arisen, such as assessing response to radiation therapy over time, registering images pre- and post-surgery, and auto-segmentation from atlases. These applications require innovative registration algorithms to achieve accurate alignment. The goal of this session is to highlight emerging registration technology and these new applications. The state of the art in image registration will be presented from an engineering perspective. Translational clinical applications will also be discussed to tie these new registration approaches together with imaging and radiation therapy applications in specific diseases such as cervical and lung cancers. Learning Objectives: To understand developing techniques and algorithms in deformable image registration that are likely to translate into clinical tools in the near future. To understand emerging imaging and radiation therapy clinical applications that require such new registration algorithms. Research supported in part by the National Institutes of Health under award numbers P01CA059827, R01CA166119, and R01CA166703. Disclosures: Phillips Medical systems (Hugo), Roger Koch (Christensen) support, Varian Medical Systems (Brock), licensing agreements from Raysearch (Brock) and Varian (Hugo).; K. Brock, Licensing Agreement - RaySearch Laboratories. Research Funding - Varian Medical Systems; G. Hugo, Research grant from National Institutes of Health, award number R01CA166119.; G. Christensen, Research support from NIH grants CA166119 and CA166703 and a gift from Roger Koch. There are no conflicts of interest.

60 APPLIED LIFE SCIENCES↗

NASA NTRS2010

Metrology Requirements of Future X-Ray Telescopes

Fundamental needs for future x-ray telescopes: a) Sharp images => excellent angular resolution. b) High throughput => large aperture areas. Generation-X optics technical challenges: a) High resolution => precision mirrors & alignment. b) Large apertures => lots of lightweight mirrors. Innovation needed for technical readiness: a) 4 top-level error terms contribute to image size. b) There are approaches to controlling those errors. Innovation needed for manufacturing readiness: Programmatic issues are at least as severe

Gubarev, Mikhail↗

NASA NTRS2010

High-Resolution X-Ray Telescopes

Fundamental needs for future x-ray telescopes: a) Sharp images => excellent angular resolution. b) High throughput => large aperture areas. Generation-X optics technical challenges: a) High resolution => precision mirrors & alignment. b) Large apertures => lots of lightweight mirrors. Innovation needed for technical readiness: a) 4 top-level error terms contribute to image size. b) There are approaches to controlling those errors. Innovation needed for manufacturing readiness. Programmatic issues are comparably challenging.

ODell, Stephen L.↗

DOE OSTI2013

Distance-preserving rigidity penalty on deformable image registration of multiple skeletal components in the neck

Purpose: This study aims at developing and testing a novel rigidity penalty suitable for the deformable registration of tightly located skeletal components in the head and neck from planning computed tomography (CT) and daily cone-beam CT (CBCT) scans of patients undergoing radiotherapy. Methods: The proposed rigidity penalty is designed to preserve intervoxel distances within each bony structure. This penalty was tested in the intensity-based B-spline deformable registration of five cervical vertebral bodies (C1–C5). The displacement vector fields (DVFs) from the registrations were compared to the DVFs generated by using rigid body motions of the cervical vertebrae, measured by the surface registration of vertebrae delineated on CT and CBCT images. Twenty five pairs of planning CT (reference) and treatment CBCTs (target) from five patients were aligned without and with the penalty. An existing penalty based on the orthonormality of the deformation gradient tensor was also tested and the effects of the penalties compared. Results: The mean magnitude of the maximum registration error with the proposed distance-preserving penalty was (0.86, 1.12, 1.33) mm compared to (2.11, 2.49, 2.46) without penalty and (1.53, 1.64, 1.64) with the existing orthonormality-based penalty. The improvement in the accuracy of the deformable image registration was also verified by comparing the Procrustes distance between the DVFs. With the proposed penalty, the average distance was 0.11 (σ 0.03 mm) which is smaller than 0.53 (0.1 mm) without penalty and 0.28 (0.04 mm) with the orthonormality-based penalty. Conclusions: The accuracy of aligning multiple bony elements was improved by using the proposed distance-preserving rigidity penalty. The voxel-based statistical analysis of the registration error shows that the proposed penalty improved the integrity of the DVFs within the vertebral bodies.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

NASA NTRS1994

Locating buildings in aerial photos

Algorithms and techniques for use in the identification and location of large buildings in digitized copies of aerial photographs are developed and tested. The building data would be used in the simulation of objects located in the vicinity of an airport that may be detected by aircraft radar. Two distinct approaches are considered. Most building footprints are rectangular in form. The first approach studied is to search for right-angled corners that characterize rectangular objects and then to connect these corners to complete the building. This problem is difficult because many nonbuilding objects, such as street corners, parking lots, and ballparks often have well defined corners which are often difficult to distinguish from rooftops. Furthermore, rooftops come in a number of shapes, sizes, shadings, and textures which also limit the discrimination task. The strategy used linear sequences of different samples to detect straight edge segments at multiple angles and to determine when these segments meet at approximately right-angles with respect to each other. This technique is effective in locating corners. The test image used has a fairly rectangular block pattern oriented about thirty degrees clockwise from a vertical alignment, and the overall measurement data reflect this. However, this technique does not discriminate between buildings and other objects at an operationally suitable rate. In addition, since multiple paths are tested for each image pixel, this is a time consuming task. The process can be speeded up by preprocessing the image to locate the more optimal sampling paths. The second approach is to rely on a human operator to identify and select the building objects and then to have the computer determine the outline and location of the selected structures. When presented with a copy of a digitized aerial photograph, the operator uses a mouse and cursor to select a target building. After a button on the mouse is pressed, with the cursor fully within the perimeter of the building, the program scans from the position of the cursor to a perimeter position where a shift in grayscale is detected. Once at the perimeter, the process traces along it, around the building, until it eventually returns to the perimeter starting point. Spatial resolution limits cause the perimeter trace to be somewhat course so that a line straightening algorithm is employed. One result is that the building corner positions become more distinctly defined.

Green, James S.↗

NASA NTRS1974

The utilization of ERTS-1-generated photographs in the evaluation of the Iranian playas as potential locations for economic and engineering development

The author has identified the following significant results. Seasonal monitoring of hydrologic conditions at three playa lakes provides a basis for constructing an annual water inventory for these lakes. Although the extreme variation in the extent of playa lakes must be considered, the principal periods of their fluctuations are generally constant. Playa lakes provide an important water source for arid region needs, and their water can be diverted and stored for use during the long, hot, and dry summer. At their 1973 maxima, approximately 400 million cu m and 794 million cu m of water were available at the lakes at Qom and Neriz playas, respectively. These lakes adjoin areas of moderately dense population that have severe annual water deficits. A preliminary road alignment across the Great Kavir in north-central Iran has been prepared from an analysis of ERTS-1 images of that area from September 2, 1972, through May 12, 1973, a total of 6 scenes. An all-weather road constructed along this alignment could reduce the distance between points north and south of the Great Kavir by as much as 700 km.

Krinsley, D. B.↗

NASA NTRS1997

Global MHD Magnetospheric Simulation of January 10, 1997 Encounter with Magnetic Cloud

We present a global MHD magnetospheric simulation of the encounter of the magnetic cloud with the terrestrial magnetosphere on January 10-11, 1997. The MHD simulation is driven by IMF and solar wind plasma measurements provided by Wind situated about 100 $R_E$ upstream from Earth. Field-aligned currents produced in the model are mapped down to the ionosphere and are directly compared to auroral images from the Polar UVI. Particular attention will be paid to the interval following the the initial shock wave arrival (around 0100 UT on the 1Oth) but preceding the passage of the magnetic cloud proper (commencing at about 0430 UT) for which there was continuous viewing of the entire auroral oval from apogee by Polar. This turbulent period is characterized by numerous dynamic pressure rises and dips and several northward and southward turnings of the IMF, all of which generate dynamic activity in the simulation that is reflected in the mapped field-aligned current patterns. As discussed by Brittnacher et al. in this session, the auroral morphology imaged by UVI during this period includes: shock wave-induced brightening of the oval followed by a pseudo-onset near midnight, several sun-aligned and curled arcs within the polar cap, an expanding polar cap cleared of arcs, and finally substorm onset at 0337 UT. These features will be directly compared to region 1 and 2 current systems as well as cusp currents in the simulation. Spacecraft magnetopause crossings are also predicted by the global simulation and will be compared to observed crossings, including numerous dayside crossings by Geotail on the 1Oth, and geosynchronous crossings early on January 11.

Elsen, R.↗

DOE OSTI2012

A spherical crystal imager for OMEGA EP

A narrowband x ray imager for the Cu Kα line at ~8 keV using a spherically bent quartz crystal has been implemented on the OMEGA EP laser at the University of Rochester. The quartz crystal is cut along the 2131 (211) planes for a 2d spacing of 0.3082 nm, resulting in a Bragg angle of 88.7°, very close to normal incidence. An optical system is used to remotely align the spherical crystal without breaking the vacuum of the target chamber. The images show a high signal-to-background ratio of typically >100:1 with laser energies ≥1 kJ at a 10-ps pulse duration and a spatial resolution of less than 10 μm.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

NASA NTRS2002

Primary Mirror Figure Maintenance of the Hobby-Eberly Telescope using the Segment Alignment Maintenance System

The Segment Alignment Maintenance System (SAMs) was installed on McDonald Observatory's Hobby-Eberly Telescope (HET) in August 2001. The SAMs became fully operational in October 2001. The SAMs uses a system of 480 inductive edge sensors to correct misalignments of the HET's 91 primary mirror segments when the segments are perturbed from their aligned reference positions. A special observer estimated and corrects for the global radius of curvature (GroC) mode, a mode unobservable by the edge sensors. The SAMs edge sensor system and (GroC) estimator are able to maintain HET's primary figure for much longer durations than previously had been observed. Telescope image quality has improved, and the amount of overhead time required from primary mirror alignment has been reduced. This paper gives a functional description of the SAMs control system and presents performance verification data. This paper also describes how the SAMs has improved the operational efficiency of the HET.

Rakoczy, John↗

NASA NTRS2005

Alignment, Assembly and Testing of High Energy X-Ray Optics

We are developing grazing-incidence x-ray imaging optics for a balloon-borne hard x-ray telescope (HERO). The HERO payload, scheduled for launch in May 2005, currently consists of 8 mirror modules each containing 12 mirror shells fabricated using electroform-nickel replication off super-polished cylindrical mandrels. An optical system developed for aligning and assembling the shells in the modules will be described. Sources for systematic errors associated with this process will be discussed and results from on-ground x-ray testing of each module will be presented.

Gubarev, Mikhail↗

DOE OSTI2014

Cine EPID evaluation of two non-commercial techniques for DIBH

Purpose: To evaluate the efficacy of two noncommercial techniques for deep inspiration breathhold (DIBH) treatment of left-sided breast cancer (LSBC) usingcine electronic portal imaging device (EPID) images. Methods: 23 875 EPID images of 65 patients treated for LSBC at two different cancer treatment centers were retrieved. At the Milford Regional Cancer Center, DIBH stability was maintained by visual alignment of inroom lasers and patient skin tattoos (TAT). At the South Shore Hospital, a distance-measuring laser device (RTSSD) was implemented. For both centers,cine EPID images were acquired at least once per week during beam-on. Chest wall position relative to image boundary was measured and tracked over the course of treatment for every patient and treatment fraction for which data were acquired. Results: Median intrabeam chest motion was 0.31 mm for the TAT method and 0.37 mm for the RTSSD method. The maximum excursions exceeded our treatment protocol threshold of 3 mm in 0.3% of cases (TAT) and 1.2% of cases (RTSSD). The authors did not observe a clinically significant difference between the two datasets. Conclusions: Both noncommercial techniques for monitoring the DIBH location provided DIBH stability within the predetermined treatment protocol parameters (<3 mm). The intreatment imaging offered by the EPID operating incine mode facilitates retrospective analysis and validation of both techniques.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

DOE OSTI2021

Key Elements of Auroral Substorm Development and their Relationship to Recent Observations of Detached Sub-Auroral Phenomena Including STEVE-like Emissions

Since Akasofu introduced the concept of the substorm in 1964, numerous refinements have been added to the phenomenological model of how auroral substorms develop. Here, we review several of the most important of these including; polar cap patches, intensifications of the Polar Activated Band (PAB) at the poleward edge of the bulge, the development of new arcs poleward, the generation of auroral streamers, the evolution of streamers into auroral torches and omega bands, the association of streamers with particle injection and BBF activity in the tail, and wedgelet-like magnetic perturbations on the ground. We also review the concept of “contact breakups” which are breakups that appear to be triggered by the arrival of streamer-like forms in the equatorward regions of the oval. Finally, we remind the community that the addition of detached sub-auroral emissions was made to the phenomenological picture of substorm develop in the late 1960s along with the concept of auroral streamers. Newer observations of detached sub-auroral (STEVE-like emissions) from the Viking/UVI and POLAR/VIS imagers are presented which confirm that they are east-west aligned bands of emission that separate away from the equatorward edge of the auroral oval in response to intensifications of the poleward edge of the bulge and subsequent streamer production. We propose a new model for the formation of detached sub-auroral (STEVE-like) emissions in which a non-linear growth of a SAPS-driven instability (e.g. like the shear-flow/ballooning instability) at the plasmapause results in the disruption of the boundary separating hot plasma sheet particle from the cold plasmaspheric plasma. It is proposed that the resulting intermixing of plasma populations leads to both the observed STEVE-like emissions and also provides a source of cold plasma on open drift paths that can feed the long-lived drainage plumes that have recently been discovered.

58 GEOSCIENCES↗

DOE OSTI2017

Atomically precise graphene nanoribbon heterojunctions from a single molecular precursor

The rational bottom-up synthesis of atomically defined graphene nanoribbon (GNR) heterojunctions represents an enabling technology for the design of nanoscale electronic devices. Synthetic strategies used thus far have relied on the random copolymerization of two electronically distinct molecular precursors to yield GNR heterojunctions. In this paper we report the fabrication and electronic characterization of atomically precise GNR heterojunctions prepared through late-stage functionalization of chevron GNRs obtained from a single precursor. Post-growth excitation of fully cyclized GNRs induces cleavage of sacrificial carbonyl groups, resulting in atomically well-defined heterojunctions within a single GNR. The GNR heterojunction structure was characterized using bond-resolved scanning tunnelling microscopy, which enables chemical bond imaging at T = 4.5 K. Scanning tunnelling spectroscopy reveals that band alignment across the heterojunction interface yields a type II heterojunction, in agreement with first-principles calculations. Finally, GNR heterojunction band realignment proceeds over a distance less than 1 nm, leading to extremely large effective fields.

77 NANOSCIENCE AND NANOTECHNOLOGY↗

DOE OSTI2023

Hybrid achromatic microlenses with high numerical apertures and focusing efficiencies across the visible

Abstract Compact visible wavelength achromats are essential for miniaturized and lightweight optics. However, fabrication of such achromats has proved to be exceptionally challenging. Here, using subsurface 3D printing inside mesoporous hosts we densely integrate aligned refractive and diffractive elements, forming thin high performance hybrid achromatic imaging micro-optics. Focusing efficiencies of 51–70% are achieved for 15μm thick, 90μm diameter, 0.3 numerical aperture microlenses. Chromatic focal length errors of less than 3% allow these microlenses to form high-quality images under broadband illumination (400–700 nm). Numerical apertures upwards of 0.47 are also achieved at the cost of some focusing efficiency, demonstrating the flexibility of this approach. Furthermore, larger area images are reconstructed from an array of hybrid achromatic microlenses, laying the groundwork for achromatic light-field imagers and displays. The presented approach precisely combines optical components within 3D space to achieve thin lens systems with high focusing efficiencies, high numerical apertures, and low chromatic focusing errors, providing a pathway towards achromatic micro-optical systems.

47 OTHER INSTRUMENTATION↗

DOE OSTI2017

A Dimensionally Aligned Signal Projection for Classification of Unintended Radiated Emissions

Characterization of unintended radiated emissions (URE) from electronic devices plays an important role in many research areas from electromagnetic interference to nonintrusive load monitoring to information system security. URE can provide insights for applications ranging from load disaggregation and energy efficiency to condition-based maintenance of equipment-based upon detected fault conditions. URE characterization often requires subject matter expertise to tailor transforms and feature extractors for the specific electrical devices of interest. We present a novel approach, named dimensionally aligned signal projection (DASP), for projecting aligned signal characteristics that are inherent to the physical implementation of many commercial electronic devices. These projections minimize the need for an intimate understanding of the underlying physical circuitry and significantly reduce the number of features required for signal classification. We present three possible DASP algorithms that leverage frequency harmonics, modulation alignments, and frequency peak spacings, along with a two-dimensional image manipulation method for statistical feature extraction. To demonstrate the ability of DASP to generate relevant features from URE, we measured the conducted URE from 14 residential electronic devices using a 2 MS/s collection system. Furthermore, a linear discriminant analysis classifier was trained using DASP generated features and was blind tested resulting in a greater than 90% classification accuracy for each of the DASP algorithms and an accuracy of 99.1% when DASP features are used in combination. Furthermore, we show that a rank reduced feature set of the combined DASP algorithms provides a 98.9% classification accuracy with only three features and outperforms a set of spectral features in terms of general classification as well as applicability across a broad number of devices.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗