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At least 649 records · Page 36
All sourcesNASA NTRSDOE OSTI
DOE OSTI2022

Disruption of the tagF Orthologue in the epa Locus Variable Region of Enterococcus faecalis Causes Cell Surface Changes and Suppresses an eep -Dependent Lysozyme Resistance Phenotype

The disease-producing capacity of the opportunistic pathogen Enterococcus faecalis is enhanced by the ability of the bacterium to evade killing by antimicrobial agents. Survival of E. faecalis in the presence of the human antimicrobial enzyme lysozyme is mediated in part by the site 2 metalloprotease Eep; however, a complete model of enterococcal lysozyme resistance has not been elucidated. To better understand the molecular basis for lysozyme resistance in E. faecalis, we analyzed Δeep suppressor mutants that acquire resistance to lysozyme through mutation of the gene OG1RF_11713, a predicted teichoic acid biosynthesis-encoding gene located within the variable region of the enterococcal polysaccharide antigen (epa) locus. Sequence comparisons revealed that OG1RF_11713 is most similar to the cytidine-5'-diphosphate (CDP)-glycerol:poly-(glycerolphosphate)glycerophosphotransferase TagF from Staphylococcus epidermidis. Inactivation of OG1RF_11713 in both the wild-type and Δeep genetic backgrounds was sufficient to increase the resistance of E. faecalis OG1RF to lysozyme. Minimal amounts of N-acetylgalactosamine were detectable in cell wall carbohydrate extracts of OG1RF_11713 deletion mutants, and this was associated with a reduction in negative cell surface charge. Targeted disruption of OG1RF_11713 was also associated with increased susceptibility to the antibiotic polymyxin B and membrane-targeting detergents and decreased susceptibility to the lantibiotic nisin. Furthermore, this work implicates OG1RF_11713 as a major determinant of cell envelope integrity and provides further validation that lysozyme resistance is intrinsically linked to the modification of enterococcal cell wall polysaccharides.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2020

Suppression of Penning discharges between the KATRIN spectrometers

Abstract The KArlsruhe TRItium Neutrino experiment (KATRIN) aims to determine the effective electron (anti)-neutrino mass with a sensitivity of 0.2eV/c $$^2$$ 2 by precisely measuring the endpoint region of the tritium $$\beta $$ β -decay spectrum. It uses a tandem of electrostatic spectrometers working as magnetic adiabatic collimation combined with an electrostatic (MAC-E) filters. In the space between the pre-spectrometer and the main spectrometer, creating a Penning trap is unavoidable when the superconducting magnet between the two spectrometers, biased at their respective nominal potentials, is energized. The electrons accumulated in this trap can lead to discharges, which create additional background electrons and endanger the spectrometer and detector section downstream. To counteract this problem, “electron catchers” were installed in the beamline inside the magnet bore between the two spectrometers. These catchers can be moved across the magnetic-flux tube and intercept on a sub-ms time scale the stored electrons along their magnetron motion paths. In this paper, we report on the design and the successful commissioning of the electron catchers and present results on their efficiency in reducing the experimental background.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗
DOE OSTI2021

Millisecond-long suppression of spectroscopic optical signals using laser filamentation

Ultrashort laser pulse filamentation in air can extend the delivery of focused laser energy to distances greatly exceeding the Rayleigh length. In this way, remote measurements can be conducted using many standard methods of analytical spectroscopy. The performance of spectroscopic techniques can be enhanced by temporal gating, which rejects the unwanted noise and background. In the present work, we investigate the thermal relaxation of air in the wake of single-filament plasmas using shadowgraphy. Here, we demonstrate that the transient change in refractive index associated with relaxation of the gas can be used to reject both continuous and time-varying spectroscopic signals, including emission from laser-produced plasmas. This method can augment temporal gating of simple optical detectors.

47 OTHER INSTRUMENTATION↗
DOE OSTI2023

Suppression of coherent interference to electric-field-induced second-harmonic (E-FISH) signals for the measurement of electric field in mesoscale confined geometries

We present spatially enhanced electric-field-induced second-harmonic (SEEFISH) generation with a chirped femtosecond beam for measurements of electric field in mesoscale confined geometries subject to destructive spurious second-harmonic generation (SHG). Spurious SHG is shown to interfere with the measured E-FISH signal coherently, and thus simple background subtraction is not sufficient for single-beam E-FISH approaches, especially in a confined system with a large surface-to-volume ratio. The results show that a chirped femtosecond beam is effective in preventing higher-order mixing and white light generation in windows near the beam focal point which further contaminates the SEEFISH signal. The successful measurements of electric field of a nanosecond dielectric barrier discharge in a test cell demonstrated that spurious SHG detected with a congruent traditional E-FISH approach can be eliminated using the SEEFISH approach.

Vorenkamp, Madeline↗
DOE OSTI2023

Numerical Modeling of Air-Blast Suppression as a Function of Explosive-Charge Burial Depth

As a chemical explosion is buried, the mechanism for acoustic wave generation transitions from fully gas-generated at the surface to completely spall-induced at full containment depth. The fully gas-generated and completely spall-induced signals in the acoustic waveform are well described; however, the transition between these two end-members eludes numerical modeling because of the complex phenomena that are involved. The phenomena of crater formation and explosive cloud evolution are simulated using an Eulerian hydrocode that incorporates geomaterials with strength and porosity. Having accurately modeled these phenomena, we can confidently predict the propagation and relative strength of the gas-generated and spall-induced pulses in the recorded acoustic waveform. The numerical predictions agree with observations from the historical Stagecoach experiment as well as modern recordings from the Source Physics Experiment. In particular, the peak pressure p generated by an explosion is initially due to the gas-generated mechanism and decays with scaled depth of burial d s (depth d scaled by the cube-root of explosive yield w 1/3 ) as exp(-d s ) but then transitions near a scaled depth of 6 m/ton 1/3 to the spall-generated mechanism in which the decay is d$_{s}^{-7/4}$. This decay form is related to the strong ground-motion attenuation relationship that affects spall strength. So these results can improve seismoacoustic inverse models for the explosive source that need to account for the gas-generated and spall-induced signals and their effect on peak pressures and other acoustic signal features.

58 GEOSCIENCES↗
DOE OSTI2024

Accessing CKM suppressed top decays at the LHC

We propose an extension of the existing experimental strategy for measuring branching fractions of top quark decays, targeting specifically t\to j_q W t → j q W , where j_q j q is a light quark jet. The improved strategy uses orthogonal b b - and q q -taggers, and adds a new observable, the number of light-quark-tagged jets, to the already commonly used observable, the fraction of b b -tagged jets in an event. Careful inclusion of the additional complementary observable significantly increases the expected statistical power of the analysis, with the possibility of excluding |V_{tb}|=1 | V t b | = 1 at 95\% 95 % C.L. at the HL-LHC, and accessing directly the standard model value of |V_{td}|^2+|V_{ts}|^2 | V t d | 2 + | V t s | 2 .

Faroughy, Darius A. (ORCID:0000000240275477)↗
DOE OSTI2021

Electron Activity (Secondary Electron & Field Emission ) Suppression by Magnetic Field Placed on the Surface of Metals And Dielectric [Slides]

Secondary electron emission happens when the surface is exposed to an oscillating electromagnetic field. It has extremely dangerous effect when resonance condition of this oscillating field and higher SEY conditions are met. The dependence of the secondary electron on primary electron energy is shown in the figure. This multiplication effect on the number of electrons in oscillating electromagnetic field is called multipacting. The problem with multipacting exist in many scientific fields like LHC, ISS, ITER involving particle accelerator, space science and fusion research. In high intensity proton rings this multiplies electron get trapped inside the potential created by proton beam called electron cloud. In High power microwave sources, rf couplers and rf window to couple the power also hugely affected by multipacting.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗
DOE OSTI2021

Integrable optics design principles for beam halo suppression in accelerator rings at the intensity frontier

RadiaSoft LLC is collaborating with Fermilab to fundamentally advance the field of particle accelerator design, in order to reduce cost and technical risk for next-generation hadron accelerators, and to more rapidly advance the intensity frontier of high energy physics. The Fermilab PI is one of the originators of the theory of integrable nonlinear magnetic lattices. Fermilab is the only laboratory in the world pursuing the experimental verification of the theory. Transferring Fermilab expertise to RadiaSoft LLC will enhance US competitiveness by enabling US industry to engage in the design of future high intensity hadron rings for spallation sources, neutrino sources, muon sources, subcritical nuclear reactors and waste transmutation facilities.

43 PARTICLE ACCELERATORS↗
DOE OSTI2024

Disruption avoidance via island suppression: the crucial roles of DIII-D and foundational research

The FESAC long range plan calls out disruption avoidance and mitigation as key remaining technical gaps. In discussing the roles of DIII-D and NSTX-U, the FESAC long range plan says “Additional research on these facilities, in combination with private and international collaborations, continuing support of existing university tokamak programs, and utilization of US expertise in theory and simulation, is needed to find solutions to remaining technical gaps. These gaps include disruption prediction, avoidance, and mitigation …”. Disruptions pose an existential threat to ITER and to FPPs. For a fusion reactor, unplanned shutdowns caused by disruptions will be a significant barrier to connecting such a reactor to the electric grid, even if disruption mitigation is successful. Disruption studies for ITER in recent years have largely focused on disruption mitigation (e.g., pellet injection), motivated by near-term deadlines for finalizing the design of the mitigation hardware. It is recognized, however, that mitigation alone will not suffice. The 2022 U.S. ITER Research Needs Workshop Report states that ”[d]isruptions are considered the largest threat to the ITER Research Program”, and that “[m]itigation should be a last resort”. As we discuss below, there are unresolved foundational issues that play a critical role in avoidance, and DIII-D is an ideal device for generating the data needed to address these issues.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗
DOE OSTI2024

Additive manufacturing enabled hot-wire apparatus with suppressed edge effect error

This invention describes a method of structuring a metal or metal coated wire in a manner such that it provides enhanced accuracy when used in a hot-wire apparatus for transient thermal conductivity measurements for low-density materials. This is accomplished by using a diameter varying structure with two ends of the wire of sufficiently small diameter that the edge-effect induced error can be reduced by generating a more uniform temperature profile along the wire, whereas in conventional apparatus the temperatures always drop at the ends of a finite wire due to its ends that are being cooled by the wire-supports.

36 MATERIALS SCIENCE↗
DOE OSTI2025

Radar clutter suppression

I have been working on something called clutter, which is an amount of “noise” caused by the surrounding environment in a radar system photo or image. The radar system is called “synthetic aperture radar” or SAR. Our group is trying to clarify the photo and hence data of an SAR image by removing clutter (and noise) from the photograph. This is done by utilizing advanced signal processing techniques and the MATLAB programming language on our computer.

Evans, Bradley [External Affiliation]↗
DOE OSTI2022

Sequential optical response suppression for chemical mixture characterization

The characterization of mixtures of non-interacting, spectroscopically similar quantum components has important applications in chemistry, biology, and materials science. We introduce an approach based on quantum tracking control that allows for determining the relative concentrations of constituents in a quantum mixture, using a single pulse which enhances the distinguishability of components of the mixture and has a length that scales linearly with the number of mixture constituents. To illustrate the method, we consider two very distinct model systems: mixtures of diatomic molecules in the gas phase, as well as solid-state materials composed of a mixture of components. A set of numerical analyses are presented, showing strong performance in both settings.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
DOE OSTI2020

Magnetic Vortex and Hyperthermia Suppression in Multigrain Iron Oxide Nanorings

Single-crystal iron oxide nanorings have been proposed as a promising candidate for magnetic hyperthermia application because of their unique shape-induced vortex-domain structure, which supports good colloidal stability and enhanced magnetic properties. However, the synthesis of single crystalline iron oxide has proven to be challenging. In this article, we showed that chemically synthesized multigrain magnetite nanorings disfavor a shape-induced magnetic vortex-domain structure. Our results indicate that the multigrain Fe 3 O 4 nanorings with an average outer diameter of ~110 nm and an inner to outer diameter ratio of ~0.5 do not show a shape-induced vortex-domain structure, which was observed in the single-crystal Fe 3 O 4 nanorings of similar dimensions. At 300 Ks, multigrain magnetite nanorings showed an effective anisotropy field of 440 Oe, which can be attributed to its high surface area and intraparticle interaction. Both calorimetric and AC loop measurements showed a moderate inductive heating efficiency of multigrain magnetite nanorings of ~300 W/g at 800 Oe. Our results shed light on the magnetic ground states of chemically synthesized multigrain Fe 3 O 4 nanorings.

36 MATERIALS SCIENCE↗
DOE OSTI2022

High Accuracy Indicators of Androgen Suppression Therapy Failure for Prostate Cancer—A Modeling Study

Prostate cancer is a serious public health concern in the United States. The primary obstacle to effective long-term management for prostate cancer patients is the eventual development of treatment resistance. Due to the uniquely chaotic nature of the neoplastic genome, it is difficult to determine the evolution of tumor composition over the course of treatment. Hence, a drug is often applied continuously past the point of effectiveness, thereby losing any potential treatment combination with that drug permanently to resistance. If a clinician is aware of the timing of resistance to a particular drug, then they may have a crucial opportunity to adjust the treatment to retain the drug’s usefulness in a potential treatment combination or strategy. In this study, we investigate new methods of predicting treatment failure due to treatment resistance using a novel mechanistic model built on an evolutionary interpretation of Droop cell quota theory. We analyze our proposed methods using patient PSA and androgen data from a clinical trial of intermittent treatment with androgen deprivation therapy. Our results produce two indicators of treatment failure. The first indicator, proposed from the evolutionary nature of the cancer population, is calculated using our mathematical model with a predictive accuracy of 87.3% (sensitivity: 96.1%, specificity: 65%). The second indicator, conjectured from the implication of the first indicator, is calculated directly from serum androgen and PSA data with a predictive accuracy of 88.7% (sensitivity: 90.2%, specificity: 85%). Our results demonstrate the potential and feasibility of using an evolutionary tumor dynamics model in combination with the appropriate data to aid in the adaptive management of prostate cancer.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2024

Suppressed Cosmic-Ray Energy Densities in Molecular Clouds from Streaming Instability-regulated Transport

Abstract Cosmic rays (CRs) are the primary driver of ionization in star-forming molecular clouds (MCs). Despite their potential impacts on gas dynamics and chemistry, no simulations of star cluster formation following the creation of individual stars have included explicit cosmic-ray transport (CRT) to date. We conduct the first numerical simulations following the collapse of a 2000 M ⊙ MC and the subsequent star formation including CRT using the STAR FORmation in Gaseous Environments framework implemented in the GIZMO code. We show that when CRT is streaming-dominated, the CR energy in the cloud is strongly attenuated due to energy losses from the streaming instability. Consequently, in a Milky Way–like environment the median CR ionization rate in the cloud is low ( ζ ≲ 2 × 10 −19 s −1 ) during the main star-forming epoch of the calculation and the impact of CRs on the star formation in the cloud is limited. However, in high-CR environments, the CR distribution in the cloud is elevated ( ζ ≲ 6 × 10 −18 ), and the relatively higher CR pressure outside the cloud causes slightly earlier cloud collapse and increases the star formation efficiency by 50% to ∼13%. The initial mass function is similar in all cases except with possible variations in a high-CR environment. Further studies are needed to explain the range of ionization rates observed in MCs and explore star formation in extreme CR environments.

Astronomy & Astrophysics↗
DOE OSTI2024

Suppression of Collisionless Magnetic Reconnection in the High Ion β, Strong Guide Field Limit

Abstract In magnetic reconnection, the ion bulk outflow speed and ion heating have been shown to be set by the available reconnecting magnetic energy, i.e., the energy stored in the reconnecting magnetic field ( B r ). However, recent simulations, observations, and theoretical works have shown that the released magnetic energy is inhibited by upstream ion plasma beta β i —the relative ion thermal pressure normalized to magnetic pressure based on the reconnecting field—for antiparallel magnetic field configurations. Using kinetic theory and hybrid particle-in-cell simulations, we investigate the effects of β i on guide field reconnection. While previous works have suggested that guide field reconnection is uninfluenced by β i , we demonstrate that the reconnection process is modified and the outflow is reduced for sufficiently large β i > ( B r 2 + B g 2 ) / B r 2 . We develop a theoretical framework that shows that this reduction is consistent with an enhanced exhaust pressure gradient, which reduces the outflow speed as v out ∝ 1 / β i . These results apply to systems in which guide field reconnection is embedded in hot plasmas, such as reconnection at the boundary of eddies in fully developed turbulence like the solar wind or the magnetosheath as well as downstream of shocks such as the heliosheath or the mergers of galaxy clusters.

Giai, Carlos A.↗
DOE OSTI2021

SARS-CoV-2 suppresses anticoagulant and fibrinolytic gene expression in the lung

Extensive fibrin deposition in the lungs and altered levels of circulating blood coagulation proteins in COVID-19 patients imply local derangement of pathways that limit fibrin formation and/or promote its clearance. We examined transcriptional profiles of bronchoalveolar lavage fluid (BALF) samples to identify molecular mechanisms underlying these coagulopathies. mRNA levels for regulators of the kallikrein–kinin (C1-inhibitor), coagulation (thrombomodulin, endothelial protein C receptor), and fibrinolytic (urokinase and urokinase receptor) pathways were significantly reduced in COVID-19 patients. While transcripts for several coagulation proteins were increased, those encoding tissue factor, the protein that initiates coagulation and whose expression is frequently increased in inflammatory disorders, were not increased in BALF from COVID-19 patients. Our analysis implicates enhanced propagation of coagulation and decreased fibrinolysis as drivers of the coagulopathy in the lungs of COVID-19 patients.

59 BASIC BIOLOGICAL SCIENCES↗